JPS54143490A - Preparation of polymer composition - Google Patents

Preparation of polymer composition

Info

Publication number
JPS54143490A
JPS54143490A JP5123978A JP5123978A JPS54143490A JP S54143490 A JPS54143490 A JP S54143490A JP 5123978 A JP5123978 A JP 5123978A JP 5123978 A JP5123978 A JP 5123978A JP S54143490 A JPS54143490 A JP S54143490A
Authority
JP
Japan
Prior art keywords
active substance
physiologically active
low temperature
polymer
vitrifiable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5123978A
Other languages
Japanese (ja)
Other versions
JPS588402B2 (en
Inventor
Isao Kaetsu
Minoru Kumakura
Masaru Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Atomic Energy Agency
Original Assignee
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Atomic Energy Research Institute filed Critical Japan Atomic Energy Research Institute
Priority to JP5123978A priority Critical patent/JPS588402B2/en
Priority to CA322,930A priority patent/CA1125698A/en
Priority to DE2908794A priority patent/DE2908794C2/en
Priority to ES478446A priority patent/ES478446A1/en
Priority to IT7967493A priority patent/IT7967493A0/en
Priority to GB7908163A priority patent/GB2017113B/en
Priority to US06/018,617 priority patent/US4321117A/en
Priority to FR7905982A priority patent/FR2419299A1/en
Priority to SE7902166A priority patent/SE7902166L/en
Priority to NL7901919A priority patent/NL7901919A/en
Publication of JPS54143490A publication Critical patent/JPS54143490A/en
Priority to US06/234,839 priority patent/US4411754A/en
Publication of JPS588402B2 publication Critical patent/JPS588402B2/en
Expired legal-status Critical Current

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  • Medicinal Preparation (AREA)
  • Polymerisation Methods In General (AREA)

Abstract

PURPOSE: To prepare a polymer composition useful as chemicals, etc., capable of slowly releasing a physiologically active substance, by radiation polymerization of a mixture of a monomer vitrifiable at a low temperature the physiologically active substance, and a polymeric material, at low temperatures.
CONSTITUTION: The mixture comprising (A) 5W50 wt.% of a natural or synthetic polymeric material (e.g. polymethyl methacrylate, etc.), (B) a monomer vitrifiable at a low temperature (e.g. hydroxyethyl methacrylate, etc.) and (C) a physiologically active substance (e.g. chemicals such as bleomycin hydrochloride, etc,), is dropped or injected into a low temperature-medium to form spherical droplets, and polymerized by radiating light or ionizing radiations below ordinary temperature to give the desired polymer. The polymer is preferably spheres having a size of 50W 5,000 μ.
COPYRIGHT: (C)1979,JPO&Japio
JP5123978A 1978-03-09 1978-04-28 Method for producing polymer composition Expired JPS588402B2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP5123978A JPS588402B2 (en) 1978-04-28 1978-04-28 Method for producing polymer composition
CA322,930A CA1125698A (en) 1978-03-09 1979-03-07 Process for preparing a polymer composition
DE2908794A DE2908794C2 (en) 1978-03-09 1979-03-07 Process for the production of a polymer preparation containing a physiologically active substance
GB7908163A GB2017113B (en) 1978-03-09 1979-03-08 Process for preparing a composition of a polymer and a physiologically active substance
IT7967493A IT7967493A0 (en) 1978-03-09 1979-03-08 PROCEDURE FOR THE PREPARATION OF A POLYMER COMPOSITION
ES478446A ES478446A1 (en) 1978-03-09 1979-03-08 Process for preparing a polymer composition
US06/018,617 US4321117A (en) 1978-03-09 1979-03-08 Process for preparing a polymer composition
FR7905982A FR2419299A1 (en) 1978-03-09 1979-03-08 PROCESS FOR MANUFACTURING A POLYMERIC COMPOSITION CONTAINING A PHYSIOLOGICALLY ACTIVE SUBSTANCE
SE7902166A SE7902166L (en) 1978-03-09 1979-03-09 PROCEDURE FOR PREPARING A POLYMER COMPOSITION
NL7901919A NL7901919A (en) 1978-03-09 1979-03-09 Polymer compsn. contg. physiologically active cpd. - with controlled release mixt., prepd. by polymerising monomers with radiation at below room temp. (NL 11.9.79)
US06/234,839 US4411754A (en) 1978-03-09 1981-02-13 Process for preparing a polymer composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5123978A JPS588402B2 (en) 1978-04-28 1978-04-28 Method for producing polymer composition

Publications (2)

Publication Number Publication Date
JPS54143490A true JPS54143490A (en) 1979-11-08
JPS588402B2 JPS588402B2 (en) 1983-02-16

Family

ID=12881382

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5123978A Expired JPS588402B2 (en) 1978-03-09 1978-04-28 Method for producing polymer composition

Country Status (1)

Country Link
JP (1) JPS588402B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58144314A (en) * 1982-02-19 1983-08-27 Japan Atom Energy Res Inst Preparation of combined substance having prolonged effect
JPS60231609A (en) * 1984-04-28 1985-11-18 Terumo Corp Liposome pharmaceutical

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58144314A (en) * 1982-02-19 1983-08-27 Japan Atom Energy Res Inst Preparation of combined substance having prolonged effect
JPS6351127B2 (en) * 1982-02-19 1988-10-13 Japan Atomic Energy Res Inst
JPS60231609A (en) * 1984-04-28 1985-11-18 Terumo Corp Liposome pharmaceutical

Also Published As

Publication number Publication date
JPS588402B2 (en) 1983-02-16

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