JPS5278900A - Improvement in organic compound - Google Patents

Improvement in organic compound

Info

Publication number: JPS5278900A
Authority: JP; Japan
Prior art keywords: carbon atoms; alkyl; hydrogen; mono; phenyl
Prior art date: 1975-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP51153514A

Other languages

English (en)

Other versions

JPS6133031B2 (ja

Inventor

Shiyuteitsu Piitaa

Fueeru Teodooru

Shiyutadoraa Pauru

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sandoz AG

Original Assignee

Sandoz AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-12-23

Filing date

1976-12-22

Publication date

1977-07-02

1975-12-23 Priority claimed from CH1668075A external-priority patent/CH620441A5/de

1976-12-22 Application filed by Sandoz AG filed Critical Sandoz AG

1977-07-02 Publication of JPS5278900A publication Critical patent/JPS5278900A/ja

1986-07-31 Publication of JPS6133031B2 publication Critical patent/JPS6133031B2/ja

Status Granted legal-status Critical Current

Links

150000002894 organic compounds Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 10
125000000217 alkyl group Chemical group 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
102000003946 Prolactin Human genes 0.000 abstract 1
108010057464 Prolactin Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
229940125688 antiparkinson agent Drugs 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Chemical group 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
229940097325 prolactin Drugs 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000004385 trihaloalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP51153514A 1975-12-23 1976-12-22 Improvement in organic compound Granted JPS5278900A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH1668075A CH620441A5 (en)	1975-12-23	1975-12-23	Process for the preparation of novel ergoline compounds
CH618876		1976-05-18

Publications (2)

Publication Number	Publication Date
JPS5278900A true JPS5278900A (en)	1977-07-02
JPS6133031B2 JPS6133031B2 (ja)	1986-07-31

Family

ID=25699142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP51153514A Granted JPS5278900A (en)	1975-12-23	1976-12-22	Improvement in organic compound

Country Status (20)

Country	Link
US (1)	US4348391A (ja)
JP (1)	JPS5278900A (ja)
AU (1)	AU514288B2 (ja)
CA (1)	CA1092100A (ja)
DE (1)	DE2656344A1 (ja)
DK (2)	DK146205C (ja)
ES (1)	ES454442A1 (ja)
FI (1)	FI763587A (ja)
FR (1)	FR2336135A1 (ja)
GB (1)	GB1567484A (ja)
HK (1)	HK3483A (ja)
IE (1)	IE44242B1 (ja)
IL (1)	IL51133A (ja)
MY (1)	MY8400060A (ja)
NL (1)	NL7614018A (ja)
NZ (1)	NZ182934A (ja)
PH (1)	PH14035A (ja)
PT (1)	PT66006B (ja)
SE (1)	SE432253B (ja)
SG (1)	SG63382G (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5753485A (en) *	1980-07-25	1982-03-30	Sandoz Ag	Ergoline derivative, manufacture and use
JPS57145875A (en) *	1981-01-14	1982-09-09	Schering Ag	Novel (2-halogen-ergolinyl)-n',n'-diethylurea derivative, manufacture and dopamine, noradrenaline and serotonin medicine containing same
JPS58150593A (ja) *	1981-12-23	1983-09-07	シエ−リング・アクチエンゲゼルシヤフト	８―エルゴリニルチオ尿素誘導体及びその製法
JPS59155382A (ja) *	1983-02-16	1984-09-04	サンド・アクチエンゲゼルシヤフト	麦角アルカロイド誘導体

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3127845A1 (de) *	1980-07-25	1982-04-22	Sandoz-Patent-GmbH, 7850 Lörrach	Ergolinderivate, verfahren zu deren herstellung, diese enthaltende pharmazeutische zusammensetzungen und ihre anwendung bei der therapeutischen behandlung
CH644606A5 (de) *	1980-09-23	1984-08-15	Sandoz Ag	Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
GB2112382B (en) *	1981-11-06	1985-03-06	Erba Farmitalia	Ergoline derivatives
DE3216870A1 (de) *	1982-05-03	1983-11-03	Schering AG, 1000 Berlin und 4709 Bergkamen	Pharmazeutische zubereitungen mit zytostatischer wirkung
HU196399B (en) *	1983-02-16	1988-11-28	Sandoz Ag	Process for producing ergoline derivatives and pharmaceutical compositions comprising such compounds
HU197569B (en) *	1984-01-12	1989-04-28	Sandoz Ag	Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
US4675322A (en) *	1984-12-10	1987-06-23	Eli Lilly And Company	1-Substituted-6-n-propyl-8β-methylthio-methylergolines
HU195810B (en) *	1984-12-24	1988-07-28	Sandoz Ag	Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
HU193317B (en) *	1985-06-12	1987-09-28	Richter Gedeon Vegyeszet	Process for producing 2-bromo-alpha-ergochristin
US4801712A (en) *	1985-06-24	1989-01-31	Eli Lilly And Company	2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
DE3535929A1 (de) *	1985-10-04	1987-04-09	Schering Ag	1,2-disubstituierte ergolinderivate
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
GB8615471D0 (en) *	1986-06-25	1986-07-30	Erba Farmitalia	T-butyl ergoline derivatives
US4798834A (en) *	1987-08-31	1989-01-17	Eli Lilly And Company	Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement
AT392945B (de) *	1988-06-27	1991-07-10	Gerhard Mader Ges M B H Ing	Lager- und transportbehaelter fuer schuettgueter und lose materialien
IT1232692B (it) *	1989-08-04	1992-03-04	Poli Ind Chimica Spa	Derivati ergolinici con attivita' dopaminergica
AU2635599A (en) *	1999-03-17	2000-10-04	Eugen Eigenmann	Use of prolactin inhibitors for the treatment of fertility problems in animal species

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3270020A (en) *		1966-08-30		Dihydro ergocornine
US3218323A (en) *		1965-11-16		Esters of i,g-dimethyl-b-ergolenyl carbamic acid
US3245996A (en) *		1966-04-12		Cyanoethyl lysergol
US3185695A (en) *		1965-05-25		Dbwethyl-ergoline ii derivatives
US3232943A (en) *		1966-02-01		Cyanoethyl ergolene and ergoline derivatives
US2533698A (en) *		1950-12-12		Urethanes containing the lysergic
CH415658A (de) *	1962-06-18	1966-06-30	Sandoz Ag	Verfahren zur Herstellung von neuen Urethanen
BE712054A (ja) *	1967-03-16	1968-07-15
US3920664A (en) *	1972-07-21	1975-11-18	Lilly Co Eli	D-2-halo-6-alkyl-8-substituted ergolines and related compounds
US3880856A (en) *	1973-06-29	1975-04-29	Lilly Co Eli	Ergoline dimers
CS171480B1 (ja) *	1974-03-19	1976-10-29
CH605936A5 (en) *	1974-07-19	1978-10-13	Sandoz Ag	8-Alpha-(Amino-or cyanomethyl)-ergoline derivs
GB1517973A (en) *	1974-07-19	1978-07-19	Sandoz Ltd	6-methyl-8alpha-n,n-dimethylsulphamoylaminoergoline i
US3904757A (en) *	1974-08-08	1975-09-09	Lilly Co Eli	Treatment of parkinsonism
US3922347A (en) *	1974-12-19	1975-11-25	Lilly Co Eli	Method of inhibiting prolactin secretion with 8-acylaminoergolenes

1976
- 1976-12-13 DE DE19762656344 patent/DE2656344A1/de active Granted
- 1976-12-14 DK DK562376A patent/DK146205C/da not_active IP Right Cessation
- 1976-12-14 FI FI763587A patent/FI763587A/fi not_active Application Discontinuation
- 1976-12-15 SE SE7614085A patent/SE432253B/xx not_active IP Right Cessation
- 1976-12-17 NL NL7614018A patent/NL7614018A/xx not_active Application Discontinuation
- 1976-12-21 IE IE2803/76A patent/IE44242B1/en unknown
- 1976-12-21 AU AU20793/76A patent/AU514288B2/en not_active Expired
- 1976-12-21 PH PH19276A patent/PH14035A/en unknown
- 1976-12-21 ES ES454442A patent/ES454442A1/es not_active Expired
- 1976-12-21 CA CA268,415A patent/CA1092100A/en not_active Expired
- 1976-12-21 IL IL51133A patent/IL51133A/xx unknown
- 1976-12-21 NZ NZ182934A patent/NZ182934A/xx unknown
- 1976-12-21 GB GB53303/76A patent/GB1567484A/en not_active Expired
- 1976-12-22 JP JP51153514A patent/JPS5278900A/ja active Granted
- 1976-12-22 FR FR7638697A patent/FR2336135A1/fr active Granted
- 1976-12-22 PT PT66006A patent/PT66006B/pt unknown
1979
- 1979-12-21 DK DK554179A patent/DK554179A/da unknown
1980
- 1980-09-22 US US06/189,068 patent/US4348391A/en not_active Expired - Lifetime
1982
- 1982-12-23 SG SG633/82A patent/SG63382G/en unknown
1983
- 1983-01-20 HK HK34/83A patent/HK3483A/xx unknown
1984
- 1984-12-30 MY MY60/84A patent/MY8400060A/xx unknown

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5753485A (en) *	1980-07-25	1982-03-30	Sandoz Ag	Ergoline derivative, manufacture and use
JPH0243752B2 (ja) *	1980-07-25	1990-10-01	Sandoz Ag
JPS57145875A (en) *	1981-01-14	1982-09-09	Schering Ag	Novel (2-halogen-ergolinyl)-n',n'-diethylurea derivative, manufacture and dopamine, noradrenaline and serotonin medicine containing same
JPH0437079B2 (ja) *	1981-01-14	1992-06-18	Schering Ag
JPS58150593A (ja) *	1981-12-23	1983-09-07	シエ−リング・アクチエンゲゼルシヤフト	８―エルゴリニルチオ尿素誘導体及びその製法
JPH0352463B2 (ja) *	1981-12-23	1991-08-12	Schering Ag
JPS59155382A (ja) *	1983-02-16	1984-09-04	サンド・アクチエンゲゼルシヤフト	麦角アルカロイド誘導体
JPH0346471B2 (ja) *	1983-02-16	1991-07-16	Sandoz Ag

Also Published As

Publication number	Publication date
CA1092100A (en)	1980-12-23
DK146205C (da)	1983-12-27
PH14035A (en)	1980-12-12
US4348391A (en)	1982-09-07
PT66006A (fr)	1977-01-01
SE432253B (sv)	1984-03-26
AU2079376A (en)	1978-06-29
SE7614085L (sv)	1977-06-24
MY8400060A (en)	1984-12-31
SG63382G (en)	1983-09-09
NZ182934A (en)	1978-12-18
FI763587A (ja)	1977-06-24
DK562376A (da)	1977-06-24
GB1567484A (en)	1980-05-14
HK3483A (en)	1983-01-20
IE44242B1 (en)	1981-09-23
DE2656344A1 (de)	1977-07-07
IL51133A (en)	1981-11-30
DK146205B (da)	1983-07-25
AU514288B2 (en)	1981-02-05
PT66006B (fr)	1978-07-06
DK554179A (da)	1979-12-21
IL51133A0 (en)	1977-02-28
DE2656344C2 (ja)	1990-11-08
NL7614018A (nl)	1977-06-27
JPS6133031B2 (ja)	1986-07-31
FR2336135B1 (ja)	1980-03-07
ES454442A1 (es)	1978-03-01
FR2336135A1 (fr)	1977-07-22

Publication	Publication Date	Title
JPS5278900A (en)	1977-07-02	Improvement in organic compound
SE7602144L (sv)	1976-09-13	Kvaternera imidazoliumforeningar
IE41426L (en)	1976-01-19	Stabilized polyalkylene glycols
GB2183476B (en)	1989-10-25	Anthihypertensive combination product
SE7601206L (sv)	1976-09-19	Acetylenderivat
SE8302379D0 (sv)	1983-04-27	Ergolinderivat
ES455909A1 (es)	1978-06-16	Procedimiento para preparar derivados de piperacina.
ES466363A1 (es)	1979-01-16	Procedimiento para la obtencion de acido n-9,10-dihidro - lisergil-m-amino-benzoico
TR22719A (tr)	1988-05-03	Yeni n-alkil(en)-n-(o,o-disuebstuee-tiofos foril)-n',n'-disuebstituee glisin amidler bunlari hazirlamaya mahsus usuel ve etkili terkip maddesi olarak bu bilesikleri ihtiva eden akarisid ensektisid ve fungisid
ES448849A1 (es)	1977-12-01	Procedimiento para preparar derivados de hexahidroacepina.
ES390424A1 (es)	1974-07-01	Un metodo de preparacion de s-oxidos de 2-(hidrocarbiltio) -2-(hidroxi-imino) acetamida.
IL56507A (en)	1984-01-31	(trihalomethyl)dimethyloxabicyclohexanone derivatives for the preparation of cis dihalovinyldimethylcyclopropanecarboxylic acids
FI811266L (fi)	1981-10-24	Antihypertensiva laktamer
ES527842A0 (es)	1985-06-16	Procedimiento para preparar derivados de benzoato de propilo o pseudopropilo
FR2312255B1 (ja)	1979-10-12
GB953978A (en)	1964-04-02	New 7-hydroxychromone derivatives
ES402561A1 (es)	1975-11-01	Procedimiento para la obtencion de derivados de la aminopi-ridacina.
ES425868A1 (es)	1976-06-01	Procedimiento para la preparacion de n-alquilcarbonatos fenil-substituidos.
ES432206A1 (es)	1976-11-01	Un procedimiento para la obtencion de alofanimidatos.
ES316769A1 (es)	1966-03-16	Un procedimiento para la preparacion de 3,4-dihidro-2-benzotiopiranos sustituidos.
ES485517A1 (es)	1980-09-01	Un procedimiento para la obtencion de nuevos derivados hete-rociclicos de nitrogeno
ES318197A1 (es)	1966-07-01	Procedimiento para la produccion de derivados de tieno-benzotiacina.
ES283886A1 (es)	1963-05-16	Procedimiento de preparación de nuevas alcohilaminas
ES439218A1 (es)	1977-05-16	Un procedimiento para la preparacion de nuevos compuestos den-(2,2-difluoralcanoil)-o-fenilendiamina sustituidos en el anillo.
ES463100A3 (es)	1978-11-16	Procedimiento para la obtencion de una composicion fungicidaa base de 3-(n-acil-n-arilamino) lactonas.