JPH08509994A - 有効成分としてリン酸ヒスタミンを用いて損傷組織を局所的に治療するための方法および組成物 - Google Patents
有効成分としてリン酸ヒスタミンを用いて損傷組織を局所的に治療するための方法および組成物Info
- Publication number
- JPH08509994A JPH08509994A JP7522874A JP52287495A JPH08509994A JP H08509994 A JPH08509994 A JP H08509994A JP 7522874 A JP7522874 A JP 7522874A JP 52287495 A JP52287495 A JP 52287495A JP H08509994 A JPH08509994 A JP H08509994A
- Authority
- JP
- Japan
- Prior art keywords
- iep
- treatment
- gel
- lesions
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 有効量のリン酸1H−イミダゾール−4−エタンアミン(IEP)と混合 した水、水溶性ゲルおよび分散剤よりなる、皮膚、口腔粘膜、性器、膣および結 膜の炎症または病変を含めた上皮炎症または病変の局所治療用組成物。 2. ***疱疹、性器疱疹、帯状疱疹、水痘帯状疱疹、アフタ性口内炎、化学療 法に伴う口内粘膜炎、光線皮膚炎、熱傷および褥瘡性潰瘍の治療用配合薬剤を製 造する方法であって、ビニル重合体を蒸留水に加え、得られる混合物をビニル重 合体混合物が湿るまで放置し、混合物を均質混合物が形成されるまで高速ブレン ダーで混合し、分散剤を加えてエマルジョンを形成し、0.00325−0.0 275重量%のリン酸1H−イミダゾール−4−エタンアミン(IEP)をエマ ルジョンに加え、これを得られる混合物が均質になるまで混合する段階よりなる 、上記の方法。 3. 約0.00325−0.0275重量%のリン酸1H−イミダゾール−4 −エタンアミン(IEP)と均質に混合したビニル重合体タイプの水溶性ゲルよ りなる、***疱疹、性器疱疹、帯状疱疹、水痘帯状疱疹、アフタ性口内炎、化学 療法に伴う口内粘膜炎、光線皮膚炎、熱傷および褥瘡性潰瘍を含めた上皮病変の 局所的治療用組成物。 4. 本質的に、約0.00325−0.0275重量%のリン酸1H−イミダ ゾール−4−エタンアミン(IEP)と均質に混合したビニル重合体タイプの水 溶性ゲルからなる、***疱疹、性器疱疹、帯状疱疹、水痘帯状疱疹、アフタ性口 内炎、化学療法に伴う口内粘膜炎、光線皮膚炎、熱傷および褥瘡性潰瘍を含めた 上皮病変の局所的治療用組成物。 5. 約0.0045−0.0067重量%のリン酸1H−イミダゾール−4− エタンアミン(IEP)と均質に混合した水溶性ビニル重合体ローションよりな る、光線皮膚炎の局所的治療用組成物。 6. 約0.0045−0.009重量%のリン酸1H−イミダゾール−4−エ タンアミン(IEP)と均質に混合した水溶性ビニル重合体ゲルよりなる、II度 の熱傷のような熱傷の局所的治療用組成物。 7. 約0.0067重量%のリン酸1H−イミダゾール−4−エタンアミン( IEP)と均質に混合した半合成水溶性重合体の目薬溶液よりなる、アレルギー 性結膜炎の局所的治療用組成物。 8. 約0.0067重量%のリン酸1H−イミダゾール−4−エタンアミン( IEP)と均質に混合した半合成水溶性重合体の目薬溶液よりなる、巨大乳頭状 結膜炎の局所的治療用組成物。 9. 約0.0045−0.009重量%のリン酸1H−イミダゾール−4−エ タンアミン(IEP)と均質に混合した水溶性ビニル重合体ゲルよりなる、褥瘡 性潰瘍の局所的治療用組成物。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1994/002282 WO1995023601A1 (en) | 1994-03-02 | 1994-03-02 | Method and composition for topical treatment of damaged tissue using histamine phosphate as active ingredient |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004034875A Division JP2004175808A (ja) | 2004-02-12 | 2004-02-12 | 有効成分としてリン酸ヒスタミンを用いて損傷組織を局所的に治療するための方法および組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08509994A true JPH08509994A (ja) | 1996-10-22 |
JP3552168B2 JP3552168B2 (ja) | 2004-08-11 |
Family
ID=22242315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52287495A Expired - Fee Related JP3552168B2 (ja) | 1994-03-02 | 1994-03-02 | 有効成分としてリン酸ヒスタミンを用いて損傷組織を局所的に治療するための方法および組成物 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0706394B1 (ja) |
JP (1) | JP3552168B2 (ja) |
AT (1) | ATE240727T1 (ja) |
CA (1) | CA2160779C (ja) |
DE (1) | DE69432703T2 (ja) |
DK (1) | DK0706394T3 (ja) |
ES (1) | ES2199961T3 (ja) |
PT (1) | PT706394E (ja) |
WO (1) | WO1995023601A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6270781B1 (en) | 1999-01-08 | 2001-08-07 | Maxim Pharmaceuticals, Inc. | Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors |
ES2225156T3 (es) | 1999-06-03 | 2005-03-16 | Maxim Pharmaceuticals, Inc. | Composiciones oftalmicas que contienen histamina y usos de las mismas. |
AU2003220624A1 (en) * | 2002-03-29 | 2003-10-13 | Maxim Pharmaceuticals, Inc. | Use of rom production and release inhibitors to treat and prevent intraocular damage |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3898325A (en) * | 1973-09-19 | 1975-08-05 | American Lipids Corp | Method and preparations for relieving pain and producing analgesia |
US4228176A (en) * | 1979-04-09 | 1980-10-14 | Nelson Research & Development Company | Thromboxane inhibition with burimamide |
CA1163561A (en) * | 1979-11-06 | 1984-03-13 | Cyril Boroda | Preparation containing nitroglycerine and optionally other medicaments and preparation thereof |
US4618490A (en) * | 1980-06-06 | 1986-10-21 | Marco Peter T De | Method of treatment of animal and human tissues damaged by burns and frank visible gangrene |
US4966892A (en) * | 1982-05-07 | 1990-10-30 | Carrington Laboratories, Inc. | Processes for preparation of aloe products products produced thereby and compositions thereof |
US4705685A (en) * | 1982-05-17 | 1987-11-10 | Mcmichael John | Methods and materials for treatment of disease states involving immunological factors |
US5176912A (en) * | 1991-01-29 | 1993-01-05 | Orestes Cabezas | Method of treating psoriasis |
-
1994
- 1994-03-02 DK DK94912176T patent/DK0706394T3/da active
- 1994-03-02 DE DE69432703T patent/DE69432703T2/de not_active Expired - Fee Related
- 1994-03-02 PT PT94912176T patent/PT706394E/pt unknown
- 1994-03-02 AT AT94912176T patent/ATE240727T1/de not_active IP Right Cessation
- 1994-03-02 JP JP52287495A patent/JP3552168B2/ja not_active Expired - Fee Related
- 1994-03-02 EP EP94912176A patent/EP0706394B1/en not_active Expired - Lifetime
- 1994-03-02 WO PCT/US1994/002282 patent/WO1995023601A1/en active IP Right Grant
- 1994-03-02 CA CA002160779A patent/CA2160779C/en not_active Expired - Fee Related
- 1994-03-02 ES ES94912176T patent/ES2199961T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE240727T1 (de) | 2003-06-15 |
DK0706394T3 (da) | 2003-09-22 |
EP0706394B1 (en) | 2003-05-21 |
ES2199961T3 (es) | 2004-03-01 |
DE69432703T2 (de) | 2004-03-25 |
EP0706394A4 (en) | 2000-06-28 |
DE69432703D1 (de) | 2003-06-26 |
CA2160779C (en) | 2008-08-26 |
CA2160779A1 (en) | 1995-09-08 |
WO1995023601A1 (en) | 1995-09-08 |
PT706394E (pt) | 2003-10-31 |
JP3552168B2 (ja) | 2004-08-11 |
EP0706394A1 (en) | 1996-04-17 |
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