JPH09104060A - Drug packing polypropylene sheet and production thereof - Google Patents
Drug packing polypropylene sheet and production thereofInfo
- Publication number
- JPH09104060A JPH09104060A JP7264281A JP26428195A JPH09104060A JP H09104060 A JPH09104060 A JP H09104060A JP 7264281 A JP7264281 A JP 7264281A JP 26428195 A JP26428195 A JP 26428195A JP H09104060 A JPH09104060 A JP H09104060A
- Authority
- JP
- Japan
- Prior art keywords
- polypropylene
- resin
- sheet
- melting
- melting points
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Compositions Of Macromolecular Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、医薬品包装の各種
包装形態、例えば一般にＰＴＰと称される固形剤包装用
として好ましく用いられる医薬品包装用ポリプロピレン
系シート及びその製造方法に関するものである。更に詳
しくは、それぞれ融点の異なるポリプロピレン系樹脂及
びポリエチレン系樹脂よりなる樹脂組成物を溶融混練
し、急冷シート化することにより得られる、特に熱成形
性に優れた医薬品包装用ポリプロピレン系シート及びそ
の製造方法に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a polypropylene sheet for drug packaging, which is preferably used for various packaging forms of drug packaging, for example, solid agent packaging generally called PTP, and a method for producing the same. More specifically, it is obtained by melt-kneading a resin composition composed of a polypropylene resin and a polyethylene resin having different melting points, respectively, to obtain a rapidly cooled sheet, and particularly a polypropylene sheet for pharmaceutical packaging excellent in thermoformability and its production. It is about the method.
【０００２】[0002]
【従来の技術】医薬品包装の分野で、固形剤包装用とし
て一般に用いられているＰＴＰ包装用シートには、従来
からポリ塩化ビニル（以下、ＰＶＣと略す）樹脂からな
るシートが用いられている。ＰＶＣ樹脂シートは、ＰＴ
Ｐ包装に要求される特性をほぼ満足する優れたシートで
あるが、防湿特性が劣る為、更なる防湿性を必要とする
製剤に対しては、ＰＴＰ包装をした後、更にアルミ箔を
含む構成のフィルムによりピロー包装を行うか、あるい
はＰＶＣ樹脂シートにポリ塩化ビニリデン樹脂をコーテ
ィングした複合シートを用いることで防湿性を補う方法
がとられてきた。しかし、これらの方法は工数が増える
ほか、包材のコストアップにつながる。2. Description of the Related Art In the field of pharmaceutical packaging, sheets made of polyvinyl chloride (hereinafter abbreviated as PVC) resin have been conventionally used as PTP packaging sheets generally used for packaging solid agents. PVC resin sheet is PT
Although it is an excellent sheet that almost satisfies the properties required for P packaging, it has a structure that further contains aluminum foil after PTP packaging for formulations that require further moisture resistance because of its poor moisture resistance. A method for supplementing the moisture resistance has been adopted by carrying out pillow packaging with the above film or by using a composite sheet in which a polyvinylidene chloride resin is coated on a PVC resin sheet. However, these methods increase man-hours and increase the cost of packaging material.
【０００３】また、最近の脱ＰＶＣの動向とＰＶＣ樹脂
よりも防湿性に優れていることから、ポリプロピレン系
樹脂からなるシートが使用され始めたが、ポリプロピレ
ン系樹脂には成形性が非常に悪いという重大な欠点があ
った。この樹脂は熱成形する際の予熱時の加熱によるド
ローダウンが大きく、良好な成形品が得られる成形時の
最適な成形温度幅が非常に狭く、成形機に対して非常に
高度な温度制御が要求され、従来の汎用成形機では成形
不良率が高く工程管理が非常に困難である。従来より、
熱成形性の良好なポリオレフィン系樹脂の開発は検討さ
れており、例えば、ポリプロピレンに比較的成形性の良
好なポリエチレンやエチレン−プロピレン共重合体、無
機フィラー、低分子量の石油樹脂をブレンドさせて改質
する試みはすでに行われている。Also, because of recent trends in PVC removal and superior moisture resistance to PVC resins, sheets made of polypropylene resins have begun to be used, but polypropylene resins have very poor moldability. There were serious drawbacks. This resin has a large drawdown due to the heating during preheating during thermoforming, and the optimum molding temperature range during molding that can obtain good molded products is very narrow, and very high temperature control for the molding machine is possible. However, the conventional general-purpose molding machine has a high molding defect rate and it is very difficult to manage the process. Conventionally,
The development of polyolefin resins with good thermoformability has been studied.For example, it has been modified by blending polypropylene with polyethylene, ethylene-propylene copolymer, inorganic filler, and low molecular weight petroleum resin, which have relatively good moldability. Attempts to quality have already been made.
【０００４】例えば、高粘度のポリプロピレンに、高粘
度のポリエチレン（低密度ポリエチレン）及び含水ケイ
酸マグネシウム粉末を添加する方法（特公昭５６−１５
７４４号公報）、ポリプロピレンに、ポリエチレン（高
密度ポリエチレン）及びエチレン−プロピレン共重合体
を添加する方法（特公昭６３−２９７０４号公報）、ポ
リプロピレンと分子量分布の狭いポリエチレンを使用
し、成形加工性・耐振動疲労性を改良する方法（特公昭
６３−５３２１３号公報）、ポリプロピレンに石油樹脂
及びエチレン−α−オレフィン共重合体を添加する方法
（特公平６−８９１９１号公報）が挙げられるが、それ
ぞれある特定の温度条件での、シート軟化緊張保持時
間、溶融体強度、絞り加工性、ドローダウン等の成形加
工性に対しては、効果は認められるものの実質的な成形
性である成形可能温度幅については改良効果がほとんど
なく、現実的な成形性については未だ満足するものが得
られていないのが実状である。また、石油樹脂等の低分
子量化合物を使用した場合には、実際上は少なからずの
ブリード、溶出が生じ、医薬品包装には衛生上使用が困
難である。For example, a method of adding high-viscosity polyethylene (low-density polyethylene) and hydrous magnesium silicate powder to high-viscosity polypropylene (Japanese Patent Publication No. 56-15).
No. 744), a method of adding polyethylene (high-density polyethylene) and an ethylene-propylene copolymer to polypropylene (Japanese Patent Publication No. 63-29704), using polypropylene and polyethylene having a narrow molecular weight distribution, A method for improving vibration fatigue resistance (Japanese Patent Publication No. 63-53213) and a method for adding a petroleum resin and an ethylene-α-olefin copolymer to polypropylene (Japanese Patent Publication No. 6-89191) are mentioned. Formable temperature range that is an effective formability, although it has an effect on sheet softening tension retention time, melt strength, drawability, drawdown, and other formability under certain temperature conditions. There is almost no improvement effect on the above, and the actual formability is not yet satisfactory. A. In addition, when a low molecular weight compound such as petroleum resin is used, a considerable amount of bleeding and elution occurs in practice, which makes it difficult to use for hygiene in pharmaceutical packaging.
【０００５】[0005]
【発明が解決しようとする課題】本発明は、熱成形性に
優れた、特に成形加工時の成形温度幅の広い医薬品包装
用ポリプロピレン系シート及びその製造方法を提供する
ことにある。SUMMARY OF THE INVENTION It is an object of the present invention to provide a polypropylene-based sheet for drug packaging, which is excellent in thermoformability and has a wide molding temperature range during molding, and a method for producing the same.
【０００６】[0006]
【課題を解決するための手段】そこで、かかる課題を解
決する為、様々な検討を行った結果、それぞれ融点が適
度な間隔で異なるポリプロピレン系樹脂とポリエチレン
系樹脂からなる樹脂組成物を溶融混練し、８０℃以下の
温度で急冷シート化を行うことにより、また更に好まし
くはそのシートに熱処理を加えることにより、また更に
好ましくはポリプロピレン系樹脂とポリエチレン系樹脂
の粘度比を調整することで、そのモルフォロジーを制御
し、ポリプロピレン系樹脂の特徴を維持しながら成形加
工時の成形温度幅が広く、成形性が極めて良好な熱成形
用ポリプロピレン系シートが得られることを見いだし、
本発明を完成するに至った。[Means for Solving the Problems] Therefore, in order to solve such problems, as a result of various investigations, as a result, a resin composition comprising polypropylene resin and polyethylene resin having different melting points at appropriate intervals is melt-kneaded. The morphology of the morphology is controlled by subjecting the sheet to a quenching sheet at a temperature of 80 ° C. or lower, more preferably by subjecting the sheet to a heat treatment, and further preferably by adjusting the viscosity ratio of the polypropylene resin and the polyethylene resin. It was found that a polypropylene-based sheet for thermoforming having a wide molding temperature range during molding and excellent moldability can be obtained while maintaining the characteristics of the polypropylene-based resin.
The present invention has been completed.
【０００７】すなわち、本発明はすべての成分の示差走
査熱量測定(熱流束型DSC)による測定(JIS K 7121)での
融点（融解ピーク温度）の中で、隣り合う２成分の融点
（融解ピーク温度）の差が、いずれも互いに８〜２０℃
であり、その最大値と最小値の差が３０℃以上ある、少
なくとも１種類以上のポリプロピレン系樹脂と少なくと
も１種類以上のポリエチレン系樹脂からなり、さらに樹
脂の種類の合計が少なくとも３種類以上である樹脂組成
物を溶融混練し、８０℃以下の温度で急冷シート化をす
ることを特徴とする医薬品包装用ポリプロピレン系シー
ト及びその製造方法に関する。That is, according to the present invention, among the melting points (melting peak temperatures) of all components measured by differential scanning calorimetry (heat flux type DSC) (JIS K 7121), the melting points of two adjacent components (melting peaks) The difference in temperature) is 8 to 20 ° C.
And at least one type of polypropylene resin and at least one type of polyethylene resin having a difference between the maximum value and the minimum value of 30 ° C. or more, and the total number of resin types is at least three or more. The present invention relates to a polypropylene-based sheet for packaging pharmaceuticals, which comprises melt-kneading a resin composition and forming a rapidly-quenched sheet at a temperature of 80 ° C. or lower, and a method for producing the same.
【０００８】[0008]
【発明の実施の形態】本発明に、用いられるポリプロピ
レン系樹脂としては、特に制限はないが、例えばプロピ
レンのホモポリマー、プロピレンとエチレンやα−オレ
フィンとのブロックコポリマー、ランダムコポリマー、
更にはこれらの混合物が挙げられる。特に高度な防湿性
・透明性・剛性を要求される場合にはそれらの特性に優
れているプロピレンのホモポリマーが好ましい。また、
これらの樹脂は２種類以上の混合物として使用してもか
まない。主成分となるポリプロピレン系樹脂の溶融粘度
としては、フィルム、シート等の押出成形性が良好であ
る、２５０℃、剪断速度121.6sec-1で300Pa・s以上のも
のが好ましい。ポリエチレン系樹脂としては、例えば高
密度ポリエチレン、中密度ポリエチレン、低密度ポリエ
チレン、直鎖状低密度ポリエチレン、超低密度ポリエチ
レン等が挙げられる。BEST MODE FOR CARRYING OUT THE INVENTION The polypropylene resin used in the present invention is not particularly limited, but for example, a homopolymer of propylene, a block copolymer of propylene and ethylene or α-olefin, a random copolymer,
Further, a mixture thereof may be mentioned. Particularly when high moisture resistance, transparency and rigidity are required, a propylene homopolymer having excellent properties is preferable. Also,
These resins may be used as a mixture of two or more kinds. The melt viscosity of the polypropylene resin as the main component is preferably 300 Pa · s or more at 250 ° C. and a shear rate of 121.6 sec −1 , which has good extrusion moldability of films, sheets and the like. Examples of the polyethylene-based resin include high-density polyethylene, medium-density polyethylene, low-density polyethylene, linear low-density polyethylene, and ultra-low-density polyethylene.
【０００９】これらのすべての成分の示差走査熱量測定
(熱流束型DSC)による測定(JIS K 7121)での融点（融解
ピーク温度）の中で、隣り合う２成分の融点（融解ピー
ク温度）の差は、いずれも互いに８〜２０℃であること
が必要である。融点の差が８℃未満の樹脂の組み合わせ
では、各樹脂の融点が接近しすぎていて、融点近傍の粘
弾性挙動の変化がほとんどなく成形可能温度幅を広げる
為には有効ではない。また、融点の差があまりに大き過
ぎると粘弾性挙動を詳細に制御することが困難になるの
で、その差は２０℃以下であることが好ましい。Differential scanning calorimetry of all these components
Among the melting points (melting peak temperatures) measured by (heat flux type DSC) (JIS K 7121), the difference between the melting points (melting peak temperatures) of two adjacent components must be 8 to 20 ° C. is required. In the case of a combination of resins having a melting point difference of less than 8 ° C., the melting points of the resins are too close to each other, and there is almost no change in viscoelastic behavior in the vicinity of the melting points, which is not effective for expanding the moldable temperature range. Further, if the difference in melting point is too large, it becomes difficult to control the viscoelastic behavior in detail, so the difference is preferably 20 ° C. or less.
【００１０】また、これらの樹脂は少なくとも３種類以
上配合する必要がある。２種類以下の場合には、広範囲
な温度域での粘弾性挙動を制御することが不可能であ
り、成形可能温度範囲をほとんど広げることはできな
い。成形性可能温度幅の改良の為には、各樹脂の融点に
より熱時の粘弾性挙動が広範囲な温度域で順次変化する
３種類以上配合することが必要である。ポリプロピレン
系樹脂及びポリエチレン系樹脂の融点の最大値と最小値
の差が、狭すぎる場合には粘弾性挙動が変化する温度範
囲が狭く、成形可能温度幅の拡大には効果的ではなく、
最大値と最小値の差が３０℃以上あることが好ましい。
また、更に広い成形可能温度幅を要求する場合には、４
０℃以上が好ましく、更に好ましくは５０℃以上であ
る。Further, it is necessary to mix at least three kinds of these resins. In the case of two or less types, it is impossible to control the viscoelastic behavior in a wide temperature range, and it is almost impossible to extend the temperature range in which molding is possible. In order to improve the moldable temperature range, it is necessary to blend three or more kinds in which the viscoelastic behavior during heating changes sequentially in a wide temperature range depending on the melting point of each resin. The difference between the maximum and minimum melting points of polypropylene-based resin and polyethylene-based resin is too narrow, the temperature range in which the viscoelastic behavior changes is narrow, and it is not effective in expanding the moldable temperature range.
The difference between the maximum value and the minimum value is preferably 30 ° C. or more.
If a wider moldable temperature range is required, 4
The temperature is preferably 0 ° C or higher, more preferably 50 ° C or higher.
【００１１】ポリエチレン系樹脂の２５０℃，剪断速度
121.6sec-1での溶融粘度(ρe)は、主成分のポリプロピ
レン系樹脂の溶融粘度(ρp)より低く、好ましくはその
粘度比(ρe/ρp)が、ρe/ρp≦0.9である。更に好まし
くは、ρe/ρp≦0.8であり、その比が小さい方がポリエ
チレン系樹脂の配合比率が少ない割合からモルフォロジ
ーの連続性が発現し、熱成形性の改良に更に効果的であ
る。ポリエチレン系樹脂の配合量は、１０〜４０重量％
である。配合量が１０重量％未満では成形性への改良効
果がほとんど期待できず、また４０重量％を越える場合
は、ポリプロピレン系樹脂の優れた特性である剛性、耐
熱性等が損なわれる。また、シートの剛性について高度
な要求がある場合には、１０〜３０重量％が好ましい。
さらに高い防湿性が必要な場合には、ポリエチレン系樹
脂として防湿性に優れる高密度ポリエチレンの配合量を
多くすることが効果的である。250 ° C. shear rate of polyethylene resin
The melt viscosity at 121.6 sec -1 (ρ e ) is lower than the melt viscosity of the main component polypropylene resin (ρ p ), preferably its viscosity ratio (ρ e / ρ p ) is ρ e / ρ p ≦ It is 0.9. More preferably, ρ e / ρ p ≦ 0.8, and the smaller the ratio is, the more continuous the morphology is, and the more effective the thermoformability is, because the blending ratio of the polyethylene resin is small. The blending amount of polyethylene resin is 10 to 40% by weight.
It is. If the blending amount is less than 10% by weight, almost no improvement effect on the moldability can be expected, and if it exceeds 40% by weight, the excellent properties such as rigidity and heat resistance of the polypropylene resin are impaired. Further, when there is a high demand for the rigidity of the sheet, 10 to 30% by weight is preferable.
When higher moisture resistance is required, it is effective to increase the amount of high-density polyethylene, which has excellent moisture resistance, as the polyethylene resin.
【００１２】本発明では、それぞれ融点が適度な間隔で
異なるポリプロピレン系樹脂と少なくとも２種類以上の
ポリエチレン系樹脂を配合すること、また更にポリプロ
ピレン系樹脂とポリエチレン系樹脂の粘度比を調整する
ことにより、そのモルフォロジーを制御し、熱時のシー
トの粘弾性挙動を広範囲で詳細にコントロール可能とな
った。その結果、熱成形時の成形加工性すなわち成形可
能温度幅を飛躍的に広げることが可能となった。更に、
必要に応じて基本的性質を損なわず、衛生上問題ない範
囲であれば添加剤、例えば染顔料、安定剤、可塑剤、帯
電防止剤、紫外線吸収剤、酸化防止剤、滑剤、充填剤、
柔軟性を付与するエラストマー等も添加することができ
る。溶融混練については、通常の溶融押出装置等が用い
られるが、より高剪断のかかる２軸混練機による樹脂温
度２００℃以上での混練が、均一分散には好ましい。ま
たシート加工は、通常Ｔ−ダイ法により行われ、８０℃
以下の温度で急冷される。透明性を求める場合には、６
０℃以下での急冷が好ましく、更に好ましくは４０℃以
下での急冷である。In the present invention, by mixing at least two kinds of polyethylene resins with polypropylene resins having different melting points at appropriate intervals, and further adjusting the viscosity ratio of the polypropylene resin and the polyethylene resin, By controlling the morphology, it became possible to control the viscoelastic behavior of the sheet when heated in a wide range and in detail. As a result, it became possible to dramatically widen the molding processability during thermoforming, that is, the moldable temperature range. Furthermore,
Additives, such as dyes and pigments, stabilizers, plasticizers, antistatic agents, ultraviolet absorbers, antioxidants, lubricants, fillers, if they do not impair the basic properties as necessary and are within a range that does not cause a problem in hygiene.
An elastomer or the like that imparts flexibility can also be added. For melt-kneading, an ordinary melt-extruding device or the like is used, but kneading at a resin temperature of 200 ° C. or higher by a twin-screw kneader that requires higher shear is preferable for uniform dispersion. Sheet processing is usually performed by the T-die method at 80 ° C.
It is rapidly cooled at the following temperatures. 6 if transparency is required
Quenching at 0 ° C. or lower is preferable, and quenching at 40 ° C. or lower is more preferable.
【００１３】この様にして得られたシートは、更なる成
形性の向上・低温での剛性の向上・防湿性の向上の為に
熱処理を行っても良い。熱処理の条件については、好ま
しくは９０〜１６０℃の温度範囲で処理を行い、徐冷さ
せ、ポリエチレン系樹脂の結晶化度を最大限まで増加さ
せることにより、熱時の弾性率変化を顕著にして成形性
を改良し、低温での弾性率を向上させ、防湿性を向上さ
せることが可能となる。１６０℃を越える温度になると
主成分となるポリプロピレン系樹脂が軟化し、外観形状
が悪化する。また、９０℃未満の温度では熱処理による
結晶化への効果がほとんどない。通常、熱処理時間は１
〜６００秒間である。熱処理時間が、あまり短いと処理
効果がなく、あまりに長すぎるとシート表面の外観が熱
により悪化しやすい。熱処理の方法については、例えば
加熱ロール、加熱空気等で行われる。シートを熱処理す
る事により、ポリエチレン系樹脂のみを軟化あるいは溶
融させ、ポリエチレン系樹脂の結晶化度を極限まで上げ
ることが可能となる。The sheet thus obtained may be subjected to a heat treatment in order to further improve moldability, rigidity at low temperature, and moisture resistance. Regarding the heat treatment condition, preferably, the treatment is carried out in a temperature range of 90 to 160 ° C., and the temperature is gradually cooled to increase the crystallinity of the polyethylene resin to the maximum, thereby making the elastic modulus change at the time of heating remarkable. It becomes possible to improve moldability, improve elastic modulus at low temperature, and improve moisture resistance. When the temperature exceeds 160 ° C., the polypropylene-based resin as the main component is softened and the external shape is deteriorated. Further, at a temperature below 90 ° C., the heat treatment has almost no effect on crystallization. Usually, heat treatment time is 1
~ 600 seconds. If the heat treatment time is too short, there is no treatment effect, and if it is too long, the appearance of the sheet surface tends to be deteriorated by heat. The heat treatment method is performed using, for example, a heating roll or heated air. By heat-treating the sheet, it is possible to soften or melt only the polyethylene resin and raise the crystallinity of the polyethylene resin to the maximum.
【００１４】[0014]
【実施例】以下実施例により、本発明を説明する。実施
例及び比較例において配合した各成分を以下に示す。溶
融粘度については、キャピログラフ１Ｃ［（株）東洋精
機製作所製］により、２５０℃，剪断速度121.6sec
-1で、長さ10mm，直径1mmのキャピラリーを使用して測
定を行った。また、融点についてはＤＳＣ２２０Ｃ［セ
イコー電子工業（株）製］により、昇温速度10℃/minで
測定を行った。The present invention will be described with reference to the following examples. The components blended in the examples and comparative examples are shown below. Regarding the melt viscosity, using Capirograph 1C [manufactured by Toyo Seiki Seisakusho], 250 ° C, shear rate 121.6 sec
The measurement was performed at -1 using a capillary with a length of 10 mm and a diameter of 1 mm. The melting point was measured by DSC220C (manufactured by Seiko Denshi Kogyo Co., Ltd.) at a heating rate of 10 ° C./min.
【００１５】《ポリプロピレン系樹脂》 ・ＰＰ （プロピレンホモポリマー；融点＝１６５℃、
溶融粘度＝５５３Pa・s） ＨＴ−６００４［チッソ
（株）製］ ・ＰＰ （プロピレン−エチレンコポリマー；融点＝１
５０℃、溶融粘度＝３８０Pa・s） 住友ノーブレンＷＦ７３２−１［住友化学工業（株）
製］<< Polypropylene Resin >> PP (Propylene Homopolymer; Melting Point = 165 ° C.,
Melt viscosity = 553 Pa · s) HT-6004 [manufactured by Chisso Corporation] -PP (propylene-ethylene copolymer; melting point = 1
50 ° C, melt viscosity = 380 Pa · s) Sumitomo Noblen WF732-1 [Sumitomo Chemical Co., Ltd.]
Made]
【００１６】《ポリエチレン系樹脂》 ・ＨＤＰＥ（高密度ポリエチレン；融点＝１３９℃、溶
融粘度＝１９２Pa・s） Ｆ６２００Ｖ［昭和電工（株）製］ ・ＬＬＤＰＥ（直鎖状低密度ポリエチレン；融点＝１２
７℃、溶融粘度＝３５７Pa・s） ウルトゼックス２０１００Ｊ［三井石油化学工業（株）
製］ ・ＬＤＰＥ（低密度ポリエチレン；融点＝１１０℃、溶
融粘度＝２７５Pa・s） スミカセンＬ７１８−Ｈ［住友化学工業（株）製］<< Polyethylene Resin >> HDPE (high density polyethylene; melting point = 139 ° C., melt viscosity = 192 Pa · s) F6200V [manufactured by Showa Denko KK] LLDPE (linear low density polyethylene; melting point = 12)
7 ° C, melt viscosity = 357 Pa · s) ULTZEX 20100J [Mitsui Petrochemical Industry Co., Ltd.]
LDPE (low density polyethylene; melting point = 110 ° C., melt viscosity = 275 Pa · s) Sumikasen L718-H [Sumitomo Chemical Co., Ltd.]
【００１６】（実施例１〜７、及び比較例１〜５）すべ
ての成分を十分ドライブレンドし、スクリュー直径３０
ｍｍ、Ｌ／Ｄ＝４７の二軸混練機［ＰＣＭ３０；（株）
池貝製］により、２５０℃、スクリュー回転数１５０r.
p.m.で溶融混練し、Ｔ−ダイ法により冷却温度３０℃で
急冷を行い、厚み０．３ｍｍの熱成形用ポリプロピレン
系シートを得た。また、熱処理については１２０℃で３
００秒間、加熱空気で処理を行った。引張試験はＡＳＴ
Ｍ−Ｄ６３８で測定した結果である。また、成形性につ
いては前記シートを、圧空方式成形機［ＦＢＰ−Ｍ２；
シーケーディ（株）製］により、一定の圧力で成形品
（直径；１０ｍｍ、高さ；６ｍｍ）を成形し、成形品の
全体の厚みが均一となる最適成形可能温度幅を判定し
た。また防湿性については、透湿度をＪＩＳ−Ｚ０２０
８に基づいて条件Ｂ、即ち温度４０℃、相対湿度９０％
で測定を行った。配合組成及び各特性値の結果を、表１
〜２に示す。(Examples 1 to 7 and Comparative Examples 1 to 5) All components were sufficiently dry blended and the screw diameter 30
mm, L / D = 47 twin-screw kneader [PCM30;
Made by Ikegai], 250 ℃, screw rotation speed 150r.
It was melt-kneaded at pm and rapidly cooled by a T-die method at a cooling temperature of 30 ° C. to obtain a polypropylene sheet for thermoforming having a thickness of 0.3 mm. In addition, heat treatment at 120 ° C for 3
The treatment was performed with heated air for 00 seconds. Tensile test is AST
It is the result measured by M-D638. Further, regarding the moldability, the above-mentioned sheet was formed into a compressed air type molding machine [FBP-M2;
A molded product (diameter: 10 mm, height: 6 mm) was molded with a constant pressure by CKDI Co., Ltd., and the optimum moldable temperature range in which the entire thickness of the molded product was uniform was determined. Regarding moisture resistance, the moisture permeability is determined by JIS-Z020.
Condition B based on No. 8, temperature 40 ° C, relative humidity 90%
Was measured. The results of the blended composition and each characteristic value are shown in Table 1.
~ 2.
【００１７】[0017]
【表１】 [Table 1]
【００１８】[0018]
【表２】 [Table 2]
【００１９】[0019]
【発明の効果】本発明により得られる医薬品包装用ポリ
プロピレン系シートは、ポリプロピレン系樹脂が有する
防湿性、物性バランス、外観に優れるとともに、成形
性、特に真空成形・圧空成形等での成形可能温度幅が非
常に広く、ＰＴＰ包装等の各種医薬品包装に好ましく利
用することができる。すなわち、本発明によると熱成形
性に優れた、特に成形加工時の成形温度幅の広い医薬品
包装用ポリプロピレン系シート及びその製造方法を提供
することができる。EFFECT OF THE INVENTION The polypropylene-based sheet for packaging pharmaceuticals obtained by the present invention is excellent in moisture resistance, balance of physical properties and appearance of polypropylene-based resin, and has moldability, particularly a temperature range in which molding is possible in vacuum molding, pressure molding, etc. Since it is very wide, it can be preferably used for various pharmaceutical packaging such as PTP packaging. That is, according to the present invention, it is possible to provide a polypropylene-based sheet for drug packaging, which has excellent thermoformability, and particularly has a wide molding temperature range during molding, and a method for producing the same.
─────────────────────────────────────────────────────
────────────────────────────────────────────────── ───
【手続補正書】[Procedure amendment]
【提出日】平成８年９月１９日[Submission date] September 19, 1996
【手続補正１】[Procedure amendment 1]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１５[Correction target item name] 0015
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１５】《ポリプロピレン系樹脂》 ・ＰＰ （プロピレンホモポリマー；融点＝１６５℃、
溶融粘度＝５５３Pa・s） ＨＴ−６００４［チッソ
（株）製］ ・ＰＰ （プロピレン−エチレンコポリマー；融点＝１
５０℃、溶融粘度＝３８０Pa・s） 住友ノーブレンＷＦ７３２−１［住友化学工業（株）
製］<< Polypropylene Resin >> PP (Propylene homopolymer; melting point = 165 ° C.,
Melt viscosity = 553 Pa · s) HT-6004 [Chisso
Co., Ltd.]-PP (Propylene-ethylene copolymer; melting point = 1
50 ° C, melt viscosity = 380 Pa · s) Sumitomo Noblen WF732-1 [Sumitomo Chemical Co., Ltd.]
Made]
【手続補正２】[Procedure amendment 2]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】００１８[Correction target item name] 0018
【補正方法】変更[Correction method] Change
【補正内容】[Correction contents]
【００１８】[0018]
【表２】 [Table 2]
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｂ２９Ｄ 7/00 Ａ６１Ｊ 1/00 ３７０Ａ // Ｂ２９Ｋ 23:00 Ｂ２９Ｌ 7:00 ─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. 6 Identification code Office reference number FI Technical display location B29D 7/00 A61J 1/00 370A // B29K 23:00 B29L 7:00
Claims (5)
束型DSC)による測定(JIS K 7121)での融点（融解ピーク
温度）の中で、融点（融解ピーク温度）が近接する２成
分の融点（融解ピーク温度）の差が、いずれも互いに８
〜２０℃であり、その最大値と最小値の差が３０℃以上
ある、少なくとも１種類以上のポリプロピレン系樹脂と
少なくとも１種類以上のポリエチレン系樹脂からなり、
さらに樹脂の種類の合計が少なくとも３種類以上である
樹脂組成物を溶融混練し、８０℃以下の温度で急冷シー
ト化をすることを特徴とする医薬品包装用ポリプロピレ
ン系シート及びその製造方法。1. Among the melting points (melting peak temperatures) measured by differential scanning calorimetry (heat flux type DSC) (JIS K 7121) of all the components, the two components whose melting points (melting peak temperatures) are close to each other The melting points (melting peak temperatures) differ from each other by 8
To 20 ° C., and the difference between the maximum value and the minimum value thereof is 30 ° C. or more, and is composed of at least one kind of polypropylene resin and at least one kind of polyethylene resin,
Further, a polypropylene-based sheet for pharmaceutical packaging, which comprises melt-kneading a resin composition having a total of at least three types of resins to form a rapidly-quenched sheet at a temperature of 80 ° C. or less, and a method for producing the same.
束型DSC)による測定(JIS K 7121)での融点（融解ピーク
温度）の中で、融点（融解ピーク温度）が近接する２成
分の融点（融解ピーク温度）の差が、いずれも互いに８
〜２０℃であり、その最大値と最小値の差が３０℃以上
ある、少なくとも１種類以上のポリプロピレン系樹脂と
少なくとも１種類以上のポリエチレン系樹脂からなり、
さらに樹脂の種類の合計が少なくとも３種類以上である
樹脂組成物を溶融混練し、８０℃以下の温度で急冷シー
ト化したシートを、９０〜１６０℃で熱処理をすること
を特徴とする医薬品包装用ポリプロピレン系シート及び
その製造方法。2. Among the melting points (melting peak temperatures) measured by differential scanning calorimetry (heat flux type DSC) (JIS K 7121) of all the components, the two melting points (melting peak temperatures) of which the two components are close to each other The melting points (melting peak temperatures) differ from each other by 8
To 20 ° C., and the difference between the maximum value and the minimum value thereof is 30 ° C. or more, and is composed of at least one kind of polypropylene resin and at least one kind of polyethylene resin,
Further, a resin composition having a total of at least three kinds of resins is melt-kneaded, and a sheet which is formed into a quenched sheet at a temperature of 80 ° C. or less is heat-treated at 90 to 160 ° C. for pharmaceutical packaging. Polypropylene sheet and method for manufacturing the same.
０〜６０重量％、及びポリエチレン系樹脂１０〜４０重
量％である請求項１又は２記載の医薬品包装用ポリプロ
ピレン系シート及びその製造方法。3. The polypropylene resin 9 is used as the resin composition.
The polypropylene-based sheet for pharmaceutical packaging according to claim 1 or 2, and the method for producing the same, wherein the content is 0 to 60% by weight and the polyethylene resin is 10 to 40% by weight.
K 7199)で、２５０℃，剪断速度121.6sec-1でのすべて
のポリエチレン系樹脂の溶融粘度(ρe)と主成分のポリ
プロピレン系樹脂の溶融粘度(ρp)との溶融粘度比(ρe/
ρp)が、ρe/ρp≦0.9である請求項１、２又は３記載の
医薬品包装用ポリプロピレン系シート及びその製造方
法。4. A measurement by a capillary rheometer (JIS
K 7199), the melt viscosity ratio (ρ e ) between the melt viscosity (ρ e ) of all polyethylene resins at 250 ° C. and a shear rate of 121.6 sec −1 and the melt viscosity (ρ p ) of the main component polypropylene resin (ρ e ). /
5. The polypropylene-based sheet for packaging pharmaceuticals according to claim 1, 2 or 3, and the method for producing the same, wherein ρ p ) is ρ e / ρ p ≦ 0.9.
K 7199)で、主成分のポリプロピレン系樹脂の２５０
℃，剪断速度121.6sec-1での溶融粘度(ρp)が、300Pa・s
以上である請求項１、２、３又は４記載の医薬品包装用
ポリプロピレン系シート及びその製造方法。5. A measurement using a capillary rheometer (JIS
K 7199), the main component is polypropylene resin 250
Melt viscosity (ρ p ) at ℃ and shear rate of 121.6sec -1 is 300Pa ・ s
The polypropylene-based sheet for packaging pharmaceuticals according to claim 1, 2, 3 or 4, and the method for producing the same.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7264281A JPH09104060A (en) | 1995-10-12 | 1995-10-12 | Drug packing polypropylene sheet and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7264281A JPH09104060A (en) | 1995-10-12 | 1995-10-12 | Drug packing polypropylene sheet and production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH09104060A true JPH09104060A (en) | 1997-04-22 |
Family
ID=17400994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7264281A Pending JPH09104060A (en) | 1995-10-12 | 1995-10-12 | Drug packing polypropylene sheet and production thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH09104060A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000127237A (en) * | 1998-10-23 | 2000-05-09 | Chuo Kagaku Co Ltd | Thermoforming sheet, talc container for packaging food and manufacture of its container |
| US8298575B2 (en) | 1998-08-05 | 2012-10-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule to accept pharmaceutical preparations for powder inhalers |
| US8662076B2 (en) | 2005-01-11 | 2014-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers |
-
1995
- 1995-10-12 JP JP7264281A patent/JPH09104060A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8298575B2 (en) | 1998-08-05 | 2012-10-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule to accept pharmaceutical preparations for powder inhalers |
| JP2000127237A (en) * | 1998-10-23 | 2000-05-09 | Chuo Kagaku Co Ltd | Thermoforming sheet, talc container for packaging food and manufacture of its container |
| JP4564112B2 (en) * | 1998-10-23 | 2010-10-20 | 中央化学株式会社 | Thermoforming sheet, food packaging talc container, and method for producing the container |
| US8662076B2 (en) | 2005-01-11 | 2014-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5439628A (en) | Method for manufacturing polypropylene film and sheet | |
| JPS5867739A (en) | Film manufacturing composition | |
| US6096831A (en) | Olefin resin composition and sheets | |
| JPH0371465B2 (en) | ||
| KR100585541B1 (en) | Polypropylene composition provided by the calendering process for transparent film and sheet, and method for preparing polypropylene transparent film and sheet using the same | |
| JPH09104060A (en) | Drug packing polypropylene sheet and production thereof | |
| JPH09104059A (en) | Thermoforming polypropylene sheet and production thereof | |
| JP3360532B2 (en) | Thermoforming resin composition and sheet | |
| KR100544398B1 (en) | Polypropylene composition provided by the calendering process for decoration sheet and method for preparing polypropylene film and sheet using the same | |
| EP0172277B1 (en) | Thermoformable propylene polymer laminated sheet | |
| JPH10237239A (en) | Resin composition for thermoforming and sheet made therefrom | |
| JP4238480B2 (en) | Polypropylene molded products | |
| EP0920990A2 (en) | Composite olefin resin laminated sheet | |
| JPH11170454A (en) | Polypropylene sheet | |
| JPH09176388A (en) | Polyolefin-based sheet for medicine packaging and its production | |
| JP7167486B2 (en) | Polypropylene laminated film | |
| JP3508448B2 (en) | Polypropylene resin composition for profile extrusion molding | |
| JPH0977926A (en) | Polypropylene resin composition for thermoforming | |
| JPH09118791A (en) | Thermoformable polyolefin sheet and its production | |
| JPH1067896A (en) | Polypropylene resin composition for sheet and sheet produced therefrom | |
| JP7253331B2 (en) | Molded sheet of thermoplastic starch/olefin resin composition and method for producing same | |
| JPH10152587A (en) | Resin composition for thermal molding and sheet | |
| KR20240029831A (en) | Antimicrobial polypropylene resin composition, method for preparing the same, and molded product comprising the same | |
| JP2000248079A (en) | Polypropylene-based sheet | |
| JP3360544B2 (en) | Method for producing resin composition for thermoforming and resin composition obtained therefrom |