JPH05271057A - Improving and curing agent for rheumatism - Google Patents
Improving and curing agent for rheumatismInfo
- Publication number
- JPH05271057A JPH05271057A JP8472192A JP8472192A JPH05271057A JP H05271057 A JPH05271057 A JP H05271057A JP 8472192 A JP8472192 A JP 8472192A JP 8472192 A JP8472192 A JP 8472192A JP H05271057 A JPH05271057 A JP H05271057A
- Authority
- JP
- Japan
- Prior art keywords
- rheumatism
- improving
- extract
- leaves
- curing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、マメ科に属するアスパ
ラサス・リネアリスの含有成分を有効成分とするリウマ
チ改善治療剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a rheumatism-improving / treating agent containing, as an active ingredient, a component contained in Aspalathus linealis belonging to the legume family.
【０００２】[0002]
【従来の技術】従来より、リウマチに対してはステロイ
ド等の免疫抑制剤などの治療剤が知られている。2. Description of the Related Art Hitherto, therapeutic agents such as immunosuppressive agents such as steroids have been known for rheumatism.
【０００３】[0003]
【発明が解決しようとする課題】しかし、ステロイド剤
などの免疫抑制剤は副作用が強く、十分な効果を得るに
は難しい。However, immunosuppressive agents such as steroids have strong side effects and it is difficult to obtain sufficient effects.
【０００４】また、リウマチは自己免疫によって生じる
自己免疫疾患であるために治療は難しく、完治すること
はなく緩解が大部分である。Since rheumatism is an autoimmune disease caused by autoimmunity, it is difficult to treat it, and it is not completely cured.
【０００５】本発明は、前記課題を解決し、リウマチを
日常経口的に摂取することで有効な症状の改善治療剤を
提供することを目的とする。An object of the present invention is to solve the above-mentioned problems and to provide an effective therapeutic agent for improving symptoms by ingesting rheumatism orally daily.
【０００６】そこで、本発明者らは、前記目的を解決す
るために鋭意研究を重ねた結果、マメ科に属するアスパ
ラサス・リネアリス抽出物が、リウマチなど自己免疫疾
患に対し優れた効果を有し、かつ副作用がなく安全に改
善できるとの知見を得て本発明を完成した。Therefore, as a result of intensive studies to solve the above-mentioned object, the present inventors have found that the Asparasus linearias extract belonging to the legume family has an excellent effect on autoimmune diseases such as rheumatism. The present invention has been completed based on the finding that there is no side effect and that it can be safely improved.
【０００７】本発明の有効成分は、アスパラサス・リネ
アリスの抽出液からなり、抽出法としては、アスパラサ
ス・リネアリスの葉または茎を水及び／または有機溶媒
で抽出し、該抽出液より抽出溶媒を留去する方法、また
はアスパラサス・リネアリスの葉または茎を粉砕するこ
とによって得ることができる。また、通常の日本茶、中
国茶、紅茶などの製法と同様に抽出してもよい。The active ingredient of the present invention comprises an extract of Aspalathus linealis. As an extraction method, leaves or stems of Aspalathus linealis are extracted with water and / or an organic solvent, and the extraction solvent is extracted from the extract. Can be obtained by distilling off or by crushing leaves or stems of Aspalathus linealis. In addition, it may be extracted in the same manner as in the production method of ordinary Japanese tea, Chinese tea, black tea and the like.
【０００８】水で抽出する場合には、アスパラサス・リ
ネアリスの５０〜１０００倍の水を加え、沸騰後、さら
に５〜３０分程度沸騰抽出するのが好ましい。また、通
常の茶と同様抽出するときは、アスパラサス・リネアリ
スの乾燥葉の５０〜５００倍の水を加え、９０〜１００
度で３〜３０分程度放置して抽出液を得る。In the case of extraction with water, it is preferable to add 50 to 1000 times as much water as Aspalathus linealis, boil and then carry out boiling extraction for about 5 to 30 minutes. Also, when extracting in the same manner as ordinary tea, add 50 to 500 times the water of dried leaves of Aspalathus linearias and add 90 to 100
The extract is obtained by leaving it for about 3 to 30 minutes.
【０００９】有機溶媒の具体例としては、メタノール、
エタノール、アセトン等が挙げられ、抽出にあたっては
温時抽出等慣用手段を用いることができる。また、抽出
液の分離も、デカンテーションや遠心分離等の慣用手段
を用いることができる。Specific examples of the organic solvent include methanol,
Ethanol, acetone and the like can be mentioned, and conventional means such as warm extraction can be used for extraction. Further, for the separation of the extract, conventional means such as decantation or centrifugation can be used.
【００１０】抽出溶媒の留去も凍結乾燥等の慣用手段を
用いることができ、また、アスパラサス・リネアリスそ
のものを粉砕して、粉末化して用いることもできる。The extraction solvent may be distilled off by using a conventional means such as freeze-drying, or Aspalathus linealis itself may be pulverized and used as a powder.
【００１１】本組成物は、有効成分を生理学的に許容さ
れうる担体、賦形剤、結合剤、希釈剤と混合し、たとえ
ば顆粒剤、粉剤、硬カプセル剤、軟カプセル剤、塗布
剤、シロップ、坐剤、注射剤として経口または非経口的
に、または、混合してそのまま溶液、粉末顆粒、錠剤、
乳剤、ゼリー状など任意の形態で単独投与、濃縮液を利
用、または他の飲食物に混合して飲食することもでき
る。The composition is prepared by mixing the active ingredient with physiologically acceptable carriers, excipients, binders and diluents, for example granules, powders, hard capsules, soft capsules, coatings and syrups. , Suppositories, orally or parenterally as injections, or as a mixture as it is, solutions, powder granules, tablets,
It can be administered alone in any form such as an emulsion or jelly, can be used as a concentrated solution, or can be mixed with other foods and drinks.
【００１２】投与量は、対象となる疾患の種類、程度に
より異なるが、飲料として常用する場合には、１〜５ｇ
乾燥葉／１溶液を１００ｍｌ〜１５００ｍｌ／日飲食す
るのが好ましい。The dose varies depending on the type and degree of the target disease, but in the case of regular use as a drink, 1 to 5 g
It is preferable to eat and drink 100 ml to 1500 ml / day of the dried leaf / 1 solution.
【００１３】アスパラサス・リネアリスは、ラットに対
する急性毒性試験で死亡例は皆無であり、生化学血液検
査および病理組織学的検査においても異常が認められな
かった。[0013] Aspalathus linealis showed no death in an acute toxicity test in rats, and no abnormality was observed in biochemical blood tests and histopathological tests.
【００１４】[0014]
【効果】本発明は、ヒトを含む哺乳動物のリウマチおよ
びリウマチ性疾患を副作用無く、迅速に改善治療するこ
とができる。[Effect] The present invention can rapidly and ameliorate rheumatism and rheumatic diseases of mammals including humans without side effects.
【００１５】[0015]
製造例 採取したアスパラサス・リネアリスの葉（茎つき）を、
５ｍｍ長に切断後、ローリング、酵素醗酵、天日乾燥の
工程を経て乾燥葉とする。乾燥葉４ｇを水１．５リット
ルで１５分間沸騰させ抽出液を得た。Production example Collected Aspalathus linealis leaves (with stem)
After cutting to a length of 5 mm, dried leaves are subjected to the steps of rolling, enzyme fermentation, and sun drying. 4 g of dried leaves were boiled with 1.5 liters of water for 15 minutes to obtain an extract.
【００１６】実施例 製造例で得た抽出液を表１に示すリウマチの患者に、１
日約１０００ｍｌを２カ月以上飲ませて症状の改善を調
べその結果を表１に示す。EXAMPLE The extract obtained in the production example was applied to the rheumatic patients shown in Table 1
Approximately 1000 ml a day was drunk for 2 months or longer, and the improvement of the symptoms was examined.
【表１】 [Table 1]
【００１７】アスパラサス・リネアリスの化学分析結果
は下記の通りである。 鉄 ２３．４０ｍｇ／１００ｇ カルシウム １８７．００ｍｇ／１００ｇ カリウム ３９８．００ｍｇ／１００ｇ マグネシウム ２０７．００ｍｇ／１００ｇ 銅 ２．２５ｐｐｍ 亜鉛 ６．７４ｐｐｍ セレン ０．１３ｐｐｍ ビタミンＥ １７．００ｍｇ／１００ｇ たんぱく質 ８．００％ フラボノイド ４１．００ｍｇ／１００ｇ 抗酸化能・ＳＯＤ様力価 ６９，０００ｕｎｉｔ／ｇ 酸不溶性蛋白成分 １５０ｍｇ／１００ｇ 香気成分 １００ｍｇ／１００ｇ 糖含有化合物 ６９０ｍｇ／１００ｇ The results of chemical analysis of Aspalathus linealis are as follows. Iron 23.40 mg / 100 g Calcium 187.00 mg / 100 g Potassium 398.00 mg / 100 g Magnesium 207.00 mg / 100 g Copper 2.25 ppm Zinc 6.74 ppm Selenium 0.13 ppm Vitamin E 17.00 mg / 100 g Protein 8.00% Flavonoids 41 0.000 mg / 100 g Antioxidant / SOD-like potency 69,000 unit / g Acid-insoluble protein component 150 mg / 100 g Aroma component 100 mg / 100 g Sugar-containing compound 690 mg / 100 g
【００１８】また香気成分として、カルボニル化合物
（１５％）、カロチノイド分解物（１７％）、炭素数２
〜１２の有機酸（２２％）、フェノール化合物（１３
％）、芳香族含酸素化合物（７％）、芳香族炭化水素
（５．５％）、テルペノイド（４％）などを含有する。
なお、酸不溶性蛋白質とは比較的分子量の大きな蛋白成
分である。As aroma components, carbonyl compound (15%), carotenoid decomposition product (17%), carbon number 2
~ 12 organic acids (22%), phenolic compounds (13
%), Aromatic oxygen-containing compounds (7%), aromatic hydrocarbons (5.5%), terpenoids (4%) and the like.
The acid-insoluble protein is a protein component having a relatively large molecular weight.
Claims (1)
成分とするリウマチ改善治療剤1. A therapeutic agent for improving rheumatism comprising an Aspalathus linealis extract as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8472192A JPH05271057A (en) | 1992-03-06 | 1992-03-06 | Improving and curing agent for rheumatism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8472192A JPH05271057A (en) | 1992-03-06 | 1992-03-06 | Improving and curing agent for rheumatism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05271057A true JPH05271057A (en) | 1993-10-19 |
Family
ID=13838551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8472192A Pending JPH05271057A (en) | 1992-03-06 | 1992-03-06 | Improving and curing agent for rheumatism |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH05271057A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2759947A1 (en) * | 2018-11-12 | 2020-05-12 | Chinchon Paya Jose Servando | Use of Aspalathus linearis as a pH indicator in cement-based materials (Machine-translation by Google Translate, not legally binding) |
-
1992
- 1992-03-06 JP JP8472192A patent/JPH05271057A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2759947A1 (en) * | 2018-11-12 | 2020-05-12 | Chinchon Paya Jose Servando | Use of Aspalathus linearis as a pH indicator in cement-based materials (Machine-translation by Google Translate, not legally binding) |
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