JPS5572140A - Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid - Google Patents

Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid

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Publication number
JPS5572140A
JPS5572140A JP14458578A JP14458578A JPS5572140A JP S5572140 A JPS5572140 A JP S5572140A JP 14458578 A JP14458578 A JP 14458578A JP 14458578 A JP14458578 A JP 14458578A JP S5572140 A JPS5572140 A JP S5572140A
Authority
JP
Japan
Prior art keywords
disubstituted
allyloxy
formula
reaction
phenylthioacetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14458578A
Other languages
Japanese (ja)
Inventor
Norio Miwa
Akira Hasegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOHO IYAKU KENKYUSHO KK
Original Assignee
TOHO IYAKU KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOHO IYAKU KENKYUSHO KK filed Critical TOHO IYAKU KENKYUSHO KK
Priority to JP14458578A priority Critical patent/JPS5572140A/en
Publication of JPS5572140A publication Critical patent/JPS5572140A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain a low toxic medicine exhibiting analgesic, antipyretic and antiphlogistic actions, etc., easily in one step, by the hydrolysis of a new 4-(4-allyloxy- 3,5-disubstituted-phenylthioacetyl)morpholine as a starting material.
CONSTITUTION: 4-Allyloxy-3,5-disubstituted-acetophenone of formula III, which is obtained by the reaction of allyl bromide and 3,5-disubstituted-4-hydroxyacetophenone of formula IV, is subjected to Willgerodt Kindler reaction, to obtain new 4-(4-allyloxy-3,5-disubstituted-phenylthioacetyl)morpholine of formula I. Then, the compound I is hydrolyzed, to obtain the desired compound of formula II (R1 is halogen or alkyl; R2 is H or halogen).
EFFECT: The reaction proceeds under extremely mild conditions, and the title compound can be obtained in high yield and high purity. Moreover, the operations are easy.
USE: Medicine having antispasmodic action.
COPYRIGHT: (C)1980,JPO&Japio
JP14458578A 1978-11-22 1978-11-22 Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid Pending JPS5572140A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14458578A JPS5572140A (en) 1978-11-22 1978-11-22 Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14458578A JPS5572140A (en) 1978-11-22 1978-11-22 Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid

Publications (1)

Publication Number Publication Date
JPS5572140A true JPS5572140A (en) 1980-05-30

Family

ID=15365524

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14458578A Pending JPS5572140A (en) 1978-11-22 1978-11-22 Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid

Country Status (1)

Country Link
JP (1) JPS5572140A (en)

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