GB1360354A - Chenodeoxycholic acid - Google Patents

Chenodeoxycholic acid

Info

Publication number
GB1360354A
GB1360354A GB280372A GB280372A GB1360354A GB 1360354 A GB1360354 A GB 1360354A GB 280372 A GB280372 A GB 280372A GB 280372 A GB280372 A GB 280372A GB 1360354 A GB1360354 A GB 1360354A
Authority
GB
United Kingdom
Prior art keywords
methyl
base
chenodeoxycholic acid
cholanate
kishner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB280372A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union International Co Ltd
Original Assignee
Union International Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union International Co Ltd filed Critical Union International Co Ltd
Priority to GB280372A priority Critical patent/GB1360354A/en
Priority to ES410785A priority patent/ES410785A1/en
Priority to SE7300810A priority patent/SE385905B/en
Priority to AU51263/73A priority patent/AU468382B2/en
Priority to DE19732302744 priority patent/DE2302744A1/en
Priority to JP910573A priority patent/JPS4995955A/ja
Publication of GB1360354A publication Critical patent/GB1360354A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1360354 Chenodeoxycholic acid UNION INTERNATIONAL CO Ltd 15 Jan 1973 [20 Jan 1972] 2803/72 Heading C2U Chenodeoxycholic acid (I) is purified by forming a mixture thereof with methanol, a base and a Ca or Sr salt (e.g. chloride or nitrate), separating and acidifying the precipitated Ca or Sr salt of I, and isolating the purified produce. The base may be an alkali metal hydroxides. ammonia, ammonium hydroxide, hydrazine hydrate or an organic nitrogenous base (a list of examples is provided). The preparation of I from cholic acid (II) by the sequence II-(a)#methyl cholate-(b)# methyl - 3α,7α - diacetoxy - 12α - hydroxy - 5#- cholanate-(c)#methyl - 3α,7α - diacetoxy - 12- oxo-5#-cholanate-(d)#I is effected with reactants as follows (a) MeOH/H 2 SO 4 ; (b) Ac 2 O/py in benzene, dioxan, THF, dimethyl sulphoxide or acetonitrile; (c) sodium chromate/H 2 O/ AcOH; (d) Wolff-Kishner, modified Wolff- Kishner or cathodic reduction followed by hydrolysis.
GB280372A 1972-01-20 1972-01-20 Chenodeoxycholic acid Expired GB1360354A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB280372A GB1360354A (en) 1972-01-20 1972-01-20 Chenodeoxycholic acid
ES410785A ES410785A1 (en) 1972-01-20 1973-01-19 Chenodeoxycholic acid
SE7300810A SE385905B (en) 1972-01-20 1973-01-19 PROCEDURE FOR PURIFICATION OF CHENODEOXICHOLIC ACID
AU51263/73A AU468382B2 (en) 1972-01-20 1973-01-19 Chenodeoxycholic acid
DE19732302744 DE2302744A1 (en) 1972-01-20 1973-01-20 METHOD FOR PURIFYING CRUDE CHENODESOXYCHOLIC ACID
JP910573A JPS4995955A (en) 1972-01-20 1973-01-20

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB280372A GB1360354A (en) 1972-01-20 1972-01-20 Chenodeoxycholic acid

Publications (1)

Publication Number Publication Date
GB1360354A true GB1360354A (en) 1974-07-17

Family

ID=9746226

Family Applications (1)

Application Number Title Priority Date Filing Date
GB280372A Expired GB1360354A (en) 1972-01-20 1972-01-20 Chenodeoxycholic acid

Country Status (6)

Country Link
JP (1) JPS4995955A (en)
AU (1) AU468382B2 (en)
DE (1) DE2302744A1 (en)
ES (1) ES410785A1 (en)
GB (1) GB1360354A (en)
SE (1) SE385905B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2613346C3 (en) * 1976-03-29 1981-07-23 Diamalt AG, 8000 München Monocline crystalline chenodeoxycholic acid and process for its preparation
FR2521430A1 (en) * 1982-02-12 1983-08-19 Pan Medica AQUEOUS URSODESOXYCHOLIC ACID SOLUTION FOR THERAPEUTIC USES, PROCESS FOR THE PREPARATION THEREOF, AND APPLICATION FOR THE TREATMENT OF BILARY LITHIASES
KR20010043558A (en) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 Meiosis regulating compounds

Also Published As

Publication number Publication date
ES410785A1 (en) 1976-04-01
AU468382B2 (en) 1976-01-08
SE385905B (en) 1976-07-26
DE2302744A1 (en) 1973-07-26
AU5126373A (en) 1974-07-25
JPS4995955A (en) 1974-09-11

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee