JPH09505811A - チャペロニン10のアンタゴニスト - Google Patents
チャペロニン10のアンタゴニストInfo
- Publication number
- JPH09505811A JPH09505811A JP7515296A JP51529695A JPH09505811A JP H09505811 A JPH09505811 A JP H09505811A JP 7515296 A JP7515296 A JP 7515296A JP 51529695 A JP51529695 A JP 51529695A JP H09505811 A JPH09505811 A JP H09505811A
- Authority
- JP
- Japan
- Prior art keywords
- cpn10
- antibody
- epf
- cells
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.cpn10又は次のアミノ酸配列を有する組換cpn10に対するアンタゴニス ト又はそれに対して産生された抗体: 2.cpn10から誘導されたペプチドに対するアンタゴニスト又はそれに対し て産生された抗体。 3.次のいずれかのアミノ酸配列を有するペプチドに対するアンタゴニスト又 はそれに対して産生された抗体: (ただし、これらのペプチドは一個のアミノ酸が欠失、付加または置換していて もよい)。 4.次のいずれかのペプチドに対するアンタゴニスト又はそれに対して産生さ れた抗体: (i)AGQAFRKFLPL; (ii)Ac−AGQAFRKFLPL; (iii)EKSQGKVLQAT (iv)A1AGQAFRKFLPLA2; (v)AGQAFRKFLPLA2; (vi)A1AGQAFRKFLPL; (vii)Ac−A1AGQAFRKFLPLA2; (viii)Ac−AGQAFRKFLPLA2; (ix)Ac−A1AGQAFRKFLPL; (x)A1EKSQGKVLQATA2; (xi)EKSQGKVLQATA2; (xii)A1EKSQGKVLQAT; (ただし、A1とA2はペプチド(i)〜(xii)のいずれかの端または両端に 付加することができるアミノ酸配列であって、当該ペプチドは一つのアミノ酸が 欠失、付加または置換していてもよい)。 5.患者に対してcpn10アンタゴニストまたは抗cpn10抗体を投与すること を特徴とする、細胞成長を抑制するか、又は免疫活性を向上させる方法。 6.患者に対してcpn10アンタゴニストまたは抗cpn10抗体を投与すること により妊娠を終了させる、請求項5の方法。 7.患者に対してcpn10アンタゴニストまたは抗cpn10抗体を投与すること により細胞成長を抑制させる、請求項5の方法。 8.細胞が腫瘍である、請求項7の方法。 9.細胞が白血病である、請求項8の方法。 10.(1)本質的に精製されたcpn10と試料とを反応させ、(2)当該試料中の 抗−cpn10抗体の量を当該抗体とcpn10の間の結合を決定することによって決 定することを特徴とする、試料中の抗cpn10抗体の測定方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPM270593 | 1993-11-30 | ||
AU2705 | 1994-09-16 | ||
AUPM8234A AUPM823494A0 (en) | 1994-09-16 | 1994-09-16 | Diagnostic and therapeutic uses of chaperonin 10 |
AU8234 | 1994-09-16 | ||
PCT/AU1994/000742 WO1995015339A1 (en) | 1993-11-30 | 1994-11-30 | Antagonists to chaperonin 10 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09505811A true JPH09505811A (ja) | 1997-06-10 |
JP3987104B2 JP3987104B2 (ja) | 2007-10-03 |
Family
ID=25644587
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51529495A Expired - Fee Related JP3545408B2 (ja) | 1993-11-30 | 1994-11-30 | シャペロニン10 |
JP51529695A Expired - Fee Related JP3987104B2 (ja) | 1993-11-30 | 1994-11-30 | シャペロニン10のアンタゴニスト |
JP2003319869A Expired - Fee Related JP3986481B2 (ja) | 1993-11-30 | 2003-09-11 | シャペロニン10 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51529495A Expired - Fee Related JP3545408B2 (ja) | 1993-11-30 | 1994-11-30 | シャペロニン10 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003319869A Expired - Fee Related JP3986481B2 (ja) | 1993-11-30 | 2003-09-11 | シャペロニン10 |
Country Status (11)
Country | Link |
---|---|
US (3) | US6113899A (ja) |
EP (2) | EP0731811B1 (ja) |
JP (3) | JP3545408B2 (ja) |
AT (1) | ATE282634T1 (ja) |
AU (2) | AU684578B2 (ja) |
CA (1) | CA2177179C (ja) |
DE (1) | DE69434137T2 (ja) |
ES (1) | ES2233938T3 (ja) |
NZ (2) | NZ276670A (ja) |
PT (1) | PT731811E (ja) |
WO (2) | WO1995015338A1 (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU684578B2 (en) * | 1993-11-30 | 1997-12-18 | University Of Queensland, The | Antagonists to chaperonin 10 |
AU751359B2 (en) * | 1997-07-10 | 2002-08-15 | Medical Research Council | Chaperone fragments |
US6007821A (en) * | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
US6475490B1 (en) | 1998-10-19 | 2002-11-05 | Fordham University | Compositions and methods for promoting tissue repair using heat shock proteins |
AUPP823999A0 (en) * | 1999-01-20 | 1999-02-11 | University Of Queensland, The | A treatment |
GB0028122D0 (en) * | 2000-11-17 | 2001-01-03 | St Georges Entpr Ltd | Method |
CN100406891C (zh) * | 2001-06-27 | 2008-07-30 | 詹森药业有限公司 | 利用EPF受体鉴定结合或调节hDRR活性的化合物以及hDRR的分离 |
AU2002952492A0 (en) | 2002-11-06 | 2002-11-21 | Cbio Limited | Chaperonin 10 immunosuppression |
GB0226105D0 (en) * | 2002-11-08 | 2002-12-18 | St Georges S Entpr Ltd | Pain relief agents |
ATE548047T1 (de) | 2004-01-16 | 2012-03-15 | Cbio Ltd | Chaperonin-10-modulation der sekretion des toll- artigen rezeptor-induzierbaren cytokins und chemokins |
EP1937723B1 (en) | 2005-08-31 | 2013-11-13 | Invion Limited | Modified chaperonin 10 |
AU2006303826B2 (en) * | 2005-10-20 | 2012-07-19 | Cbio Limited | Treatment of hypersensitivity |
EP1951282A4 (en) * | 2005-10-20 | 2009-09-02 | Cbio Ltd | TREATMENT OF HYPERSENSITIVITY |
WO2007098557A1 (en) | 2006-03-02 | 2007-09-07 | Cbio Limited | Regulation of immune responses by modulation of the function of antigen presenting cells |
CA2720617A1 (en) | 2008-04-11 | 2009-10-15 | Cbio Limited | Modified cpn10 and prr signalling |
CN102711793A (zh) * | 2009-10-09 | 2012-10-03 | 悉生物有限公司 | 伴侣蛋白10变异体 |
US20110243921A1 (en) * | 2010-03-30 | 2011-10-06 | Cbio Limited | Prevention and treatment of cutaneous lupus erythematosus |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0262119A1 (en) * | 1985-03-12 | 1988-04-06 | University Of Queensland | Method for detecting early pregnancy factor (epf) in mammals, purifying epf and method for producing a monoclonal antibody |
AU599021B2 (en) * | 1985-03-12 | 1990-07-12 | University Of Queensland, The | Method for detecting early pregnancy factor (epf) in mammals,purifying epf and method for producing a monoclonal antibody |
AU1086988A (en) * | 1986-12-22 | 1988-07-15 | University Of Queensland, The | Method of treatment of mammals using antibodies to early pregnancy factor (epf) |
WO1988004779A1 (en) * | 1986-12-22 | 1988-06-30 | University Of Queensland | Method of treatment of mammals using antibodies to early pregnancy factor (epf) |
AU684578B2 (en) * | 1993-11-30 | 1997-12-18 | University Of Queensland, The | Antagonists to chaperonin 10 |
-
1994
- 1994-11-30 AU AU11036/95A patent/AU684578B2/en not_active Ceased
- 1994-11-30 NZ NZ276670A patent/NZ276670A/en not_active IP Right Cessation
- 1994-11-30 ES ES95902003T patent/ES2233938T3/es not_active Expired - Lifetime
- 1994-11-30 CA CA002177179A patent/CA2177179C/en not_active Expired - Fee Related
- 1994-11-30 JP JP51529495A patent/JP3545408B2/ja not_active Expired - Fee Related
- 1994-11-30 PT PT95902003T patent/PT731811E/pt unknown
- 1994-11-30 EP EP95902003A patent/EP0731811B1/en not_active Expired - Lifetime
- 1994-11-30 EP EP95902005A patent/EP0733071A4/en not_active Withdrawn
- 1994-11-30 WO PCT/AU1994/000740 patent/WO1995015338A1/en active IP Right Grant
- 1994-11-30 JP JP51529695A patent/JP3987104B2/ja not_active Expired - Fee Related
- 1994-11-30 WO PCT/AU1994/000742 patent/WO1995015339A1/en not_active Application Discontinuation
- 1994-11-30 AU AU11034/95A patent/AU684577B2/en not_active Ceased
- 1994-11-30 NZ NZ276672A patent/NZ276672A/en not_active IP Right Cessation
- 1994-11-30 AT AT95902003T patent/ATE282634T1/de not_active IP Right Cessation
- 1994-11-30 DE DE69434137T patent/DE69434137T2/de not_active Expired - Lifetime
-
1996
- 1996-05-29 US US08/654,618 patent/US6113899A/en not_active Expired - Lifetime
-
1999
- 1999-02-23 US US09/255,703 patent/US6417334B1/en not_active Expired - Fee Related
-
2002
- 2002-05-21 US US10/151,006 patent/US7358329B2/en not_active Expired - Fee Related
-
2003
- 2003-09-11 JP JP2003319869A patent/JP3986481B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0731811A1 (en) | 1996-09-18 |
EP0733071A1 (en) | 1996-09-25 |
DE69434137D1 (en) | 2004-12-23 |
ES2233938T3 (es) | 2005-06-16 |
US7358329B2 (en) | 2008-04-15 |
NZ276670A (en) | 1998-01-26 |
DE69434137T2 (de) | 2005-12-01 |
US6417334B1 (en) | 2002-07-09 |
AU684578B2 (en) | 1997-12-18 |
EP0733071A4 (en) | 1997-02-26 |
AU1103695A (en) | 1995-06-19 |
WO1995015338A1 (en) | 1995-06-08 |
EP0731811A4 (en) | 2003-05-28 |
EP0731811B1 (en) | 2004-11-17 |
JPH09506431A (ja) | 1997-06-24 |
ATE282634T1 (de) | 2004-12-15 |
CA2177179C (en) | 2006-10-17 |
AU1103495A (en) | 1995-06-19 |
JP3545408B2 (ja) | 2004-07-21 |
JP2004067698A (ja) | 2004-03-04 |
US6113899A (en) | 2000-09-05 |
JP3987104B2 (ja) | 2007-10-03 |
WO1995015339A1 (en) | 1995-06-08 |
AU684577B2 (en) | 1997-12-18 |
JP3986481B2 (ja) | 2007-10-03 |
CA2177179A1 (en) | 1995-06-08 |
PT731811E (pt) | 2005-04-29 |
US20030175280A1 (en) | 2003-09-18 |
NZ276672A (en) | 1998-01-26 |
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