JPH11332836A - Dullness evaluation method of skin - Google Patents
Dullness evaluation method of skinInfo
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- JPH11332836A JPH11332836A JP16604898A JP16604898A JPH11332836A JP H11332836 A JPH11332836 A JP H11332836A JP 16604898 A JP16604898 A JP 16604898A JP 16604898 A JP16604898 A JP 16604898A JP H11332836 A JPH11332836 A JP H11332836A
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- skin
- dullness
- value
- keratinocytes
- evaluating
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Abstract
Description
【０００１】[0001]
【発明の属する技術分野】この発明は、テープストリッ
ピング法にて採取した角質細胞の形態，多重剥離度，メ
ラニン量及び肌の分光反射率を用いて、肌のくすみを客
観的にかつ総合的に評価できるようにする、肌のくすみ
評価方法に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for objectively and comprehensively measuring the dullness of skin by using the morphology, multiple exfoliation, melanin content and skin spectral reflectance of keratinocytes collected by a tape stripping method. The present invention relates to a method for evaluating the dullness of the skin so that it can be evaluated.
【０００２】[0002]
【従来の技術】人の肌状態を表す用語として、「くす
み」という用語がしばしば使用される。くすみは、肌の
外観を表現する用語であり、具体的には肌の赤みが減少
して黄味が増し、肌のつやや透明感が減少したり、皮膚
表面の凹凸などによる影によって明度が低下して暗く見
える状態を総合的に表すものである。肌のくすみの測定
方法には、肌色の明度又は色相を測色計にて測定する方
法、肌の不均一性，皮膚の凹凸を画像解析装置を用いて
測定する方法、皮膚の透明感の指標として光の透過度を
分光光度計を用いて測定する方法、肌のつやを示す指標
として光沢値を光沢計を用いて測定する方法などが知ら
れている。しかしながら、くすみは、肌の状態を外観か
ら総合的に評価する用語であり、上記のような測定のみ
では、くすみを総合的に評価することができず、官能評
価に頼らざるを得なかった。2. Description of the Related Art The term "dullness" is often used as a term representing a human skin condition. Dullness is a term that expresses the appearance of the skin.Specifically, the redness of the skin decreases and the yellowness increases, the brightness and transparency of the skin decrease, and the brightness is reduced by shadows due to unevenness on the skin surface. It is a comprehensive representation of the state where it looks darker and lower. Methods for measuring skin dullness include measuring the lightness or hue of skin color with a colorimeter, measuring unevenness of skin, and unevenness of skin using an image analyzer, and an index of skin clarity. There are known a method of measuring the light transmittance using a spectrophotometer, a method of measuring a gloss value as an index indicating the gloss of the skin using a gloss meter, and the like. However, dullness is a term that comprehensively evaluates the condition of the skin from the appearance, and dullness cannot be comprehensively evaluated only by the above-described measurement, and it is necessary to rely on sensory evaluation.
【０００３】[0003]
【発明が解決しようとする課題】本発明においては、肌
のくすみを人間による官能評価を必要とせず、客観的に
かつ総合的に評価する方法を提供することを目的とす
る。SUMMARY OF THE INVENTION An object of the present invention is to provide a method for objectively and comprehensively evaluating the dullness of the skin without the need for human sensory evaluation.
【０００４】[0004]
【課題を解決するための手段】上記課題を解決するた
め、鋭意検討を行った結果、テープストリッピング法に
て採取した角質細胞の形態，多重剥離度，メラニン量及
び肌の分光反射率を用いることにより、上記課題が解決
できることを見いだし、本発明を完成するに至った。Means for Solving the Problems In order to solve the above problems, as a result of intensive studies, the use of morphology, multiple exfoliation, melanin content and skin spectral reflectance of keratinocytes collected by a tape stripping method is used. As a result, they have found that the above problems can be solved, and have completed the present invention.
【０００５】すなわち本発明は、分光測色機にて７００
ｎｍ，６４０ｎｍ，５７０ｎｍ，４６０ｎｍ，及び４３
０ｎｍの波長における肌の分光反射率、及びＬ*値及び
ｂ*値を測定し、さらにテープストリッピング法にて採
取した角質細胞の多重剥離度，メラニン量，細胞形態を
画像解析により解析し、得られた数値に一定の重みづけ
処理を施すことにより、くすみを総合的に評価するもの
である。That is, the present invention relates to a spectrophotometer for measuring 700
nm, 640 nm, 570 nm, 460 nm, and 43
The spectral reflectance of the skin, the L * value and the b * value at a wavelength of 0 nm were measured, and the multiple exfoliation degree, the amount of melanin, and the cell morphology of the keratinocytes collected by the tape stripping method were analyzed by image analysis. The dullness is comprehensively evaluated by performing a predetermined weighting process on the given numerical values.
【０００６】[0006]
【発明の実施の形態】本発明において、分光反射率を測
定する肌の部位としては、特に限定されないが、頬，
額，顎等の顔面、上腕内側部、首筋等が例示される。そ
の中でも顔面皮膚の状態を評価する目的には、顔面で測
定することが好ましい。BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, the skin site for measuring the spectral reflectance is not particularly limited.
Examples include the face such as the forehead and the chin, the inner part of the upper arm, the neck muscle, and the like. Among them, for the purpose of evaluating the condition of the facial skin, it is preferable to perform measurement on the face.
【０００７】本発明において分光反射率を測定する機器
としては、各波長の分光反射率をそれぞれ測定できる機
器であれば特に限定されない。分光反射率を測定する際
の光源としては、国際照明委員会（Ｃｏｍｍｉｓｓｉｏ
ｎ Ｉｎｔｅｒｎａｔｉｏｎａｌｅ ｄｅ ｌ’Ｅｃｌ
ａｒｉａｇｅ，ＣＩＥ）で標準光源として採用されてい
る光源の内、Ｃ光源が好ましく用いられる。In the present invention, the instrument for measuring the spectral reflectance is not particularly limited as long as it can measure the spectral reflectance of each wavelength. As a light source for measuring the spectral reflectance, the International Commission on Illumination (Commissio)
n Internationale de l'Ecl
arage, CIE), the C light source is preferably used.
【０００８】本発明においては、測色した肌の７００ｎ
ｍ，６４０ｎｍ，５７０ｎｍ，５４０ｎｍ，４６０ｎ
ｍ，及び４３０ｎｍにおける分光反射率及びＬ*値，ｂ*
値より、４６０ｎｍと４３０ｎｍの分光反射率の差、７
００ｎｍと６４０ｎｍの分光反射率の差、５４０ｎｍと
５７０ｎｍの分光反射率の差、及びｂ*／Ｌ*値を算出し
て、くすみ評価に用いる。[0008] In the present invention, 700n of the colorimetric skin
m, 640 nm, 570 nm, 540 nm, 460 n
m, and spectral reflectance at 430 nm and L * value, b *
From the values, the difference between the spectral reflectance at 460 nm and 430 nm, 7
The difference between the spectral reflectances of 00 nm and 640 nm, the difference between the spectral reflectances of 540 nm and 570 nm, and the b * / L * value are calculated and used for the evaluation of dullness.
【０００９】多重剥離度の測定 テープストリッピング法により採取した角質細胞の画像
をコンピュータに取り込み、画像解析ソフトを用いて細
胞の多重度を観察し、ヒストグラムを作成し、多重剥離
度を式３により算出する。Measurement of Degree of Multiple Exfoliation An image of keratinocytes collected by the tape stripping method is taken into a computer, the degree of multiplicity of cells is observed using image analysis software, a histogram is created, and the degree of multiple exfoliation is calculated by Equation 3. I do.
【００１０】[0010]
【数３】 (Equation 3)
【００１１】メラニン量定量方法 テープストリッピング法により採取した角質細胞を、フ
ォンタナ・マッソン染色法等の染色法を用いてメラニン
を染色し、染色した角質細胞の画像をコンピュータに取
り込み、画像解析ソフトを用い、２値化処理を施すこと
により、細胞１個当たりに占めるメラニンの割合を面積
％で示す。Melanin quantification method The keratinocytes collected by the tape stripping method are stained with melanin using a staining method such as Fontana-Masson staining method, an image of the stained keratinocytes is loaded into a computer, and image analysis software is used. The ratio of melanin per cell by performing the binarization process is indicated by area%.
【００１２】細胞形態の判定 テープストリッピング法により採取した角質細胞を、顕
微鏡で観察することにより細胞形態の判定を行うことが
できる。本発明において細胞形態は、細胞の有核率，細
胞の輪郭の明瞭度，及び細胞の密度により判定した。細
胞の有核率は「有核率４分の１未満：４点」，「有核率
４分の１以上２分の１未満：３点」，「有核率２分の１
以上４分の３未満：２点」，「有核率４分の３以上１未
満：１点」，「有核率１：０点」として、細胞の輪郭の
明瞭度は「輪郭が明瞭である：４点」，「輪郭がかなり
明瞭である：３点」，「輪郭が少し不明瞭である：２
点」，「輪郭がかなり不明瞭である：１点」，「輪郭が
不明瞭である：０点」、細胞の密度は「細胞同士が結合
したまま剥離し、細胞間の隙間がほとんどない：４
点」，「細胞同士がやや離れて剥離し、細胞間の隙間が
少し見られる：３点」，「細胞同士が離れてまばらに剥
離し、細胞間の隙間も大きい：２点」，「細胞同士の結
合がほとんどなく、まばらに剥離：１点」，「殆ど細胞
が剥離せず、個々の細胞がまばらに剥離している程度：
０点」を基準に、予め用意しておいた標準となる剥離細
胞の画像を参考に評価し、有核率，輪郭の明瞭度，及び
細胞密度の評価点の合計を、細胞形態の評価点とした。Determination of Cell Morphology The cell morphology can be determined by observing the keratinocytes collected by the tape stripping method with a microscope. In the present invention, the cell morphology was determined based on the nucleation rate of the cells, the clarity of the cell outline, and the cell density. The nucleation rate of the cells is "nucleation rate less than 1/4: 4 points", "nucleation rate is 1/4 or more and less than 1/2: 3 points", "nucleation rate is 1/2"
The clarity of the outline of the cell is “Clear outline is clear and the nucleation rate is 1 point” and “nucleated rate is less than 1: 1 point” and “nucleated rate is 1: 0 point”. "There are 4 points", "The contour is quite clear: 3 points", "The contour is slightly unclear: 2"
"Point", "outline is unclear: 1 point", "outline is unclear: 0 point", and cell density is "separated while cells are bonded, and there is almost no gap between cells: 4
"Points", "Cells detached slightly apart from each other and gaps between cells are slightly seen: 3 points", "Cells separated apart and sparsely separated, and gaps between cells were large: 2 points", "Cells" There is hardly any bond between each other, and sparse detachment: 1 point "," Degree of detachment of individual cells sparsely with few cells detached:
Based on the “0 point” as a reference, the evaluation was performed with reference to a previously prepared image of a standard exfoliated cell, and the total of the evaluation points for nucleation rate, contour clarity, and cell density was evaluated for the cell morphology evaluation point. And
【００１３】なお、多重剥離度及び細胞形態の判定にお
いては、テープストリッピング法により採取した細胞を
そのまま用いることもできるが、より正確な評価を行う
ために角質細胞を染色した後画像解析に供することが好
ましい。角質細胞の染色法としては、ヘマトキシリン・
エオジン（ＨＥ）染色、メチレンブルー・ローダミンＢ
染色、ゲンチアナバイオレット・ブリリアントグリーン
染色等が一般に用いられる。In the determination of the degree of multiple detachment and cell morphology, cells collected by the tape stripping method can be used as they are. However, in order to perform a more accurate evaluation, keratinocytes must be stained and then subjected to image analysis. Is preferred. Keratinocyte staining methods include hematoxylin and
Eosin (HE) staining, methylene blue rhodamine B
Staining, gentian violet brilliant green staining, and the like are generally used.
【００１４】次に、重みづけ処理を施す方法として、主
成分分析による解析法、重回帰分析による解析法が例示
される。主成分分析及び重回帰分析による解析法により
くすみ指数はそれぞれ式１及び式２で示された。Next, examples of the method of performing the weighting process include an analysis method based on principal component analysis and an analysis method based on multiple regression analysis. The dullness index was shown by the formulas 1 and 2 by the analysis method using the principal component analysis and the multiple regression analysis.
【数１】(Equation 1)
【００１５】上記式１で得られたくすみ指数を用いて、
表１に示す基準により肌のくすみを判断することができ
る。Using the dullness index obtained by the above equation 1,
The dullness of the skin can be determined based on the criteria shown in Table 1.
【００１６】[0016]
【表１】 [Table 1]
【００１７】[0017]
【数２】(Equation 2)
【００１８】上記式２で得られたくすみ指数を用いる場
合、表２に示す基準により肌のくすみを判断することが
できる。When the dullness index obtained by the above equation 2 is used, the dullness of the skin can be determined based on the criteria shown in Table 2.
【００１９】[0019]
【表２】 [Table 2]
【００２０】[0020]
【実施例】２０代〜４０代の健常女性４３名を被験者と
して、肌の分光反射率を測定し、角質細胞の多重剥離
度，メラニン量，細胞形態を判定し、式２及び式３に基
づきくすみ指数を算出した。同時に、官能評価により、
くすみを評価し、くすみ指数との相関を求め、図１及び
図２に示した。官能評価は、専門の官能評価者３名によ
る合議でくすみを表３に示す５段階で評価した。EXAMPLE Using 43 healthy women in their 20s and 40s as subjects, the spectral reflectance of the skin was measured, and the multiple exfoliation degree of keratinocytes, the amount of melanin, and the cell morphology were determined. The dullness index was calculated. At the same time, by sensory evaluation,
The dullness was evaluated, and the correlation with the dullness index was obtained. The results are shown in FIGS. 1 and 2. In the sensory evaluation, dullness was evaluated in five stages shown in Table 3 by discussion by three specialized sensory evaluators.
【００２１】[0021]
【表３】 [Table 3]
【００２２】肌の分光反射率の測定は、分光測色計（ミ
ノルタＣＭ−２０２２）を用い、Ｃ光源，２度視野条件
下で、頬部の直径５ｍｍの範囲で行った。被験者は測色
の３０分前に統一された洗顔料で洗顔を行い、基礎化粧
品などを何もつけない状態で、室温２０度，相対湿度５
０％，無風の恒温恒湿室内で環境に馴化させた後、測色
を行った。また、角質細胞の多重剥離度，メラニン量，
細胞形態は、測色を行った被験者に対し、測色後直ち
に、テープストリッピング法にて頬部２ヶ所の角質細胞
を採取した。採取した角質細胞のひとつは、ブリリアン
トグリーン０．５重量％，ゲンチアナバイオレット１重
量％混合水溶液にて染色し、多重剥離度及び細胞形態の
測定に供し、もう一方はフォンタナ・マッソン染色を行
い、メラニン量の定量を行った。The spectral reflectance of the skin was measured using a spectrocolorimeter (Minolta CM-2022) under the condition of a C light source and a 2 degree visual field in a range of 5 mm in diameter of the cheek. Subjects wash their face 30 minutes before color measurement with a standardized facial cleanser, without applying any basic cosmetics, room temperature 20 ° C, relative humidity 5
After acclimatization to the environment in a 0%, constant-temperature, constant-humidity room with no wind, colorimetry was performed. In addition, multiple exfoliation of keratinocytes, melanin content,
As for the cell morphology, keratinocytes at two cheeks were collected by a tape stripping method immediately after the color measurement of the subject who performed the color measurement. One of the collected keratinocytes was stained with a mixed aqueous solution of 0.5% by weight of brilliant green and 1% by weight of gentian violet, and subjected to measurement of multiple exfoliation and cell morphology, and the other was stained with Fontana-Masson and stained with melanin. The quantity was quantified.
【００２３】図１及び図２に示したとおり、官能評価値
とくすみ指数の間には良好な相関関係が認められ、官能
評価値とくすみ指数の相関係数はそれぞれ、０．７９及
び−０．８２であった。As shown in FIGS. 1 and 2, a good correlation was observed between the sensory evaluation value and the dullness index, and the correlation coefficients between the sensory evaluation value and the dullness index were 0.79 and −0, respectively. Was .82.
【００２４】[0024]
【発明の効果】肌の分光反射率，測色値及び角質細胞の
多重剥離度，メラニン量，細胞形態の測定結果に基づ
き、式１または式２を用いることにより、くすみを総合
的且つ客観的に評価することができた。The dullness is comprehensively and objectively determined by using the expression 1 or 2 based on the measurement results of the spectral reflectance of the skin, the colorimetric value and the multiple exfoliation degree of the keratinocytes, the amount of melanin and the cell morphology. Could be evaluated.
【図１】実施例において、官能評価値と式１により算出
したくすみ指数の相関を示す図である。FIG. 1 is a diagram showing a correlation between a sensory evaluation value and a dullness index calculated by Expression 1 in Examples.
【図２】実施例において、官能評価値と式２により算出
したくすみ指数の相関を示す図である。FIG. 2 is a diagram showing a correlation between a sensory evaluation value and a dullness index calculated by Expression 2 in Examples.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 ＦＩ Ｇ０１Ｎ 33/50 Ｇ０１Ｎ 33/50 Ｑ (72)発明者 榊 幸子 滋賀県八日市市岡田町字野上112−１ 株 式会社ノエビア製品研究所内 (72)発明者 大江 昌彦 滋賀県八日市市岡田町字野上112−１ 株 式会社ノエビア製品研究所内 (72)発明者 大橋 奈穂 滋賀県八日市市岡田町字野上112−１ 株 式会社ノエビア製品研究所内──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 6 Identification symbol FI G01N 33/50 G01N 33/50 Q (72) Inventor Sachiko Sakaki 112-1 Nogami, Okada-cho, Yokaichi-shi, Shiga Pref. In the laboratory (72) Inventor Masahiko Oe 112-1 Nogami, Okada-cho, Yokaichi-shi, Shiga Pref.Noevir Products Research Institute (72) Inventor Naho Ohashi 112-1 Nogami, Okada-cho, Yokaichi, Shiga Pref. In the laboratory
Claims (3)
質細胞の形態，多重剥離度，メラニン量、及び７００ｎ
ｍ，６４０ｎｍ，５７０ｎｍ，４６０ｎｍ及び４３０ｎ
ｍの波長における肌の分光反射率、及びＬ*値及びｂ*値
を測定し、得られた測定値に重みづけ処理を行うことに
より、肌のくすみを評価する方法。1. The morphology, multiple exfoliation degree, melanin content, and 700 n of keratinocytes collected by tape stripping
m, 640 nm, 570 nm, 460 nm and 430 n
A method of measuring the spectral reflectance, L * value, and b * value of the skin at a wavelength of m, and weighting the measured values to evaluate the dullness of the skin.
特徴とする、請求項１に記載の肌のくすみを評価する方
法。 【数１】 2. The method for evaluating dullness of skin according to claim 1, wherein a weighting process is performed using Expression 1. (Equation 1)
特徴とする、請求項１に記載の肌のくすみを評価する方
法。 【数２】 3. The method for evaluating dullness of skin according to claim 1, wherein a weighting process is performed using Expression 2. (Equation 2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16604898A JPH11332836A (en) | 1998-05-28 | 1998-05-28 | Dullness evaluation method of skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16604898A JPH11332836A (en) | 1998-05-28 | 1998-05-28 | Dullness evaluation method of skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11332836A true JPH11332836A (en) | 1999-12-07 |
Family
ID=15824004
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|---|---|---|---|
| JP16604898A Withdrawn JPH11332836A (en) | 1998-05-28 | 1998-05-28 | Dullness evaluation method of skin |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003192531A (en) * | 2002-02-28 | 2003-07-09 | Noevir Co Ltd | Skin care preparation aiming at increase of scattered light on skin surface |
| JP2004073327A (en) * | 2002-08-12 | 2004-03-11 | Naris Cosmetics Co Ltd | Colorimetric method for skin, inorganic powder composition effective to remove darkness of skin, and cosmetic material using the same |
| JP2008245666A (en) * | 2007-03-29 | 2008-10-16 | Tokiwa Yakuhin Kogyo Kk | Skin pigmentation evaluating method and its presentation method |
| JP2010046309A (en) * | 2008-08-22 | 2010-03-04 | Shiseido Co Ltd | Evaluation method and evaluation device of dullness of skin |
| JP2011107027A (en) * | 2009-11-19 | 2011-06-02 | Pola Chemical Industries Inc | Judging method of skin |
| JP5306651B2 (en) * | 2005-09-02 | 2013-10-02 | ポーラ化成工業株式会社 | Method for determining skin condition and method for predicting skin thickness |
| JP2014213065A (en) * | 2013-04-26 | 2014-11-17 | 株式会社 資生堂 | Skin dullness evaluation device, skin dullness evaluation method, and skin dullness evaluation program |
| CN104688180A (en) * | 2013-12-09 | 2015-06-10 | 中国工程物理研究院流体物理研究所 | Whitening effect judging method based on spectral imaging |
| JP2019207752A (en) * | 2018-05-28 | 2019-12-05 | 東洋インキＳｃホールディングス株式会社 | Color changing method and color changing device |
-
1998
- 1998-05-28 JP JP16604898A patent/JPH11332836A/en not_active Withdrawn
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003192531A (en) * | 2002-02-28 | 2003-07-09 | Noevir Co Ltd | Skin care preparation aiming at increase of scattered light on skin surface |
| JP2004073327A (en) * | 2002-08-12 | 2004-03-11 | Naris Cosmetics Co Ltd | Colorimetric method for skin, inorganic powder composition effective to remove darkness of skin, and cosmetic material using the same |
| JP5306651B2 (en) * | 2005-09-02 | 2013-10-02 | ポーラ化成工業株式会社 | Method for determining skin condition and method for predicting skin thickness |
| JP2008245666A (en) * | 2007-03-29 | 2008-10-16 | Tokiwa Yakuhin Kogyo Kk | Skin pigmentation evaluating method and its presentation method |
| JP2010046309A (en) * | 2008-08-22 | 2010-03-04 | Shiseido Co Ltd | Evaluation method and evaluation device of dullness of skin |
| JP2011107027A (en) * | 2009-11-19 | 2011-06-02 | Pola Chemical Industries Inc | Judging method of skin |
| JP2014213065A (en) * | 2013-04-26 | 2014-11-17 | 株式会社 資生堂 | Skin dullness evaluation device, skin dullness evaluation method, and skin dullness evaluation program |
| CN104688180A (en) * | 2013-12-09 | 2015-06-10 | 中国工程物理研究院流体物理研究所 | Whitening effect judging method based on spectral imaging |
| JP2019207752A (en) * | 2018-05-28 | 2019-12-05 | 東洋インキＳｃホールディングス株式会社 | Color changing method and color changing device |
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