JPS5569583A - Pyrido 3,2,1-jk carbazole derivative - Google Patents

Pyrido 3,2,1-jk carbazole derivative

Info

Publication number
JPS5569583A
JPS5569583A JP14273178A JP14273178A JPS5569583A JP S5569583 A JPS5569583 A JP S5569583A JP 14273178 A JP14273178 A JP 14273178A JP 14273178 A JP14273178 A JP 14273178A JP S5569583 A JPS5569583 A JP S5569583A
Authority
JP
Japan
Prior art keywords
compound
formula
pyrido
reacted
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14273178A
Other languages
Japanese (ja)
Other versions
JPS6113718B2 (en
Inventor
Hiroshi Ishikawa
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP14273178A priority Critical patent/JPS5569583A/en
Priority to DE2953973A priority patent/DE2953973C2/de
Priority to DE19792914258 priority patent/DE2914258A1/en
Priority to DE2953974A priority patent/DE2953974C2/de
Priority to IT48690/79A priority patent/IT1196531B/en
Priority to DK149379A priority patent/DK160306C/en
Priority to NO791224A priority patent/NO152788C/en
Priority to AU46037/79A priority patent/AU529330B2/en
Priority to MX786779U priority patent/MX6158E/en
Priority to FI791191A priority patent/FI66612C/en
Priority to ES480274A priority patent/ES480274A1/en
Priority to AT269179A priority patent/AT376673B/en
Priority to PT6947479A priority patent/PT69474A/en
Priority to SU792751555A priority patent/SU993818A3/en
Priority to CA000325376A priority patent/CA1153374A/en
Priority to CH343379A priority patent/CH640853A5/en
Priority to GB7913039A priority patent/GB2019844B/en
Priority to FR7909338A priority patent/FR2422658A1/en
Priority to GB7913040A priority patent/GB2020279B/en
Priority to NLAANVRAGE7902905,A priority patent/NL180664C/en
Publication of JPS5569583A publication Critical patent/JPS5569583A/en
Priority to US06/195,691 priority patent/US4416884A/en
Priority to AT290183A priority patent/AT377986B/en
Publication of JPS6113718B2 publication Critical patent/JPS6113718B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I and its salts.
EXAMPLE: 1-Piperazinyl-7a,8,9,10,11,11a-hexahydro-4H-pyrido[ 3,2,1-jk ]carbazole- 4-oxo-5-carboxylic acid hydrochloride.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria, particularly pseudomonas aeruginosa and hemolytic streptococci. Intermediate for the synthesis of penicillanic acid derivatives.
PROCESS: A compound of formula II: (X is halogen) is reacted with a compound of formula III: (R1 and R2 are lower alkyl groups) in the presence or absence of a solvent, e.g. methanol, at room temperature to 150°C to give a compound, which is cyclized to form a compound of formula IV. The resulting compound is hydrolyzed in the presence of a catalyst to afford a compound, which is reacted with a compound of formula V in an inert solvent, e.g. methanol, at 100W250°C to yield the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP14273178A 1978-04-12 1978-11-17 Pyrido 3,2,1-jk carbazole derivative Granted JPS5569583A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
JP14273178A JPS5569583A (en) 1978-11-17 1978-11-17 Pyrido 3,2,1-jk carbazole derivative
DE2953973A DE2953973C2 (en) 1978-04-12 1979-04-09
DE19792914258 DE2914258A1 (en) 1978-04-12 1979-04-09 PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS, METHODS OF PREPARING THEREOF, AND AGENTS CONTAINING THEM
DE2953974A DE2953974C2 (en) 1978-04-12 1979-04-09
IT48690/79A IT1196531B (en) 1978-04-12 1979-04-10 PIPERAZINYL-BENZOETEROCYCLIC COMPOUNDS PROCEDURE FOR THE PRODUCTION AND PHARMACEUTICAL PREPARATION CONTAINING THEM
DK149379A DK160306C (en) 1978-08-31 1979-04-10 METHOD OF ANALOGUE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
NO791224A NO152788C (en) 1978-08-31 1979-04-10 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS.
AT269179A AT376673B (en) 1978-08-31 1979-04-11 METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
MX786779U MX6158E (en) 1978-08-31 1979-04-11 PROCEDURE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCICLICOS DERIVATIVES
FI791191A FI66612C (en) 1978-08-31 1979-04-11 FAR OIL FRAMSTAELLNING AV NYA SAOSOM ANTIMICROBICA ANAENDBARA PIPERAZINYLBENSOHETEROCYCLISKA FOERENINGAR
ES480274A ES480274A1 (en) 1978-08-31 1979-04-11 Method of preparing piperacinilbenzoheterociclicos and intermediate compounds. (Machine-translation by Google Translate, not legally binding)
AU46037/79A AU529330B2 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
PT6947479A PT69474A (en) 1978-08-31 1979-04-11 PROCESS FOR PREPARING PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS
SU792751555A SU993818A3 (en) 1978-08-31 1979-04-11 Process for preparing derivatives of piperazinyl benzoheterocyclic compounds or their acid addition salts
CA000325376A CA1153374A (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterocyclic compounds
CH343379A CH640853A5 (en) 1978-04-12 1979-04-11 Piperazinylbenzoheterozyklische compounds and preparation bacteriostatic what this includes.
GB7913039A GB2019844B (en) 1978-04-12 1979-04-12 Lactam series compound
FR7909338A FR2422658A1 (en) 1978-04-12 1979-04-12 PIPERAZINYL-BENZOHETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USES
GB7913040A GB2020279B (en) 1978-04-12 1979-04-12 Piperazinylbenzoheterocyclic compounds
NLAANVRAGE7902905,A NL180664C (en) 1978-04-12 1979-04-12 1,8-ALKYLENE-3-CARBOXY-4-OXO-7-PIPERAZINOQUINOLINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, AND ANTI-MICROBILE PREPARATIONS CONTAINING SUCH A COMPOUND AS AN ACTIVE SUBSTANCE.
US06/195,691 US4416884A (en) 1978-04-12 1980-10-09 Piperazinylbenzoheterocyclic compounds
AT290183A AT377986B (en) 1978-08-31 1983-08-11 METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14273178A JPS5569583A (en) 1978-11-17 1978-11-17 Pyrido 3,2,1-jk carbazole derivative

Publications (2)

Publication Number Publication Date
JPS5569583A true JPS5569583A (en) 1980-05-26
JPS6113718B2 JPS6113718B2 (en) 1986-04-15

Family

ID=15322261

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14273178A Granted JPS5569583A (en) 1978-04-12 1978-11-17 Pyrido 3,2,1-jk carbazole derivative

Country Status (1)

Country Link
JP (1) JPS5569583A (en)

Also Published As

Publication number Publication date
JPS6113718B2 (en) 1986-04-15

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