JPS5583775A - 13,14-epoxyprostaglandin - Google Patents

13,14-epoxyprostaglandin

Info

Publication number
JPS5583775A
JPS5583775A JP15629978A JP15629978A JPS5583775A JP S5583775 A JPS5583775 A JP S5583775A JP 15629978 A JP15629978 A JP 15629978A JP 15629978 A JP15629978 A JP 15629978A JP S5583775 A JPS5583775 A JP S5583775A
Authority
JP
Japan
Prior art keywords
group
compound
formula
alkyl
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15629978A
Other languages
Japanese (ja)
Other versions
JPS6215549B2 (en
Inventor
Hisao Nishiyama
Kiyotaka Ono
Shintaro Nishio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP15629978A priority Critical patent/JPS5583775A/en
Publication of JPS5583775A publication Critical patent/JPS5583775A/en
Publication of JPS6215549B2 publication Critical patent/JPS6215549B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 is H, 1W12C alkyl, 3W12C cycloalkyl, substituted phenyl group, etc.; R2 is 3W12C alkyl, cycloalkyl group, etc. which may have 0W5 oxygen atoms linked to any positions; X is C=0 or H-C... OH; Y is H-C...OH, H-C...CH2OH, or H-C...OMe, Z is -CH=CH-, etc.; W is H or 1W3C alkyl group).
EXAMPLE: 13,14-α-Epoxy-PGF2αmethyl ester.
USE: Medicines having smooth muscle stimulating, gastric secretion inhibitory, antidepressive, corpus luteum regressive, and blood platelet antiagglutinative actions. The α-epoxy group at the 14-position is characteristic and affects the 15-α-hydroxy group stereospecifically.
PROCESS: The allyl alcohol moiety of the compound of formula II is epoxidized sterically selectively to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP15629978A 1978-12-20 1978-12-20 13,14-epoxyprostaglandin Granted JPS5583775A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15629978A JPS5583775A (en) 1978-12-20 1978-12-20 13,14-epoxyprostaglandin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15629978A JPS5583775A (en) 1978-12-20 1978-12-20 13,14-epoxyprostaglandin

Publications (2)

Publication Number Publication Date
JPS5583775A true JPS5583775A (en) 1980-06-24
JPS6215549B2 JPS6215549B2 (en) 1987-04-08

Family

ID=15624767

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15629978A Granted JPS5583775A (en) 1978-12-20 1978-12-20 13,14-epoxyprostaglandin

Country Status (1)

Country Link
JP (1) JPS5583775A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254704A (en) * 1991-05-20 1993-10-19 Chisso Corporation Optically active epoxides and a process for the production thereof
JP2004346080A (en) * 1992-09-21 2004-12-09 Allergan Inc Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivative as medicine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254704A (en) * 1991-05-20 1993-10-19 Chisso Corporation Optically active epoxides and a process for the production thereof
JP2004346080A (en) * 1992-09-21 2004-12-09 Allergan Inc Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivative as medicine

Also Published As

Publication number Publication date
JPS6215549B2 (en) 1987-04-08

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