ES466363A1 - Procedimiento para la obtencion de acido n-9,10-dihidro - lisergil-m-amino-benzoico - Google Patents
Procedimiento para la obtencion de acido n-9,10-dihidro - lisergil-m-amino-benzoicoInfo
- Publication number
- ES466363A1 ES466363A1 ES78466363A ES466363A ES466363A1 ES 466363 A1 ES466363 A1 ES 466363A1 ES 78466363 A ES78466363 A ES 78466363A ES 466363 A ES466363 A ES 466363A ES 466363 A1 ES466363 A1 ES 466363A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- carbon atoms
- dihydrolysergyl
- acid amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para la obtención del ácido N-9m, 10-dihidro-lisergil-m-amino-benzoico puede llevarse a cabo en forma análoga a los métodos de condensación conocidos para la producción de amidas de ácido lisérgico análogas. Como derivados funcionales, reactivos, de un ácido de fórmula II pueden usarse, por ejemplo, el cloruro de ácido, la azida de ácido, el anhídrido mixto de un ácido de fórmula II con ácido sulfúrico o trifluoacético, pero con preferencia el producto de la reacción de un ácido de fórmula II con el amidocloruro obtenido de cloruro de oxalilo y dimetilformamida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH107077 | 1977-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES466363A1 true ES466363A1 (es) | 1979-01-16 |
Family
ID=4201739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES78466363A Expired ES466363A1 (es) | 1977-01-28 | 1978-01-26 | Procedimiento para la obtencion de acido n-9,10-dihidro - lisergil-m-amino-benzoico |
Country Status (21)
Country | Link |
---|---|
US (2) | US4180581A (es) |
JP (1) | JPS5395999A (es) |
AT (1) | ATA59078A (es) |
AU (1) | AU3281078A (es) |
BE (1) | BE863366A (es) |
CA (1) | CA1105008A (es) |
DE (1) | DE2802023A1 (es) |
DK (1) | DK28278A (es) |
ES (1) | ES466363A1 (es) |
FI (1) | FI780168A (es) |
FR (1) | FR2378781A1 (es) |
GB (1) | GB1595606A (es) |
IE (1) | IE46385B1 (es) |
IL (1) | IL53901A (es) |
IT (1) | IT7847795A0 (es) |
NL (1) | NL7800817A (es) |
NZ (1) | NZ186329A (es) |
PH (1) | PH14096A (es) |
PT (1) | PT67586B (es) |
SE (1) | SE7800633L (es) |
ZA (1) | ZA78521B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526892A (en) * | 1981-03-03 | 1985-07-02 | Farmitalia Carlo Erba, S.P.A. | Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas |
GB2173189B (en) * | 1985-02-21 | 1988-04-27 | Maruko Pharmaceutical Co | Ergoline derivatives and salts thereof and pharmaceutical compositions thereof |
GB8515528D0 (en) * | 1985-06-19 | 1985-07-24 | Erba Farmitalia | Ergoline derivatives |
DE3931819A1 (de) * | 1989-09-20 | 1991-03-28 | Schering Ag | 13-brom und 13, 14-dibrom-ergoline, ihre herstellung und verwendung in arzneimitteln |
US5441961A (en) * | 1992-08-27 | 1995-08-15 | Eli Lilly And Company | Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines |
CA2125288C (en) * | 1992-12-24 | 2004-11-23 | Sergio Mantegani | Serotoninergic ergoline derivatives |
AUPO395396A0 (en) * | 1996-12-02 | 1997-01-02 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3228942A (en) * | 1966-01-11 | Methyl and i,g-dimeti-iyl ergoline i compounds | ||
GB1112909A (en) * | 1964-09-15 | 1968-05-08 | Sandoz Ltd | Ergoline derivatives |
IL41409A (en) * | 1972-02-04 | 1977-04-29 | Richter Gedeon Vegyeszet | Lysergic acid amides and process for their preparation |
CA990287A (en) * | 1972-09-26 | 1976-06-01 | Sandoz Patents Limited | 13-bromo-lysergic acid compounds |
US3904633A (en) * | 1973-02-05 | 1975-09-09 | Richter Gedeon Vegyeszet | Lysergic amides |
HU172649B (hu) * | 1975-04-24 | 1978-11-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh biologicheski aktivnykh lizergamidov |
-
1978
- 1978-01-18 DE DE19782802023 patent/DE2802023A1/de not_active Withdrawn
- 1978-01-19 FI FI780168A patent/FI780168A/fi not_active Application Discontinuation
- 1978-01-19 SE SE7800633A patent/SE7800633L/xx unknown
- 1978-01-19 DK DK28278A patent/DK28278A/da not_active Application Discontinuation
- 1978-01-23 GB GB2605/78A patent/GB1595606A/en not_active Expired
- 1978-01-24 NL NL7800817A patent/NL7800817A/xx not_active Application Discontinuation
- 1978-01-26 IE IE182/78A patent/IE46385B1/en unknown
- 1978-01-26 BE BE184673A patent/BE863366A/xx unknown
- 1978-01-26 NZ NZ186329A patent/NZ186329A/xx unknown
- 1978-01-26 PT PT67586A patent/PT67586B/pt unknown
- 1978-01-26 IL IL53901A patent/IL53901A/xx unknown
- 1978-01-26 ES ES78466363A patent/ES466363A1/es not_active Expired
- 1978-01-26 IT IT7847795A patent/IT7847795A0/it unknown
- 1978-01-26 US US05/872,639 patent/US4180581A/en not_active Expired - Lifetime
- 1978-01-26 CA CA295,744A patent/CA1105008A/en not_active Expired
- 1978-01-27 FR FR7802311A patent/FR2378781A1/fr active Granted
- 1978-01-27 ZA ZA00780521A patent/ZA78521B/xx unknown
- 1978-01-27 AT AT0059078A patent/ATA59078A/de not_active Application Discontinuation
- 1978-01-27 JP JP746678A patent/JPS5395999A/ja active Pending
- 1978-01-27 PH PH20718A patent/PH14096A/en unknown
- 1978-01-27 AU AU32810/78A patent/AU3281078A/en active Pending
-
1979
- 1979-06-04 US US06/044,916 patent/US4248871A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT67586A (en) | 1978-02-01 |
IL53901A (en) | 1981-01-30 |
IE780182L (en) | 1978-07-28 |
US4180581A (en) | 1979-12-25 |
GB1595606A (en) | 1981-08-12 |
ATA59078A (de) | 1981-06-15 |
US4248871A (en) | 1981-02-03 |
NL7800817A (nl) | 1978-08-01 |
DE2802023A1 (de) | 1978-08-03 |
AU3281078A (en) | 1979-08-02 |
FR2378781B1 (es) | 1980-08-29 |
IL53901A0 (en) | 1978-04-30 |
PH14096A (en) | 1981-02-10 |
DK28278A (da) | 1978-07-29 |
ZA78521B (en) | 1979-09-26 |
NZ186329A (en) | 1980-11-14 |
BE863366A (fr) | 1978-07-26 |
FR2378781A1 (fr) | 1978-08-25 |
JPS5395999A (en) | 1978-08-22 |
SE7800633L (sv) | 1978-07-29 |
CA1105008A (en) | 1981-07-14 |
FI780168A (fi) | 1978-07-29 |
PT67586B (en) | 1981-02-02 |
IT7847795A0 (it) | 1978-01-26 |
IE46385B1 (en) | 1983-05-18 |
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