JPS5610135A - Preparation of di-n-propylmalonic acid - Google Patents
Preparation of di-n-propylmalonic acidInfo
- Publication number
- JPS5610135A JPS5610135A JP8525579A JP8525579A JPS5610135A JP S5610135 A JPS5610135 A JP S5610135A JP 8525579 A JP8525579 A JP 8525579A JP 8525579 A JP8525579 A JP 8525579A JP S5610135 A JPS5610135 A JP S5610135A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- reaction medium
- raw material
- alkali metal
- metal hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain readily the titled compound with high yields useful as an intermediate for di-n-propylacetic acid, a preventive and remedy for epilepsy, by hydrolyzing di-n-proplycyanoacetic acid as a raw material with an alkali metal hydroxide in a reaction medium under heating.
CONSTITUTION: A di-n-proplycyanoacetic acid or di-n-propyl cyanoacetate shown by formula I (R is H or lower alkyl) is hydrolyzed with an alkali metal hydroxide in a reaction medium, usually in a water medium under heating, to give di-n-propylmalonic acid shown by the formula II. When di-n-propyl cyanoacetate is used as the raw material, the addition of an organic solvent, e.g., ethanol, to be mixed with water as the reaction medium, is preferable. The alkali metal hydroxide in an excess amount based on the raw material compound, preferably about 5W20 times equivalent weight, is used in a concentration of 10W40wt% in the reaction medium solution.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8525579A JPS5610135A (en) | 1979-07-04 | 1979-07-04 | Preparation of di-n-propylmalonic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8525579A JPS5610135A (en) | 1979-07-04 | 1979-07-04 | Preparation of di-n-propylmalonic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5610135A true JPS5610135A (en) | 1981-02-02 |
Family
ID=13853458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8525579A Pending JPS5610135A (en) | 1979-07-04 | 1979-07-04 | Preparation of di-n-propylmalonic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5610135A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58128829U (en) * | 1982-02-25 | 1983-08-31 | 工業技術院長 | gear assembly equipment |
JPS60217028A (en) * | 1984-04-11 | 1985-10-30 | Nissan Motor Co Ltd | Parts driving apparatus |
JPH01306137A (en) * | 1988-06-02 | 1989-12-11 | Fujitsu Ten Ltd | Method for inserting shaft and device thereof |
-
1979
- 1979-07-04 JP JP8525579A patent/JPS5610135A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58128829U (en) * | 1982-02-25 | 1983-08-31 | 工業技術院長 | gear assembly equipment |
JPS6320513Y2 (en) * | 1982-02-25 | 1988-06-07 | ||
JPS60217028A (en) * | 1984-04-11 | 1985-10-30 | Nissan Motor Co Ltd | Parts driving apparatus |
JPH0123259B2 (en) * | 1984-04-11 | 1989-05-01 | Nissan Motor | |
JPH01306137A (en) * | 1988-06-02 | 1989-12-11 | Fujitsu Ten Ltd | Method for inserting shaft and device thereof |
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