JPS5535056A - 3-substituted acetophenone and its preparation - Google Patents
3-substituted acetophenone and its preparationInfo
- Publication number
- JPS5535056A JPS5535056A JP10891478A JP10891478A JPS5535056A JP S5535056 A JPS5535056 A JP S5535056A JP 10891478 A JP10891478 A JP 10891478A JP 10891478 A JP10891478 A JP 10891478A JP S5535056 A JPS5535056 A JP S5535056A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- ester
- give
- substituted
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A 3-subslituted acetophenone of formula I: (X's are H, or may form O atom).
EXAMPLE: 3-Benzylacetophenone.
USE: An intermediate for the synthesis of 2-(3-benzoylphenyl)-propionic acid, an antiphlogistic and analgesic.
PROCESS: A 3-substituted benzoic acid of formula II is reacted with a halogenating agent, e.g. thionyl chloride, to give an acid halide of formula III: (Y is halogen), which is coupled with a malonic diester to form a 3-substituted benzoylmalonic ester of formula IV: (R is lower alkyl group). The ester is decomposed in a mixture of acids, e.g. acetic and conc. sulfuric acids, under heating to give the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10891478A JPS5535056A (en) | 1978-09-04 | 1978-09-04 | 3-substituted acetophenone and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10891478A JPS5535056A (en) | 1978-09-04 | 1978-09-04 | 3-substituted acetophenone and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5535056A true JPS5535056A (en) | 1980-03-11 |
Family
ID=14496834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10891478A Pending JPS5535056A (en) | 1978-09-04 | 1978-09-04 | 3-substituted acetophenone and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5535056A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01118139A (en) * | 1987-10-30 | 1989-05-10 | Konica Corp | Photosensitive body |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5116636A (en) * | 1974-07-29 | 1976-02-10 | Nisshin Flour Milling Co | 22 * chikanariiru * puropionsanno seiho |
JPS5165730A (en) * | 1974-12-03 | 1976-06-07 | Fujikawa Kk | FUENIRUARUKANKARUBONSANJUDOTAINO SEIHO |
JPS5236642A (en) * | 1975-06-24 | 1977-03-22 | Chinoin Gyogyszer Es Vegyeszet | Production of substituted phenylalkyl carboxylic acid |
JPS5334744A (en) * | 1976-09-11 | 1978-03-31 | Kyowa Hakko Kogyo Co Ltd | Preparation of 2-(4-alkylphenyl)propionic acids |
JPS557225A (en) * | 1978-06-28 | 1980-01-19 | Sanpo Kagaku Kenkyusho:Kk | Preparation of propionic acid derivative |
-
1978
- 1978-09-04 JP JP10891478A patent/JPS5535056A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5116636A (en) * | 1974-07-29 | 1976-02-10 | Nisshin Flour Milling Co | 22 * chikanariiru * puropionsanno seiho |
JPS5165730A (en) * | 1974-12-03 | 1976-06-07 | Fujikawa Kk | FUENIRUARUKANKARUBONSANJUDOTAINO SEIHO |
JPS5236642A (en) * | 1975-06-24 | 1977-03-22 | Chinoin Gyogyszer Es Vegyeszet | Production of substituted phenylalkyl carboxylic acid |
JPS5334744A (en) * | 1976-09-11 | 1978-03-31 | Kyowa Hakko Kogyo Co Ltd | Preparation of 2-(4-alkylphenyl)propionic acids |
JPS557225A (en) * | 1978-06-28 | 1980-01-19 | Sanpo Kagaku Kenkyusho:Kk | Preparation of propionic acid derivative |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01118139A (en) * | 1987-10-30 | 1989-05-10 | Konica Corp | Photosensitive body |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5731615A (en) | Remedy for skin disease with keratinization | |
JPS5535056A (en) | 3-substituted acetophenone and its preparation | |
JPS574987A (en) | Pyridoindolecarboxylic acid derivative and its preparation | |
JPS5625133A (en) | Preparation of fluorine-containing carboxylic acid ester | |
JPS54128567A (en) | 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative | |
JPS5665838A (en) | Preparation of beta-alkoxymethoxymethyl halide | |
JPS5515460A (en) | Novel 2-substituted-benzoylpropionic acid derivative | |
JPS5555135A (en) | Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid | |
JPS5618942A (en) | Novel terephthalic acid and its preparation | |
JPS54144347A (en) | 3-(2-fluoro-4-biphenylyl)-2-butanone | |
JPS5466640A (en) | Novel acrylophenone derivative and its preparation | |
JPS55122784A (en) | Novel acetic acid derivative and its preparation | |
JPS57167961A (en) | Alpha-thio-alpha-(6-methoxy-naphth-2-yl)propionic acid ester | |
JPS5673064A (en) | Isoquinoline derivative | |
JPS5572139A (en) | Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid | |
JPS5524142A (en) | 2-oxo-3-4-(1,3-dioxo-2-isoindolinyl)phenylbutanamide and its preparation | |
JPS54117457A (en) | Diacylsteroid derivative | |
JPS54135791A (en) | 7-methoxycephalosporin compound, its preparation, and antibacterial agent containing the compound as main component | |
JPS5479265A (en) | 2-(2,2-dihalovinyl)thiophene and its preparation | |
JPS5645467A (en) | Pantolactone derivative and its preparation | |
JPS5572140A (en) | Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid | |
JPS53103436A (en) | Preparation of bis(benzamido)benzoic acids | |
JPS5745151A (en) | Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative | |
JPS5527110A (en) | Benzanilide derivative | |
JPS559039A (en) | Novel propionic acid amide derivative and its preparation |