JPS56100786A - 1-azaerythrinan derivative - Google Patents

1-azaerythrinan derivative

Info

Publication number
JPS56100786A
JPS56100786A JP416080A JP416080A JPS56100786A JP S56100786 A JPS56100786 A JP S56100786A JP 416080 A JP416080 A JP 416080A JP 416080 A JP416080 A JP 416080A JP S56100786 A JPS56100786 A JP S56100786A
Authority
JP
Japan
Prior art keywords
formula
compound
azaerythrinan
give
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP416080A
Other languages
Japanese (ja)
Other versions
JPS6019911B2 (en
Inventor
Hiroshi Murai
Shingo Matsumura
Iwao Morita
Kenji Kazuno
Hiroshi Enomoto
Kiyoshi Kimura
Yutaka Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP55004160A priority Critical patent/JPS6019911B2/en
Publication of JPS56100786A publication Critical patent/JPS56100786A/en
Publication of JPS6019911B2 publication Critical patent/JPS6019911B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:1-Azaerythrinan derivatives of formula I (Y is -CH2-, -OCH2-; R1, R2, R3 are H, lower alkoxy; R4 is lower alkyl) and their acid adducts. EXAMPLE:16,17-Dimethoxy-1-methyl-1-azaerythrinan. USE:Analgesic: they have an activity of depressing the central nervous system. PREPARATION:A compound of formula II (R5 is lower alkyl) or formula III is reduced with a metal hydride to give the compound of formula I. The compound of formula II is obtained by the thermal condensation between a compound of formula IV (R6 is alkyl) and another compound of formula V followed by heating under acidic conditions. At the same time, a compound of formula VI also is obtained, which is alkylated at the 1 position to give the compound of formula III. The reduction of a compound of formula II or III is effected, e.g., using LiA1H4 in an inert organic solvent to give the titled compound in high yield.
JP55004160A 1980-01-17 1980-01-17 1-Azaerythrinane derivative Expired JPS6019911B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55004160A JPS6019911B2 (en) 1980-01-17 1980-01-17 1-Azaerythrinane derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55004160A JPS6019911B2 (en) 1980-01-17 1980-01-17 1-Azaerythrinane derivative

Publications (2)

Publication Number Publication Date
JPS56100786A true JPS56100786A (en) 1981-08-12
JPS6019911B2 JPS6019911B2 (en) 1985-05-18

Family

ID=11576982

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55004160A Expired JPS6019911B2 (en) 1980-01-17 1980-01-17 1-Azaerythrinane derivative

Country Status (1)

Country Link
JP (1) JPS6019911B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997832A (en) * 1988-04-20 1991-03-05 Ciba-Geigy Corporation Heterotetracyclic lactam derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10362273B2 (en) 2011-08-05 2019-07-23 Honeywell International Inc. Systems and methods for managing video data
US10523903B2 (en) 2013-10-30 2019-12-31 Honeywell International Inc. Computer implemented systems frameworks and methods configured for enabling review of incident data

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997832A (en) * 1988-04-20 1991-03-05 Ciba-Geigy Corporation Heterotetracyclic lactam derivatives

Also Published As

Publication number Publication date
JPS6019911B2 (en) 1985-05-18

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