JPS5569583A - Pyrido 3,2,1-jk carbazole derivative - Google Patents
Pyrido 3,2,1-jk carbazole derivativeInfo
- Publication number
- JPS5569583A JPS5569583A JP14273178A JP14273178A JPS5569583A JP S5569583 A JPS5569583 A JP S5569583A JP 14273178 A JP14273178 A JP 14273178A JP 14273178 A JP14273178 A JP 14273178A JP S5569583 A JPS5569583 A JP S5569583A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- pyrido
- reacted
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I and its salts.
EXAMPLE: 1-Piperazinyl-7a,8,9,10,11,11a-hexahydro-4H-pyrido[ 3,2,1-jk ]carbazole- 4-oxo-5-carboxylic acid hydrochloride.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria, particularly pseudomonas aeruginosa and hemolytic streptococci. Intermediate for the synthesis of penicillanic acid derivatives.
PROCESS: A compound of formula II: (X is halogen) is reacted with a compound of formula III: (R1 and R2 are lower alkyl groups) in the presence or absence of a solvent, e.g. methanol, at room temperature to 150°C to give a compound, which is cyclized to form a compound of formula IV. The resulting compound is hydrolyzed in the presence of a catalyst to afford a compound, which is reacted with a compound of formula V in an inert solvent, e.g. methanol, at 100W250°C to yield the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14273178A JPS5569583A (en) | 1978-11-17 | 1978-11-17 | Pyrido 3,2,1-jk carbazole derivative |
DE2953973A DE2953973C2 (en) | 1978-04-12 | 1979-04-09 | |
DE19792914258 DE2914258A1 (en) | 1978-04-12 | 1979-04-09 | PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS, METHODS OF PREPARING THEREOF, AND AGENTS CONTAINING THEM |
DE2953974A DE2953974C2 (en) | 1978-04-12 | 1979-04-09 | |
IT48690/79A IT1196531B (en) | 1978-04-12 | 1979-04-10 | PIPERAZINYL-BENZOETEROCYCLIC COMPOUNDS PROCEDURE FOR THE PRODUCTION AND PHARMACEUTICAL PREPARATION CONTAINING THEM |
DK149379A DK160306C (en) | 1978-08-31 | 1979-04-10 | METHOD OF ANALOGUE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF |
NO791224A NO152788C (en) | 1978-08-31 | 1979-04-10 | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS. |
AT269179A AT376673B (en) | 1978-08-31 | 1979-04-11 | METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
MX786779U MX6158E (en) | 1978-08-31 | 1979-04-11 | PROCEDURE FOR THE PREPARATION OF PIPERAZINYLBENZOHETEROCICLICOS DERIVATIVES |
FI791191A FI66612C (en) | 1978-08-31 | 1979-04-11 | FAR OIL FRAMSTAELLNING AV NYA SAOSOM ANTIMICROBICA ANAENDBARA PIPERAZINYLBENSOHETEROCYCLISKA FOERENINGAR |
ES480274A ES480274A1 (en) | 1978-08-31 | 1979-04-11 | Method of preparing piperacinilbenzoheterociclicos and intermediate compounds. (Machine-translation by Google Translate, not legally binding) |
AU46037/79A AU529330B2 (en) | 1978-04-12 | 1979-04-11 | Piperazinylbenzoheterocyclic compounds |
PT6947479A PT69474A (en) | 1978-08-31 | 1979-04-11 | PROCESS FOR PREPARING PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS |
SU792751555A SU993818A3 (en) | 1978-08-31 | 1979-04-11 | Process for preparing derivatives of piperazinyl benzoheterocyclic compounds or their acid addition salts |
CA000325376A CA1153374A (en) | 1978-04-12 | 1979-04-11 | Piperazinylbenzoheterocyclic compounds |
CH343379A CH640853A5 (en) | 1978-04-12 | 1979-04-11 | Piperazinylbenzoheterozyklische compounds and preparation bacteriostatic what this includes. |
GB7913039A GB2019844B (en) | 1978-04-12 | 1979-04-12 | Lactam series compound |
FR7909338A FR2422658A1 (en) | 1978-04-12 | 1979-04-12 | PIPERAZINYL-BENZOHETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USES |
GB7913040A GB2020279B (en) | 1978-04-12 | 1979-04-12 | Piperazinylbenzoheterocyclic compounds |
NLAANVRAGE7902905,A NL180664C (en) | 1978-04-12 | 1979-04-12 | 1,8-ALKYLENE-3-CARBOXY-4-OXO-7-PIPERAZINOQUINOLINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, AND ANTI-MICROBILE PREPARATIONS CONTAINING SUCH A COMPOUND AS AN ACTIVE SUBSTANCE. |
US06/195,691 US4416884A (en) | 1978-04-12 | 1980-10-09 | Piperazinylbenzoheterocyclic compounds |
AT290183A AT377986B (en) | 1978-08-31 | 1983-08-11 | METHOD FOR PRODUCING NEW PIPERAZINYLBENZOHETEROCYCLIC COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14273178A JPS5569583A (en) | 1978-11-17 | 1978-11-17 | Pyrido 3,2,1-jk carbazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5569583A true JPS5569583A (en) | 1980-05-26 |
JPS6113718B2 JPS6113718B2 (en) | 1986-04-15 |
Family
ID=15322261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14273178A Granted JPS5569583A (en) | 1978-04-12 | 1978-11-17 | Pyrido 3,2,1-jk carbazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5569583A (en) |
-
1978
- 1978-11-17 JP JP14273178A patent/JPS5569583A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6113718B2 (en) | 1986-04-15 |
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