JPH0518617B2 - - Google Patents
Info
- Publication number
- JPH0518617B2 JPH0518617B2 JP58228998A JP22899883A JPH0518617B2 JP H0518617 B2 JPH0518617 B2 JP H0518617B2 JP 58228998 A JP58228998 A JP 58228998A JP 22899883 A JP22899883 A JP 22899883A JP H0518617 B2 JPH0518617 B2 JP H0518617B2
- Authority
- JP
- Japan
- Prior art keywords
- tank
- source
- liquid preparation
- circulation path
- raw materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 238000002360 preparation method Methods 0.000 claims description 24
- 239000002994 raw material Substances 0.000 claims description 17
- 239000012153 distilled water Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 239000012856 weighed raw material Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000003186 pharmaceutical solution Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/008—Feed or outlet control devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Accessories For Mixers (AREA)
Description
【発明の詳細な説明】
本発明は薬液等の溶液を自動的に調製するのに
用いられる装置に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an apparatus used for automatically preparing solutions such as pharmaceutical solutions.
従来、溶液の調製はプロペラ攪拌機などを有す
る調液タンクに溶剤と被溶解薬剤を逐次添加して
行なつていたが、溶液の調製後に引続きタンクの
洗浄、乾燥、滅菌の工程を自動的に連続して且つ
確実に行ないうる装置はなかつた。また従来の装
置では人手により、或いは複雑な仕込装置により
工程にしたがつて被溶解薬剤を逐次タンクに仕込
むため、タンクが開放状態となり、そのため被溶
解薬剤の飛散、或いは攪拌時の空気巻込みが生じ
やすい欠点があつた。またこのため攪拌羽根の回
転数もあまり上げることができず、かわりに加熱
による溶解促進を行なつたりしていたが、加熱に
よる品質劣化を招くことがあつた。また調製済液
の送液後の装置の洗浄、乾燥、滅菌の各処理も人
手を介して装置の移動、解体、組立作業等をとも
ないながら行なわねばならず、完全を期し難い欠
点があつた。 Previously, solutions were prepared by sequentially adding the solvent and drug to be dissolved into a preparation tank equipped with a propeller stirrer, etc., but now the tank is automatically washed, dried, and sterilized in succession after the solution is prepared. There was no device that could do this reliably. In addition, in conventional equipment, the drug to be dissolved is sequentially charged into the tank according to the process by hand or by a complicated charging device, so the tank is in an open state, which prevents the scattering of the drug to be dissolved or the entrainment of air during stirring. There were some shortcomings that were easy to occur. Also, for this reason, the rotational speed of the stirring blade could not be increased very much, and instead heating was used to promote dissolution, but this sometimes resulted in quality deterioration due to heating. In addition, cleaning, drying, and sterilization of the device after sending the prepared solution must be performed manually while moving, disassembling, and assembling the device, making it difficult to ensure perfection.
そこで本発明は従来装置の欠点を解消し、溶液
の調製と装置の洗浄、乾燥、滅菌等の工程を完全
に自動化しうる装置の提供を目的とする。 SUMMARY OF THE INVENTION It is an object of the present invention to provide an apparatus that overcomes the drawbacks of conventional apparatuses and can completely automate processes such as solution preparation, cleaning, drying, and sterilization of the apparatus.
本発明を図面と共に具体的に説明する。第１図
は本発明の実施例を示す装置の全体構成図、第２
図は本発明の装置によつて行なわれる自動調液作
業のフローチヤート図である。 The present invention will be specifically explained with reference to the drawings. Fig. 1 is an overall configuration diagram of a device showing an embodiment of the present invention;
The figure is a flowchart of automatic liquid preparation work performed by the apparatus of the present invention.
調液タンク４０が薬液等の溶液を調製する主タ
ンクである。蓋４０ａ、ジヤケツト４０ｂが付設
されている。本発明では従来設けられていた攪拌
羽根は調液タンク４０内には設けられない。攪拌
羽根に代るものとして、本発明は調液タンク４０
に対して液の循環を行なう循環路Ａ１，Ａ２，Ａ
３，Ａ４，Ａ５を設ける。調液タンク４０内の液
はこの循環路を通つて複数回循環することにより
原料の攪拌、溶解が促進される。循環路にはサブ
タンク４２，４２と水位計４３が設けられる。こ
のサブタンク４２，４２と水位計４３は前者が管
路Ａ２、後者が管路A3に設けられることにより
夫々循環路に並列に配されている。サブタンク４
２，４２は原料仕込用の小さな球形タンクで、管
路A2に対して取付け取外し自在としている。こ
のタンク４２は、例えば複数種類の原料を投入す
る際に、前記調液タンク４０に直接投入する原料
に対して最初から一諸に投入するのが好ましくな
いような原料を別にして供給するためのタンクで
あり、秤量済の原料をタンク４２に入れた状態で
管路A2にセツテイングする。タンク４２の個数
は１ないし複数個を使用する。水位計４３は管路
A3が液の循環状態にないときに前記調液タンク
４０に対して連通管を構成してタンク４０内の水
位を測定する。また循環路には濾過器４４が並列
に配される。循環路A1，A2，A3，A4，A5による
液の循環は循環ポンプ４１により行なわれる。調
液タンク４０の底部から抜出された液はポンプ４
１により循環せられ、管路A2とA3の片方または
双方、及び管路A4とA5の片方または双方を通つ
て調液タンク４０の上部に戻る。また循環路には
蓋留水源５１、RO水源５２、窒素源５３、空気
源５４の供給源５０が接続される。調液タンク４
０に対して前記供給源５０の他に、タンク４０上
部に直接接続される供給源６０が設けられる。こ
の供給源６０は蒸留水源６１、窒素源６２、蒸気
源６３、アルカリ源６４、酸源６５を有してい
る。一方、調液タンク４０の上端部からオーバー
フロ水排出用の排液路C1調液タンク４０の下端
部に循環路の一部を共用した廃液路C2がそれぞ
れ設けられ、また循環炉の一部から管路内の液を
排出する排液路C3が分岐している。 The liquid preparation tank 40 is a main tank for preparing solutions such as chemical solutions. A lid 40a and a jacket 40b are attached. In the present invention, the conventional stirring blade is not provided in the liquid preparation tank 40. As an alternative to the stirring blade, the present invention uses a liquid preparation tank 40.
Circulation paths A1, A2, A for circulating liquid to
3, A4, and A5 are provided. The liquid in the liquid preparation tank 40 is circulated multiple times through this circulation path, thereby promoting stirring and dissolution of the raw materials. Sub tanks 42, 42 and a water level gauge 43 are provided in the circulation path. The sub-tanks 42, 42 and the water level gauge 43 are arranged in parallel in the circulation path, with the former being provided in the pipe A2 and the latter in the pipe A3 . sub tank 4
2 and 42 are small spherical tanks for charging raw materials, which can be attached to and removed from pipe A2 . This tank 42 is used, for example, to supply raw materials that are not preferably added all at once to the raw materials that are directly charged into the liquid preparation tank 40, separately when charging a plurality of types of raw materials. The weighed raw material is placed in the tank 42 and set in the pipe A2 . One or more tanks 42 are used. Water level gauge 43 is a pipe
When A 3 is not in a liquid circulation state, a communication pipe is constructed with respect to the liquid preparation tank 40 to measure the water level in the tank 40. Further, a filter 44 is arranged in parallel in the circulation path. Circulation of the liquid through the circulation paths A 1 , A 2 , A 3 , A 4 , and A 5 is performed by a circulation pump 41 . The liquid extracted from the bottom of the liquid preparation tank 40 is sent to the pump 4.
1 and returns to the upper part of the liquid preparation tank 40 through one or both of the pipes A 2 and A 3 and one or both of the pipes A 4 and A 5 . Also connected to the circulation path are supply sources 50 of a lid retained water source 51, an RO water source 52, a nitrogen source 53, and an air source 54. Liquid preparation tank 4
In addition to the supply source 50, a supply source 60 is provided which is directly connected to the upper part of the tank 40. This supply source 60 has a distilled water source 61, a nitrogen source 62, a steam source 63, an alkali source 64, and an acid source 65. On the other hand, a drain passage C 1 for discharging overflow water is provided from the upper end of the liquid preparation tank 40, and a waste liquid passage C2 , which shares a part of the circulation path, is provided at the lower end of the liquid preparation tank 40. A drainage path C3 that drains the liquid inside the pipe branches from a part of the pipe.
調液タンク４０の外周部のジヤツケツト４０ｂ
に対して調液タンク４０内温度を調節するための
温度調節源７０，８０が接続される。調節源７
０，８０として、ジヤケツト４０ｂ下部から冷却
源７２、温水源７１、及びリターン用のジヤツケ
ツト４０ｂ上部からの冷水源８１、温水源８２、
急加熱用の蒸気源８３が設けられる。調液タンク
４０内外の状態は、PHセンサ４６で溶液のペーハ
が、また温度センサ４７，４８で調液タンク４０
内、ジヤツケツト４０ｂの温度が測定される。タ
ンク４０内水位は前記水位計４３で測定される。 Jacket 40b on the outer periphery of the liquid preparation tank 40
Temperature control sources 70 and 80 for controlling the temperature inside the liquid preparation tank 40 are connected to the liquid preparation tank 40 . Adjustment source 7
0,80, a cooling source 72, a hot water source 71 from the bottom of the jacket 40b, a cold water source 81, a hot water source 82 from the top of the jacket 40b for return,
A steam source 83 for rapid heating is provided. The internal and external conditions of the liquid preparation tank 40 are determined by the PH sensor 46, the pH of the solution, and the temperature sensors 47 and 48.
Among them, the temperature of the jacket 40b is measured. The water level in the tank 40 is measured by the water level gauge 43.
以上で述べた各装置、部材及びそれらに設けら
れるバルブV1〜V27類は集中制御部４５により制
御される。集中制御部４５はマイクロコンピユー
タを内蔵し、調製される溶液の種類に応じてセツ
トされたプログラムにしたがつて循環ポンプ４１
や各バルブV1〜V27の作動、開閉を指示する。ま
た水位計４３、PHセンサ４６、温度センサ４７，
４８からの情報を適性値と比較して供給源５０，
６０、温度調節源７０，８０の供給を指令する。 Each of the devices and members described above and the valves V 1 to V 27 provided thereon are controlled by the centralized control section 45 . The central control unit 45 has a built-in microcomputer and controls the circulation pump 41 according to a program set according to the type of solution to be prepared.
and instructs the operation, opening and closing of each valve V 1 to V 27 . Also, water level gauge 43, PH sensor 46, temperature sensor 47,
The information from 48 is compared with the suitability value and the source 50,
60, commanding the supply of temperature control sources 70, 80;
実施例の装置において原料の仕込みは人手によ
り行なう。ワンタツチの開閉蓋４０ａを開いて原
料を投入すると共に、当初から混合を好まない他
の原料を入れたサブタンク４２を管路A2に設置
する。原料と蒸留水をタンク４０内に入れた後の
攪拌は液を循環させることにより行なう。この場
合、管路を選択することができる。例えばタンク
４０内に投入された原料をまず溶解し、しかる後
にサブタンク４２内の原料と混合して溶解する場
合は、まず管路A1，A2，A5を開いてポンプ４１
で循環溶解し、次に管路をA1，A3，A4に変更し
て循環溶解しつつ濾過器４４で不要物を濾過し、
さらに管路をA1，A2，A5に変更してサブタンク
４２内の原料を追加溶解することができる。その
他管路A2とA3の片方又は両方、管路A4とA5の片
方又は両方を用いて循環させることができる。溶
解が終わり液を排出した後の洗浄では、RO水源
５２からRO水を、又蒸留水源６１から蒸留水を
タンク４０及び循環路A1〜A5に供給し、循環さ
せて行なう。又、滅菌工程では蒸気源６３から高
圧の蒸気を供給し、又ジヤケツト４０ｂにも蒸気
源８３から蒸気を供給する。乾燥工程では空気源
５４から温風をタンク４０及び循環路A1〜A5に
供給する。この様な本発明の装置による使用例を
第２図のフローチヤートに沿つて説明する。原料
Ａ，Ｂ，Ｃを用いる場合、秤量済の原料Ａを調液
タンク４０に投入し、また秤量済の原料Ｂ，Ｃを
それぞれサブタンク４２，４２に入れて管路A2
にセツトする。この手作業の後開始ボタンを押す
ことにより溶液の自動調製が開始される。まずバ
ルブV10，V14，V18，V20、及びV1が開いて蒸留
水源５１から蒸留水が供給される。水位計４３に
より水位が測定され、所定量に達するとバルブ
V1が閉じる。ここまでが原料、溶剤の投入工程
である。投入が終わると原料の溶解攪拌の工程へ
移行する。これを符号○ In the apparatus of the embodiment, the raw materials are added manually. The one-touch opening/closing lid 40a is opened to input raw materials, and a sub-tank 42 containing other raw materials that do not like to be mixed from the beginning is installed in the pipe A2 . After the raw materials and distilled water are put into the tank 40, stirring is performed by circulating the liquid. In this case, the conduit can be selected. For example, if the raw material put into the tank 40 is first melted and then mixed with the raw material in the sub-tank 42 to be dissolved, first open the pipes A 1 , A 2 , A 5 and then open the pump 41.
Then, the pipes are changed to A 1 , A 3 , and A 4 to circulate and dissolve, while filtering unnecessary substances with a filter 44.
Further, by changing the pipe lines to A 1 , A 2 , and A 5 , the raw material in the sub-tank 42 can be additionally melted. In addition, circulation can be performed using one or both of pipes A 2 and A 3 , and one or both of pipes A 4 and A 5 . After the dissolution is completed and the liquid is discharged, cleaning is performed by supplying RO water from the RO water source 52 and distilled water from the distilled water source 61 to the tank 40 and the circulation paths A 1 to A 5 and circulating them. Further, in the sterilization process, high pressure steam is supplied from the steam source 63, and steam is also supplied from the steam source 83 to the jacket 40b. In the drying process, hot air is supplied from the air source 54 to the tank 40 and the circulation paths A 1 to A 5 . An example of the use of the apparatus of the present invention will be explained with reference to the flowchart shown in FIG. When using raw materials A, B, and C, the weighed raw material A is put into the liquid preparation tank 40, and the weighed raw materials B and C are put into the sub tanks 42 and 42, respectively, and the pipe A 2
Set to . After this manual operation, automatic preparation of the solution is started by pressing the start button. First, the valves V 10 , V 14 , V 18 , V 20 , and V 1 are opened to supply distilled water from the distilled water source 51 . The water level is measured by the water level gauge 43, and when it reaches a predetermined level, a valve is opened.
V 1 closes. This is the step of adding raw materials and solvent. Once the addition is complete, the process moves on to the process of dissolving and stirring the raw materials. This is marked ○
Claims (1)
から抜出した液を前記タンク上部へ循環させる循
環路、その循環ポンプ、循環路に配置させられる
原料仕込用のサブタンク、循環路へ接続される蒸
溜水源、空気源等の各供給源、前記調液タンク上
部へ直接接続する蒸留水源、蒸気源、アルカリ
源、酸源等の各供給源、調液タンクの底部と上端
部及び前記循環路の一部に配設される排液路、及
び原料の溶解、排出、洗浄、滅菌、乾燥等の各工
程をプログラム制御する集中制御部とを有するこ
とを特徴とする薬液等の溶液自動調製用装置。 ２ サブタンクは取外し自在の球形タンクとし、
秤量済の原料を入れた状態でセツテイングするよ
うにした特許請求の範囲第１項記載の薬液等の溶
液自動調製用装置。[Scope of Claims] 1. A liquid preparation tank for preparing a solution, a circulation path for circulating the liquid extracted from the bottom of the tank to the top of the tank, a circulation pump thereof, a sub-tank for feeding raw materials disposed in the circulation path, and a circulation path. Each supply source, such as a distilled water source and an air source, connected to the channel, each supply source, such as a distilled water source, a steam source, an alkali source, an acid source, etc., directly connected to the upper part of the liquid preparation tank, and the bottom and upper end of the liquid preparation tank. and a drainage path disposed in a part of the circulation path, and a central control unit that programmatically controls each step of dissolving, discharging, washing, sterilizing, drying, etc. of the raw material. Device for automatic solution preparation. 2 The sub-tank is a removable spherical tank,
2. The device for automatically preparing a solution such as a medicinal solution according to claim 1, wherein the device is set up with weighed raw materials placed therein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58228998A JPS60122031A (en) | 1983-12-02 | 1983-12-02 | Apparatus for automatically preparing solution such as chemical liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58228998A JPS60122031A (en) | 1983-12-02 | 1983-12-02 | Apparatus for automatically preparing solution such as chemical liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60122031A JPS60122031A (en) | 1985-06-29 |
| JPH0518617B2 true JPH0518617B2 (en) | 1993-03-12 |
Family
ID=16885153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58228998A Granted JPS60122031A (en) | 1983-12-02 | 1983-12-02 | Apparatus for automatically preparing solution such as chemical liquid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60122031A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61118127A (en) * | 1984-11-13 | 1986-06-05 | Kurabo Ind Ltd | Mixing apparatus of chemical for semiconductor |
| DE4200848C1 (en) * | 1992-01-15 | 1993-06-17 | Gkn Automotive Ag, 5200 Siegburg, De | Synchronous rotating ball joint - with selective hardening of guide surfaces and ball paths |
-
1983
- 1983-12-02 JP JP58228998A patent/JPS60122031A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60122031A (en) | 1985-06-29 |
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