JPS5555165A - N-(benzoylmercapto substituted acyl)-histidine - Google Patents
N-(benzoylmercapto substituted acyl)-histidineInfo
- Publication number
- JPS5555165A JPS5555165A JP10541479A JP10541479A JPS5555165A JP S5555165 A JPS5555165 A JP S5555165A JP 10541479 A JP10541479 A JP 10541479A JP 10541479 A JP10541479 A JP 10541479A JP S5555165 A JPS5555165 A JP S5555165A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- histidine
- substituted acyl
- benzoylmercapto
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002252 acyl group Chemical group 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 238000003436 Schotten-Baumann reaction Methods 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- UIJGNTRUPZPVNG-UHFFFAOYSA-N benzenecarbothioic s-acid Chemical compound SC(=O)C1=CC=CC=C1 UIJGNTRUPZPVNG-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Abstract
NEW MATERIAL:N-(Benzoylmercapto substituted acyl)-histidine of formula V: (n is 1 or 2).
USE: Drugs for arteriosclerosis or an intermediate for the novel compound of formula I which is one of the drugs.
PROCESS: A halogen substituted acyl halogenide of formula II is reacted with histidine of formula III by the Schotten-Baumann method to give an N-(halogen substituted acyl)-histidine of formula IV which is reacted with an alkali thiobenzoate or its aqueous solution to form the desired compound of formula V. The resulting compound is treated with an aqueous ammonia to afford the compound of formula I. Histidine of formula III may be any one of optically active isomers or racemic modifications.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54105414A JPS5934185B2 (en) | 1979-08-18 | 1979-08-18 | N-(benzoylmercapto-substituted acyl)-histidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54105414A JPS5934185B2 (en) | 1979-08-18 | 1979-08-18 | N-(benzoylmercapto-substituted acyl)-histidine |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2883976A Division JPS52111572A (en) | 1976-03-16 | 1976-03-16 | Nn*mercapto substituted acyl**hystidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5555165A true JPS5555165A (en) | 1980-04-22 |
| JPS5934185B2 JPS5934185B2 (en) | 1984-08-21 |
Family
ID=14406941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54105414A Expired JPS5934185B2 (en) | 1979-08-18 | 1979-08-18 | N-(benzoylmercapto-substituted acyl)-histidine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5934185B2 (en) |
-
1979
- 1979-08-18 JP JP54105414A patent/JPS5934185B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5934185B2 (en) | 1984-08-21 |
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