JPH09502724A - 新規なプロゲステロン送達方法とその効果 - Google Patents
新規なプロゲステロン送達方法とその効果Info
- Publication number
- JPH09502724A JPH09502724A JP7509291A JP50929195A JPH09502724A JP H09502724 A JPH09502724 A JP H09502724A JP 7509291 A JP7509291 A JP 7509291A JP 50929195 A JP50929195 A JP 50929195A JP H09502724 A JPH09502724 A JP H09502724A
- Authority
- JP
- Japan
- Prior art keywords
- progesterone
- polymer
- vagina
- serum
- levels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.女性にプロゲステロンを送達する方法であって、プロゲステロンを伴った架 橋ポリカルボン酸ポリマーを膣内に、膣の分泌転換の惹起に十分で、しかもプロ ゲステロンの血清中レベルを少なくとも48時間の間6.0ng/ml未満に維 持する量で挿入することを含む方法。 2.膣内に10〜200mgのプロゲステロンを挿入することを特徴とする請求 項1に記載の方法。 3.プロゲステロンの血清中レベルを1〜4ng/mlとすることを特徴とする 請求項1に記載の方法。 4.ポリマーをポリカルボフィルとすることを特徴とする請求項1に記載の方法 。 5.膣内にアジュバントも挿入することを特徴とする請求項1に記載の方法。 6.膣をエストラジオールで活性化(prime)しておくことを特徴とする請 求項1に記載の方法。 7.ポリマーを該ポリマーの0.1〜6.0重量%の量の架橋剤で架橋させるこ とを特徴とする請求項1に記載の方法。 8.プロゲステロンの血清中レベルを1〜6ng/mlに 維持しながら子宮内膜において分泌転換を惹起する方法。 9.前記プロゲステロンレベルを、架橋ポリカルボン酸ポリマー及びプロゲステ ロンを含有する薬物送達系を膣内に挿入することによって達成することを特徴と する請求項8に記載の方法。 10.膣内に10〜200mgのプロゲステロンを挿入することを特徴とする請 求項9に記載の方法。 11.プロゲステロンの血清中レベルを1〜4ng/mlとすることを特徴とす る請求項9に記載の方法。 12.ポリマーをポリカルボフィルとすることを特徴とする請求項9に記載の方 法。 13.薬物送達系に少なくとも1種のアジュバントも含有させることを特徴とす る請求項9に記載の方法。 14.膣をエストラジオールで活性化しておくことを特徴とする請求項9に記載 の方法。 15.ポリマーを該ポリマーの0.1〜6.0重量%の量の架橋剤で架橋させる ことを特徴とする請求項9に記載の方法。 16.プロゲステロンの送達を子宮内膜を標的として行なう方法であって、架橋 ポリカルボン酸ポリマー及びプロゲ ステロンを含有する薬物送達系を膣内に挿入することを含む方法。 17.膣内に10〜200mgのプロゲステロンを挿入することを特徴とする請 求項16に記載の方法。 18.達成されるプロゲステロンの血清中レベルが1〜4ng/mlであること を特徴とする請求項16に記載の方法。 19.ポリマーをポリカルボフィルとすることを特徴とする請求項16に記載の 方法。 20.薬物送達系に少なくとも1種のアジュバントも含有させることを特徴とす る請求項16に記載の方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/122,371 US5543150A (en) | 1993-09-15 | 1993-09-15 | Method of progesterone delivery and affect thereof |
US08/122,371 | 1993-09-15 | ||
US122,371 | 1993-09-15 | ||
PCT/US1994/010270 WO1995007699A1 (en) | 1993-09-15 | 1994-09-13 | Novel method of progesterone delivery and affect thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09502724A true JPH09502724A (ja) | 1997-03-18 |
JP3143474B2 JP3143474B2 (ja) | 2001-03-07 |
Family
ID=22402302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP07509291A Expired - Lifetime JP3143474B2 (ja) | 1993-09-15 | 1994-09-13 | 新規なプロゲステロン送達方法とその効果 |
Country Status (27)
Country | Link |
---|---|
US (1) | US5543150A (ja) |
EP (1) | EP0719146B1 (ja) |
JP (1) | JP3143474B2 (ja) |
KR (1) | KR100278553B1 (ja) |
AT (1) | ATE174796T1 (ja) |
BR (1) | BR9407475A (ja) |
CA (1) | CA2171939C (ja) |
CO (1) | CO4290332A1 (ja) |
DE (1) | DE69415543T2 (ja) |
DK (1) | DK0719146T3 (ja) |
ES (1) | ES2126783T3 (ja) |
FI (1) | FI115444B (ja) |
GR (1) | GR3029314T3 (ja) |
HU (1) | HU221583B (ja) |
IL (1) | IL110972A (ja) |
LT (1) | LT4072B (ja) |
LV (1) | LV11527B (ja) |
MA (1) | MA23329A1 (ja) |
MY (1) | MY111484A (ja) |
NO (1) | NO308585B1 (ja) |
NZ (1) | NZ273816A (ja) |
PE (1) | PE50795A1 (ja) |
PH (1) | PH30813A (ja) |
RU (1) | RU2148393C1 (ja) |
UA (1) | UA37244C2 (ja) |
WO (1) | WO1995007699A1 (ja) |
ZA (1) | ZA947073B (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002503637A (ja) * | 1997-09-12 | 2002-02-05 | コロンビア・ラボラトリーズ・(バミューダ)・リミテッド | 月経困難症と早期分娩の治療のための薬学的組成物 |
JP2002529494A (ja) * | 1998-11-18 | 2002-09-10 | フェリング ベスローテン フェンノートシャップ | プロゲステロン含有経膣投与用錠剤およびその調製法 |
JP2004500317A (ja) * | 1998-08-25 | 2004-01-08 | コロンビア・ラボラトリーズ・(バミューダ)・リミテッド | 長時間放出性の口腔生物接着性錠剤 |
JP2007509032A (ja) * | 2003-09-03 | 2007-04-12 | ミスコン トレイディング エス.エー. | 子宮内膜症の処置のための方法 |
JP2007528864A (ja) * | 2003-07-16 | 2007-10-18 | イタルファルマコ,ソシエダ アノニマ | 半固体粘膜接着製剤 |
JP2013522361A (ja) * | 2010-03-22 | 2013-06-13 | リプロス セラピューティクス インコーポレイテッド | 抗黄体ホルモンの無毒送達のための組成物および方法 |
US9545411B2 (en) | 2012-11-02 | 2017-01-17 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
US10328022B2 (en) | 2012-05-31 | 2019-06-25 | Repros Therapeutics Inc. | Formulations and methods for vaginal delivery of antiprogestins |
JP2020524690A (ja) * | 2017-06-22 | 2020-08-20 | ヴィラマル リミテッド | 薬物送達のための組成物およびその使用方法 |
US12016953B2 (en) | 2018-11-30 | 2024-06-25 | Viramal Limited | Method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
Families Citing this family (65)
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US5869081A (en) * | 1996-06-28 | 1999-02-09 | The Population Council | Progesterone vaginal ring for treatment of infertility |
US5985861A (en) * | 1996-11-04 | 1999-11-16 | Columbia Laboratories, Inc. | Progesterone for treating or reducing ischemia |
US6056972A (en) * | 1997-02-26 | 2000-05-02 | Dimera, Llc | Method for reducing coronary artery reactivity |
US6602487B1 (en) | 1997-02-26 | 2003-08-05 | Dimera Incorporated | Methods and tests for producing and for inhibiting coronary artery vasospasms |
EP1356806A1 (en) * | 1997-09-12 | 2003-10-29 | Columbia Laboratories (Bermuda) Limited | A pharmaceutical composition for treating dysmenorrhea and premature labor |
US7153845B2 (en) * | 1998-08-25 | 2006-12-26 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US8765177B2 (en) * | 1997-09-12 | 2014-07-01 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US20040234606A1 (en) * | 1997-09-12 | 2004-11-25 | Levine Howard L. | Localized vaginal delivery without detrimental blood levels |
AU9449398A (en) * | 1997-10-10 | 1999-05-03 | Imperial College Innovations Ltd. | Use of csaidtm compounds for the management of uterine contractions |
US6306914B1 (en) * | 1997-10-21 | 2001-10-23 | Columbia Laboratories, Inc. | Progestin therapy for maintaining amenorrhea |
AU4406899A (en) * | 1998-05-20 | 1999-12-06 | Bent Formby | Progesterone treatment of cancer |
US20070178139A1 (en) * | 1998-11-18 | 2007-08-02 | Yankov Vladimir I | Vaginally administratable progesterone-containing tablets and method for preparing same |
US6479045B2 (en) | 1999-12-22 | 2002-11-12 | Columbia Laboratories, Inc. | Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis |
US6544553B1 (en) * | 1999-12-28 | 2003-04-08 | Watson Pharmaceuticals, Inc. | Dosage forms and methods for oral delivery of progesterone |
GB0001449D0 (en) * | 2000-01-21 | 2000-03-08 | Cortendo Ab | Compositions |
GB0009914D0 (en) | 2000-04-20 | 2000-06-07 | Metris Therapeutics Limited | Device |
US7544348B2 (en) * | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
CA2441352C (en) * | 2001-02-15 | 2010-05-25 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
US20060073174A1 (en) * | 2001-08-16 | 2006-04-06 | Access Pharmaceuticals, Inc. | Adherent and erodible film to treat a moist surface of a body tissue |
US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
US8425892B2 (en) | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
US20030114394A1 (en) * | 2001-10-29 | 2003-06-19 | Levine Howard L. | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
US20080182841A1 (en) * | 2001-10-29 | 2008-07-31 | Levine Howard L | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
US7709026B2 (en) | 2001-10-29 | 2010-05-04 | Columbia Laboratories, Inc. | Low concentration of peroxide for treating or preventing vaginal infections |
US7572780B2 (en) | 2003-01-21 | 2009-08-11 | Dimera, Incorporated | Method and kit for reducing the symptoms of peripheral vascular disease |
EP1620060B1 (en) * | 2003-04-29 | 2010-03-24 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
UA90095C2 (en) * | 2003-09-03 | 2010-04-12 | Мискон Трейдинг С.А. | Method for the treatment of endometriosis |
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US10016442B2 (en) * | 2005-06-16 | 2018-07-10 | Allergan Pharmaceuticals International Limited | Estrogen compositions for vaginal administration |
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US8828981B2 (en) * | 2007-02-06 | 2014-09-09 | George Creasy | Progesterone for the treatment or prevention of spontaneous preterm birth |
ES2310968B1 (es) | 2007-06-25 | 2010-02-08 | Italfarmaco, S.A. | Uso de estriol en bajas dosis. |
JP2010539245A (ja) * | 2007-09-14 | 2010-12-16 | 日東電工株式会社 | 薬物担体 |
US12011423B2 (en) | 2007-11-06 | 2024-06-18 | Foraviset Ltd. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
GB0723882D0 (en) * | 2007-12-07 | 2008-01-23 | Univ Leicester | Methods for the detection of a threatened miscarriage |
BRPI0905946B8 (pt) | 2008-02-04 | 2021-05-25 | Ferring Bv | anel intravaginal monolítico e processo para a produção de um anel intravaginal monolítico |
US9107696B2 (en) | 2008-08-06 | 2015-08-18 | Emory University | Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus |
ES2344673B1 (es) | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
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ES2344675B1 (es) | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
US9375437B2 (en) | 2010-06-18 | 2016-06-28 | Lipocine Inc. | Progesterone containing oral dosage forms and kits |
US8435972B2 (en) | 2010-09-02 | 2013-05-07 | Emory University | Method for the treatment of central nervous system cancers and compositions related thereto |
US9168303B2 (en) * | 2011-07-15 | 2015-10-27 | Universiteit Gent | Intravaginal delivery system |
US8951996B2 (en) | 2011-07-28 | 2015-02-10 | Lipocine Inc. | 17-hydroxyprogesterone ester-containing oral compositions and related methods |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
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US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
CN103239389A (zh) * | 2013-06-03 | 2013-08-14 | 南京泽恒医药技术开发有限公司 | 一种治疗先兆性流产的***缓释凝胶的制备方法 |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
EP3174542A4 (en) | 2014-07-29 | 2018-01-03 | TherapeuticsMD, Inc. | Transdermal cream |
MX2017016823A (es) | 2015-06-22 | 2018-03-12 | Lipocine Inc | Composiciones orales que contienen éster de 17- hydroxiprogesterona y métodos relacionados. |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
BR112018070199A2 (pt) | 2016-04-01 | 2019-01-29 | Therapeuticsmd Inc | composição farmacêutica de hormônio esteroide |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
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1993
- 1993-09-15 US US08/122,371 patent/US5543150A/en not_active Expired - Lifetime
-
1994
- 1994-09-13 EP EP94928089A patent/EP0719146B1/en not_active Expired - Lifetime
- 1994-09-13 ES ES94928089T patent/ES2126783T3/es not_active Expired - Lifetime
- 1994-09-13 KR KR1019960701325A patent/KR100278553B1/ko not_active IP Right Cessation
- 1994-09-13 DE DE69415543T patent/DE69415543T2/de not_active Expired - Lifetime
- 1994-09-13 HU HU9600669A patent/HU221583B/hu unknown
- 1994-09-13 JP JP07509291A patent/JP3143474B2/ja not_active Expired - Lifetime
- 1994-09-13 RU RU96108813A patent/RU2148393C1/ru active
- 1994-09-13 AT AT94928089T patent/ATE174796T1/de active
- 1994-09-13 UA UA96030993A patent/UA37244C2/uk unknown
- 1994-09-13 CA CA002171939A patent/CA2171939C/en not_active Expired - Lifetime
- 1994-09-13 DK DK94928089T patent/DK0719146T3/da active
- 1994-09-13 WO PCT/US1994/010270 patent/WO1995007699A1/en active IP Right Grant
- 1994-09-13 BR BR9407475A patent/BR9407475A/pt not_active Application Discontinuation
- 1994-09-13 NZ NZ273816A patent/NZ273816A/en not_active IP Right Cessation
- 1994-09-14 ZA ZA947073A patent/ZA947073B/xx unknown
- 1994-09-14 MA MA23649A patent/MA23329A1/fr unknown
- 1994-09-14 IL IL110972A patent/IL110972A/en not_active IP Right Cessation
- 1994-09-14 MY MYPI94002436A patent/MY111484A/en unknown
- 1994-09-15 CO CO94041745A patent/CO4290332A1/es unknown
- 1994-09-15 PH PH49001A patent/PH30813A/en unknown
- 1994-09-15 PE PE1994250745A patent/PE50795A1/es not_active IP Right Cessation
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1996
- 1996-03-11 LT LT96-027A patent/LT4072B/lt not_active IP Right Cessation
- 1996-03-14 NO NO961044A patent/NO308585B1/no not_active IP Right Cessation
- 1996-03-15 FI FI961221A patent/FI115444B/fi not_active IP Right Cessation
- 1996-04-15 LV LVP-96-113A patent/LV11527B/en unknown
-
1999
- 1999-02-10 GR GR990400400T patent/GR3029314T3/el unknown
Patent Citations (2)
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