JPS55102567A - Nicotinoylpantethine derivative - Google Patents

Nicotinoylpantethine derivative

Info

Publication number
JPS55102567A
JPS55102567A JP952179A JP952179A JPS55102567A JP S55102567 A JPS55102567 A JP S55102567A JP 952179 A JP952179 A JP 952179A JP 952179 A JP952179 A JP 952179A JP S55102567 A JPS55102567 A JP S55102567A
Authority
JP
Japan
Prior art keywords
nicotinoylpantethine
lipodistrophy
formula
derivative
dimethylbutylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP952179A
Other languages
Japanese (ja)
Other versions
JPS6151585B2 (en
Inventor
Tosaku Miki
Akira Eriguchi
Kinya Kameda
Kazufumi Abiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP952179A priority Critical patent/JPS55102567A/en
Publication of JPS55102567A publication Critical patent/JPS55102567A/en
Publication of JPS6151585B2 publication Critical patent/JPS6151585B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

NEW MATERIAL:Nicotinoylpantethine derivatives of formula I (R1WR3 are H, nicotinoyl, where all of them are not hydrogen atoms at the same time) or their acid adducts.
EXAMPLE: 2, 4-Dihydroxy-N-[2-[(2-mercaptoethyl)carbamoyl]ethyl]-3, 3-dimethylbutylamide S-nicotinate.
USE: Lipodistrophy improver: they are effective on various kinds of diseases caused by lipodistrophy, e.g., hyperlipemia, arteriosclerosis, diabetes or alcoholic fatty liver and the suitable dosage is 200W2,000mg/day, man.
PREPARATION: Pantethine is made to react with nicotinic chloride in the presence of a tertiary amine, e.g., pyridine, as an acid acceptor with appropriate heat, preferably at 40W50°C to give the objective compound of formula I. When necessary, a reaction solvent may be employed.
COPYRIGHT: (C)1980,JPO&Japio
JP952179A 1979-01-30 1979-01-30 Nicotinoylpantethine derivative Granted JPS55102567A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP952179A JPS55102567A (en) 1979-01-30 1979-01-30 Nicotinoylpantethine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP952179A JPS55102567A (en) 1979-01-30 1979-01-30 Nicotinoylpantethine derivative

Publications (2)

Publication Number Publication Date
JPS55102567A true JPS55102567A (en) 1980-08-05
JPS6151585B2 JPS6151585B2 (en) 1986-11-10

Family

ID=11722562

Family Applications (1)

Application Number Title Priority Date Filing Date
JP952179A Granted JPS55102567A (en) 1979-01-30 1979-01-30 Nicotinoylpantethine derivative

Country Status (1)

Country Link
JP (1) JPS55102567A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323855A2 (en) * 1988-01-06 1989-07-12 Daiichi Pharmaceutical Co., Ltd. Pantethine as inhibitory agent of hepatic fibrosis

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61143289U (en) * 1985-02-25 1986-09-04

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0323855A2 (en) * 1988-01-06 1989-07-12 Daiichi Pharmaceutical Co., Ltd. Pantethine as inhibitory agent of hepatic fibrosis

Also Published As

Publication number Publication date
JPS6151585B2 (en) 1986-11-10

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