JPS57169480A - Production of indole derivative - Google Patents
Production of indole derivativeInfo
- Publication number
- JPS57169480A JPS57169480A JP56054392A JP5439281A JPS57169480A JP S57169480 A JPS57169480 A JP S57169480A JP 56054392 A JP56054392 A JP 56054392A JP 5439281 A JP5439281 A JP 5439281A JP S57169480 A JPS57169480 A JP S57169480A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- isopropyloxazolidin
- amine
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PURPOSE: The reaction between a specific isocyano compound and a specific lithium amide gives the titled derivative used as a synthetic intermediate of β- receptor blocking agent, remedy for arrhythmia and arterial diseases, simply and economically.
CONSTITUTION: For example, a nitrotoluene derivative of formulaI(Z is 5- methyl-3-alkyloxazolidin-2-one residue) is reduced to an amine of formula II and the amine is converted into an isocyano compound of formula III (R is alkyl) such as 5-(2-methyl-3-isocyanophenyl)-oxymethyl-3-isopropyloxazolidin-2-one. The isocyano compound is made to react with lithium amide of formula IV (R1 is alkyl, aralkyl, aryl) such as Li-diisopropylamide to give the objective compound of formula V such as 5-(4-indolyloxymethyl)-3-isopropyloxazolidin-2-one.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56054392A JPS57169480A (en) | 1981-04-13 | 1981-04-13 | Production of indole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56054392A JPS57169480A (en) | 1981-04-13 | 1981-04-13 | Production of indole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57169480A true JPS57169480A (en) | 1982-10-19 |
Family
ID=12969405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56054392A Pending JPS57169480A (en) | 1981-04-13 | 1981-04-13 | Production of indole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57169480A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN118026909A (en) * | 2024-04-11 | 2024-05-14 | 江西师范大学 | Preparation method of 3, 3-diaryl indolenine series compounds |
-
1981
- 1981-04-13 JP JP56054392A patent/JPS57169480A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN118026909A (en) * | 2024-04-11 | 2024-05-14 | 江西师范大学 | Preparation method of 3, 3-diaryl indolenine series compounds |
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