JPH11504659A - (−)−trans−N−p−フルオロベンゾイルメチル−4−(p−フルオロフェニル)−3−[[3,4−(メチレンジオキシ)フェノキシ]メチル]−ピペリジンの新規製造法 - Google Patents
(−)−trans−N−p−フルオロベンゾイルメチル−4−(p−フルオロフェニル)−3−[[3,4−(メチレンジオキシ)フェノキシ]メチル]−ピペリジンの新規製造法Info
- Publication number
- JPH11504659A JPH11504659A JP9530630A JP53063097A JPH11504659A JP H11504659 A JPH11504659 A JP H11504659A JP 9530630 A JP9530630 A JP 9530630A JP 53063097 A JP53063097 A JP 53063097A JP H11504659 A JPH11504659 A JP H11504659A
- Authority
- JP
- Japan
- Prior art keywords
- fluorophenyl
- phenoxy
- trans
- methyl
- methylenedioxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(−)−トランス−(p−フルオロフェニル)−3−[[3,4−(メチ レンジオキシ)フェノキシ]メチル]−ピペリジン酢酸塩を2−クロロ−又は2 −ブロモ−4′−フルオロアセトフェノンと炭素数1から4のアルカノール中で かつ塩基の存在下で該反応混合物を高温で反応させる工程、及び所望により、該 反応生成物を対応する酸との反応により薬理学的に許容し得る付加塩に転換する 工程を含む、(−)−トランス−N−p−フルオロベンゾイルメチル−4−(p −フルオロフェニル)−3−[[3,4−(メチレンジオキシ)フェノキシ]メ チル]−ピペリジン及びその薬理学的に許容し得る付加塩の製造方法。 2.前記の2−クロロ−または2−ブロモ−4′−フルオロアセトフェノンが 2−クロロ−4′−フルオロアセトフェノンである、請求項1記載の方法。 3.前記の炭素数1から4のアルカノールがメタノールおよびエタノールであ る、請求項1または請求項2記載の方法。 4.前記の対応する酸が塩酸である、請求項1から請求項3のいずれか1項に 記載の方法。 5.(−)−trans−N−p−フルオロベンゾイルメチル−4−(p−フ ルオロフェニル)−3−[[3,4−(メチレンジオキシ)フェノキシ]メチル ]−ピペリジンを、薬理学的に許容しうる塩として、好ましくは塩酸塩として、 単離する、請求項1から請求項4のいずれか1項に記載の方法。 6.前記の塩基が鉱物質塩基である、請求項1から請求項5のいずれか1項に 記載の方法。 7.前記の鉱物質塩基がアルカリ金属炭酸塩及び/または重炭酸塩である、請 求項6記載の方法。 8.前記の反応を該反応混合物の沸騰温度で行なう、請求項1から請求項7の いずれか1項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09600481A ES2117557B1 (es) | 1996-02-29 | 1996-02-29 | Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina. |
ES9600481 | 1996-02-29 | ||
PCT/EP1997/001007 WO1997031915A1 (en) | 1996-02-29 | 1997-02-28 | NEW PROCESS FOR PREPARING (-)-TRANS-N-p-FLUOROBENZOYLMETHYL-4-(p-FLUOROPHENYL)-3-[[3,4-(METHYLENEDIOXY)PHENOXY]METHYL]-PIPERIDINE |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11504659A true JPH11504659A (ja) | 1999-04-27 |
Family
ID=8293999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9530630A Ceased JPH11504659A (ja) | 1996-02-29 | 1997-02-28 | (−)−trans−N−p−フルオロベンゾイルメチル−4−(p−フルオロフェニル)−3−[[3,4−(メチレンジオキシ)フェノキシ]メチル]−ピペリジンの新規製造法 |
Country Status (17)
Country | Link |
---|---|
US (1) | US5973155A (ja) |
EP (1) | EP0823907B1 (ja) |
JP (1) | JPH11504659A (ja) |
AT (1) | ATE180481T1 (ja) |
AU (1) | AU705887B2 (ja) |
BR (1) | BR9702123A (ja) |
CA (1) | CA2217171C (ja) |
DE (1) | DE69700236T2 (ja) |
DK (1) | DK0823907T3 (ja) |
ES (1) | ES2117557B1 (ja) |
GR (1) | GR3030683T3 (ja) |
IL (1) | IL121995A (ja) |
NO (1) | NO312549B1 (ja) |
NZ (1) | NZ328932A (ja) |
TW (1) | TW416941B (ja) |
WO (1) | WO1997031915A1 (ja) |
ZA (1) | ZA971074B (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3108097A (en) * | 1997-06-10 | 1998-12-30 | Synthon B.V. | 4-phenylpiperidine compounds |
GB9808896D0 (en) * | 1998-04-25 | 1998-06-24 | Smithkline Beecham Plc | Novel compound |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
CA2422055A1 (en) * | 2000-09-11 | 2002-03-21 | Sepracor, Inc. | Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3426784A1 (de) * | 1984-07-20 | 1986-01-30 | Bosch Gmbh Robert | Magnetoresistiver sensor zur abgabe von elektrischen signalen |
DK231088D0 (da) * | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
ES2102295B1 (es) * | 1994-03-18 | 1998-04-01 | Ferrer Int | Nuevos compuestos derivados de la n-benzoilmetil-piperidina. |
GB2297550B (en) * | 1995-02-06 | 1997-04-09 | Smithkline Beecham Plc | Paroxetine hydrochloride anhydrate substantially free of bound organic solvent |
JPH11505229A (ja) * | 1995-05-17 | 1999-05-18 | ノボ ノルディスク アクティーゼルスカブ | 4−アリール−ピペリジン誘導体を製造する方法 |
-
1996
- 1996-02-29 ES ES09600481A patent/ES2117557B1/es not_active Expired - Fee Related
-
1997
- 1997-01-31 TW TW086101103A patent/TW416941B/zh active
- 1997-02-10 ZA ZA9701074A patent/ZA971074B/xx unknown
- 1997-02-28 JP JP9530630A patent/JPH11504659A/ja not_active Ceased
- 1997-02-28 DE DE69700236T patent/DE69700236T2/de not_active Expired - Fee Related
- 1997-02-28 WO PCT/EP1997/001007 patent/WO1997031915A1/en active IP Right Grant
- 1997-02-28 DK DK97906144T patent/DK0823907T3/da active
- 1997-02-28 BR BR9702123-7A patent/BR9702123A/pt not_active Application Discontinuation
- 1997-02-28 AU AU20940/97A patent/AU705887B2/en not_active Ceased
- 1997-02-28 NZ NZ328932A patent/NZ328932A/en unknown
- 1997-02-28 IL IL12199597A patent/IL121995A/xx not_active IP Right Cessation
- 1997-02-28 AT AT97906144T patent/ATE180481T1/de not_active IP Right Cessation
- 1997-02-28 EP EP97906144A patent/EP0823907B1/en not_active Expired - Lifetime
- 1997-02-28 CA CA002217171A patent/CA2217171C/en not_active Expired - Fee Related
- 1997-02-28 US US08/945,442 patent/US5973155A/en not_active Expired - Fee Related
- 1997-10-27 NO NO19974958A patent/NO312549B1/no unknown
-
1999
- 1999-07-05 GR GR990401765T patent/GR3030683T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
BR9702123A (pt) | 1999-12-28 |
DE69700236T2 (de) | 1999-09-30 |
TW416941B (en) | 2001-01-01 |
ES2117557A1 (es) | 1998-08-01 |
IL121995A (en) | 2001-01-28 |
ES2117557B1 (es) | 1999-07-01 |
NO312549B1 (no) | 2002-05-27 |
AU705887B2 (en) | 1999-06-03 |
AU2094097A (en) | 1997-09-16 |
EP0823907A1 (en) | 1998-02-18 |
DK0823907T3 (da) | 1999-11-08 |
NZ328932A (en) | 1998-04-27 |
DE69700236D1 (de) | 1999-07-01 |
ZA971074B (en) | 1997-11-18 |
WO1997031915A1 (en) | 1997-09-04 |
EP0823907B1 (en) | 1999-05-26 |
NO974958L (no) | 1997-10-27 |
ATE180481T1 (de) | 1999-06-15 |
US5973155A (en) | 1999-10-26 |
GR3030683T3 (en) | 1999-11-30 |
IL121995A0 (en) | 1998-03-10 |
CA2217171A1 (en) | 1997-09-04 |
CA2217171C (en) | 2001-09-11 |
NO974958D0 (no) | 1997-10-27 |
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