JPH0534330B2 - - Google Patents
Info
- Publication number
- JPH0534330B2 JPH0534330B2 JP59134425A JP13442584A JPH0534330B2 JP H0534330 B2 JPH0534330 B2 JP H0534330B2 JP 59134425 A JP59134425 A JP 59134425A JP 13442584 A JP13442584 A JP 13442584A JP H0534330 B2 JPH0534330 B2 JP H0534330B2
- Authority
- JP
- Japan
- Prior art keywords
- aluminum hydroxide
- acid
- modified aluminum
- composition according
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical class [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 71
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 39
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 23
- 239000004408 titanium dioxide Substances 0.000 claims description 21
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 16
- 150000008064 anhydrides Chemical class 0.000 claims description 14
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 11
- 239000003205 fragrance Substances 0.000 claims description 10
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 7
- 210000000214 mouth Anatomy 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 3
- 125000004437 phosphorous atom Chemical group 0.000 claims description 2
- 238000004381 surface treatment Methods 0.000 claims 1
- 238000005498 polishing Methods 0.000 description 17
- 230000000694 effects Effects 0.000 description 15
- 239000000606 toothpaste Substances 0.000 description 15
- 235000011007 phosphoric acid Nutrition 0.000 description 10
- 239000002002 slurry Substances 0.000 description 9
- 229940034610 toothpaste Drugs 0.000 description 9
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 230000006872 improvement Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229910052783 alkali metal Inorganic materials 0.000 description 6
- -1 alkali metal salts Chemical class 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 4
- 239000003082 abrasive agent Substances 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 238000011086 high cleaning Methods 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 229960002684 aminocaproic acid Drugs 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 description 2
- 230000000471 effect on teeth Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 150000003016 phosphoric acids Chemical class 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000007494 plate polishing Methods 0.000 description 2
- 238000002407 reforming Methods 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000011780 sodium chloride Chemical group 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229960000401 tranexamic acid Drugs 0.000 description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 240000000467 Carum carvi Species 0.000 description 1
- 235000005747 Carum carvi Nutrition 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- YDHWWBZFRZWVHO-UHFFFAOYSA-N [hydroxy(phosphonooxy)phosphoryl] phosphono hydrogen phosphate Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O YDHWWBZFRZWVHO-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
- 229950010221 alexidine Drugs 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229910000318 alkali metal phosphate Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 235000005300 cardamomo Nutrition 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- NFCRBQADEGXVDL-UHFFFAOYSA-M cetylpyridinium chloride monohydrate Chemical compound O.[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NFCRBQADEGXVDL-UHFFFAOYSA-M 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 239000010636 coriander oil Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 229910001651 emery Inorganic materials 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000010643 fennel seed oil Substances 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 239000008235 industrial water Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 229910000400 magnesium phosphate tribasic Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940074371 monofluorophosphate Drugs 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 229940094996 pepsodent Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical group 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940005657 pyrophosphoric acid Drugs 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical group 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229940048098 sodium sarcosinate Drugs 0.000 description 1
- ILJOYZVVZZFIKA-UHFFFAOYSA-M sodium;1,1-dioxo-1,2-benzothiazol-3-olate;hydrate Chemical compound O.[Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 ILJOYZVVZZFIKA-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 229940048102 triphosphoric acid Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Description
産業上の利用分野
本発明は、歯牙に対する適度な研磨性及び優れ
た清掃効果を有すると共に、歯面に対する光沢付
与効果が高い歯磨、プロフイラキスペースト等の
口腔用組成物に関する。
従来技術及びその問題点
一般に、歯磨やプロフイラキスペースト等の口
腔用組成物としては、ステイン、プラーク、食べ
かす等の歯に付着、沈着したものを物理的作用に
より効率よく除去する能力が高く、清掃能が優れ
ていると共に、歯面を損傷することがないマイル
ドな研磨性、琢磨性を有し、かつ歯に対し優れた
光沢を付与し、歯面を平滑にしてプラーク、歯石
の沈着を防止し得るものが望まれる。
この場合、ステイン、プラーク、食べかす等の
物理的除去の効率は、研磨剤の研磨力を高くする
ことによつて高めることができ、特に従来は研磨
力を高めることで歯面の清掃効果を向上させるこ
とが行なわれていたが、研磨力を高めることと、
歯面の損傷を防止し、また歯面に光沢を付与する
こととは一般に相反し、研磨力を高めれば高める
程、歯面を削り、傷つけ易くなり、楔状欠損を引
き起す場合も生じさせ、また、研磨力が高すぎ、
歯面を損傷させる程、歯面の光沢を低下させる。
特に、プロフイラキスペーストにおいては、強固
に沈着したステイン、プラーク、歯石等を除去す
ることが主要な目的であるため、研磨力を充分に
大きくする点に注意が払われ、歯面損傷への配慮
が殆んどなされていないのが現状である。歯磨の
場合には、それでも歯面を傷つけない配慮がなさ
れているものの、歯面の光沢を向上させるものは
非常に少ない。このため、従来より歯面を損傷さ
せることがないと共に、歯面に光沢を付与し、し
かも適度の研磨力を有して清掃効果に優れた研磨
剤が求められていた。
なお従来、α−アルミナや二酸化チタンが歯面
に光沢を付与する効果があることは知られている
が、研磨力の高い研磨剤と組合せて用いると、研
磨力の高い研磨剤によつて歯面が損傷され、その
光沢付与効果が十分発揮されない場合があり、ま
た研磨力の低い研磨剤との組合せでは清掃性に問
題が生じる。
発明の特徴
本発明者らは、歯面に対する光沢付与効果が高
く、しかも清掃力が高い上、研磨力が適度な口腔
用組成物につき鋭意研究を行なつた結果、水酸化
アルミニウムを酸又はその塩で処理することによ
つて得られる改質水酸化アルミニウム、なかでも
回転衝撃粉砕機を用いて製造した水酸化アルミニ
ウムを酸又はその塩で処理することによつて得ら
れる改質水酸化アルミニウムと、α化率15〜85％
のアルミナ無水物及び／又はルチル型の結晶構造
を有するものが70重量％以上含まれている二酸化
チタンとを併用した場合、歯牙に対する適度な研
磨性及び優れた清掃効果を有すると共に、歯面に
対する光沢付与効果に優れた口腔用組成物が得ら
れることを知見した。
即ち、本発明者らは、上述した改質水酸化アル
ミニウム、なかでも回転衝撃粉砕機による改質水
酸化アルミニウムが優れた低研磨・高清掃性を有
し、この改質水酸化アルミニウムとα化率15〜85
％のアルミナ無水物及び／又はルチル型の結晶構
造を有するものが70重量％以上含まれている二酸
化チタンとを併用することにより、これらの相乗
作用によつて低研磨性、高清掃効果、高光沢付与
効果という特性に極めて優れた口腔用組成物が得
られることを知見し本発明をなすに至つたもので
ある。
以下、本発明につき更に詳しく説明する。
発明の構成
本発明に係る口腔用組成物は、水酸化アルミニ
ウムを酸又はその塩で処理することによつて得ら
れる改質水酸化アルミニウムとα化率15〜85％の
アルミナ無水物及び／又はルチル型の結晶構造を
有するものが70重量％以上含まれている二酸化チ
タンとを配合してなるものである。
本発明に用いる改質水酸化アルミニウムは、水
酸化アルミニウムを酸又はその塩で処理すること
により得られるもので、この場合、改質に用いら
れる水酸化アルミニウムとしては特に制限はな
く、通常の方法で得られる市販品を用いることが
できる。なお、使用する水酸化アルミニウムの平
均粒度は処理性の点で１〜30μ、特に３〜20μと
することが好ましい。この場合、水酸化アルミニ
ウムは、ボールミル、ジエツトミル、或いは回転
衝撃粉砕機等を用いて所望の形状、粒度に粉砕し
たものが好適に用いられ、これにより得られる改
質水酸化アルミニウムの研磨力を種々に調整する
ことができる。この場合、本発明においては、回
転衝撃粉砕機を用いて粉砕した水酸化アルミニウ
ムを酸又はその塩で処理することによつて得られ
る改質水酸化アルミニウムを用いることが特に好
ましく、このものは振動ボールミルやジエツトミ
ルを用いて粉砕した水酸化アルミニウムを酸又は
その塩で処理することによつて得られる改質水酸
化アルミニウムに比べ、研磨力が同程度の場合に
は平均粒径が大きく、従つて研磨力が同程度の場
合には清掃力が高いため、この回転衝撃粉砕機に
よる改質水酸化アルミニウムを用いることにより
低研磨高清掃性に特に優れた口腔用組成物を得る
ことができる。
また、前記水酸化アルミニウムの改質に用いる
酸や塩としては、無機酸、有機酸及びそれらの塩
を使用することができる。無機酸及びその塩とし
てはリン酸、硫酸、塩酸及びそれらの塩等が例示
され、有機酸及びその塩としては酢酸、シユウ
酸、酒石酸、コハク酸及びそれらの塩等が例示さ
れるが、これらのなかではリン酸及びその塩が好
ましく用いられ、このような改質水酸化アルミニ
ウムはその10％（重量％、以下同じ）水スラリー
のPHが通常５〜８程度であり、改質していない水
酸化アルミニウムの10％水スラリーのPHが通常９
前後であるのと比べてかなり低いので、組成物が
高PHに調製されることがなく、従つて香料成分、
特にエステル系の香料成分の分解、劣化を抑制で
き、このため種々の香料成分を用いて自由に調香
し得るものである。
ここで、リン酸及びその塩としては、オルトリ
ン酸（H3PO4）、ピロリン酸（H4P2O7）、メタリ
ン酸（HPO4）、三リン酸（H5P3O10）、四リン酸
（H6P4O13）．、ポリメタリン酸（HPO3）ｎ）な
どの縮合リン酸及びこれらのアルカリ金属塩など
が挙げられ、これらの１種又は２種以上を組合せ
て用いることができる。なお、アルカリ金属塩と
してはリン酸水素−アルカリ金属塩
（MH2PO4）、リン酸水素二アルカリ金属塩
（M2HPO4）、リン酸三アルカリ金属塩（M3PO4）
などが挙げられる。
水酸化アルミニウムを酸又はその塩で処理する
方法は特に制限されないが、例えば水酸化アルミ
ニウムを酸又はその塩の水溶液に懸濁し、中和処
理を行なうことによつつて改質を行なわせる方法
が好適に採用し得る。この場合、水酸化アルミニ
ウムは酸又はその塩の水溶液の10〜90重量％スラ
リー、特に30〜70重量％スラリーとすることが好
ましく、酸の濃度は添加する水酸化アルミニウム
の濃度によつても変化するが、0.05モル／ｌ〜５
モル／ｌとすることが好ましい。また、反応は10
〜50℃、特に20〜30℃において２〜50時間、特に
２〜30時間行なうことが好ましく、反応中撹拌を
行なうことが好ましい。
上記操作終了後は、濾過してスラリーから除去
した水酸化アルミニウムを水等で洗浄し、乾燥す
ることによつて改質水酸化アルミニウムを得るも
のである。
なお、上述した改質操作において、前記酸又は
塩の１種又は２種以上を同時に用いて１回もしく
は繰り返して回質操作を行なうこともできるが、
互に異なる２種以上の酸又は塩を用いてそれぞれ
改質操作を繰り返すこともできる。例えば、水酸
化アルミニウムを最初に硫酸、塩酸等で処理し、
次にリン酸で処理するなどのこともできる。
上述した改質水酸化アルミニウムのうちでは、
とりわけリン酸又はその塩、特にオルトリン酸又
はそのアルカリ金属塩で処理することによつて得
られたものが好適である。このリン酸又はその塩
で改質されたものは粒子表面にリン酸アルミニウ
ム含有層が形成されているものであるが、この種
の改質水酸化アルミニウムを使用する場合、表面
のリン酸アルミニウム含有層が全てリン酸アルミ
ニウムで形成されているものを用いても良く、水
酸化アルミニウムとリン酸アルミニウムとが共存
しているものを用いても良いが、ESCA
（Electron Spectroscopy for Chemical
Analysis）により表面分析を行なつた場合にリ
ン酸アルミニウム含有層中のリン原子が0.1〜10
％の存在を示すものを用いることが好ましい。な
お、上記改質水酸化アルミニウムとしては、リン
酸アルミニウム含有層の厚さが10〜1000Åのもの
が好ましく、また改質水酸化アルミニウム中の
P2O5分が0.01〜0.5％であるものが好ましい。
本発明においては、上記改質水酸化アルミニウ
ムを練歯磨等の口腔用組成物に配合するものであ
る。この場合改質水酸化アルミニウムとしては、
これを水に10重量％の割合で懸濁したスラリーの
PHが４〜８であり、銅板研磨値が１〜10mgである
ものを用いることが好ましい。なお、銅板研磨値
は、改質水酸化アルミニウムを50％配合した通常
の処方の練歯磨を作成し、これを50ｇとり、40ｇ
の60％グリセリンに分散させて傾斜型研磨試験機
（pepsodent type）を用いて２万ストローク行な
つた場合の研磨性である〔「最近化粧品科学」（薬
事日報社：昭和55年４月10日）第184頁参照〕。
また、改質水酸化アルミニウムとしては、これ
を研磨剤に用いる場合、平均粒径が１〜30μ、特
に７〜25μとすることが好ましく、平均粒径が
30μより大きいとザラツキ感が生じる場合があ
り、1μより小さいと研磨性に劣る場合がある。
しかし、琢磨剤として用いる場合はより細かな粒
径のものも使用し得る。
更に、本発明においては、α−アルミナ及び／
又は二酸化チタンを口腔用組成物に配合するもの
である。
この場合、本発明に用いるα−アルミナとして
は、α化率15〜85％、望ましくは20〜80％のアル
ミナ無水物（Al2O3）を用いるもので、この種の
アルミナ無水物を用いることにより、歯面にいつ
そう優れた光沢を付与することができる。なお、
α化率15〜85％のアルミナ無水物とは、α−
Al2O3，γ−Al2O3、無定形Al2O3などが適当な割
合に組み合わさつたもので、Ｘ線回析的にそのア
ルミナ無水物のα−Al2O3のピークをα化率100
％のアルミナ無水物（α−Al2O3）のピークと比
較した場合、そのピークがα化率100％のアルミ
ナ無水物（α−Al2O3）の15〜85％にあるものを
指称する。具体的には、α化率100％のα−
Al2O3との間で（012）面及び（116）面での回折
Ｘ線強度比を求め、その平均値が15〜85％にある
ものを指称する。ここで、α化率15〜85％のアル
ミナ無水物はその１種を単独で用いても２種以上
を混合して用いてもよい。また、α化率15〜85％
のアルミナ無水物を他のアルミナ無水物もしくは
水和物と併用するようにしてもよい。なお、上記
α化率15〜85％のアルミナ無水物は、バイヤー法
によつて製造することができ、バイヤー法による
製造プロセスにおいて、焼成温度を適宜コントロ
ールすることにより、所望のα化率を有するアル
ミナ無水物を得ることができる。
更に、本発明に用いるα−アルミナの平均粒径
は必ずしも制限はないが、10μ以下、望ましくは
5μ以下、特に0.1〜3μであることが好ましく、粒
径が大きすぎると光沢付与効果が低下する場合が
生じる。特に、平均粒径5μ以下であることが光
沢付与及び研磨力の点から最も好適である。
また、本発明に用いる二酸化チタンとしては、
ルチル型の結晶構造を有するものを70％以上含有
するものを用いるもので、この種の二酸化チタン
を用いることにより、歯面にいつそう優れた光沢
を付与することができる。
なお、本発明に用いる二酸化チタンは、表面処
理が施されていないものであること、また純度が
98.5％以上であることが光沢向上効果の点で好ま
しい。
更に、本発明に用いる二酸化チタンの平均粒径
は必ずしも制限はないが、0.1〜0.8μ、特に0.1〜
0.5μであることが好ましく、粒径が大きすぎると
光沢付与効果が低下する場合が生じる。
なお、本発明においては、上記改質水酸化アル
ミニウム、α−アルミナ、二酸化チタンの配合量
に制限はないが、改質水酸化アルミニウム及びα
−アルミナを併用する場合は改質水酸化アルミニ
ウム100重量部に対してα−アルミナ0.1〜100重
量部、特に0.2〜50重量部を用いることが好まし
く、改質水酸化アルミニウム及び二酸化チタンを
併用する場合は改質水酸化アルミニウム100重量
部に対して二酸化チタン0.1〜100重量部、特に１
〜70重量部を用いることが好ましい。なお、改質
水酸化アルミニウムとα−アルミナ及び／又は二
酸化チタンとの合計配合量は通常組成物全体の５
〜95％、特に練歯磨の場合は５〜50％とすること
が好ましい。
この場合、本発明においては、研磨剤、光沢剤
を上記改質水酸化アルミニウムとα−アルミナ及
び／又は二酸化チタンとからのみ構成することも
できるが、他の研磨剤と併用してもよい。ここ
で、他の研磨剤としては、例えばリン酸水素カル
シウム・２水和物、リン酸水素カルシウム・無水
和物、炭酸カルシウム、ピロリン酸カルシウム、
不溶性メタリン酸ナトリウム、沈降性シリカ、ア
ルミノシリケート、酸化アルミニウム、微結晶セ
ルロース、レジン、第３リン酸マグネシウム、炭
酸マグネシウム等が挙げられる。また、従来の水
酸化アルミニウムも改質水酸化アルミニウムの特
性を著しく損なわない範囲で配合できる。なお、
改質水酸化アルミニウムを他の研磨剤と併用する
場合、その割合は制限されず、改質水酸化アルミ
ニウムを主研磨剤として用いてもよく、他の研磨
剤を主研磨剤として用いてもよく、これらは口腔
用組成物の使用目的等に応じて決められるが、本
発明改質水酸化アルミニウムを研磨剤中20〜100
％、特に40〜100％の使用量とすることが好まし
い。
更に、本発明口腔用組成物中には、塩化リゾチ
ーム、デキストラナーゼ、溶菌酵素、ムタナー
ゼ、クロルヘキシジン又はその塩、ソルビン酸、
アレキシジン、ヒノキチオール、セチルピリジニ
ウムクロライド、アルキルグリシン、アルキルジ
アミノエチルグリシン塩、アラントイン、ε−ア
ミノカプロン酸、トラネキサム酸、アズレン、ビ
タミンＥ、モノフルオロリン酸ナトリウム、フツ
化ナトリウム、フツ化第１錫、水溶性第１もしく
は第２リン酸塩、第四級アンモニウム化合物、塩
化ナトリウム等の有効成分を配合でき、本発明口
腔用組成物はこれら有効成分、特にフツ素含優化
合物、クロルヘキシジン類、デキストラナーゼ、
トラネキサム酸、イプシロンアミノカプロン酸、
アラントインクロルヒドロキシアルミニウム、塩
化ナトリウムなどを安定に配合させることができ
る。
本発明口腔用組成物には、その種類等に応じて
更に他の成分を配合することができる。例えば、
カルボキシメチルセルロース、ヒドロキシエチル
セルロース、アルギン酸塩、カラゲナン、アラビ
アガム、ポリビニルアルコール等の粘結剤、ポリ
エチレングリコール、ソルビトール、グリセリ
ン、プロピレングリコール等の粘稠剤、ラウリル
硫酸ナトリウム、ドデシルベンゼンスルホン酸ナ
トリウム、水素添加ココナツツ脂肪酸モノグリセ
リドモノ硫酸ナトリウム、ラウリルスルホ酢酸ナ
トリウム、Ｎ−ラウロイルザルコシン酸ナトリウ
ム、Ｎ−アシルグルタミン酸塩、ラウロイルジエ
タノールアマイド、シヨ糖脂肪産エステル等の発
泡剤、サツカリンナトリウム、ステビオサイド、
ネオヘスペリジルジヒドロカルコン、グリチルリ
チン、ペリラルチン、ｐ−メトキシンナミツクア
ルデヒド、ソーマチンなどの甘味剤、防腐剤、香
料成分などを配合し得る。この場合、本発明の口
腔用組成物は、上述した改質水酸化アルミニウム
を配合したことにより、PHを低くできるため、香
料が保存中に分解、劣化することが良好に抑制で
きる。従つて、本発明口腔用組成物中にはメント
ール、カルボン、ペパーミント油、スペアミント
油、アネトール、エステル系香料アクセント分、
ラクトン系香料アクセント分、アルデヒド系香料
アクセント分、フエノール系香料アクセント分、
その他MONTCLAIR，N.J.（U.S.A）により発行
されたSTEFFEN ARCTANDERによる
“Perfume and Flavor Chemicals”に記載され
た香料成分、更にオレンジ油、レモン油、クロー
ブ油、カシア油、フエンネル油、カルダモン油、
シンナモン油、コリアンダー油、ユーカリ油、キ
ヤラウエイ油、セージ油、タイム油などの精油と
いつた種々の香料成分を有効に配合することがで
きる。
本発明口腔用組成物は、上述した成分を用いて
常法により製造することができるが、練歯磨を製
造する場合はそのPHを５〜８とすることが好まし
い。この場合、本発明の改質水酸化アルミニウム
はPHが低いので、組成物のPHを５〜８の範囲に容
易に調整し得、かつこのPH範囲に長期間に亘り安
定に保持される。
また、本発明口腔用組成物は、プラスチツク容
器、アルミニウムの片面又は両面をプラスチツク
でラミネートしたラミネート容器、アルミニウム
等の金属容器に充填することができるが、本発明
口腔用組成物はアルミニウムの腐蝕を抑制できる
ため、アルミニウムチユーブなどを支障なく用い
ることができるものである。なお、本発明組成物
において、モノフルオロリン酸アルカリ金属塩や
塩化マグネシウムの配合はアルミニウムの腐蝕を
更に顕著に抑制し得る。
発明の効果
以上説明したように、本発明に係る口腔用組成
物は、水酸化アルミニウムを酸又はその塩で処理
することによつて得られる改質水酸化アルミニウ
ムとα−アルミナ及び／又は二酸化チタンとを配
合してなることにより、歯牙に対する適度な研磨
性及び優れた清掃効果を有すると共に、歯面に対
する光沢付与効果が高いものである。
次に、本発明に用いる改質水酸化アルミニウム
の製造例を示す。
製造例 １
高白色水酸化アルミニウムを回転衝撃型粉砕機
を用いて粉砕したもの（平均粒径6μ＜光透過法
＞）に水（純水又は工業用水、以下同じ）を加え
て撹拌し、50％スラリーを調製する、次いで、こ
れに正リン酸水溶液（濃度2mol／ｌ）を加え、
室温で２〜４時間撹拌して中和処理した後、スラ
リーを過する。その後、残渣に水を加えて50％
スラリーを調製し、これを撹拌し、次いで過す
るという洗浄操作を２回繰り返し、最後に残渣を
乾燥して改質水酸化アルミニウムを得た。
この水酸化アルミニウムは、表面がリン酸アル
ミニウムで被覆されているものであつた。
次に、上記製造例により得られた改質水酸化ア
ルミニウムの粒子表面をESCA及びFT−IR
（Fourier Tranformation Infrared）により分析
した。
ESCAによる分析結果
結果は第１、２表の通りである。なお、第１
表は構成イオンの定量分析結果、第２表はリン
の状態分析を行なつた結果であり、比較のため
市販（未改質）水酸化アルミニウム、これにリ
ン酸アルミニウムを混合したもの、及びリン酸
アルミニウムの分析結果を併記する。
INDUSTRIAL APPLICATION FIELD The present invention relates to oral compositions, such as toothpastes and profilakis pastes, which have moderate abrasiveness and excellent cleaning effects on teeth, and are highly effective in imparting gloss to tooth surfaces. Prior art and its problems In general, oral compositions such as toothpastes and profilakis pastes have a high ability to efficiently remove stains, plaque, food particles, and other substances that have adhered to or deposited on teeth by physical action. It has excellent polishing and polishing properties that do not damage the tooth surface, and it also gives excellent gloss to the tooth surface, smoothing the tooth surface and preventing the deposition of plaque and tartar. What is possible is desired. In this case, the efficiency of physical removal of stains, plaque, food particles, etc. can be increased by increasing the abrasive power of the abrasive. In particular, in the past, increasing the abrasive power improved the tooth surface cleaning effect. However, increasing the polishing power and
Preventing damage to the tooth surface and adding gloss to the tooth surface are generally contradictory, and the higher the polishing power, the more easily the tooth surface will be scraped and damaged, and may even cause wedge-shaped defects. Also, the polishing power is too high,
The more the tooth surface is damaged, the more it reduces the gloss of the tooth surface.
In particular, since the main purpose of profilakis paste is to remove strongly deposited stains, plaque, tartar, etc., care is taken to ensure that the polishing force is sufficiently high, and consideration is given to damage to the tooth surface. Currently, very little is being done. When brushing teeth, care is taken not to damage the tooth surface, but there are very few things that can improve the gloss of the tooth surface. For this reason, there has been a demand for an abrasive that does not damage tooth surfaces, gives gloss to tooth surfaces, has appropriate abrasive power, and has excellent cleaning effects. It is known that α-alumina and titanium dioxide have the effect of imparting gloss to the tooth surface, but when used in combination with a highly abrasive abrasive, the abrasive with a high abrasive power may cause the tooth surface to become glossy. The surface may be damaged and its gloss imparting effect may not be fully exhibited, and if it is used in combination with an abrasive with low abrasive power, cleaning performance may be problematic. Features of the Invention The present inventors have conducted extensive research into oral compositions that have a high glossing effect on tooth surfaces, high cleaning power, and moderate abrasive power. Modified aluminum hydroxide obtained by treating with salt, especially modified aluminum hydroxide obtained by treating aluminum hydroxide produced using a rotary impact mill with an acid or a salt thereof. , gelatinization rate 15-85%
When used in combination with titanium dioxide containing 70% by weight or more of alumina anhydride and/or rutile-type crystal structure, it has moderate abrasiveness and excellent cleaning effect on teeth, and has a good cleaning effect on tooth surfaces. It has been found that an oral composition with excellent gloss imparting effect can be obtained. That is, the present inventors have found that the above-mentioned modified aluminum hydroxide, especially the modified aluminum hydroxide produced by a rotary impact crusher, has excellent low polishing and high cleaning properties, and that this modified aluminum hydroxide and gelatinized rate 15~85
% alumina anhydride and/or titanium dioxide containing 70% by weight or more of rutile type crystal structure, the synergistic action of these results in low abrasiveness, high cleaning effect, and high The present invention was based on the discovery that an oral composition with extremely excellent gloss-imparting properties can be obtained. The present invention will be explained in more detail below. Composition of the Invention The oral composition according to the present invention comprises modified aluminum hydroxide obtained by treating aluminum hydroxide with an acid or a salt thereof, anhydrous alumina with a gelatinization rate of 15 to 85%, and/or It is made by blending titanium dioxide, which contains 70% by weight or more of rutile-type crystal structure. The modified aluminum hydroxide used in the present invention is obtained by treating aluminum hydroxide with an acid or its salt. In this case, there is no particular restriction on the aluminum hydroxide used for modification, and a normal method can be used. A commercially available product can be used. Note that the average particle size of the aluminum hydroxide used is preferably 1 to 30 microns, particularly 3 to 20 microns, from the viewpoint of processability. In this case, it is preferable to use aluminum hydroxide that has been pulverized into the desired shape and particle size using a ball mill, jet mill, rotary impact pulverizer, etc., and the abrasive power of the resulting modified aluminum hydroxide can be varied in various ways. can be adjusted to In this case, in the present invention, it is particularly preferable to use modified aluminum hydroxide obtained by treating aluminum hydroxide pulverized using a rotary impact pulverizer with an acid or its salt; Compared to modified aluminum hydroxide obtained by treating aluminum hydroxide ground using a ball mill or jet mill with an acid or its salt, the average particle size is larger when the polishing power is the same, and therefore Since the cleaning power is high when the polishing power is about the same, by using the modified aluminum hydroxide produced by this rotary impact crusher, it is possible to obtain an oral cavity composition that is particularly excellent in low polishing and high cleaning performance. Moreover, as the acid or salt used for modifying the aluminum hydroxide, inorganic acids, organic acids, and salts thereof can be used. Examples of inorganic acids and their salts include phosphoric acid, sulfuric acid, hydrochloric acid, and their salts, and examples of organic acids and their salts include acetic acid, oxalic acid, tartaric acid, succinic acid, and their salts. Among these, phosphoric acid and its salts are preferably used, and such modified aluminum hydroxide has a 10% (wt%) water slurry with a pH of usually about 5 to 8, and is not modified. The pH of 10% water slurry of aluminum hydroxide is usually 9.
Since the pH is considerably lower than that before and after, the composition is not prepared to have a high pH, and therefore the fragrance ingredients,
In particular, it is possible to suppress the decomposition and deterioration of ester-based perfume components, and therefore it is possible to freely create perfumes using various perfume components. Here, phosphoric acid and its salts include orthophosphoric acid (H 3 PO 4 ), pyrophosphoric acid (H 4 P 2 O 7 ), metaphosphoric acid (HPO 4 ), triphosphoric acid (H 5 P 3 O 10 ), Tetraphosphoric acid (H 6 P 4 O 13 ). , condensed phosphoric acids such as polymetaphosphoric acid (HPO 3 ) n), and alkali metal salts thereof, and these can be used alone or in combination of two or more. In addition, the alkali metal salts include hydrogen phosphate-alkali metal salt (MH 2 PO 4 ), di-alkali metal hydrogen phosphate (M 2 HPO 4 ), and tri-alkali metal phosphate (M 3 PO 4 ).
Examples include. The method of treating aluminum hydroxide with an acid or a salt thereof is not particularly limited, but for example, a method of suspending aluminum hydroxide in an aqueous solution of an acid or a salt thereof and performing a neutralization treatment to carry out modification is possible. It can be suitably adopted. In this case, the aluminum hydroxide is preferably a 10 to 90% by weight slurry of an aqueous solution of an acid or its salt, particularly a 30 to 70% by weight slurry, and the concentration of the acid varies depending on the concentration of the aluminum hydroxide added. However, 0.05 mol/l ~ 5
Preferably it is mol/l. Also, the reaction is 10
It is preferable to carry out the reaction at -50°C, particularly 20-30°C, for 2-50 hours, especially 2-30 hours, and it is preferable to carry out stirring during the reaction. After the above operation is completed, the aluminum hydroxide removed from the slurry by filtration is washed with water or the like and dried to obtain modified aluminum hydroxide. In addition, in the above-mentioned reforming operation, it is also possible to perform the reforming operation once or repeatedly using one or more of the acids or salts at the same time,
The modification operation can also be repeated using two or more different acids or salts. For example, aluminum hydroxide is first treated with sulfuric acid, hydrochloric acid, etc.
It can then be treated with phosphoric acid, etc. Among the modified aluminum hydroxides mentioned above,
Particularly preferred are those obtained by treatment with phosphoric acid or its salts, especially orthophosphoric acid or its alkali metal salts. Products modified with this phosphoric acid or its salt have an aluminum phosphate-containing layer formed on the particle surface, but when using this type of modified aluminum hydroxide, the aluminum phosphate-containing layer on the surface A layer in which the entire layer is made of aluminum phosphate may be used, or a layer in which aluminum hydroxide and aluminum phosphate coexist may be used, but ESCA
(Electron Spectroscopy for Chemical
Analysis), the phosphorus atoms in the aluminum phosphate containing layer are 0.1 to
It is preferable to use one that indicates the presence of %. The above-mentioned modified aluminum hydroxide preferably has an aluminum phosphate-containing layer thickness of 10 to 1000 Å, and
Preferably, P 2 O 5 min is 0.01-0.5%. In the present invention, the above-mentioned modified aluminum hydroxide is blended into oral compositions such as toothpaste. In this case, the modified aluminum hydroxide is
This is slurry suspended in water at a ratio of 10% by weight.
It is preferable to use one having a pH of 4 to 8 and a copper plate polishing value of 1 to 10 mg. In addition, the copper plate polishing value is calculated by preparing a regular toothpaste containing 50% modified aluminum hydroxide, taking 50g of it, and adding 40g of it.
This is the abrasiveness when dispersed in 60% glycerin and subjected to 20,000 strokes using an inclined abrasive tester (pepsodent type). ), see page 184]. In addition, when using modified aluminum hydroxide as an abrasive, it is preferable that the average particle size is 1 to 30μ, particularly 7 to 25μ;
If it is larger than 30μ, a rough feeling may occur, and if it is smaller than 1μ, the polishing properties may be poor.
However, when used as a polishing agent, finer particle sizes can also be used. Furthermore, in the present invention, α-alumina and/or
Alternatively, titanium dioxide is blended into an oral composition. In this case, the α-alumina used in the present invention is alumina anhydride (Al 2 O 3 ) with a α-ization rate of 15 to 85%, preferably 20 to 80%, and this type of alumina anhydride is used. By doing so, excellent gloss can be imparted to the tooth surface. In addition,
Alumina anhydride with a gelatinization rate of 15 to 85% is α-
Al 2 O 3 , γ-Al 2 O 3 , amorphous Al 2 O 3 , etc. are combined in appropriate proportions, and the peak of α-Al 2 O 3 of the alumina anhydride is conversion rate 100
When compared with the peak of alumina anhydride (α-Al 2 O 3 ) with a gelatinization rate of 100%, the peak is between 15 and 85% of that of alumina anhydride (α-Al 2 O 3 ) with a gelatinization rate of 100%. do. Specifically, α− with a α conversion rate of 100%
The diffraction X-ray intensity ratio between the (012) plane and the (116) plane with Al 2 O 3 is determined, and the average value is 15 to 85%. Here, the alumina anhydride having a gelatinization rate of 15 to 85% may be used alone or in combination of two or more. Also, the gelatinization rate is 15-85%
The alumina anhydride may be used in combination with other alumina anhydrides or hydrates. Note that the alumina anhydride with a pregelatinization rate of 15 to 85% can be produced by the Bayer method, and can have a desired pregelatinization rate by appropriately controlling the firing temperature in the Bayer method manufacturing process. Alumina anhydride can be obtained. Further, the average particle size of α-alumina used in the present invention is not necessarily limited, but is preferably 10μ or less,
The particle size is preferably 5 μm or less, particularly 0.1 to 3 μm; if the particle size is too large, the gloss imparting effect may deteriorate. In particular, it is most preferable to have an average particle size of 5 μm or less in terms of gloss imparting and polishing power. In addition, as titanium dioxide used in the present invention,
Titanium dioxide containing 70% or more of rutile-type crystal structure is used, and by using this type of titanium dioxide, excellent gloss can be imparted to tooth surfaces. The titanium dioxide used in the present invention must not be surface-treated and its purity must be
It is preferable that it is 98.5% or more from the viewpoint of gloss improvement effect. Furthermore, the average particle size of titanium dioxide used in the present invention is not necessarily limited, but is 0.1 to 0.8μ, particularly 0.1 to 0.8μ.
The particle size is preferably 0.5 μm, and if the particle size is too large, the gloss imparting effect may deteriorate. In the present invention, there is no limit to the amount of the modified aluminum hydroxide, α-alumina, and titanium dioxide;
- When alumina is used in combination, it is preferable to use 0.1 to 100 parts by weight, particularly 0.2 to 50 parts by weight, of α-alumina per 100 parts by weight of modified aluminum hydroxide, and in combination with modified aluminum hydroxide and titanium dioxide. In this case, 0.1 to 100 parts by weight of titanium dioxide per 100 parts by weight of modified aluminum hydroxide, especially 1
It is preferred to use ~70 parts by weight. The total amount of modified aluminum hydroxide, α-alumina and/or titanium dioxide is usually 5% of the total composition.
~95%, especially in the case of toothpaste, preferably 5-50%. In this case, in the present invention, the abrasive and brightener may be composed only of the above-mentioned modified aluminum hydroxide and α-alumina and/or titanium dioxide, but may be used in combination with other abrasives. Here, other abrasives include, for example, calcium hydrogen phosphate dihydrate, calcium hydrogen phosphate anhydrate, calcium carbonate, calcium pyrophosphate,
Examples include insoluble sodium metaphosphate, precipitated silica, aluminosilicate, aluminum oxide, microcrystalline cellulose, resin, tertiary magnesium phosphate, and magnesium carbonate. Further, conventional aluminum hydroxide can also be blended within a range that does not significantly impair the properties of the modified aluminum hydroxide. In addition,
When modified aluminum hydroxide is used in combination with other abrasives, the ratio is not limited, and modified aluminum hydroxide may be used as the main abrasive, or other abrasives may be used as the main abrasive. Although these are determined depending on the purpose of use of the oral composition, the modified aluminum hydroxide of the present invention is mixed in an abrasive with a concentration of 20 to 100%.
%, particularly preferably 40 to 100%. Furthermore, the oral composition of the present invention contains lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexidine or a salt thereof, sorbic acid,
Alexidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethylglycine salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin E, sodium monofluorophosphate, sodium fluoride, stannous fluoride, water-soluble The oral composition of the present invention can contain active ingredients such as primary or secondary phosphates, quaternary ammonium compounds, and sodium chloride.
tranexamic acid, epsilon aminocaproic acid,
Allantoin chlorohydroxyaluminum, sodium chloride, etc. can be stably blended. The oral composition of the present invention may further contain other components depending on its type. for example,
Binder such as carboxymethyl cellulose, hydroxyethyl cellulose, alginate, carrageenan, gum arabic, polyvinyl alcohol, thickening agent such as polyethylene glycol, sorbitol, glycerin, propylene glycol, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, hydrogenated coconut Foaming agents such as fatty acid monoglyceride monosulfate sodium, sodium lauryl sulfoacetate, N-lauroyl sodium sarcosinate, N-acyl glutamate, lauroyl diethanolamide, sucrose fatty ester, saccharin sodium, stevioside,
Sweeteners such as neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, p-methoxinamicaldehyde, thaumatin, preservatives, flavor components, etc. may be blended. In this case, the oral composition of the present invention can lower the pH by incorporating the above-mentioned modified aluminum hydroxide, and therefore can effectively suppress decomposition and deterioration of the fragrance during storage. Therefore, the oral composition of the present invention contains menthol, carvone, peppermint oil, spearmint oil, anethole, ester fragrance accent,
Lactone fragrance accent, aldehyde fragrance accent, phenol fragrance accent,
Other fragrance ingredients listed in "Perfume and Flavor Chemicals" by STEFFEN ARCTANDER published by MONTCLAIR, NJ (USA), as well as orange oil, lemon oil, clove oil, cassia oil, fennel oil, cardamom oil,
Various fragrance ingredients can be effectively blended with essential oils such as cinnamon oil, coriander oil, eucalyptus oil, caraway oil, sage oil, and thyme oil. The oral composition of the present invention can be produced by a conventional method using the above-mentioned components, but when producing a toothpaste, it is preferable to have a pH of 5 to 8. In this case, since the modified aluminum hydroxide of the present invention has a low PH, the PH of the composition can be easily adjusted to a range of 5 to 8, and the PH of the composition can be stably maintained in this PH range for a long period of time. Furthermore, the oral composition of the present invention can be filled into a plastic container, a laminate container made of aluminum laminated on one or both sides with plastic, or a metal container made of aluminum or the like. Since this can be suppressed, aluminum tubes and the like can be used without any problems. In addition, in the composition of the present invention, the addition of an alkali metal monofluorophosphate or magnesium chloride can further significantly suppress corrosion of aluminum. Effects of the Invention As explained above, the oral composition according to the present invention comprises modified aluminum hydroxide obtained by treating aluminum hydroxide with an acid or a salt thereof, and α-alumina and/or titanium dioxide. By blending these, it has moderate abrasiveness and excellent cleaning effect on teeth, and also has a high gloss imparting effect on tooth surfaces. Next, an example of manufacturing modified aluminum hydroxide used in the present invention will be shown. Production example 1 Highly white aluminum hydroxide was ground using a rotary impact grinder (average particle size 6μ <light transmission method>), water (pure water or industrial water, hereinafter the same) was added and stirred, % slurry, then add orthophosphoric acid aqueous solution (concentration 2 mol/l) to this,
After neutralization by stirring at room temperature for 2-4 hours, the slurry is filtered. Then add water to the residue to make 50%
The washing operation of preparing a slurry, stirring it, and then filtering it was repeated twice, and finally the residue was dried to obtain modified aluminum hydroxide. The surface of this aluminum hydroxide was coated with aluminum phosphate. Next, the particle surface of the modified aluminum hydroxide obtained in the above production example was examined using ESCA and FT-IR.
(Fourier Tranformation Infrared). Results of analysis using ESCA The results are shown in Tables 1 and 2. In addition, the first
Table 2 shows the results of quantitative analysis of constituent ions, and Table 2 shows the results of state analysis of phosphorus.For comparison, commercially available (unmodified) aluminum hydroxide, aluminum phosphate mixed with it, and phosphorus The analysis results of aluminum acid are also listed.
【表】【table】
上記製造例１、２で得た改質水酸化アルミニウ
ムを研磨剤として下記組成の練歯磨を調製し、こ
れら練歯磨の調製直後及び所定期間保存後のPHを
測定した。
また、比較のため、改質を行なつていない水酸
化アルミニウム（市販水酸化アルミニウム）を用
いて同様の実験を行なつた。
結果を第３表に示す。
錬歯磨組成
研磨剤 46％
60％ソルビツト 26％
カルボキシメチルイセルロースナトリウム 0.8％
カラギーナン 0.3％
ラウリル硫酸ナトリウム 1.8％
ゲル化性シリカ 3.0％
プロピレングリコール 2.5％
サツカリンナトリウム 0.18％
ブチルパラベン 0.002％
エチルパラベン 0.005％
塩酸クロルヘキシジン 0.001％
香 料 1.0％
精製水 残
合計 100.0％
Toothpastes having the following composition were prepared using the modified aluminum hydroxide obtained in Production Examples 1 and 2 as an abrasive, and the pH of these toothpastes was measured immediately after preparation and after storage for a predetermined period of time. For comparison, a similar experiment was conducted using unmodified aluminum hydroxide (commercially available aluminum hydroxide). The results are shown in Table 3. Toothpaste composition Abrasive 46% 60% Sorbit 26% Sodium carboxymethyl cellulose 0.8% Carrageenan 0.3% Sodium lauryl sulfate 1.8% Gellable silica 3.0% Propylene glycol 2.5% Sodium saccharin 0.18% Butyl paraben 0.002% Ethyl paraben 0.005% Chlorhexidine hydrochloride 0.001% Fragrance 1.0% Purified water Total balance 100.0%
第４表に示す組成の実施例１〜６、比較例１〜
４の練歯磨をそれぞれ常法により調製し、これら
練歯磨の光沢向上度及び研磨力を下記方法により
調べた。結果を第４表に示す。
光沢向上度測定法
５×５mmの大きさにカツトした牛歯を樹脂に包
埋し、牛歯エナメル表面を回転研磨機で平滑に
し、次いでNo.1200のエメリー紙研磨、リン酸水素
カルシウム・無水和物による研磨、バフ研磨によ
り光沢計（日本電色工業社GLOSS METER VG
−10）の光沢度で80.0±2.0にエナメル表面を処
置した。
次に、試料の練歯磨10ｇを40％ソルビツト溶液
30mlに懸濁してなるサスペンシヨンを上記牛歯を
セツトした研磨容器に注入し水平型研磨試験機に
より荷重200ｇ、7000ストローク／40分の条件で
ブラツシングし、光沢計により光沢度の増減を測
定し、初期光沢度からの差を光沢向上度とした。
この場合、目視で充分に光沢ありと認められる
レベルは光沢向上度＋20以上、光沢ありと認めら
れるレベルは＋15以上である。
なお、ブラツシングのブラシとしては、毛束数
44個、毛の太さ８ミル（約0.2mm）、毛の長さ12mm
のナイロン（62）材質で、材質の硬さが家庭品品
質表示法でＭのものを使用した。
研磨力測定法
試料の練歯磨45ｇを60％グリセリン35ｇに懸濁
してなるサスペンシヨンを用い、重荷200ｇにお
いてJISH−3361（ビツカース硬度120）の銅板を
水平型研磨試験機により２時間で２万回ブラツシ
ング（ブラツシングのブラシとしては光沢向上度
試験と同じものを使用した）し、銅板摩耗量を測
定した。
Examples 1 to 6 and Comparative Examples 1 to 6 with the compositions shown in Table 4
Each of the toothpastes No. 4 was prepared by a conventional method, and the gloss improvement and polishing power of these toothpastes were examined by the following method. The results are shown in Table 4. Gloss improvement measurement method A bovine tooth cut into a size of 5 x 5 mm was embedded in resin, the surface of the bovine tooth enamel was smoothed with a rotary polisher, and then polished with No. 1200 emery paper and calcium hydrogen phosphate anhydrous. Gloss meter (Nippon Denshoku Kogyo Co., Ltd. GLOSS METER VG)
-10) The enamel surface was treated to a gloss level of 80.0±2.0. Next, add 10g of the sample toothpaste to a 40% sorbitol solution.
The suspension made of 30ml was poured into a polishing container with the above bovine teeth set in it, and brushed with a horizontal polishing tester under the conditions of 200g load and 7000 strokes/40 minutes, and the increase/decrease in gloss was measured with a glossmeter. The difference from the initial gloss level was defined as the gloss improvement level. In this case, the level that is visually recognized as sufficiently glossy is +20 or higher in terms of gloss improvement, and the level that is visually recognized as glossy is +15 or higher. In addition, as a brush for brushing, the number of hair strands
44 pieces, hair thickness 8 mil (approx. 0.2 mm), hair length 12 mm
The material used was nylon (62) with a hardness rating of M according to the Household Goods Quality Indication Act. Abrasive force measurement method Using a suspension consisting of 45 g of sample toothpaste suspended in 35 g of 60% glycerin, a copper plate of JISH-3361 (Vickers hardness 120) was polished 20,000 times in 2 hours using a horizontal polishing tester under a load of 200 g. Brushing was performed (the same brush used in the gloss improvement test was used) and the amount of wear of the copper plate was measured.
【表】【table】
【表】
第４表の結果より、改質水酸化アルミニウムと
α−アルミナ又は二酸化チタンとを併用した実施
例の練歯磨は、改質していない市販水酸化アルミ
ニウムとα−アルミナ又は二酸化チタンとを併用
した比較例の練歯磨に比べ、研磨力が同程度の場
合には光沢向上度が高く、本発明口腔用組成物が
光沢付与効果に優れていることが認められた。[Table] From the results in Table 4, the toothpaste of the example using modified aluminum hydroxide and α-alumina or titanium dioxide combined with unmodified commercially available aluminum hydroxide and α-alumina or titanium dioxide Compared to the toothpaste of the comparative example in which the abrasive force was the same, the degree of gloss improvement was higher, and it was confirmed that the oral composition of the present invention has an excellent gloss imparting effect.
Claims (1)
ることによつて得られる改質水酸化アルミニウム
と、α化率15〜85％のアルミナ無水物及び／又は
ルチル型の結晶構造を有するものが70重量％以上
含まれている二酸化チタンとを配合してなること
を特徴とする口腔用組成物。 ２ 改質水酸化アルミニウムとして、水酸化アル
ミニウムをリン酸又はその塩で処理することによ
つて得られる粒子表面にリン酸アルミニウム含有
層が形成されたものを用いた特許請求の範囲第１
項に記載の口腔用組成物。 ３ 改質水酸化アルミニウム中のP2O5分が0.01〜
0.5重量％である特許請求の範囲第２項記載の口
腔用組成物。 ４ 改質水酸化アルミニウムとして、リン酸アル
ミニウム含有層中のリン原子が0.1〜10重量％の
存在を示すものを用いた特許請求の範囲第２項又
は第３項記載の口腔用組成物。 ５ 改質水酸化アルミニウムとして、リン酸アル
ミニウム含有層の厚さが10〜1000Åのものを用い
た特許請求の範囲第２項乃至第４項いずれか記載
の口腔用組成物。 ６ 改質水酸化アルミニウムの平均粒子径が１〜
30μである特許請求の範囲第１項乃至第５項いず
れか記載の口腔用組成物。 ７ アルミナ無水物の平均粒径が10μ以下である
特許請求の範囲第１項乃至第６項いずれか記載の
口腔用組成物。 ８ 二酸化チタンが、0.1〜0.8μの平均粒子径を
有し、表面処理が施されていない純度98.5％以上
のものである特許請求の範囲第１項乃至第６項い
ずれか記載の口腔用組成物。 ９ 組成物のPHが５〜８である特許請求の範囲第
１項乃至第８項いずれか記載の口腔用組成物。 １０ エステル系香料を配合した特許請求の範囲
第１項乃至第９項いずれか記載の口腔用組成物。[Claims] 1. Modified aluminum hydroxide obtained by treating aluminum hydroxide with an acid or its salt, and anhydrous alumina and/or rutile crystal structure with a gelatinization rate of 15 to 85%. An oral cavity composition characterized in that it is blended with titanium dioxide containing 70% by weight or more of titanium dioxide having the following properties. 2. Claim 1 uses, as the modified aluminum hydroxide, particles in which an aluminum phosphate-containing layer is formed on the surface of particles obtained by treating aluminum hydroxide with phosphoric acid or its salt.
Oral composition as described in section. 3 P 2 O in modified aluminum hydroxide 5 minutes is 0.01~
The oral composition according to claim 2, which contains 0.5% by weight. 4. The oral cavity composition according to claim 2 or 3, wherein the modified aluminum hydroxide contains 0.1 to 10% by weight of phosphorus atoms in the aluminum phosphate-containing layer. 5. The oral cavity composition according to any one of claims 2 to 4, wherein the modified aluminum hydroxide has an aluminum phosphate-containing layer having a thickness of 10 to 1000 Å. 6 The average particle size of modified aluminum hydroxide is 1 to
The oral composition according to any one of claims 1 to 5, which has a particle size of 30μ. 7. The oral cavity composition according to any one of claims 1 to 6, wherein the alumina anhydride has an average particle size of 10 μm or less. 8. The composition for oral cavity according to any one of claims 1 to 6, wherein the titanium dioxide has an average particle diameter of 0.1 to 0.8 μ, is not subjected to surface treatment, and has a purity of 98.5% or more. thing. 9. The oral composition according to any one of claims 1 to 8, wherein the composition has a pH of 5 to 8. 10. The oral cavity composition according to any one of claims 1 to 9, which contains an ester fragrance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13442584A JPS6115821A (en) | 1984-06-29 | 1984-06-29 | Composition for oral cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13442584A JPS6115821A (en) | 1984-06-29 | 1984-06-29 | Composition for oral cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6115821A JPS6115821A (en) | 1986-01-23 |
| JPH0534330B2 true JPH0534330B2 (en) | 1993-05-21 |
Family
ID=15128078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13442584A Granted JPS6115821A (en) | 1984-06-29 | 1984-06-29 | Composition for oral cavity |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6115821A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS613322A (en) * | 1984-06-14 | 1986-01-09 | Mitsubishi Electric Corp | Magnetic disc device |
-
1984
- 1984-06-29 JP JP13442584A patent/JPS6115821A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS613322A (en) * | 1984-06-14 | 1986-01-09 | Mitsubishi Electric Corp | Magnetic disc device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6115821A (en) | 1986-01-23 |
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