JPS5585562A - O-halogen substituted butyrophenone derivative and preparation of its salt - Google Patents

O-halogen substituted butyrophenone derivative and preparation of its salt

Info

Publication number
JPS5585562A
JPS5585562A JP14506479A JP14506479A JPS5585562A JP S5585562 A JPS5585562 A JP S5585562A JP 14506479 A JP14506479 A JP 14506479A JP 14506479 A JP14506479 A JP 14506479A JP S5585562 A JPS5585562 A JP S5585562A
Authority
JP
Japan
Prior art keywords
formula
preparation
halogen substituted
salt
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14506479A
Other languages
Japanese (ja)
Other versions
JPS5545544B2 (en
Inventor
Kikuo Sasajima
Masaru Nakao
Isamu Maruyama
Keiichi Ono
Shigenari Katayama
Shigeo Inaba
Hisao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP14506479A priority Critical patent/JPS5585562A/en
Publication of JPS5585562A publication Critical patent/JPS5585562A/en
Publication of JPS5545544B2 publication Critical patent/JPS5545544B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:An o-halogen substituted butyrophenone derivative shown by the formula I (Z is formula II or III) and its acceptable salts in its preparation.
EXAMPLE: 8-[ γ-( 2,4-Difluorobenzoyl )propyl ]-1-phenyl-1,3,8-triazospiro[ 4,5 ]decane-4-one.
USE: Useful in itself as a drug for a mental disease, an anodyne, a sedative, a hypotensive agent and a synthetic intermediate for a drug, e.g., a mental disease or a tranquilizer.
PREPARATION: A compound, e.g., 1-( 2,4-difluorophenyl )-1,1-ethylenedioxy-4- chlorobutane, shown by the formula IV (Y is carbonyl-protective group in the form of C=Y; X is reactive ester of alcohol) is condensed with a piperidine derivative, e.g., 1-phenyl-1,3,8-triazaspiro[4,5]decane-4-one, etc., shown by the formula H-Z in a proper solvent, and the carbonyl-protective group is hydrolyzed to give the desired compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP14506479A 1979-11-08 1979-11-08 O-halogen substituted butyrophenone derivative and preparation of its salt Granted JPS5585562A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14506479A JPS5585562A (en) 1979-11-08 1979-11-08 O-halogen substituted butyrophenone derivative and preparation of its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14506479A JPS5585562A (en) 1979-11-08 1979-11-08 O-halogen substituted butyrophenone derivative and preparation of its salt

Publications (2)

Publication Number Publication Date
JPS5585562A true JPS5585562A (en) 1980-06-27
JPS5545544B2 JPS5545544B2 (en) 1980-11-18

Family

ID=15376538

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14506479A Granted JPS5585562A (en) 1979-11-08 1979-11-08 O-halogen substituted butyrophenone derivative and preparation of its salt

Country Status (1)

Country Link
JP (1) JPS5585562A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995288A (en) * 1982-11-22 1984-06-01 Sumitomo Chem Co Ltd Novel radioactive iodospiroperidol and its preparation
JP2003513088A (en) * 1999-10-29 2003-04-08 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and methods for their preparation
JP2007126474A (en) * 1999-12-06 2007-05-24 Euro-Celtique Sa Triazospiro compound having nociceptin receptor affinity

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995288A (en) * 1982-11-22 1984-06-01 Sumitomo Chem Co Ltd Novel radioactive iodospiroperidol and its preparation
JPH0532394B2 (en) * 1982-11-22 1993-05-14 Sumitomo Chemical Co
JP2003513088A (en) * 1999-10-29 2003-04-08 ベーリンガー インゲルハイム ファルマ コマンディトゲゼルシャフト Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and methods for their preparation
JP2007126474A (en) * 1999-12-06 2007-05-24 Euro-Celtique Sa Triazospiro compound having nociceptin receptor affinity

Also Published As

Publication number Publication date
JPS5545544B2 (en) 1980-11-18

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