JPH05271059A - Improving and curing agent for constipation - Google Patents
Improving and curing agent for constipationInfo
- Publication number
- JPH05271059A JPH05271059A JP4084723A JP8472392A JPH05271059A JP H05271059 A JPH05271059 A JP H05271059A JP 4084723 A JP4084723 A JP 4084723A JP 8472392 A JP8472392 A JP 8472392A JP H05271059 A JPH05271059 A JP H05271059A
- Authority
- JP
- Japan
- Prior art keywords
- improving
- constipation
- curing agent
- leaves
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、マメ科に属するアスパ
ラサス・リネアリスの含有成分を有効成分とする便秘改
善・治療剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a constipation-improving / therapeutic agent containing, as an active ingredient, a component of Aspalathus linealis belonging to the legume family.
【０００２】[0002]
【従来の技術】従来より、便秘改善治療剤は数多く知ら
れている。2. Description of the Related Art Many therapeutic agents for improving constipation have been known.
【０００３】[0003]
【発明が解決しようとする課題】しかし、その多くは、
治療効果が弱く、人体に害がなく飲食も可能な、また他
の飲食と混合して使用できるものは知られていない。However, many of them are
There is no known one that has a weak therapeutic effect, is harmless to the human body, can be eaten and drinks, and can be used as a mixture with other foods and drinks.
【０００５】本発明は、前記課題を解決し、便秘改善治
療薬を提供することを目的とする。It is an object of the present invention to solve the above problems and provide a therapeutic agent for improving constipation.
【０００６】そこで、本発明者らは、前記目的を解決す
るために鋭意研究を重ねた結果、マメ科に属するアスパ
ラサス・リネアリス抽出物が、便秘改善治療薬として効
果があり、かつ人体、家畜など哺乳動物に対して副作用
がなく安全な便秘改善治療剤であるとの知見を得て本発
明を完成した。Therefore, as a result of intensive studies to solve the above-mentioned object, the present inventors have found that an Aspalathus linealis extract belonging to the family of legumes is effective as a therapeutic agent for improving constipation, and is effective for humans and livestock. The present invention has been completed based on the finding that it is a safe therapeutic drug for constipation with no side effects on mammals.
【０００７】本発明の有効成分は、アスパラサス・リネ
アリスの抽出液からなり、抽出法としては、アスパラサ
ス・リネアリスの葉または茎を水及び／または有機溶媒
で抽出し、該抽出液より抽出溶媒を留去する方法、また
はアスパラサス・リネアリスの葉または茎を粉砕するこ
とによって得ることができる。また、通常の日本茶、中
国茶、紅茶などの製法と同様に抽出してもよい。The active ingredient of the present invention comprises an extract of Aspalathus linealis. As an extraction method, leaves or stems of Aspalathus linealis are extracted with water and / or an organic solvent, and the extraction solvent is extracted from the extract. Can be obtained by distilling off or by crushing leaves or stems of Aspalathus linealis. In addition, it may be extracted in the same manner as in the production method of ordinary Japanese tea, Chinese tea, black tea and the like.
【０００８】水で抽出する場合には、アスパラサス・リ
ネアリスの５０〜１０００倍の水を加え、沸騰後、さら
に５〜３０分程度沸騰抽出するのが好ましい。また、通
常の茶と同様抽出するときは、アスパラサス・リネアリ
スの乾燥葉の５０〜５００倍の８０〜１００度の湯で３
〜３０分程度放置して抽出液を得る。In the case of extraction with water, it is preferable to add 50 to 1000 times as much water as Aspalathus linealis, boil and then carry out boiling extraction for about 5 to 30 minutes. Also, when extracting in the same way as ordinary tea, use 3 to 50 times the hot water of 80 to 100 degrees, which is 50 to 500 times the dry leaves of Aspalathus linearis.
Leave for about 30 minutes to obtain an extract.
【０００９】有機溶媒の具体例としては、メタノール、
エタノール、アセトン等があげられ、抽出にあたって温
時抽出等慣用手段を用いることができる。また、抽出液
の分離も、デカンテーションや遠心分離等の慣用手段を
用いることができる。Specific examples of the organic solvent include methanol,
Examples of the solvent include ethanol and acetone, and a conventional means such as warm extraction can be used for extraction. Further, for the separation of the extract, conventional means such as decantation or centrifugation can be used.
【００１０】抽出溶媒の留去も凍結乾燥等の慣用手段を
用いることができる。また、アスパラサス・リネアリス
そのものを粉砕して、粉末化して用いることもできる。A conventional means such as freeze-drying can be used for distilling off the extraction solvent. Also, Aspalathus linealis itself can be crushed and used as a powder.
【００１１】本組成物は、有効成分を生理学的に許容さ
れうる担体、賦形剤、結合剤、希釈剤と混合し、たとえ
ば顆粒剤、粉剤、硬カプセル剤、軟カプセル剤、塗布
剤、シロップ、坐剤、注射剤として経口または非経口的
に、または、混合してそのまま溶液、粉末顆粒、錠剤、
乳剤、ゼリー状など任意の形態で単独投与、濃縮液を利
用、または他の飲食物に混合して飲食することもでき
る。The composition is prepared by mixing the active ingredient with physiologically acceptable carriers, excipients, binders and diluents, for example granules, powders, hard capsules, soft capsules, coatings and syrups. , Suppositories, orally or parenterally as injections, or as a mixture as it is, solutions, powder granules, tablets,
It can be administered alone in any form such as an emulsion or jelly, can be used as a concentrated solution, or can be mixed with other foods and drinks.
【００１２】投与量は、対象となる疾患の種類、程度に
より異なるが、飲料として常用する場合には、１〜５ｇ
乾燥葉／リットル溶液を１００ｍｌ〜１５００ｍｌ／日
飲食するのが好ましい。The dose varies depending on the type and degree of the target disease, but in the case of regular use as a drink, 1 to 5 g
It is preferable to eat and drink 100 ml to 1500 ml / day of the dried leaf / liter solution.
【００１３】アスパラサス・リネアリスは、ラットに対
する急性毒性試験で死亡例は皆無であり、生化学的血液
検査及び病理組織学的検査においても異常がみとめられ
なかった。[0013] Aspalathus linealis had no deaths in an acute toxicity test in rats, and no abnormality was found in biochemical blood tests and histopathological examinations.
【００１４】[0014]
【効果】本発明は、特に女性に多い便秘を、副作用なく
改善治療することができ、また他の飲食物を混合して用
いることができる。[Effect] The present invention can improve and treat constipation, which is common in women, without any side effects, and can be used by mixing with other foods and drinks.
【００１５】[0015]
製造例 採取したアスパラサス・リネアリスの葉（茎つき）を５
ｍｍ長に切断後、ローリング、酵素醗酵、天日乾燥の工
程を経て乾燥葉とする。乾燥葉１〜５ｇを、水１．５〜
２リットルで５〜３０分間沸騰させ抽出液を得た。Example of production 5 collected Aspalathus linealis leaves (with stem)
After cutting to mm length, the leaves are dried by rolling, enzymatic fermentation and sun drying. 1-5 g of dried leaves, 1.5- of water
The extract was obtained by boiling at 2 liters for 5 to 30 minutes.
【００１６】製造例で得た抽出液を、便秘症状を呈する
人に一日約１リットルを２週間飲用させた後、便秘症状
の改善を調べた。その結果を表１に示す。The extract obtained in the production example was given to a person exhibiting constipation symptoms by drinking about 1 liter per day for 2 weeks, and then the improvement of constipation symptoms was examined. The results are shown in Table 1.
【表１】 [Table 1]
【００１７】アスパラサス・リネアリスの化学分析結果
は下記の通りである。 鉄 ２３．４０ｍｇ／１００ｇ カルシウム １８７．００ｍｇ／１００ｇ カリウム ３９８．００ｍｇ／１００ｇ マグネシウム ２０７．００ｍｇ／１００ｇ 銅 ２．２５ｐｐｍ 亜鉛 ６．７４ｐｐｍ セレン ０．１３ｐｐｍ ビタミンＥ １７．００ｍｇ／１００ｇ たんぱく質 ８．００％ フラボノイド ４１．００ｍｇ／１００ｇ 抗酸化能・ＳＯＤ様力価 ６９，０００ｕｎｉｔ／ｇ 酸不溶性蛋白成分 １５０ｍｇ／１００ｇ 香気成分 １００ｍｇ／１００ｇ 糖含有化合物 ６９０ｍｇ／１００ｇ The results of chemical analysis of Aspalathus linealis are as follows. Iron 23.40 mg / 100 g Calcium 187.00 mg / 100 g Potassium 398.00 mg / 100 g Magnesium 207.00 mg / 100 g Copper 2.25 ppm Zinc 6.74 ppm Selenium 0.13 ppm Vitamin E 17.00 mg / 100 g Protein 8.00% Flavonoids 41 0.000 mg / 100 g Antioxidant / SOD-like potency 69,000 unit / g Acid-insoluble protein component 150 mg / 100 g Aroma component 100 mg / 100 g Sugar-containing compound 690 mg / 100 g
【００１８】また香気成分として、カルボニル化合物
（１５％）、カロチノイド分解物（１７％）、炭素数２
〜１２の有機酸（２２％）、フェノール化合物（１３
％）、芳香族含酸素化合物（７％）、芳香族炭化水素
（５．５％）、テルペノイド（４％）などを含有する。
なお、酸不溶性蛋白質とは比較的分子量の大きな蛋白成
分である。As aroma components, carbonyl compound (15%), carotenoid decomposition product (17%), carbon number 2
~ 12 organic acids (22%), phenolic compounds (13
%), Aromatic oxygen-containing compounds (7%), aromatic hydrocarbons (5.5%), terpenoids (4%) and the like.
The acid-insoluble protein is a protein component having a relatively large molecular weight.
Claims (1)
成分とする便秘改善・治療剤。1. A constipation-improving / treating agent comprising an Aspalathus linealis extract as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4084723A JP2724524B2 (en) | 1992-03-06 | 1992-03-06 | Constipation improvement / treatment agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4084723A JP2724524B2 (en) | 1992-03-06 | 1992-03-06 | Constipation improvement / treatment agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05271059A true JPH05271059A (en) | 1993-10-19 |
| JP2724524B2 JP2724524B2 (en) | 1998-03-09 |
Family
ID=13838609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4084723A Expired - Fee Related JP2724524B2 (en) | 1992-03-06 | 1992-03-06 | Constipation improvement / treatment agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2724524B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100506824B1 (en) * | 2002-12-12 | 2005-08-11 | 주식회사 케이티앤지 | Crude Drug Compositions for treating or preventing intestinal disease and constipation |
| WO2008110551A1 (en) * | 2007-03-12 | 2008-09-18 | Zadec Aps | An anti-diabetic extract of rooibos |
-
1992
- 1992-03-06 JP JP4084723A patent/JP2724524B2/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100506824B1 (en) * | 2002-12-12 | 2005-08-11 | 주식회사 케이티앤지 | Crude Drug Compositions for treating or preventing intestinal disease and constipation |
| WO2008110551A1 (en) * | 2007-03-12 | 2008-09-18 | Zadec Aps | An anti-diabetic extract of rooibos |
| US8877717B2 (en) | 2007-03-12 | 2014-11-04 | Zadec Aps | Anti-diabetic extract of rooibos |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2724524B2 (en) | 1998-03-09 |
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