JPS57169480A - Production of indole derivative - Google Patents

Production of indole derivative

Info

Publication number
JPS57169480A
JPS57169480A JP56054392A JP5439281A JPS57169480A JP S57169480 A JPS57169480 A JP S57169480A JP 56054392 A JP56054392 A JP 56054392A JP 5439281 A JP5439281 A JP 5439281A JP S57169480 A JPS57169480 A JP S57169480A
Authority
JP
Japan
Prior art keywords
formula
compound
isopropyloxazolidin
amine
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56054392A
Other languages
Japanese (ja)
Inventor
Kiyonori Yokogoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PAAMAKEMU AJIA KK
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Original Assignee
PAAMAKEMU AJIA KK
PAAMAKEMU ASIA KK
Permachem Asia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PAAMAKEMU AJIA KK, PAAMAKEMU ASIA KK, Permachem Asia Ltd filed Critical PAAMAKEMU AJIA KK
Priority to JP56054392A priority Critical patent/JPS57169480A/en
Publication of JPS57169480A publication Critical patent/JPS57169480A/en
Pending legal-status Critical Current

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  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PURPOSE: The reaction between a specific isocyano compound and a specific lithium amide gives the titled derivative used as a synthetic intermediate of β- receptor blocking agent, remedy for arrhythmia and arterial diseases, simply and economically.
CONSTITUTION: For example, a nitrotoluene derivative of formulaI(Z is 5- methyl-3-alkyloxazolidin-2-one residue) is reduced to an amine of formula II and the amine is converted into an isocyano compound of formula III (R is alkyl) such as 5-(2-methyl-3-isocyanophenyl)-oxymethyl-3-isopropyloxazolidin-2-one. The isocyano compound is made to react with lithium amide of formula IV (R1 is alkyl, aralkyl, aryl) such as Li-diisopropylamide to give the objective compound of formula V such as 5-(4-indolyloxymethyl)-3-isopropyloxazolidin-2-one.
COPYRIGHT: (C)1982,JPO&Japio
JP56054392A 1981-04-13 1981-04-13 Production of indole derivative Pending JPS57169480A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56054392A JPS57169480A (en) 1981-04-13 1981-04-13 Production of indole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56054392A JPS57169480A (en) 1981-04-13 1981-04-13 Production of indole derivative

Publications (1)

Publication Number Publication Date
JPS57169480A true JPS57169480A (en) 1982-10-19

Family

ID=12969405

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56054392A Pending JPS57169480A (en) 1981-04-13 1981-04-13 Production of indole derivative

Country Status (1)

Country Link
JP (1) JPS57169480A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118026909A (en) * 2024-04-11 2024-05-14 江西师范大学 Preparation method of 3, 3-diaryl indolenine series compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118026909A (en) * 2024-04-11 2024-05-14 江西师范大学 Preparation method of 3, 3-diaryl indolenine series compounds

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