JPS55118489A - Heterocyclic ring condensed naphthyridine derivative - Google Patents

Heterocyclic ring condensed naphthyridine derivative

Info

Publication number
JPS55118489A
JPS55118489A JP2651879A JP2651879A JPS55118489A JP S55118489 A JPS55118489 A JP S55118489A JP 2651879 A JP2651879 A JP 2651879A JP 2651879 A JP2651879 A JP 2651879A JP S55118489 A JPS55118489 A JP S55118489A
Authority
JP
Japan
Prior art keywords
compound
formula
derivative
heterocyclic ring
ring condensed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2651879A
Other languages
Japanese (ja)
Other versions
JPS6237637B2 (en
Inventor
Yoshiaki Tanaka
Norio Suzuki
Kazunori Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP2651879A priority Critical patent/JPS55118489A/en
Publication of JPS55118489A publication Critical patent/JPS55118489A/en
Publication of JPS6237637B2 publication Critical patent/JPS6237637B2/ja
Granted legal-status Critical Current

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Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

NEW MATERIAL:A heterocyclic ring condensed naphthyridine derivative of formula I (X is O or S; R is lower alkyl group), and its salt.
EXAMPLE: 8-Ethyl-5,8-dihydro-5-oxofuro[2,3-b]1,8-naphthyridine-6-carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria.
PROCESS: A compound of formula II (R' is R) is alkylated to form a compound of formula III (R" is R), which is converted into an 6-NH2 derivative, which is led to an 7-OH derivative via the 6-CN and 6-CHO derivatives. The resulting 7-OH derivative is reacted with a bromomalonic ester to form a compound of formula VIII a compound of formula IX. The compound thus obtained is decarboxylated partly by heating in a solvent, e.g. quinoline, in the presence of copper powder to afford the compound of formula Ia.
COPYRIGHT: (C)1980,JPO&Japio
JP2651879A 1979-03-07 1979-03-07 Heterocyclic ring condensed naphthyridine derivative Granted JPS55118489A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2651879A JPS55118489A (en) 1979-03-07 1979-03-07 Heterocyclic ring condensed naphthyridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2651879A JPS55118489A (en) 1979-03-07 1979-03-07 Heterocyclic ring condensed naphthyridine derivative

Publications (2)

Publication Number Publication Date
JPS55118489A true JPS55118489A (en) 1980-09-11
JPS6237637B2 JPS6237637B2 (en) 1987-08-13

Family

ID=12195690

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2651879A Granted JPS55118489A (en) 1979-03-07 1979-03-07 Heterocyclic ring condensed naphthyridine derivative

Country Status (1)

Country Link
JP (1) JPS55118489A (en)

Also Published As

Publication number Publication date
JPS6237637B2 (en) 1987-08-13

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