JPS5572140A - Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid - Google Patents
Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acidInfo
- Publication number
- JPS5572140A JPS5572140A JP14458578A JP14458578A JPS5572140A JP S5572140 A JPS5572140 A JP S5572140A JP 14458578 A JP14458578 A JP 14458578A JP 14458578 A JP14458578 A JP 14458578A JP S5572140 A JPS5572140 A JP S5572140A
- Authority
- JP
- Japan
- Prior art keywords
- disubstituted
- allyloxy
- formula
- reaction
- phenylthioacetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain a low toxic medicine exhibiting analgesic, antipyretic and antiphlogistic actions, etc., easily in one step, by the hydrolysis of a new 4-(4-allyloxy- 3,5-disubstituted-phenylthioacetyl)morpholine as a starting material.
CONSTITUTION: 4-Allyloxy-3,5-disubstituted-acetophenone of formula III, which is obtained by the reaction of allyl bromide and 3,5-disubstituted-4-hydroxyacetophenone of formula IV, is subjected to Willgerodt Kindler reaction, to obtain new 4-(4-allyloxy-3,5-disubstituted-phenylthioacetyl)morpholine of formula I. Then, the compound I is hydrolyzed, to obtain the desired compound of formula II (R1 is halogen or alkyl; R2 is H or halogen).
EFFECT: The reaction proceeds under extremely mild conditions, and the title compound can be obtained in high yield and high purity. Moreover, the operations are easy.
USE: Medicine having antispasmodic action.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14458578A JPS5572140A (en) | 1978-11-22 | 1978-11-22 | Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14458578A JPS5572140A (en) | 1978-11-22 | 1978-11-22 | Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5572140A true JPS5572140A (en) | 1980-05-30 |
Family
ID=15365524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14458578A Pending JPS5572140A (en) | 1978-11-22 | 1978-11-22 | Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5572140A (en) |
-
1978
- 1978-11-22 JP JP14458578A patent/JPS5572140A/en active Pending
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