JPS5463025A - 2-methacryloxyethylphosphorylcholine - Google Patents

2-methacryloxyethylphosphorylcholine

Info

Publication number
JPS5463025A
JPS5463025A JP13008177A JP13008177A JPS5463025A JP S5463025 A JPS5463025 A JP S5463025A JP 13008177 A JP13008177 A JP 13008177A JP 13008177 A JP13008177 A JP 13008177A JP S5463025 A JPS5463025 A JP S5463025A
Authority
JP
Japan
Prior art keywords
formula
compound
react
useful
room temp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13008177A
Other languages
Japanese (ja)
Other versions
JPS6021599B2 (en
Inventor
Junichi Yamauchi
Hidekazu Masuhara
Norio Nakabayashi
Yoshinori Kadoma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP13008177A priority Critical patent/JPS6021599B2/en
Publication of JPS5463025A publication Critical patent/JPS5463025A/en
Publication of JPS6021599B2 publication Critical patent/JPS6021599B2/en
Expired legal-status Critical Current

Links

Abstract

NEW MATERIAL:2-Methacryloxyethylphosphorylcholine of formula I.
USE: Useful as a row material of polymer. The copolymer obtained by the graft polymerization of the compound shows excellent affinity to living organisms and is useful as a material of artificial organs, catheters, artificial skin, and for implanting.
PROCESS: 2-Hydroxyethylmethacrylate and bromoethylphosphoryl dichloride are made to react at -20°-room temp. in the presence of a tertiary base; the resulting 2-methacryloxyethyl-2'-bromoethylhydrogen phosphate III is mixed with a methanol solution of trimethylamine and allowed to react at room temp.; and AgBr is eliminated from the reactin product using Ag carbonate to give the crystalized objective compound of formula I. The compound of formula II is obtained by the reaction of phosphorus oxychloride with ethylenebromohydrin.
COPYRIGHT: (C)1979,JPO&Japio
JP13008177A 1977-10-28 1977-10-28 2-methacryloxyethylphosphorylcholine Expired JPS6021599B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13008177A JPS6021599B2 (en) 1977-10-28 1977-10-28 2-methacryloxyethylphosphorylcholine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13008177A JPS6021599B2 (en) 1977-10-28 1977-10-28 2-methacryloxyethylphosphorylcholine

Publications (2)

Publication Number Publication Date
JPS5463025A true JPS5463025A (en) 1979-05-21
JPS6021599B2 JPS6021599B2 (en) 1985-05-28

Family

ID=15025522

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13008177A Expired JPS6021599B2 (en) 1977-10-28 1977-10-28 2-methacryloxyethylphosphorylcholine

Country Status (1)

Country Link
JP (1) JPS6021599B2 (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036155A2 (en) * 1980-03-17 1981-09-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Polymerisable phospholipids, process for their preparation, polymeric phospholipids, process for their preparation as well as the use of the polymeric phospholipids
JPS60119955A (en) * 1983-12-02 1985-06-27 鶴田　禎二 Synthetic polymer body for living body material
EP0273107A2 (en) * 1986-12-11 1988-07-06 National Starch and Chemical Investment Holding Corporation Alpha-aminomethylene phosphonate betaines and polymers prepared therewith
FR2698003A1 (en) * 1992-11-17 1994-05-20 Pola Chem Ind Inc Cosmetic compsns. contg. a homopolymer of 2-methacryloyl:oxy:ethyl:phosphoryl:choline - have moisture retaining action on skin and hair
US5453467A (en) * 1991-08-30 1995-09-26 Biocompatibles Limited Polymer treatments
WO1996031566A1 (en) 1995-04-03 1996-10-10 Nof Corporation Process for producing an aqueous solution of phosphorylcholine group bearing polymer and aqueous solution of phosphorylcholine group bearing polymer
WO2001034700A1 (en) 1999-11-09 2001-05-17 Nof Corporation Composition for hydrogel, hydrogel, and use thereof
US6258371B1 (en) 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
JP2001288209A (en) * 2000-04-10 2001-10-16 Nof Corp Preparation method of polymer containing phosphorylcholine analogous group
US6395800B1 (en) 1992-12-23 2002-05-28 Biocompatibles Limited Polymeric blends with zwitterionic groups
JP2005239989A (en) * 2004-02-24 2005-09-08 Yasuhiko Iwasaki Method for producing polyphosphoric acid having living radical polymerization-initiating group and use of the same
JP2005255969A (en) * 2004-03-12 2005-09-22 Yasuhiko Iwasaki Method for producing biodegradable polymer and application thereof
JP2010095719A (en) * 2008-10-15 2010-04-30 Tyco Healthcare Group Lp Hydroxamate composition
WO2010058848A1 (en) * 2008-11-21 2010-05-27 日本メディカルマテリアル株式会社 Graft polymerization method and product obtained thereby
JP2010527402A (en) * 2007-05-14 2010-08-12 タイコ ヘルスケア グループ リミテッド パートナーシップ Furanone copolymer
WO2010122817A1 (en) * 2009-04-24 2010-10-28 株式会社ネクスト２１ Resin product for medical use and respiration-assisting tube
WO2011125618A1 (en) 2010-03-31 2011-10-13 旭化成クラレメディカル株式会社 Substrate for ligand immobilization and method for producing same
WO2013128633A1 (en) 2012-03-02 2013-09-06 日油株式会社 Contact lens care preparation and packaging solution
WO2015080176A1 (en) 2013-11-28 2015-06-04 東レ株式会社 Anti-thrombotic material
US9340561B2 (en) 2011-09-16 2016-05-17 Nissan Chemical Industries, Ltd. Organic silicon compound and silane coupling agent containing the same
WO2023276858A1 (en) 2021-06-29 2023-01-05 日油株式会社 Soft contact lens solution

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036155A2 (en) * 1980-03-17 1981-09-23 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Polymerisable phospholipids, process for their preparation, polymeric phospholipids, process for their preparation as well as the use of the polymeric phospholipids
EP0036155A3 (en) * 1980-03-17 1982-01-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Polymerisable phospholipids, process for their preparation, polymeric phospholipids, process for their preparation as well as the use of the polymeric phospholipids
JPS60119955A (en) * 1983-12-02 1985-06-27 鶴田　禎二 Synthetic polymer body for living body material
JPH0414033B2 (en) * 1983-12-02 1992-03-11 Teiji Tsuruta
EP0273107A2 (en) * 1986-12-11 1988-07-06 National Starch and Chemical Investment Holding Corporation Alpha-aminomethylene phosphonate betaines and polymers prepared therewith
US5453467A (en) * 1991-08-30 1995-09-26 Biocompatibles Limited Polymer treatments
FR2698003A1 (en) * 1992-11-17 1994-05-20 Pola Chem Ind Inc Cosmetic compsns. contg. a homopolymer of 2-methacryloyl:oxy:ethyl:phosphoryl:choline - have moisture retaining action on skin and hair
US6395800B1 (en) 1992-12-23 2002-05-28 Biocompatibles Limited Polymeric blends with zwitterionic groups
WO1996031566A1 (en) 1995-04-03 1996-10-10 Nof Corporation Process for producing an aqueous solution of phosphorylcholine group bearing polymer and aqueous solution of phosphorylcholine group bearing polymer
US6258371B1 (en) 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
WO2001034700A1 (en) 1999-11-09 2001-05-17 Nof Corporation Composition for hydrogel, hydrogel, and use thereof
JP2001288209A (en) * 2000-04-10 2001-10-16 Nof Corp Preparation method of polymer containing phosphorylcholine analogous group
JP2005239989A (en) * 2004-02-24 2005-09-08 Yasuhiko Iwasaki Method for producing polyphosphoric acid having living radical polymerization-initiating group and use of the same
JP2005255969A (en) * 2004-03-12 2005-09-22 Yasuhiko Iwasaki Method for producing biodegradable polymer and application thereof
JP2010527402A (en) * 2007-05-14 2010-08-12 タイコ ヘルスケア グループ リミテッド パートナーシップ Furanone copolymer
JP2010095719A (en) * 2008-10-15 2010-04-30 Tyco Healthcare Group Lp Hydroxamate composition
JP5566906B2 (en) * 2008-11-21 2014-08-06 京セラメディカル株式会社 Graft polymerization method and product thereof
US8795841B2 (en) 2008-11-21 2014-08-05 Japan Medical Materials Corporation Graft polymerization method and product obtained thereby
WO2010058848A1 (en) * 2008-11-21 2010-05-27 日本メディカルマテリアル株式会社 Graft polymerization method and product obtained thereby
WO2010122817A1 (en) * 2009-04-24 2010-10-28 株式会社ネクスト２１ Resin product for medical use and respiration-assisting tube
JPWO2010122817A1 (en) * 2009-04-24 2012-10-25 株式会社ネクスト２１ Medical plastic products and breathing assistance tubes
US8957173B2 (en) 2009-04-24 2015-02-17 Next21 K.K. Resin product for medical use and respiration-assisting tube
WO2011125618A1 (en) 2010-03-31 2011-10-13 旭化成クラレメディカル株式会社 Substrate for ligand immobilization and method for producing same
US9340561B2 (en) 2011-09-16 2016-05-17 Nissan Chemical Industries, Ltd. Organic silicon compound and silane coupling agent containing the same
WO2013128633A1 (en) 2012-03-02 2013-09-06 日油株式会社 Contact lens care preparation and packaging solution
WO2015080176A1 (en) 2013-11-28 2015-06-04 東レ株式会社 Anti-thrombotic material
WO2023276858A1 (en) 2021-06-29 2023-01-05 日油株式会社 Soft contact lens solution

Also Published As

Publication number Publication date
JPS6021599B2 (en) 1985-05-28

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