JPH0495010A - Cosmetic - Google Patents
CosmeticInfo
- Publication number
- JPH0495010A JPH0495010A JP21327790A JP21327790A JPH0495010A JP H0495010 A JPH0495010 A JP H0495010A JP 21327790 A JP21327790 A JP 21327790A JP 21327790 A JP21327790 A JP 21327790A JP H0495010 A JPH0495010 A JP H0495010A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- proteoglycan
- cosmetic
- hair
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 27
- 239000000284 extract Substances 0.000 claims abstract description 23
- 239000007787 solid Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 12
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract description 11
- 102000004169 proteins and genes Human genes 0.000 abstract description 11
- 108090000623 proteins and genes Proteins 0.000 abstract description 11
- 239000006071 cream Substances 0.000 abstract description 9
- 239000006210 lotion Substances 0.000 abstract description 9
- 230000003750 conditioning effect Effects 0.000 abstract description 6
- 239000003906 humectant Substances 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 2
- 238000009499 grossing Methods 0.000 abstract 2
- 230000000052 comparative effect Effects 0.000 description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 235000018102 proteins Nutrition 0.000 description 9
- 102000008186 Collagen Human genes 0.000 description 8
- 108010035532 Collagen Proteins 0.000 description 8
- 229920001436 collagen Polymers 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 8
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 6
- 230000003020 moisturizing effect Effects 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 5
- 229920002674 hyaluronan Polymers 0.000 description 5
- 229960003160 hyaluronic acid Drugs 0.000 description 5
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 4
- 102000016942 Elastin Human genes 0.000 description 4
- 108010014258 Elastin Proteins 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- -1 Polyoxyethylene Polymers 0.000 description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 4
- 229920002549 elastin Polymers 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 238000007665 sagging Methods 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 229940058015 1,3-butylene glycol Drugs 0.000 description 3
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 3
- 239000004909 Moisturizer Substances 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 description 3
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000001333 moisturizer Effects 0.000 description 3
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000036620 skin dryness Effects 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- 229920000045 Dermatan sulfate Polymers 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 2
- 229940051593 dermatan sulfate Drugs 0.000 description 2
- 229960000735 docosanol Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- AYOOGWWGECJQPI-NSHDSACASA-N n-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1h-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine Chemical compound N1C(OC(C)C)=CC(N2C3=NC(N[C@@H](C)C=4N=CC(F)=CN=4)=CC=C3N=C2)=N1 AYOOGWWGECJQPI-NSHDSACASA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 239000001587 sorbitan monostearate Substances 0.000 description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 description 2
- 229940035048 sorbitan monostearate Drugs 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- OUKRGIPWAITDTM-UHFFFAOYSA-N 12-octylhexacosan-12-ol Chemical compound CCCCCCCCCCCCCCC(O)(CCCCCCCC)CCCCCCCCCCC OUKRGIPWAITDTM-UHFFFAOYSA-N 0.000 description 1
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- ONPGOSVDVDPBCY-CQSZACIVSA-N 6-amino-5-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-n-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NN=1)N)=CC=1C(=O)NC(C=C1)=CC=C1C(=O)N1CCN(C)CC1 ONPGOSVDVDPBCY-CQSZACIVSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920002567 Chondroitin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229910001037 White iron Inorganic materials 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 1
- 229940094517 chondroitin 4-sulfate Drugs 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002298 density-gradient ultracentrifugation Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229960000789 guanidine hydrochloride Drugs 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- VZUGBLTVBZJZOE-KRWDZBQOSA-N n-[3-[(4s)-2-amino-1,4-dimethyl-6-oxo-5h-pyrimidin-4-yl]phenyl]-5-chloropyrimidine-2-carboxamide Chemical compound N1=C(N)N(C)C(=O)C[C@@]1(C)C1=CC=CC(NC(=O)C=2N=CC(Cl)=CN=2)=C1 VZUGBLTVBZJZOE-KRWDZBQOSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- SZYJELPVAFJOGJ-UHFFFAOYSA-N trimethylamine hydrochloride Chemical compound Cl.CN(C)C SZYJELPVAFJOGJ-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は新規な化粧料に関する。さらに詳しくは、プロ
テオグリカン抽出液を有効成分として含有せしめた、保
湿作用及び水分ロスを防ぎ、皮膚及び毛髪をなめらかに
するコンディショニング効果に優ね 皮膚の伸び、弾力
性に対する改瞭作用に優れた老化防止化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a novel cosmetic. More specifically, it contains proteoglycan extract as an active ingredient, which has excellent moisturizing and conditioning effects that prevent water loss and smooth the skin and hair.It also has an anti-aging effect that improves skin elongation and elasticity. Regarding cosmetics.
皮膚や毛髪の保湿及び水分ロスを防ぐ目的で化粧料には
、グリセリン、 １．３−ブチレングリコール、イソプ
レングリコール、ポリエチレングリコール、ソルビトー
ル等の多価アルコール類、また、セリン、プロリン、グ
ルタミン酸等のアミノ酸類が配合されている。さらに、
ヒアルロン酸、コンドロイチン硫酸ナトリウム、デル
マタン硫酸等のムコ多糖類も同様の目的で配合されてい
る。To moisturize the skin and hair and prevent moisture loss, cosmetics contain polyhydric alcohols such as glycerin, 1,3-butylene glycol, isoprene glycol, polyethylene glycol, and sorbitol, as well as amino acids such as serine, proline, and glutamic acid. are combined. moreover,
Mucopolysaccharides such as hyaluronic acid, sodium chondroitin sulfate, and dermatan sulfate are also included for similar purposes.
一方、皮膚の伸び、弾力性改善の目的で、水溶性コラー
ゲン、エラスチン等のタンパク類、 また、加水分解コ
ラーゲン、加水分解エラスチン等のポリペブタイド類が
化粧料に配合されている。On the other hand, for the purpose of improving skin stretch and elasticity, proteins such as water-soluble collagen and elastin, and polypeptides such as hydrolyzed collagen and hydrolyzed elastin are incorporated into cosmetics.
グリセリン、 １．３−ブチレングリコール等の多価ア
ルコール類は高湿度下では、化粧料に配合した場合、皮
膚や毛髪の保湿剤として有効に働く。Under high humidity conditions, polyhydric alcohols such as glycerin and 1,3-butylene glycol function effectively as moisturizers for the skin and hair when incorporated into cosmetics.
しかし、低湿度下では、これら多価アルコール類は、逆
に皮膚や毛髪の水分を化粧品中にとりこんでしまい、皮
膚や毛髪の保湿剤としては適当ではない。However, under low humidity conditions, these polyhydric alcohols conversely absorb moisture from the skin and hair into cosmetics, making them unsuitable as moisturizers for the skin and hair.
セリン、 プロリン、グルタミン酸等のアミノ酸類を保
湿剤として化粧料に配合する場合、糖類が共存するとメ
イラード反応により褐変要具してしまう問題がある。When amino acids such as serine, proline, and glutamic acid are incorporated into cosmetics as moisturizing agents, there is a problem in that browning occurs due to the Maillard reaction if sugars are present.
ヒアルロン酸やコンドロイチン硫酸ナトリウム等のムコ
多糖類は、生体由来の保湿剤としては非常に保湿効果に
優れたものである。しかし、皮膚の伸ひ、弾力性の改善
効果については、タンパク類やポリペブタイト類と比較
するとけっして優れているとは言えない。Mucopolysaccharides such as hyaluronic acid and sodium chondroitin sulfate have extremely excellent moisturizing effects as biologically derived moisturizers. However, it cannot be said to be superior to proteins and polypebutites in improving skin stretch and elasticity.
水溶性コラーゲンやエラスチン等のタンパク類、加水分
解コラーゲンや加水分解エラスチン等のポリペブタイド
類は、化粧料に配合した場合、皮膚の伸び、弾力性改善
に優れている。しかし、皮膚や毛髪の保湿効果について
は、ムコ多！Ｍ類と比較するとけっして優れているとは
言えない。Proteins such as water-soluble collagen and elastin, and polypeptides such as hydrolyzed collagen and hydrolyzed elastin, when incorporated into cosmetics, are excellent in improving skin stretch and elasticity. However, when it comes to moisturizing effects on the skin and hair, there is a lot to be said for! It cannot be said that it is superior in comparison to M class.
そこで、保湿効果と皮膚の伸び、弾力性改善効果を併せ
もつ化粧料を得るために、 ヒアルロン酸やコンドロイ
チン硫酸等のムコ多糖類とコラーゲン等のタンパク類を
併用する試みかなされてきた。Therefore, attempts have been made to combine mucopolysaccharides such as hyaluronic acid and chondroitin sulfate with proteins such as collagen in order to obtain cosmetics that have both a moisturizing effect and an effect of improving skin elongation and elasticity.
しかし、ムコ多糖類とタンパク類を併用し化粧料に配合
すると白色沈鍛を生二 安定性に問題かあり実用化はな
されていなかった。However, when mucopolysaccharides and proteins are combined in cosmetics, there is a problem with the stability of the white cast iron, so it has not been put to practical use.
本発明者らは、このような事情に鑑み、鋭ａ′研究を重
ねた結果、生体抽出物のムコ多糖とタシバク質の複合体
であるプロテオグリカンの抽出液を配合した化粧料は、
保湿作用及び水分ロスを防ぎ、皮膚及び毛髪を滑らかに
するコンデショニング効果に優ね かつ、皮膚の伸び、
弾力性に対する改善作用を併せもつことを見いだし、本
発明を完成するに至った。In view of these circumstances, the present inventors have conducted extensive research and found that a cosmetic containing an extract of proteoglycan, which is a complex of biological extracts mucopolysaccharide and tacibacterium, is
Excellent conditioning effect that moisturizes and prevents moisture loss, smooths the skin and hair, and helps to stretch the skin.
It was discovered that the material also has the effect of improving elasticity, and the present invention was completed.
すなわち、本発明は、プロテオグリカン抽出液を含有す
ることを特徴とする化粧料である。本発明に使用するプ
ロテオグリカン抽出液の配合量は、固形分１０重量％以
下の抽出液を化粧料全体中の０．００１〜７０．０重量
％である。好ましくは０、０１〜５０．０重量％である
。０．００１重量％以下であると本発明で言う効果が充
分発揮せれず好ましくない。また、７０．０重量％以上
の配合も可能であるか、効果の顕著な増加も認められず
、べたつき等が感じられ使用感が悪くなり、経済的でな
い。That is, the present invention is a cosmetic characterized by containing a proteoglycan extract. The amount of the proteoglycan extract used in the present invention is 0.001 to 70.0% by weight of the entire cosmetic composition, with a solid content of 10% by weight or less. Preferably it is 0.01 to 50.0% by weight. If it is less than 0.001% by weight, the effects referred to in the present invention cannot be sufficiently exhibited, which is not preferable. It is also possible to incorporate 70.0% by weight or more, but no significant increase in effectiveness is observed, the feeling of use becomes poor due to stickiness, etc., and it is not economical.
本発明に使用するプロテオグリカン抽出液とは、ムコ多
糖類蛋白質複合体の抽出液のことである。The proteoglycan extract used in the present invention is an extract of a mucopolysaccharide protein complex.
ムコ多糖類蛋白質複合体は、蛋白質のポリペプチド鎖に
数本ないしは、数十本のムコ多糖類の鎖か結合し、５〜
５０％の蛋白質を含む、分子量１００万から１０００万
はとの分子構造の酸性ムコ多糖類−蛋白質複合体である
。構成酸性ムコ多糖類は、主としてヒアルロン酸、コン
ドロイチン−４−硫酸、コンドロイチン−６＝硫酸、デ
ルマタン硫酸、コンドロイチン６．９−硫酸、コンドロ
イチン、ヘパリン、ヘパリチン硫酸、ケラト硫酸などが
ある。A mucopolysaccharide-protein complex consists of several or dozens of mucopolysaccharide chains bonded to the polypeptide chain of a protein.
It is an acidic mucopolysaccharide-protein complex containing 50% protein and having a molecular weight of 1 million to 10 million. The constituent acidic mucopolysaccharides mainly include hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate, chondroitin-6.9-sulfate, chondroitin, heparin, heparitin sulfate, and keratosulfate.
このプロテオグリカン抽出液は、高等動物の結合組織か
ら抽出されたものである。さらに詳しくは、多くの組繊
細胞間の空間を満たすシェリー状の細胞間質や細胞間セ
メント、軟骨、鍵、皮膚、及び関節を滑らかにする性液
から抽出されたものである。This proteoglycan extract is extracted from connective tissue of higher animals. More specifically, it is extracted from the sherry-like intercellular space that fills the spaces between many tissue cells, the intercellular cement, cartilage, keys, skin, and sexual fluid that lubricates the joints.
その製造方法は、例えば牛より摘出した結合組織を水冷
下で、血管、脂肪等を除去し、スライスする。次に、
０．０５Ｍ酢酸ナトリウムでｐＨ５゜８に調製した４Ｍ
塩酸グアニジンで抽出を行なう。The manufacturing method involves, for example, removing connective tissue from a cow under water cooling, removing blood vessels, fat, etc., and then slicing it. next,
4M adjusted to pH 5°8 with 0.05M sodium acetate
Extraction is performed with guanidine hydrochloride.
抽出後、遠心分離を行い、得られた上澄液を１０倍量の
０．０５Ｍ酢酸ナトリウム（ｐＨ５，８）に冷温下、１
２時間透析したのち、密度勾配超遠心（２５，ＯＯＯｒ
ｐｍ、２０℃、４５時間）で分画する。この分画の底部
を採取して得られたものに、必要に応じて防腐剤を添加
する。このプロテオグリカン抽出液は、蛋白質量として
０．３５〜０゜６５重量％であり、固形分として１０重
量％以下である。After extraction, centrifugation is performed, and the resulting supernatant is added to 10 times the amount of 0.05M sodium acetate (pH 5,8) under cold temperature for 1 hour.
After dialysis for 2 hours, density gradient ultracentrifugation (25,OOOr
pm, 20°C, 45 hours). If necessary, a preservative is added to the bottom of this fraction. This proteoglycan extract has a protein content of 0.35 to 0.65% by weight, and a solid content of 10% by weight or less.
なお、本発明の化粧料は通常の製造方法に従って実施す
る事ができる。本発明の化粧料は前記の必須成分に加え
て必要に応じて本発明の効果を損なわない範囲内で、化
粧品一般に用いられる各種成分、すなわち油脂類、ロウ
類、炭化水素類、脂肪酸類、アルコール類、合成エステ
ル類、界面活性剤、保湿剤、増粘剤、無機物、香料、薬
剤、精製水等を配合することができる。Incidentally, the cosmetic composition of the present invention can be produced according to a conventional manufacturing method. In addition to the above-mentioned essential ingredients, the cosmetic of the present invention may contain various ingredients commonly used in cosmetics, such as oils and fats, waxes, hydrocarbons, fatty acids, and alcohol, if necessary, within a range that does not impair the effects of the present invention. esters, synthetic esters, surfactants, humectants, thickeners, inorganic substances, fragrances, drugs, purified water, etc. can be blended.
次に、実施例をあげて本発明をさらに詳細に説明するが
１本発明はこれにより限定されるものではない。なお、
以下の実施例に配合されたプロテオグリカン抽出液は、
前記記載の製造方・法に従い調製したものである。Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited thereto. In addition,
The proteoglycan extract blended in the following examples is:
It was prepared according to the manufacturing method described above.
実施例−１化 粧 水
■エチルアルコール １０．０■香料
適 量■ポリオキシ
エチレン（２０）硬化ヒマシ油 ０．４■グリセリン
５． ０■１，３−ブチレ
ングリコール ４．０■プロテオグリカン抽出
液 １０．０■バラオキシ安息香酸メチル
０．１■クエン酸
０・ ５■クエン酸ナトリウム
０．３［相］精製水を加えて全量を１００とする。Example-1 Makeup Water ■ Ethyl alcohol 10.0 ■ Fragrance appropriate amount ■ Polyoxyethylene (20) hydrogenated castor oil 0.4 ■ Glycerin
5. 0 ■ 1,3-butylene glycol 4.0 ■ Proteoglycan extract 10.0 ■ Methyl roseoxybenzoate
0.1 ■ Citric acid
0. 5■ Sodium citrate
0.3 [Phase] Add purified water to make the total volume 100.
■に■〜■を溶解し、 Ａとする。次に、■〜■を［相
］に溶解して、 Ｂとする。ＢにＡを添加した後、Ｎｏ
、５Ｃのろ紙でろ過する。Dissolve ■ to ■ in ■ to obtain A. Next, ① to ② are dissolved in [phase] to obtain B. After adding A to B, No.
, filter through 5C filter paper.
実施例−２クリーム
■スクワラン ５． ０■ベ
ヘニルアルコール １．５■セチルア
ルコール ０．５■ポリオキシエチ
レン（２０）
ソルビタンモノステアレート １．２■ソルビタン
モノステアレート ０．８■ポリオキシエチレ
ン（２０）
セチルエーテル ２．５Ｃ吸着精製ラ
ノリン ４．０■ミリスチルオクチ
ルドデカノール ８．０■ステアリン酸
１．２＠１．３−ブチレングリコール
６．００パラオキシ安息香酸メチル
０．４０プロテオグリカン抽出液５．０
［相］香料 適 量０
精製水にて全量を１００とする
■〜■を８０℃で溶解し、Ａとする。［相］、■を■に
８０℃で溶解し、Ｂとする。ＡにＢを撹拌しなから乳化
し、７０℃で■を添加し、 ４０℃で０を添加し、 ３
０℃まで撹拌しながら冷却する。Example-2 Cream ■ Squalane 5. 0 ■ Behenyl alcohol 1.5 ■ Cetyl alcohol 0.5 ■ Polyoxyethylene (20) Sorbitan monostearate 1.2 ■ Sorbitan monostearate 0.8 ■ Polyoxyethylene (20) Cetyl ether 2.5C adsorption purified lanolin 4 .0 ■ Myristyl octyldodecanol 8.0 ■ Stearic acid
[email protected] glycol 6.00 Methyl paraoxybenzoate
0.40 Proteoglycan extract 5.0 [Phase] Flavor Appropriate amount 0
① to ② were dissolved at 80°C to make the total amount 100 with purified water and designated as A. [Phase] Dissolve ■ in ■ at 80°C to obtain B. Emulsify B into A without stirring, add ■ at 70℃, add 0 at 40℃, 3
Cool with stirring to 0°C.
実施例−３乳 液
■スクワラン ３・ ０■マ
イクロクリスタリンワツクス ２．０■ワセリン
１．０■ステアリルア
ルコール ０．７■ソルビタンモノステ
アリン酸エステル １．２■ソルビタンセスキオレイン
酸エステル １．３■ポリオキシエチレン（２０）
ソルビタンモノオレイン酸エステル ２．２■１，３
−ブチレングリコール ５．０■パラオキシ安
息香酸メチル ０． ２［相］プロテオグリ
カン ３０．００香料
適 量＠精製水にて全量を１００と
する
■〜■を８０℃で溶解し、Ａとする。■、■を＠に８０
℃で溶解し、Ｂとする。ＡにＢを撹拌しながら乳化し、
７０℃で■を添加し、 ４０℃で［相］を添加し、
３０℃まで撹拌しながら冷却する。Example-3 Emulsion ■ Squalane 3.0 ■ Microcrystalline wax 2.0 ■ Vaseline 1.0 ■ Stearyl alcohol 0.7 ■ Sorbitan monostearate 1.2 ■ Sorbitan sesquioleate 1.3 ■ Poly Oxyethylene (20) Sorbitan monooleate 2.2■1,3
-Butylene glycol 5.0 ■Methyl paraoxybenzoate 0. 2 [Phase] Proteoglycan 30.00 Flavor
Dissolve (1) to (2) at 80°C with an appropriate amount of purified water to make the total amount 100, and refer to A. ■、■ to @80
Dissolve at ℃ and call it B. Emulsify A with B while stirring,
Add ■ at 70℃, add [phase] at 40℃,
Cool to 30°C with stirring.
実施例−４パック
■カルボキシメチルセルロース
■１，３−ブチレングチコール
■グリセリン
■ニーチルアルコール
■ポリオキシエチレン（２０）
ラウリルエーテル
０゜
■香料
■プロテオグリカン抽出液
■精製水にて全量を１００とする
適量
０゜
■〜■を■に６０℃で溶解し、■を添加して、 ３０℃
まで撹拌しながら冷却する。Example - 4 packs ■ Carboxymethyl cellulose ■ 1,3-butylene gtycol ■ Glycerin ■ Nithyl alcohol ■ Polyoxyethylene (20) Lauryl ether 0゜ ■ Fragrance ■ Proteoglycan extract ■ Appropriate amount to make the total volume 100 with purified water 0゜■ ~ ■ Dissolve in ■ at 60℃, add ■, and heat to 30℃
Cool while stirring until cooled.
実施例−５リンス ■塩化モノステアリル トリメチルアンモニウム ■塩化レジステアリ ル。Example-5 Rinse ■Monostearyl chloride Trimethylammonium ■Chloride resin Le.
ジメチルアンモニウム １．５■セチル
アルコール ２．５■ベヘニルア
ルコール ０． ５■流動パラフイン
３７０ ５．０■グリセリン
５．０■パラオキシ安息香酸メチル
０． ２■香 料
適 量■プロテオグリカン抽出液
３．０［相］精製水にて全量を１００とする
■〜■を７５℃で溶解し、Ａとする。■、■を［相］に
７０℃で溶解し、Ｂとするａ ＡにＢを撹拌しながら乳
化し、 ６０℃で■を添加し、 ４０℃で■を添加し、
３０℃まで撹拌しながら冷却する。Dimethylammonium 1.5 ■ Cetyl alcohol 2.5 ■ Behenyl alcohol 0. 5■Liquid paraffin 370 5.0■Glycerin
5.0 ■ Methyl paraoxybenzoate
0. 2■Fragrance
Appropriate amount ■ Proteoglycan extract
3.0 [Phase] Dissolve (1) to (2) at 75°C to make the total amount 100 with purified water to obtain A. Dissolve ■ and ■ in [phase] at 70℃ and make B.a Emulsify B with A while stirring, add ■ at 60℃, add ■ at 40℃,
Cool to 30°C with stirring.
本発明の化粧料は、ムコ多糖類蛋白質複合体のプロテオ
グリカン抽象出港を配合することにより、保湿作用及び
水分ロスを防ぎ、皮膚及び毛髪を滑らかにするコンデシ
ョニング効果に擾れ、かつ、皮膚の伸び、弾力性に対す
る優れた改善作用を併せもつ化粧料である。By incorporating proteoglycan abstraction of mucopolysaccharide protein complex, the cosmetic of the present invention has a moisturizing effect, prevents water loss, has a conditioning effect that smooths the skin and hair, and has a conditioning effect that makes the skin stretch. It is a cosmetic that also has an excellent effect on improving elasticity.
次に、本発明の効果について、水分保持試験、ヒト皮膚
の伸び、弾力性改善試験、長期連用試験。Next, regarding the effects of the present invention, a moisture retention test, a human skin elongation and elasticity improvement test, and a long-term use test were conducted.
での結果を示す。The results are shown below.
（水分保持試験）
試 験 方、法
１グル一プ８名づつの女性モニター（１９歳〜５３歳）
に、実施例−１、実施例−１ａ〜実施例−１ｅ、比較例
−１、比較例−２の化粧水を、前腕圧側部に塗布し、
１０分、３０分、 ６０分、 １２０分、 １８０分後
の電気伝導度をＩ、 Ｂ、Ｓ社製高周波インピーダン
スメーターＭｏｄｅ１．ＩＢ ３５２にて測定した。(Water retention test) Test method: 8 female monitors per group (19 to 53 years old)
, apply the lotion of Example-1, Example-1a to Example-1e, Comparative Example-1, and Comparative Example-2 to the pressure side of the forearm,
The electrical conductivity after 10 minutes, 30 minutes, 60 minutes, 120 minutes, and 180 minutes was measured using a high-frequency impedance meter Model 1 manufactured by I, B, and S companies. Measured with IB 352.
実施例−１ａ〜実施例−１ｅ 化粧水
実施例−１の化粧水の■プロテオグリカン抽出液の配合
量を以下の配合量とした化粧入プロテオグリカン配合量
（％）
実施例−１ａ Ｏ，００５
実施例−１ｂ ０．０２
実施例−１ｃ ５．０
実施例−１ｄ４０．０
実施例−１ｅ ６０，０
比較例−１化粗水
実施例−１の化粧水の■プロテオグリカンを１３−ブチ
レングリコールとし、他は同様に調製した。Example-1a to Example-1e Lotion of lotion Example-1 Proteoglycan content (%) in which the proteoglycan extract was blended as follows Example-1a O,005 Example -1b 0.02 Example-1c 5.0 Example-1d40.0 Example-1e 60.0 Comparative example-1 crude water Lotion ■ Proteoglycan of Example-1 is 13-butylene glycol, etc. was prepared similarly.
比較例−２化粧水
実施例−１の化粧水の■プロテオグリカンを加水分解コ
ラーゲンとし、他は同様に調製した。Comparative Example 2 Lotion The lotion of Example 1 was prepared in the same manner except that the proteoglycan was replaced with hydrolyzed collagen.
試 験 結 果
保水性試験の結果を表−１に示す。表−１の結果から明
らかなように、プロテオグリカンを配合した実施例−１
、実施例−１ｂ、実施例−ＩＣ１実施例−１ｄの化粧水
は、実施例−１８、比較例１、比較例−２の化粧水と比
較して、優れた保水性と使用感をもった新規化粧料であ
る。Test Results The results of the water retention test are shown in Table-1. As is clear from the results in Table 1, Example 1 containing proteoglycan
, Example-1b, Example-IC1 The lotion of Example-1d had excellent water retention and feel when compared to the lotion of Example-18, Comparative Example 1, and Comparative Example-2. This is a new cosmetic.
なお、実施例−２、実施例−３、実施例−４についても
、同様に優れた保水性の結果が得られた。In addition, similarly excellent water retention results were obtained for Example-2, Example-3, and Example-4.
（皮膚の伸び、弾力性試験）
民−１一方一塵
女性モニター４０名（２４歳〜５２歳）に、実施例−２
、実施例−２ａ〜実施例−２ｅ、比較例−３、比較例−
４のクリームを一日一回、 １ケ月間前腕屈側部に塗布
した。１ケ月後に皮膚の伸び、弾力性を、日本ニーロチ
ツク社製のキュートメ−ターＳＥＭ４７４にて測定した
。(Skin elongation and elasticity test) Civilian-1 On the other hand, 40 female monitors (24 to 52 years old) were tested in Example-2.
, Example-2a to Example-2e, Comparative Example-3, Comparative Example-
Cream No. 4 was applied once a day to the flexor side of the forearm for one month. One month later, the elongation and elasticity of the skin were measured using a cutometer SEM474 manufactured by Nippon Nirochiku Co., Ltd.
実施例−２ａ〜実施例−２ｅ クリーム実施例−２のク
リームの＠プロテオグリカン抽出液の配合量を以下の配
合量としたクリーム。Example-2a to Example-2e Cream Cream with the following blending amount of proteoglycan extract in the cream of Example-2.
プロテオグリカン配合量（％）
０．００７
０．１５
１．０
４０．０
５５．０
実施例−２ａ
実施例−２ｂ
実施例−２０
実施例−２ｄ
実施例−２ｅ
比較例−３
実施例−２のクリームの＠プロテオグリカンをグリセリ
ンとし、他は同様に調製した。Proteoglycan content (%) 0.007 0.15 1.0 40.0 55.0 Example-2a Example-2b Example-20 Example-2d Example-2e Comparative example-3 Example-2 The cream was prepared in the same manner except that the proteoglycan was replaced with glycerin.
比較例−４
実施例−２のクリームの＠プロテオグリカンを水溶性コ
ラーゲンとし、他は同様に調製した。Comparative Example-4 The cream of Example-2 was prepared in the same manner except that water-soluble collagen was used as @proteoglycan.
Ｋ−監一旦−１ 皮膚の伸び、弾力性試験の結果を表−２に示す。K-Supervisor-1 The results of the skin elongation and elasticity tests are shown in Table 2.
表−２から明かなように、本発明の実施例−２、実施例
−２ｂ、 実施例−２ｃ、実施例−２ｄは実施例−２
ａ、実施例−２ｅ、比較例−３、比較例−４と比較して
皮膚の伸び、弾力性の改善に優ね使用感に優れた新規化
粧料である。なお、実施例−１、実施例−３、実施例−
４についても同様に優れた皮膚の伸び、弾力性の改善結
果が得られた。As is clear from Table-2, Example-2, Example-2b, Example-2c, and Example-2d of the present invention are Example-2
This is a new cosmetic that has improved skin stretch and elasticity and has an excellent feel when used compared to Example 2e, Comparative Example 3, and Comparative Example 4. In addition, Example-1, Example-3, Example-
Similarly, excellent improvement in skin stretch and elasticity was obtained for Example 4.
以下余白
注）皮膚の伸びは、キュートメ−ターＳＥＭ４７４で吸
引した時の値であり、弾力性はもとの状態にもどる度合
で示される。Note in the margin below: The elongation of the skin is the value obtained when suctioned with a cutometer SEM474, and the elasticity is expressed as the degree to which the skin returns to its original state.
（長期連用試験）
試験方法
肌のかさつき、はり、たるみ、しわに悩む女性モニター
（３５歳〜５８歳）を被験者として、 １グル一プ１０
名づつ、実施例−３、実施例−３ａ〜実施例−３ｅ、比
較例−５、比較例−６の乳液を１ケ月間毎日使用させた
。 １ケ月後の肌のかさつき、はり、たるみ、しわにつ
いて、自覚所見によりその改善度合を判定した。(Long-term continuous use test) Test method Female monitors (35 to 58 years old) who suffer from dryness, firmness, sagging, and wrinkled skin were the subjects, and 1 group of 10
The emulsions of Example 3, Examples 3a to 3e, Comparative Example 5, and Comparative Example 6 were used daily for one month. One month later, the degree of improvement in skin dryness, firmness, sagging, and wrinkles was determined based on subjective findings.
実施例−３ａ〜実施例−３ｅ 乳 液
実施例−３の乳液の［相］プロテオグリカン抽出液の配
合量を以下の配合量としたクリーム。Example-3a to Example-3e Emulsion A cream containing the [phase] proteoglycan extract of the emulsion of Example-3 in the following amount.
プロテオグリカン配合量（％）
実施例−３ａ ０．００５
実施例−３ｂ ００２０
実施例−３ｃ １．０
実施例−３ｄ５．０
実施例−３ｅ ６０，０
比較例−５乳 液
実施例−３の乳液の［相］プロテオグリカンをヒアルロ
ン酸水溶液とし、他は同様に調製した。Proteoglycan content (%) Example-3a 0.005 Example-3b 0020 Example-3c 1.0 Example-3d5.0 Example-3e 60.0 Comparative Example-5 Emulsion Emulsion of Example-3 The [phase] proteoglycan was an aqueous hyaluronic acid solution, and the others were prepared in the same manner.
比較例−６乳 液
実施例−３の乳液の［相］プロテオグリカンを水溶性コ
ラーゲンとし、他は同様に調製した。Comparative Example-6 Emulsion [Phase] The emulsion of Example-3 was prepared in the same manner except that the proteoglycan was water-soluble collagen.
試 験 結 果
長期連用試験結果を表−３に示す。表−３から明かなよ
うに１本発明の実施例−３、実施例−３ｂ、実施例−３
Ｃ１実施例−３ｄは、比較例−５、比較例−６と比較し
て肌のかさつき、はり、たるみ、しわの改善に優れた、
使用感に優れた新規化粧料である。Test Results The long-term continuous use test results are shown in Table 3. As is clear from Table 3, 1 Example-3, Example-3b, Example-3 of the present invention
C1 Example-3d was excellent in improving skin dryness, firmness, sagging, and wrinkles compared to Comparative Example-5 and Comparative Example-6.
This is a new cosmetic that is easy to use.
なお、実施例−１、実施例−２、実施例−４についても
同様に、肌のかさつき、はり、たるみ、しわの改善に優
れた結果が得られた。In addition, in Example-1, Example-2, and Example-4, excellent results were similarly obtained in improving skin dryness, firmness, sagging, and wrinkles.
以下余白 長期連用試験結果Margin below Long-term continuous use test results
Claims (2)
する化粧料。(1) A cosmetic characterized by containing a proteoglycan extract.
抽出液が、０．０１〜５０．０重量％含有せられてなる
特許請求の範囲第１項記載の化粧料。(2) The cosmetic according to claim 1, which contains 0.01 to 50.0% by weight of a proteoglycan extract with a solid content of 10% by weight or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21327790A JPH0495010A (en) | 1990-08-10 | 1990-08-10 | Cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21327790A JPH0495010A (en) | 1990-08-10 | 1990-08-10 | Cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0495010A true JPH0495010A (en) | 1992-03-27 |
Family
ID=16636446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21327790A Pending JPH0495010A (en) | 1990-08-10 | 1990-08-10 | Cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0495010A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06345636A (en) * | 1993-06-08 | 1994-12-20 | Nonogawa Shoji Kk | Cosmetic |
| JP2013040313A (en) * | 2011-08-19 | 2013-02-28 | Eriko Muraoka | Body shampoo |
| JP2017048151A (en) * | 2015-09-03 | 2017-03-09 | 地方独立行政法人青森県産業技術センター | Collagen gel shrinkage promoter, anti-saccharification agent and skin external preparation |
| JP2017125164A (en) * | 2016-01-15 | 2017-07-20 | 地方独立行政法人青森県産業技術センター | High water holding modified proteoglycan |
| JP2020075875A (en) * | 2018-11-06 | 2020-05-21 | 日油株式会社 | Hair cosmetic |
| JP2020117653A (en) * | 2019-01-28 | 2020-08-06 | 株式会社パイロットコーポレーション | Ink composition for writing instruments, and writing instrument including the same |
| JP2020125319A (en) * | 2015-09-03 | 2020-08-20 | 地方独立行政法人青森県産業技術センター | Anti-glycation agent and external skin preparation |
| JP2021038171A (en) * | 2019-09-03 | 2021-03-11 | 日油株式会社 | Disinfection composition |
-
1990
- 1990-08-10 JP JP21327790A patent/JPH0495010A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06345636A (en) * | 1993-06-08 | 1994-12-20 | Nonogawa Shoji Kk | Cosmetic |
| JP2013040313A (en) * | 2011-08-19 | 2013-02-28 | Eriko Muraoka | Body shampoo |
| JP2017048151A (en) * | 2015-09-03 | 2017-03-09 | 地方独立行政法人青森県産業技術センター | Collagen gel shrinkage promoter, anti-saccharification agent and skin external preparation |
| JP2020125319A (en) * | 2015-09-03 | 2020-08-20 | 地方独立行政法人青森県産業技術センター | Anti-glycation agent and external skin preparation |
| JP2017125164A (en) * | 2016-01-15 | 2017-07-20 | 地方独立行政法人青森県産業技術センター | High water holding modified proteoglycan |
| JP2020075875A (en) * | 2018-11-06 | 2020-05-21 | 日油株式会社 | Hair cosmetic |
| JP2020117653A (en) * | 2019-01-28 | 2020-08-06 | 株式会社パイロットコーポレーション | Ink composition for writing instruments, and writing instrument including the same |
| JP2021038171A (en) * | 2019-09-03 | 2021-03-11 | 日油株式会社 | Disinfection composition |
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