JPS5481216A - Production acid amide - Google Patents

Production acid amide

Info

Publication number
JPS5481216A
JPS5481216A JP14791377A JP14791377A JPS5481216A JP S5481216 A JPS5481216 A JP S5481216A JP 14791377 A JP14791377 A JP 14791377A JP 14791377 A JP14791377 A JP 14791377A JP S5481216 A JPS5481216 A JP S5481216A
Authority
JP
Japan
Prior art keywords
reaction
mineral
reaction accelerator
acid amide
carboxyalkane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14791377A
Other languages
Japanese (ja)
Other versions
JPS5642594B2 (en
Inventor
Osamu Akazawa
Katsumasa Yamamoto
Michio Fujimoto
Yukihiro Miyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP14791377A priority Critical patent/JPS5481216A/en
Publication of JPS5481216A publication Critical patent/JPS5481216A/en
Publication of JPS5642594B2 publication Critical patent/JPS5642594B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: The reaction of ω-amino-α-carboxyalkane with mercaptoaminoalkane is conducted in the presence of a carbodiimide in an organic solvent using a mineral or organic sulfonic acid as a reaction accelerator to produce acid amide in high yeild.
CONSTITUTION: The reaction of an ω-amino-α-carboxyalkane or its alkali or alkaline earth metal salt with an ω-mercapto-α-aminoalkane or its disulfide or mineral acid salt is conducted in the presence of a carbodiimide and a reaction accelerator as mineral or organic sulfonic acid in an organic solvent to produce a compound having amide linkages.
EFFECT: The reagents used in the present invention are inexpensive and the amount of the reaction accelerator is required only about 1/10 of that required in the conventional process using 1-hydroxybenztriazole or succinimide. Further the use of water-containing pyridine or DMF as a solvent increases the yield.
COPYRIGHT: (C)1979,JPO&Japio
JP14791377A 1977-12-09 1977-12-09 Production acid amide Granted JPS5481216A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14791377A JPS5481216A (en) 1977-12-09 1977-12-09 Production acid amide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14791377A JPS5481216A (en) 1977-12-09 1977-12-09 Production acid amide

Publications (2)

Publication Number Publication Date
JPS5481216A true JPS5481216A (en) 1979-06-28
JPS5642594B2 JPS5642594B2 (en) 1981-10-06

Family

ID=15440927

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14791377A Granted JPS5481216A (en) 1977-12-09 1977-12-09 Production acid amide

Country Status (1)

Country Link
JP (1) JPS5481216A (en)

Also Published As

Publication number Publication date
JPS5642594B2 (en) 1981-10-06

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