JPS55102567A - Nicotinoylpantethine derivative - Google Patents
Nicotinoylpantethine derivativeInfo
- Publication number
- JPS55102567A JPS55102567A JP952179A JP952179A JPS55102567A JP S55102567 A JPS55102567 A JP S55102567A JP 952179 A JP952179 A JP 952179A JP 952179 A JP952179 A JP 952179A JP S55102567 A JPS55102567 A JP S55102567A
- Authority
- JP
- Japan
- Prior art keywords
- nicotinoylpantethine
- lipodistrophy
- formula
- derivative
- dimethylbutylamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
NEW MATERIAL:Nicotinoylpantethine derivatives of formula I (R1WR3 are H, nicotinoyl, where all of them are not hydrogen atoms at the same time) or their acid adducts.
EXAMPLE: 2, 4-Dihydroxy-N-[2-[(2-mercaptoethyl)carbamoyl]ethyl]-3, 3-dimethylbutylamide S-nicotinate.
USE: Lipodistrophy improver: they are effective on various kinds of diseases caused by lipodistrophy, e.g., hyperlipemia, arteriosclerosis, diabetes or alcoholic fatty liver and the suitable dosage is 200W2,000mg/day, man.
PREPARATION: Pantethine is made to react with nicotinic chloride in the presence of a tertiary amine, e.g., pyridine, as an acid acceptor with appropriate heat, preferably at 40W50°C to give the objective compound of formula I. When necessary, a reaction solvent may be employed.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP952179A JPS55102567A (en) | 1979-01-30 | 1979-01-30 | Nicotinoylpantethine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP952179A JPS55102567A (en) | 1979-01-30 | 1979-01-30 | Nicotinoylpantethine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55102567A true JPS55102567A (en) | 1980-08-05 |
JPS6151585B2 JPS6151585B2 (en) | 1986-11-10 |
Family
ID=11722562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP952179A Granted JPS55102567A (en) | 1979-01-30 | 1979-01-30 | Nicotinoylpantethine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55102567A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0323855A2 (en) * | 1988-01-06 | 1989-07-12 | Daiichi Pharmaceutical Co., Ltd. | Pantethine as inhibitory agent of hepatic fibrosis |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61143289U (en) * | 1985-02-25 | 1986-09-04 |
-
1979
- 1979-01-30 JP JP952179A patent/JPS55102567A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0323855A2 (en) * | 1988-01-06 | 1989-07-12 | Daiichi Pharmaceutical Co., Ltd. | Pantethine as inhibitory agent of hepatic fibrosis |
Also Published As
Publication number | Publication date |
---|---|
JPS6151585B2 (en) | 1986-11-10 |
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