JPH05255048A - Hair nourishing agent - Google Patents

Abstract

PURPOSE:To obtain a hair nourishing agent having excellent effects on hair growth, hair nourishment, prevention of hair removal, prevention of dandruff, etc. CONSTITUTION:The hair nourishing agent comprises (A) an extract of Aconitum chinense Sieb. and (B) 2,4-diamino-6-piperidinopirimidin-3-oxide or 7-chloro-3- methyl-2H-1,2,4-benzothiadiazine-1,1-oxide which has been used for treating hypertension as an antihypertensive agent by internal use in a content ratio of 0.0001-20.0wt.% component A (calculated as dried substance) and 0.01-5.0wt.% component B. In extracting Aconitum chinense Sieb., 1000-5,000ml solvent is used based on 100g Aconitum chinense Sieb. and the extraction is carried out preferably at room temperature to the boiling point of the solvent under normal pressure. The hair nourishing agent is properly mixed with a coloring matter, a perfume, a germicide, an antiseptic, a keratin solubilizer, an antiinflammatory agent, a hair nourishing agent, vitamins, an antioxidant, a refreshing agent and other galenical extract drugs, etc.

Description

【発明の詳細な説明】Detailed Description of the Invention

【０００１】[0001]

【産業上の利用分野】本発明は、育毛効果及び養毛効
果、脱毛予防、ふけ防止等の効果に優れた養毛料に関す
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent which is excellent in hair growth effect, hair nourishing effect, hair loss prevention, dandruff prevention and the like.

【０００２】[0002]

【従来技術】脱毛症は様々な要因が複雑に絡みあって生
じていると考えられており、発生機作が未だ充分に解明
されていないのが現状である。従来より、各種の薬剤を
配合した養毛料が脱毛の予防や治療に用いられてきてい
るが、脱毛を抑制して発毛、養毛を促すに充分有効な薬
剤は未だ見出されていない。2. Description of the Related Art Alopecia is considered to be caused by various factors intricately intertwined with each other, and the mechanism of occurrence is still unclear. Conventionally, a hair nourishing agent containing various agents has been used for the prevention and treatment of hair loss, but a drug effective enough to suppress hair loss and promote hair growth and hair nourishment has not yet been found.

【０００３】本発明の養毛料の原料に用いる附子は、古
来中国において神農本草経に記載され、漢方医学上種々
の漢方処方中に汎用される重要な生薬として知られるも
ので、キンポウゲ科（Ｒａｎｕｎｃｕｌａｃｅａｅ）の
トリカブト属植物（Ａｃｏｎｉｔｕｍ ｓｐｅｃｉｅ
ｓ）の塊根から調製される。特開平３−２７１２１３号
に、この基源植物であるトリカブトの根、茎又は葉の抽
出物を含有することを特徴とした発毛・育毛剤が提案さ
れているが、トリカブトの抽出物単独使用であり、発
毛、育毛効果は不充分であった。[0003] The fusi, which is used as a raw material for the hair nourishing agent of the present invention, has been described in China since ancient times as a herbal sutra and is known as an important crude drug that is widely used in various Kampo prescriptions in Kampo medicine. ) Aconitum species (Aconitum specie)
s) tuberous root. Japanese Patent Laid-Open No. 3-271213 proposes a hair growth and hair-growing agent characterized by containing an extract of the root, stem or leaf of aconite, which is the source plant, but the extract of aconite alone is used. The hair growth and hair growth effects were insufficient.

【０００４】[0004]

【発明が解決しようとする課題】本発明者は、上記事情
に鑑み、鋭意研究を重ねた結果、附子の抽出物と２，４
−ジアミノ−６−ピヘリジノピリミジン−３−オキシド
または７−クロロ−３−メチル−２Ｈ−１，２，４−ベ
ンゾチアジアジン−１，１−ジオキシドとを配合するこ
とによって、安全性が高く、マウス毛成長促進、ヒト頭
髪毛成長促進に優れた効果を示し、更に、ふけ防止効果
にも著効を呈することを見出して本発明を完成するに至
った。即ち、本発明の目的は、育毛、養毛、脱毛予防、
ふけ防止等の効果に優れた養毛料を提供することにあ
る。DISCLOSURE OF THE INVENTION In view of the above circumstances, the inventor of the present invention has conducted extensive studies and as a result, it has been found that the extract of Fuzi and 2,4
By blending with -diamino-6-pyhelidinopyrimidine-3-oxide or 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide, safety can be improved. The present invention has been completed by finding that it is highly effective in promoting mouse hair growth and human hair growth, and that it is also highly effective in preventing dandruff. That is, the object of the present invention is hair growth, hair nourishment, hair loss prevention,
It is to provide a hair nourishing agent having an excellent effect of preventing dandruff.

【０００５】[0005]

【課題を解決するための手段】本発明は、附子の抽出物
と２，４−ジアミノ−６−ピヘリジノピリミジン−３−
オキシドまたは７−クロロ−３−メチル−２Ｈ−１，
２，４−ベンゾチアジアジン−１，１−ジオキシドとを
配合してなる養毛料である。DISCLOSURE OF THE INVENTION The present invention relates to the extract of fusi and 2,4-diamino-6-pyhelidinopyrimidine-3-
Oxide or 7-chloro-3-methyl-2H-1,
A hair nourishing agent containing 2,4-benzothiadiazine-1,1-dioxide.

【０００６】本発明の養毛料に使用する原料生薬の附子
は、キンポウゲ科（Ｒａｎｕｎｃｕｌａｃｅａｅ）のト
リカブト属植物（Ａｃｏｎｉｔｕｍ ｓｐｅｃｉｅｓ）
の塊根から調製されたものであればよく、その基源及び
産地を限定するものではない。また、一般に、トリカブ
ト属植物には猛毒性アコニチン系アルカロイドを含有し
ており、その使用に際しては細心の注意を要するもので
あるため、より好ましくは加熱処理等の減毒調製された
加工附子と称するものを用いるのがよい。[0006] The ingredient of the crude drug used for the hair nourishing agent of the present invention is the aconitum species of the genus Ranunculaceae (Aconitum species).
As long as it is prepared from the root tuber, the source and the place of production thereof are not limited. Further, in general, aconite plants contain a highly toxic aconitine alkaloid, and since careful attention is required when using it, it is more preferably referred to as a processed aconitant prepared by detoxification such as heat treatment. It is better to use one.

【０００７】附子の基源植物としては、例えば、中国四
州省産の栽培種カラトリカブト（Ａｃｏｎｉｔｕｍ ｃ
ａｒｍｉｃｈａｅｌｉ Ｄｅｂｘ））、中国各地の野性
種（Ａｃｏｎｉｔｕｍ ｋｕｓｎｅｚｏｆｆｉｉ Ｒｅ
ｉｃｈｂ．）など、朝鮮産のミツバトリカブト（Ａｃｏ
ｎｉｔｕｍ ｔｒｉｐｈｙｌｌｕｍ Ｎａｋａｉ）、キ
バナトリカブト（Ａｃｏｎｉｔｕｍ ｃｏｒｅａｎｕｍ
Ｒａｐ．）、日本産のオクトリカブト（Ａｃｏｎｉｔ
ｕｍ ｊａｐｏｎｉｃｕｍ Ｔｈｕｎｂ．）、ハナトリ
カブト（Ａｃｏｎｉｔｕｍ ｃｈｉｎｅｎｓｅ Ｐａｘ
ｔ．）などが挙げられる。特に中国四州省産のカラトリ
カブトが、一定の栽培法で、品質の安定性および供給の
面で好ましい。[0007] Examples of the source plant of the apricot include, for example, a cultivar Aconitum c.
armichaeli Debx), a wild species (Aconitum kusnezoffii Re) from all over China.
ichb. ) Such as Korean honey beetle (Aco
nitum triphyllum Nakai, Aconitum coreanum
Rap. ), Japanese octopus beetle (Aconit)
um japonicum Thunb. ), Aconitum chinese Pax
t. ) And the like. Particularly, the agar beetle produced in Sichuan Province of China is preferable in terms of quality stability and supply with a certain cultivation method.

【０００８】また減毒加工法としては、特許公告昭３７
−１８４９８号に提案されている、塊根をオートクレー
ブ中で１００〜１３０℃、圧力１．０〜１．５ｋｇ／ｃ
ｍ2２０〜４０分間加圧、加熱処理して調製する方法
が、簡便で、有効かつ安全な生薬を安定に生産できるこ
とから特に好ましい方法である。この方法で調製された
例として、日本薬局方外規品の商品名「加工ブシ末」が
挙げられる。また主に中国で行われている方法として、
水洗した塊根を苦汁液に数日間浸漬して乾燥するか、あ
るいは、更に蒸す、煮沸などの処理をくり返した後乾燥
して調製する方法または塊根を水洗し縦割りして鮮時に
灰中に埋没させ、加熱、加圧等を施し乾燥して調製する
方法などがある。この方法で調製した例としては中国四
州省産の附子瓣（日本では炮附子と称する）として市販
されているものが一定の品質で充分減毒されており好ま
しい。As the detoxification processing method, Japanese Patent Publication No. 37
No. 18498 proposed, tuber roots in an autoclave at 100 to 130 ° C., pressure 1.0 to 1.5 kg / c.
The method of preparing by applying pressure and heat treatment for 20 to 40 minutes is a particularly preferable method because it is possible to stably produce a crude drug which is simple, effective and safe. An example of the product prepared by this method is "Processed bush powder", which is a brand name product of the Japanese Pharmacopoeia. Also, as a method mainly used in China,
Soak the water-washed tuberous root in bitter juice for several days to dry it, or repeat the treatment such as steaming and boiling and then dry it, or wash the tuber with water and split it vertically and bury it in ash when fresh. Then, heating, pressurizing, etc. are applied and dried to prepare. As an example prepared by this method, a commercially available product of Fuzi gourd produced in Sichuan Province of China (referred to as Fuzi Fuzi in Japan) is preferable because it is sufficiently detoxified with a certain quality.

【０００９】本発明の附子の抽出物は、附子を溶剤で抽
出した場合に附子から溶剤に移行し、た成分を言い、こ
の抽出物は溶剤を除去した後の乾燥物の状態で使用する
こともでき、また溶剤に溶解した状態で使用することも
できる。後者の場合には抽出溶剤は本発明の養毛料中で
基剤の一部を構成する。The extract of the adzuki bean of the present invention refers to a component which is transferred from the adduct to the solvent when the advent is extracted with a solvent, and this extract is used in a dry state after removing the solvent. It can also be used in the state of being dissolved in a solvent. In the latter case, the extraction solvent will form part of the base in the hair restorer of the invention.

【００１０】溶剤としては水、アルコール類、例えばメ
タノール、エタノール、ブタノールエーテル類、例えば
ジエチルエーテル、ジオキサン、ケトン類、例えばアセ
トン脂肪属炭化水素類、例えばペンタン、ヘキサン、シ
クロヘキサン、エステル類、例えば酢酸エチル等を使用
することができる。抽出物を溶剤除去して乾燥物として
使用する場合には、上記の任意の溶剤を単独でまたは混
合して使用することができる。しかしながら抽出物を溶
剤に溶解した状態で使用する場合には人体に有害な作用
を有しない水、エタノール、またはこれらの混合物を用
いるのが好ましい。Solvents include water, alcohols such as methanol, ethanol, butanol ethers such as diethyl ether, dioxane, ketones such as acetone aliphatic hydrocarbons such as pentane, hexane, cyclohexane, esters such as ethyl acetate. Etc. can be used. When the extract is removed by solvent and used as a dried product, any of the above-mentioned solvents can be used alone or in combination. However, when the extract is used in a state of being dissolved in a solvent, it is preferable to use water, ethanol, or a mixture thereof, which has no harmful effect on the human body.

【００１１】抽出に際して、附子はそのまま使用するこ
ともでき、また破砕または粉砕して使用し、溶剤との接
触を改良することもできる。附子と溶剤との比率は特に
限定されないが、抽出効率及び便利さの観点から附子１
００ｇ当たり１００〜５０００ｍｌの溶剤を使用するの
が好ましい。抽出温度は室温〜常圧下での溶剤の沸点の
範囲とするのが便利であり、抽出時間は抽出温度、攪拌
の有無等により異なるが、３０分〜２週間の範囲とする
のが好ましい。Upon extraction, the adjunct may be used as it is, or may be crushed or crushed to improve contact with a solvent. Although the ratio of the adjunct to the solvent is not particularly limited, the adjunct 1 is taken into consideration from the viewpoint of extraction efficiency and convenience.
Preference is given to using 100 to 5000 ml of solvent per 00 g. The extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent under normal pressure, and the extraction time is preferably in the range of 30 minutes to 2 weeks, although it varies depending on the extraction temperature, the presence or absence of stirring and the like.

【００１２】一方、本発明の養毛料に用いる２，４−ジ
アミノ−６−ピヘリジノピリミジン−３−オキシド（以
下、化合物Ａと略記する）、及び７−クロロ−３−メチ
ル−２Ｈ−１，２，４−ベンゾチアジアジン−１，１−
ジオキシド（以下、化合物Ｂと略記する）は公知の物質
であり，ミノキシジル、ジアゾキシドと言う名称で血圧
降下剤として用いられているものである。いずれも内服
による高血圧治療に使用されてきたが、服用者の中に多
毛症の副作用が認められることから、外用による脱毛症
の治療薬、あるいは養毛剤としての開発が進められてい
るものである。化合物Ａに関しては、米国特許４１３９
６１９号に、化合物Ｂに関しては特開昭５６−６５８１
１号に、これらを使用する発明が開示されている。On the other hand, 2,4-diamino-6-pyhelidinopyrimidine-3-oxide (hereinafter abbreviated as compound A) and 7-chloro-3-methyl-2H-1 used in the hair nourishing composition of the present invention. , 2,4-benzothiadiazine-1,1-
Dioxide (hereinafter abbreviated as compound B) is a known substance and is used as a hypotensive agent under the names minoxidil and diazoxide. Both have been used for the treatment of hypertension by internal use, but since the side effect of hirsutism is observed in the recipients, development is being promoted as a therapeutic drug for alopecia by external use or as a hair restorer. For compound A, see US Pat.
No. 619, the compound B is disclosed in JP-A-56-6581.
No. 1 discloses an invention using them.

【００１３】本発明者は、養毛料中に配合する上記構成
成分に関して鋭意研究した結果、本発明の附子の抽出物
と、化合物Ａまたは化合物Ｂとを組み合わせて配合する
と、育毛効果、養毛効果、脱毛予防、ふけ防止効果など
の効果を相乗的に増大することを見出した。The present inventor has conducted extensive studies on the above-mentioned constituents to be incorporated in a hair nourishment, and as a result, when the extract of the fusi of the present invention and Compound A or Compound B are combined in combination, a hair-growing effect and a hair-growth effect are obtained. It was found that the effects such as hair loss prevention and dandruff prevention are synergistically increased.

【００１４】本発明の附子の抽出物と化合物Ａまたは化
合物Ｂの配合割合は、当該養毛料の剤型などにより適宜
選択されるものであるが、養毛料の総量を基準として、
附子の抽出物は、０．０００１〜２０．０ｗｔ％（乾燥
物換算）、化合物Ａまたは化合物Ｂは、０．０１〜５．
０ｗｔ％であればよく、各々の配合量の下限未満では、
本発明の目的とする効果に充分でなく、一方、上限を超
えてもその増加分に見合った効果の向上は望めないもの
である。The compounding ratio of the extract of the fusi of the present invention and the compound A or the compound B is appropriately selected according to the dosage form of the hair restorer, etc., but is based on the total amount of the hair restorer.
The extract of Bushi is 0.0001 to 20.0 wt% (dry matter conversion), and the compound A or the compound B is 0.01 to 5%.
It may be 0 wt%, and below the lower limit of each blending amount,
The effect aimed at by the present invention is not sufficient, and on the other hand, even if the upper limit is exceeded, it is impossible to expect an improvement in the effect commensurate with the increase.

【００１５】本発明の養毛料は、常法に従って、ヘアー
トニック、ヘアーローション、ヘアークリーム、シャン
プー、リンス、ヘアーフォーム、ヘアージェル等の剤型
にすることが可能である。The hair nourishing agent of the present invention can be made into a dosage form such as a hairnic, a hair lotion, a hair cream, a shampoo, a rinse, a hair foam and a hair gel according to a conventional method.

【００１６】本発明の養毛料には、色素、香料、殺菌
剤、防腐剤、角質溶解剤、消炎剤、抗アンドロゲン剤、
養毛剤、ビタミン類、抗酸化剤、清涼剤、他の生薬抽出
物等を本発明の目的を達成する範囲内で適宜配合するこ
とができる。The hair nourishing agent of the present invention includes pigments, fragrances, bactericides, preservatives, keratolytic agents, anti-inflammatory agents, anti-androgens,
Hair nourishing agents, vitamins, antioxidants, cooling agents, extracts of other herbal medicines and the like can be appropriately added within the range that achieves the object of the present invention.

【００１７】[0017]

【実施例】以下、実施例および比較例に基づいて本発明
を詳説する。なお、実施例に記載のマウス毛成長促進効
果試験法、ヒト頭髪毛成長促進効果試験法および実用試
験法を下記に示す。EXAMPLES The present invention will be described in detail below based on examples and comparative examples. The mouse hair growth promoting effect test method, human hair growth promoting effect test method and practical test method described in Examples are shown below.

【００１８】（１）マウス毛成長促進効果試験 Ｃ３Ｈマウス（雄・７週齢）の背部中央の体毛をバリカ
ン及びシェーバー等で毛刈し、試料を毛刈り部位に１日
１回、一匹当り０．２ｍｌ塗布した。一試料に対して動
物は一群１０匹使用した。実験開始後１５日目にマウス
背部の写真撮影を行い、毛刈り面積及び発毛面積を算出
し、発毛率（％）を求め１０例の平均値により、毛成長
促進効果を判定した。(1) Mouse Hair Growth Promoting Effect Test C3H mice (male, 7 weeks old) were shaved with a hair clipper and shaver on the central back hair of a mouse, and the sample was cut at the shaved site once a day per animal. 0.2 ml was applied. For each sample, 10 animals were used per group. On the fifteenth day after the start of the experiment, the back of the mouse was photographed, the hair cutting area and the hair growth area were calculated, the hair growth rate (%) was calculated, and the hair growth promoting effect was determined by the average value of 10 cases.

【００１９】（２）ヒト頭髪毛成長促進効果試験法 男性型脱毛症患者である被試験者１０名の頭部の耳の上
５ｃｍの位置の頭髪を左右２カ所において直径１ｃｍの
円型状に剃毛した被験部位に、実施例または比較例の試
料を左側に毎日朝夕２回、約３ｍｌ塗布し、無処置の右
側と比較した。効果の判定は、試験開始後２８日目に、
左右の被験部位の毛髪各々２０本ずつを剃毛し、左側
（実施例または比較例を塗布）の毛２０本の長さの平均
値（Ｂ）を右側（無処置）の毛２０本の長さの平均値
（Ａ）で除した値を求めて評価した。判定結果は、被試
験者１０名の（Ｂ）／（Ａ）の平均値で示した。(2) Human hair growth promoting effect test method Hair of 5 cm above the ears of the heads of 10 test subjects who are androgenetic alopecia are circularly shaped with a diameter of 1 cm at two left and right positions. About 3 ml of the sample of Example or Comparative Example was applied to the left side of the shaved test site twice daily in the morning and evening, and compared with the untreated right side. Evaluation of the effect is 28 days after the start of the test,
20 hairs on each of the left and right test sites are shaved, and the average value (B) of the lengths of 20 hairs on the left side (applied Example or Comparative Example) is calculated as the length of 20 hairs on the right side (untreated). The value obtained by dividing the average value (A) of the sacks was obtained and evaluated. The determination result was shown by the average value of (B) / (A) of 10 test subjects.

【００２０】（３）実用試験法 男性型脱毛症患者である被試験者２０名の頭部に毎日朝
夕２回、連続６カ月間試料を塗布した後の効果を評価し
た。試験結果は、育毛効果、脱毛予防効果、ふけ防止効
果の各項目に対して、「生毛が剛毛化したあるいは生毛
が増加した」、「脱毛が少なくなった」、「ふけが少な
くなった」と回答した人数で示した。(3) Practical test method Twenty test subjects, who are male pattern baldness patients, were coated with the sample twice daily in the morning and evening for consecutive 6 months, and the effect was evaluated. The test results were "hair bristling or increased hair loss", "less hair loss", "less dandruff" for each item of hair growth effect, hair loss prevention effect, and dandruff prevention effect. The number of people who answered

【００２１】製造例１（抽出物の調製） （１）中国四州省産附子（川烏頭、または干附子として
市販のもの）の乾燥塊根の破砕物をオートクレーブ中で
１００〜１３０℃、１〜１．５ｋｇ／ｃｍ² に調製し、
４０分間加圧、加熱処理する。加工処理した附子１００
ｇを１５００ｍｌの７０ｖ／ｖ％エタノール（以降、ｖ
／ｖ％を％に略記する）に、常温（２０〜２５℃）にて
１６時間浸し、上澄液をろ取して、４５℃、減圧下にて
３時間濃縮し、溶媒を溜去して、褐色の抽出物を１１．
７ｇ得た。Production Example 1 (Preparation of Extract) (1) A crushed product of dried tuberous roots of Zhuzi (commercially available as river crow or dried Zhizi) from Sichuan Province, China, in an autoclave at 100 to 130 ° C., 1 to Adjust to 1.5 kg / cm ² ,
Pressurize and heat treatment for 40 minutes. Azushi 100 processed
g to 1500 ml of 70 v / v% ethanol (hereinafter, v
/ V% is abbreviated to%) at room temperature (20 to 25 ° C.) for 16 hours, the supernatant liquid is collected by filtration, concentrated at 45 ° C. under reduced pressure for 3 hours, and the solvent is distilled off. The brown extract to 11.
7 g was obtained.

【００２２】（２）製造例１（１）と同様に加工処理し
た中国四州省産附子１００ｇを１５００ｍｌの４０％エ
タノールに、常温（２０〜２５℃）にて１６時間浸し、
上澄液をろ取して４５℃、減圧下にて４時間濃縮し、溶
媒を溜去して、褐色の抽出液を１３．４ｇ得た。(2) Preparation Example 1 100 g of Shishibu Province, China processed in the same manner as in (1) was immersed in 1500 ml of 40% ethanol for 16 hours at room temperature (20 to 25 ° C.),
The supernatant was collected by filtration and concentrated under reduced pressure at 45 ° C. for 4 hours, and the solvent was distilled off to obtain 13.4 g of a brown extract.

【００２３】（３）中国四州省産の炮附子（附子瓣とし
て市販のもの）を５０ｇを５００ｍｌの７０％エタノー
ルに、常温（２０〜２５℃）にて１６時間浸し、上澄液
をろ取し、４５℃で減圧下にて２時間濃縮し、溶媒を溜
去した後、褐色の抽出物５．３ｇを得た。(3) 50 g of Zhifuzi (commercially available as Zhizi) produced in Sichuan Province of China was immersed in 500 ml of 70% ethanol for 16 hours at room temperature (20 to 25 ° C.), and the supernatant was filtered. After collecting and concentrating at 45 ° C. under reduced pressure for 2 hours and distilling off the solvent, 5.3 g of a brown extract was obtained.

【００２４】（４）日本薬局方外規品加工ブシ末５０ｇ
を５００ｍｌの４０％エタノールに、常温（２０〜２５
℃）にて１０時間浸し、上澄液をろ取し、４５℃、減圧
下にて３時間濃縮し、溶媒を溜去した後、褐色の抽出物
６．１ｇを得た。(4) Japanese Pharmacopoeia, Non-standard product processing, Bushi powder 50g
In 500 ml of 40% ethanol at room temperature (20-25
C.) for 10 hours, the supernatant was collected by filtration, concentrated under reduced pressure at 45.degree. C. for 3 hours, and the solvent was distilled off to obtain 6.1 g of a brown extract.

【００２５】実施例１〜１１、比較例１〜６（ヘアート
ニック） 下記に記載の成分組成において、製造例１で調製した附
子の抽出物と、化合物Ａまたは化合物Ｂを配合して各々
のヘアートニックを調製し、前記の諸試験を実施した。Examples 1 to 11 and Comparative Examples 1 to 6 (Heartnick) In the composition of the components described below, the extract of the aconifolia prepared in Production Example 1 and the compound A or the compound B were blended to obtain the respective hairs. Tonics were prepared and the tests described above were performed.

【００２６】 （１）組成 成 分 配合量（ｗｔ％） ─────────────────────────────────── エタノール ６０．０ 附子の抽出物、化合物Ａ、化合物Ｂ等 表１、表２記載 プロピレングリコール １．０ 香料 ０．１ 精製水 総量を１００．０とする残量 ───────────────────────────────────(1) Composition Component content (wt%) ──────────────────────────────────── Ethanol 60.0 Extract of Fuzi, Compound A, Compound B, etc. Table 1 and Table 2 Propylene glycol 1.0 Perfume 0.1 Purified water Remaining amount to make total amount 100.0 ────────── ───────────────────────────

【００２７】（２）調製法 附子の抽出物、化合物Ａ、化合物Ｂ及び香料をエタノー
ル中に、プロピレングリコールを精製水にそれぞれ溶解
し、各溶液を攪拌しながら均一に混合して各々のヘアー
トニックを調製した。(2) Preparation Method The extract of Fuzi, compound A, compound B and fragrance are dissolved in ethanol, and propylene glycol is dissolved in purified water. Was prepared.

【００２８】（３）特性 各ヘアートニックの諸試験を実施した結果は、表１、表
２に示す如く、本発明の附子の抽出物単独配合である比
較例１〜４や化合物Ａまたは化合物Ｂ単独配合である比
較例５，６は毛成長促進効果が低く、また養毛、ふけ防
止効果が認められなかった。これに対して本発明の附子
の抽出物と化合物Ａや化合物Ｂとを同時に配合した実施
例１〜１１の本発明の養毛料は、マウスおよびヒトにお
いて高い毛成長促進効果を示し、実用試験の結果も良好
な結果を示した。尚、実施例１〜１１はヒト皮膚での諸
試験において皮膚刺激は生じなかった。(3) Characteristics As shown in Tables 1 and 2, the results obtained by conducting various tests of each Heartonic show that Comparative Examples 1 to 4 and Compound A or Compound B in which the extract of the adzuki bean of the present invention is used alone. Comparative Examples 5 and 6, which were used alone, had a low hair growth-promoting effect, and neither hair nourishment nor dandruff preventing effect was observed. On the other hand, the hair nourishing agent of the present invention of Examples 1 to 11 in which the extract of the abalone of the present invention and the compound A or the compound B are simultaneously mixed shows a high hair growth promoting effect in mice and humans, The results also showed good results. In addition, in Examples 1 to 11, skin irritation did not occur in various tests on human skin.

【００２９】[0029]

【表１】 [Table 1]

【００３０】[0030]

【表２】 [Table 2]

【００３１】[0031]

【発明の効果】以上記載の如く、本発明が、顕著な毛成
長促進効果を示し、育毛効果、脱毛予防、およびふけ防
止効果に優れる養毛料を提供することは明らかである。EFFECTS OF THE INVENTION As described above, it is apparent that the present invention provides a hair nourishing agent which exhibits a remarkable hair growth promoting effect and is excellent in hair growth effect, hair loss prevention and dandruff prevention effect.

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.⁵ 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ａ６１Ｋ 31/54 7252−4Ｃ 35/78 ＡＤＡ Ｆ 7180−4Ｃ ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display location A61K 31/54 7252-4C 35/78 ADA F 7180-4C

Claims (1)

【特許請求の範囲】[Claims] 【請求項１】 附子の抽出物と２，４−ジアミノ−６−
ピヘリジノピリミジン−３−オキシドまたは７−クロロ
−３−メチル−２Ｈ−１，２，４−ベンゾチアジアジン
−１，１−ジオキシドとを配合してなる養毛料。1. An extract of Fuzi and 2,4-diamino-6-
A hair nourishing agent containing phelidinopyrimidine-3-oxide or 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide.