JPS56100784A - Indolizine derivative - Google Patents

Indolizine derivative

Info

Publication number: JPS56100784A
Authority: JP; Japan
Prior art keywords: formula; alkyl; compound; englobement; analgesic
Prior art date: 1980-01-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP401280A

Other languages

English (en)

Inventor

Takanori Oe

Minoru Moriwaki

Kazuhiro Goto

Masao Kudome

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Welfide Corp

Original Assignee

Welfide Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-01-16

Filing date

1980-01-16

Publication date

1981-08-12

1980-01-16 Application filed by Welfide Corp filed Critical Welfide Corp

1980-01-16 Priority to JP401280A priority Critical patent/JPS56100784A/ja

1981-01-13 Priority to EP81900262A priority patent/EP0043858B1/en

1981-01-13 Priority to PCT/JP1981/000007 priority patent/WO1981002013A1/ja

1981-01-13 Priority to DE8181900262T priority patent/DE3163121D1/de

1981-01-13 Priority to US06/297,696 priority patent/US4386092A/en

1981-08-12 Publication of JPS56100784A publication Critical patent/JPS56100784A/ja

Status Pending legal-status Critical Current

Links

125000003406 indolizinyl group Chemical class C=1(C=CN2C=CC=CC12)* 0.000 title 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
230000000202 analgesic effect Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
206010061218 Inflammation Diseases 0.000 abstract 1
230000001133 acceleration Effects 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000003356 anti-rheumatic effect Effects 0.000 abstract 1
239000003435 antirheumatic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000003327 cancerostatic effect Effects 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
YYRGKNSWKVPQBS-UHFFFAOYSA-N ethyl 2,4-dioxo-4-(2-phenylindolizin-3-yl)butanoate Chemical compound C1=C2C=CC=CN2C(C(=O)CC(=O)C(=O)OCC)=C1C1=CC=CC=C1 YYRGKNSWKVPQBS-UHFFFAOYSA-N 0.000 abstract 1
HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical compound C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
210000002540 macrophage Anatomy 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

JP401280A 1980-01-16 1980-01-16 Indolizine derivative Pending JPS56100784A (en)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
JP401280A JPS56100784A (en)	1980-01-16	1980-01-16	Indolizine derivative
EP81900262A EP0043858B1 (en)	1980-01-16	1981-01-13	Hetero ring-substituted oxoalkanoic acid derivatives
PCT/JP1981/000007 WO1981002013A1 (en)	1980-01-16	1981-01-13	Hetero ring-substituted oxoalkanoic acid derivatives
DE8181900262T DE3163121D1 (de)	1980-01-16	1981-01-13	Hetero ring-substituted oxoalkanoic acid derivatives
US06/297,696 US4386092A (en)	1980-01-16	1981-01-13	Heterocyclic-substituted oxoalkanoic acid derivatives

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP401280A JPS56100784A (en)	1980-01-16	1980-01-16	Indolizine derivative

Publications (1)

Publication Number	Publication Date
JPS56100784A true JPS56100784A (en)	1981-08-12

Family

ID=11573050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP401280A Pending JPS56100784A (en)	1980-01-16	1980-01-16	Indolizine derivative

Country Status (5)

Country	Link
US (1)	US4386092A (ja)
EP (1)	EP0043858B1 (ja)
JP (1)	JPS56100784A (ja)
DE (1)	DE3163121D1 (ja)
WO (1)	WO1981002013A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4880824A (en) *	1987-09-21	1989-11-14	Ortho Pharmaceutical Corporation	Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers
US5260451A (en) *	1989-05-11	1993-11-09	Merckle Gmbh	Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE3915450A1 (de) *	1989-05-11	1990-11-15	Gerd Prof Dr Dannhardt	Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
FR2699919B1 (fr) *	1992-12-24	1995-01-27	Synthelabo	Dérivés d'imidazole, leur procédé de préparation et leur application en thérapeutique.
EP1086091A4 (en) *	1998-06-03	2001-10-10	Merck & Co Inc	HIV INTEGRASE INHIBITORS
CA2329134A1 (en) *	1998-06-03	1999-12-09	David L. Clark	Hiv integrase inhibitors
US6262055B1 (en) *	1998-06-03	2001-07-17	Merck & Co., Inc.	HIV integrase inhibitors
US6380249B1 (en)	1998-06-03	2002-04-30	Merck & Co., Inc.	HIV integrase inhibitors
US6306891B1 (en) *	1998-06-03	2001-10-23	Merck & Co., Inc.	HIV integrase inhibitors
GB9816358D0 (en) *	1998-07-27	1998-09-23	Angeletti P Ist Richerche Bio	Enzyme inhibitors
WO2000006529A1 (en)	1998-07-27	2000-02-10	Istituto Di Ricerche Di Biologia Molecolare P Angeletti S.P.A.	Diketoacid-derivatives as inhibitors of polymerases
AP2001002169A0 (en)	1998-12-25	2001-06-30	Shionogi & Co	Aromatic heterocycle compounds having hiv intergrase inhibiting activities
DE10004157A1 (de)	2000-02-01	2001-08-02	Merckle Gmbh Chem Pharm Fabrik	4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
ATE482208T1 (de) *	2004-03-10	2010-10-15	Us Of America Represented By T	Chinolin-4-one als inhibitoren der retroviralen integrase zur behandlung von hiv, aids und aids- related complex (arc)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1076089A (en) *	1965-11-09	1967-07-19	Selvi & C Lab Bioterapico	New derivatives of imidazo [1,2-a]-pyridine and a process for the manufacture thereof
CH621126A5 (ja) *	1974-02-07	1981-01-15	Plantex Ltd
GB1493043A (en) *	1975-11-19	1977-11-23	Auto Security Prod Ltd	Locking device

1980
- 1980-01-16 JP JP401280A patent/JPS56100784A/ja active Pending
1981
- 1981-01-13 DE DE8181900262T patent/DE3163121D1/de not_active Expired
- 1981-01-13 US US06/297,696 patent/US4386092A/en not_active Expired - Fee Related
- 1981-01-13 WO PCT/JP1981/000007 patent/WO1981002013A1/ja active IP Right Grant
- 1981-01-13 EP EP81900262A patent/EP0043858B1/en not_active Expired

Also Published As

Publication number	Publication date
EP0043858A4 (en)	1982-05-10
EP0043858A1 (en)	1982-01-20
DE3163121D1 (de)	1984-05-24
EP0043858B1 (en)	1984-04-18
WO1981002013A1 (en)	1981-07-23
US4386092A (en)	1983-05-31

Publication	Publication Date	Title
JPS56100784A (en)	1981-08-12	Indolizine derivative
JPS5788170A (en)	1982-06-01	Thiazolidone derivative
JPS57192342A (en)	1982-11-26	Isoprenylamine derivative
JPS57192340A (en)	1982-11-26	Isoprenylamine derivative
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JPS55151549A (en)	1980-11-26	Production of guanidinocaproic ester
JPS57212188A (en)	1982-12-27	Imidazobenzoxazine derivative and its preparation
JPS5798232A (en)	1982-06-18	1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
JPS554334A (en)	1980-01-12	Pyranopyrazole derivative
JPS55105643A (en)	1980-08-13	Novel cyclohexanecarboxylic acid derivative
JPS57131738A (en)	1982-08-14	Novel cyclohexanecarboxylic acid derivative
JPS5750952A (en)	1982-03-25	Benzoic acid derivative
JPS55143973A (en)	1980-11-10	Phenylacetic acid derivative
JPS572257A (en)	1982-01-07	Preparation of 4-hydroxybenzylnitrile derivative
JPS5527161A (en)	1980-02-27	Production of alcohol or its ether derivative
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JPS57131745A (en)	1982-08-14	Novel cyclohexanecarboxylic acid derivative
JPS54130599A (en)	1979-10-09	Furoindole derivative
JPS5639074A (en)	1981-04-14	Pyrimidine derivative
JPS5716840A (en)	1982-01-28	Phneylacetic acid derivative
JPS5731656A (en)	1982-02-20	S-alkyl-n-acetyl-cysteinamide and its preparation
JPS55104216A (en)	1980-08-09	Production of substituted arylacetic acid derivative
JPS5515426A (en)	1980-02-02	Pyranopyrrole derivative
JPS57171946A (en)	1982-10-22	Novel oxyacetic acid derivative, its preparation, and blood lipid level depressing agent containing said derivative as active component