JPH03279315A - External preparation of skin - Google Patents
External preparation of skinInfo
- Publication number
- JPH03279315A JPH03279315A JP2079654A JP7965490A JPH03279315A JP H03279315 A JPH03279315 A JP H03279315A JP 2079654 A JP2079654 A JP 2079654A JP 7965490 A JP7965490 A JP 7965490A JP H03279315 A JPH03279315 A JP H03279315A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- external preparation
- protein
- tranexamic acid
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 16
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 16
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims abstract description 14
- 229960000401 tranexamic acid Drugs 0.000 claims abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 238000000354 decomposition reaction Methods 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 4
- -1 vitamin ester Chemical class 0.000 abstract description 16
- 235000018102 proteins Nutrition 0.000 abstract description 14
- 108010035532 Collagen Proteins 0.000 abstract description 6
- 102000008186 Collagen Human genes 0.000 abstract description 6
- 229920001436 collagen Polymers 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 238000002156 mixing Methods 0.000 abstract description 6
- 108010010803 Gelatin Proteins 0.000 abstract description 5
- 229920000159 gelatin Polymers 0.000 abstract description 5
- 239000008273 gelatin Substances 0.000 abstract description 5
- 235000019322 gelatine Nutrition 0.000 abstract description 5
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 5
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 108010073771 Soybean Proteins Proteins 0.000 abstract description 3
- 108010068370 Glutens Proteins 0.000 abstract description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract description 2
- 235000019710 soybean protein Nutrition 0.000 abstract description 2
- 229930003231 vitamin Natural products 0.000 abstract description 2
- 229940088594 vitamin Drugs 0.000 abstract description 2
- 239000011782 vitamin Substances 0.000 abstract description 2
- 235000013343 vitamin Nutrition 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 235000021312 gluten Nutrition 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 31
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 15
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 9
- 239000006071 cream Substances 0.000 description 9
- 239000003205 fragrance Substances 0.000 description 9
- 239000006210 lotion Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- 238000007796 conventional method Methods 0.000 description 8
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 8
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 7
- QZKRHPLGUJDVAR-UHFFFAOYSA-K EDTA trisodium salt Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O QZKRHPLGUJDVAR-UHFFFAOYSA-K 0.000 description 7
- 238000005342 ion exchange Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 229940055577 oleyl alcohol Drugs 0.000 description 7
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 108010014258 Elastin Proteins 0.000 description 5
- 102000016942 Elastin Human genes 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 229920002549 elastin Polymers 0.000 description 5
- 235000011118 potassium hydroxide Nutrition 0.000 description 5
- 229940099259 vaseline Drugs 0.000 description 5
- 239000005018 casein Substances 0.000 description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
- 235000021240 caseins Nutrition 0.000 description 4
- 229940082500 cetostearyl alcohol Drugs 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 4
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 229940032094 squalane Drugs 0.000 description 4
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 230000037394 skin elasticity Effects 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- 108010076119 Caseins Proteins 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 239000004373 Pullulan Substances 0.000 description 2
- 229920001218 Pullulan Polymers 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- WAATURCSKZMXLM-UHFFFAOYSA-N ethyl 4-hydroxybenzoate;methyl 4-hydroxybenzoate Chemical compound COC(=O)C1=CC=C(O)C=C1.CCOC(=O)C1=CC=C(O)C=C1 WAATURCSKZMXLM-UHFFFAOYSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 2
- 235000019423 pullulan Nutrition 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 description 1
- OIZKACIUYANPGU-KVVVOXFISA-N 2,3-dihydroxypropyl (z)-octadec-9-enoate;sodium Chemical compound [Na].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO OIZKACIUYANPGU-KVVVOXFISA-N 0.000 description 1
- GCAJDUHNFZFJNX-UHFFFAOYSA-N 2,3-dihydroxypropyl octadecanoate;sodium Chemical compound [Na].CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO GCAJDUHNFZFJNX-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010038061 Chymotrypsinogen Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010028690 Fish Proteins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- 102000051325 Glucagon Human genes 0.000 description 1
- 102000006947 Histones Human genes 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000003505 Myosin Human genes 0.000 description 1
- 108060008487 Myosin Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- BDWFYHUDXIDTIU-UHFFFAOYSA-N ethanol;propane-1,2,3-triol Chemical compound CCO.OCC(O)CO BDWFYHUDXIDTIU-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003631 expected effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000037393 skin firmness Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 150000004370 vitamin A ester derivatives Chemical class 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、新規な皮膚外用剤に関し、さらに詳しくは、
皮膚の新陳代謝を活発にし、皮膚の弾力性を増し、皮膚
の保護と水分の保持性に優れた効果を有する皮膚外用剤
に関する。[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a novel skin preparation for external use, and more specifically,
This invention relates to an external skin preparation that activates skin metabolism, increases skin elasticity, and has excellent effects on skin protection and moisture retention.
皮膚を組織学的に解析すると、真皮にはコラーゲン繊維
と弾力繊維が網状を形成しており、それが皮膚の弾力性
と引っ張り強度をもたらしているとされている。近年、
動物より得られたこれら繊維から可溶性繊維分子を抽出
する等により得られたコラーゲンやエラスチンか皮膚の
保護並びに保湿剤として皮膚外用剤に配合されてきた。Histological analysis of the skin shows that the dermis has a network of collagen fibers and elastic fibers, which gives the skin its elasticity and tensile strength. recent years,
Collagen and elastin obtained by extracting soluble fiber molecules from these fibers obtained from animals have been incorporated into external skin preparations as skin protection and moisturizing agents.
また同様の観点からゼラチン、カゼイン、大豆蛋白等の
配合も提案されている。Also, from the same point of view, combinations of gelatin, casein, soybean protein, etc. have also been proposed.
従来の技術
しかしながら、これら蛋白の皮膚外用剤への単独の配合
では、その期待される作用効果がいまだ充分ではなく、
またそのため配合量を増加すれば皮膚外用剤の安定性に
悪影響をおよほすこと、ベタツキか生ずること等の欠点
を有していた。Conventional technology However, the expected effects are not yet fully achieved when these proteins are incorporated alone into external skin preparations.
Furthermore, if the amount of the preparation for external use is increased, the stability of the preparation for external use on the skin is adversely affected and the preparation becomes sticky.
発明の目的
本発明者等は上記の事情に鑑み、鋭意研究した結果、蛋
白および蛋白分解物よりなる群から選ばれる一種または
二種以上と、トラネキサム酸、もしくはその塩類、もし
くはその誘導体とを配合した皮膚外用剤は、水分の保持
性が相乗的に増大し、皮膚を滑らかとなし、適度の「潤
い」と［はり」を与えることを見出し、この知見にもと
すいて本発明を完成するに至った。Purpose of the Invention In view of the above-mentioned circumstances, the present inventors have conducted extensive research, and have developed a blend of one or more selected from the group consisting of proteins and protein decomposition products, and tranexamic acid, salts thereof, or derivatives thereof. It was discovered that the skin external preparation synergistically increases water retention, makes the skin smooth, and provides appropriate "moisturization" and "firmness", and based on this knowledge, the present invention was completed. reached.
すなわち本発明は蛋白及び蛋白分解物よりなる群から選
ばれる一種または二種以上と、トラネキサム酸、もしく
はその塩類、もしくはその誘導体、またはこれらの混合
物とを配合することを特徴とする皮膚外用剤である。That is, the present invention is a skin external preparation characterized by blending one or more selected from the group consisting of proteins and protein decomposition products, and tranexamic acid, salts thereof, derivatives thereof, or mixtures thereof. be.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明に用いられる蛋白及び蛋白分解物としては、大豆
蛋白、小麦蛋白、グルテリン、グルカゴン、コラーゲン
、ゼラチン、エラスチン、卵白リゾチーム、アミラーゼ
、フィブリノーゲン、ミオシン、エノラーゼ、キモトリ
プシノーゲン、ヒストン、魚肉蛋白、アビジン、ペプシ
ン、グロブリン、カゼイン、サクシニル化カゼイン及び
それらの塩等を挙げることができるが、本発明はこれら
に限定されるものではない。The proteins and protein decomposition products used in the present invention include soy protein, wheat protein, glutelin, glucagon, collagen, gelatin, elastin, egg white lysozyme, amylase, fibrinogen, myosin, enolase, chymotrypsinogen, histones, fish protein, avidin, Examples include pepsin, globulin, casein, succinylated casein and salts thereof, but the present invention is not limited thereto.
本発明の皮膚外用剤には上記の蛋白及び蛋白分解物の中
から一種または二種以上が適宜選択され配合される。One or more of the above-mentioned proteins and protein decomposition products are suitably selected and blended into the skin external preparation of the present invention.
蛋白及び蛋白分解物の配合量は、本発明の皮膚外用剤中
、０．０１〜２０重量％、好ましくは、０．０１〜１０
重量％である。The blending amount of protein and protein decomposition product is 0.01 to 20% by weight, preferably 0.01 to 10% by weight in the skin external preparation of the present invention.
Weight%.
配合量が、０．０１重量％未満では皮膚に対する保湿効
果があられれに＜＜、逆に２０重量％以上加えても効果
の増加は実質上望めず、さらにベタツキ等の点で問題が
生ずる場合もあり好ましくない。If the blending amount is less than 0.01% by weight, the moisturizing effect on the skin will be poor. On the other hand, if it is added in an amount of 20% by weight or more, no increase in the effect can be expected, and problems such as stickiness may occur. There is also something undesirable.
本発明に用いられるトラネキサム酸、もしくはその塩類
もしくはその誘導体は抗プラスミン剤として一般に用い
られており、化粧品用途では、安全性が高いことを特徴
とする成分として知られている。（特願昭４２−３６９
８０）またその製造法は特許第２４０６１１号、特許第
２４２６６４号、特許第４８０４１１号、特許第４８８
１６８号によって知られている。Tranexamic acid, salts thereof, or derivatives thereof used in the present invention are generally used as anti-plasmin agents, and are known as components characterized by high safety in cosmetic applications. (Special application 1972-369
80) The manufacturing method is disclosed in Japanese Patent No. 240611, Japanese Patent No. 242664, Japanese Patent No. 480411, and Japanese Patent No. 488.
Known by No. 168.
トラネキサム酸は融点２６２〜２６７°Ｃ１白色の結晶
または粉末で臭いはなく、味は苦い。トラネキサム酸の
塩は通常使用される塩として、Ｍｇ、Ｃａ、に等の金属
塩類、硫酸塩等があり、誘導体としてはビタミンＡ酸エ
ステル、ビタミンＡエステル、ビタ・ミンＥエステル、
ビタミンＣエステル、ビタミンＤエステル等のビタミン
エステル類、フェニルエステル類、Ｎ、Ｎ−マレオイル
ミノトラネキサム酸等が挙げられるが、これらに限定さ
れるものではない。Tranexamic acid is a white crystal or powder with a melting point of 262-267° C1, no odor, and a bitter taste. Commonly used salts of tranexamic acid include metal salts such as Mg, Ca, and sulfate, and derivatives include vitamin A acid ester, vitamin A ester, vitamin E ester,
Examples include, but are not limited to, vitamin esters such as vitamin C ester and vitamin D ester, phenyl esters, N,N-maleoylminotranexamic acid, and the like.
本発明においては上記トラネキサム酸、もしくはその塩
類、もしくはその誘導体の中から一種または二種以上が
任意に選ばれて用いられ、その配合量は、皮膚外用剤全
量中の０．１〜３０重量％であり、好ましくは６〜２０
重量％である。In the present invention, one or more of the above-mentioned tranexamic acid, its salts, or its derivatives are arbitrarily selected and used, and the blending amount is 0.1 to 30% by weight of the total amount of the skin external preparation. and preferably 6 to 20
Weight%.
本発明の皮膚外用剤には上記の必須構成成分に加えて、
必要に応じて、通常医薬品、化粧品分野で用いられるそ
の他の成分、例えばエデト酸、二、三または四ナトリウ
ム、クエン酸ナトリウム、メタリン酸ナトリウム酸の金
属イオン封鎖剤、ブチルヒドロキシトルエン（ＢＨＴ）
、没食子酸プロピル、ｄ−α−トコフェロール等の酸
か防止剤、界面活性剤、紫外線吸収剤、香料、水、エタ
ノール、イソプロパツール等のアルコール類、増粘剤、
色剤、粉末、薬剤、クエン酸、リンゴ酸等の有機酸、リ
ン酸等の無機酸等を本発明の効果を損なわない範囲内で
用いることができる。In addition to the above-mentioned essential components, the skin external preparation of the present invention includes:
If necessary, other ingredients commonly used in the pharmaceutical and cosmetic fields, such as edetic acid, di-, tri- or tetrasodium, sodium citrate, sodium metaphosphate sequestering agents, butylated hydroxytoluene (BHT)
, acid inhibitors such as propyl gallate and d-α-tocopherol, surfactants, ultraviolet absorbers, fragrances, water, alcohols such as ethanol and isopropanol, thickeners,
Colorants, powders, drugs, organic acids such as citric acid and malic acid, and inorganic acids such as phosphoric acid can be used within the range that does not impair the effects of the present invention.
本発明の皮膚外用剤の剤型は任意であり、溶液系、可溶
化系、乳化系、粉末分散系、水−油二層系、水−油一粉
末三層系等、どのような剤型でもかまわない。The dosage form of the skin external preparation of the present invention is arbitrary, such as solution type, solubilized type, emulsion type, powder dispersion type, water-oil two-layer type, water-oil one-powder three-layer type, etc. But it doesn't matter.
また、本発明の皮膚外用剤の用途も任意であり、化粧水
、乳液、クリーム、パック等のフエーシャル用またはボ
ディー用皮膚外用剤やヘアトニック、ヘアクリーム、シ
ャンプー、ヘアリンス等の頭髪用皮膚外用剤に用いるこ
とができる。In addition, the use of the external skin preparation of the present invention is arbitrary, and external skin preparations for facial or body use such as lotions, emulsions, creams, and packs, and external skin preparations for hair such as hair tonics, hair creams, shampoos, and hair rinses. It can be used for.
本発明の皮膚外用剤は、皮膚の新陳代謝を活発にし、皮
膚の粘弾力を増し、皮膚の保護と水分の保持性に優れ、
適度なうるおい、肌のハリを与えさらに、美白効果にも
優れた皮膚外用剤である。The external skin preparation of the present invention activates skin metabolism, increases skin elasticity, has excellent skin protection and moisture retention,
It is an external skin preparation that provides appropriate moisture and firmness to the skin, and also has excellent whitening effects.
次４こ実施例をあげて、本発明を具体的に説明する。本
発明はこれにより限定されるものではない。配合量は重
量％である。The present invention will be specifically explained with reference to the following four examples. The present invention is not limited thereby. The blending amount is in weight%.
実使用試験
３０名の女性を各３群に分はパネルとした。サンプルと
して下記の実施例１〜３及び比較例１〜３を用いた。In the actual use test, 30 women were divided into three groups into panels. The following Examples 1 to 3 and Comparative Examples 1 to 3 were used as samples.
第１群には実施例１及び比較例１の化粧水を、第２群に
は実施例２及び比較例２のクリームを、第３群には実施
例３及び比較例３の化粧水を使用テストさせた。The first group used the lotion of Example 1 and Comparative Example 1, the second group used the cream of Example 2 and Comparative Example 2, and the third group used the lotion of Example 3 and Comparative Example 3. Tested it.
毎日朝と夜の２回、洗顔後実施例の化粧料を適量顔面左
側に、比較例の化粧料を顔面右側に、２週間にわたって
、塗布することにより行った。評価は、下記の３項目に
つきその有効性を判定した。Twice a day, in the morning and at night, after washing the face, an appropriate amount of the cosmetic of the example was applied to the left side of the face and the cosmetic of the comparative example was applied to the right side of the face for two weeks. The evaluation was based on the effectiveness of the following three items.
結果を表１〜表６に示す。The results are shown in Tables 1 to 6.
実施例１ 化粧水 エタノール ２−ピロリドン−５− カルボン酸ナトリウム ポリオキシエチレン（２０モル） 重量％ ８．０ ２．０ １．８ オレイルアルコールエーテル トラネキサム酸 コラーゲン プルラン ホホバ油 苛性カリ ＥＤＴＡ−３Ｎａ 香 料 イオン交換水 〈製法〉 常法により化粧水を製造した。Example 1 Lotion ethanol 2-pyrrolidone-5- sodium carboxylate Polyoxyethylene (20 moles) weight% 8.0 2.0 1.8 oleyl alcohol ether tranexamic acid collagen pullulan jojoba oil caustic potash EDTA-3Na fragrance ion exchange water <Manufacturing method> A lotion was produced by a conventional method.
０．１ ０．５ ０．０５ ０．５ ０．０１５ ０．０Ｉ Ｏｌｌ 量 残 比較例１ 化粧水 エタノール ２−ピロリドン−５− カルボン酸ナトリウム ポリオキシエチレン（２０モル） オレイルアルコールエーテル コラーゲン プルラン 重量％ ８．０ ２．０ １．８ ０．５ ０．０５ ホホバ油 苛性カリ ＥＤＴＡ−３Ｎａ 香 料 イオン交換水 く製法〉 常法により化粧水を製造した。0.1 0.5 0.05 0.5 0.015 0.0I Oll amount Residue Comparative Example 1 Lotion ethanol 2-pyrrolidone-5- sodium carboxylate Polyoxyethylene (20 moles) oleyl alcohol ether collagen pullulan weight% 8.0 2.0 1.8 0.5 0.05 jojoba oil caustic potash EDTA-3Na fragrance ion exchange water Manufacturing method A lotion was produced by a conventional method.
０．５ ０．０１５ ０．０１ ０．１ 残 量 実施例２ クリーム １．３−ブチレングリコール ポリエチレングリコール４０００ グリセリン スクワラン ワセリン セトステアリルアルコール ポリオキシエチレン（２０モル） オレイルアルコールエーテル グリセリールモノステアレート トラネキサム酸のＮａ塩 エラスチン 重量％ ５．０ １．０ ２．０ ２０．０ ５．０ ３．０ １．５ １．５ ２０．０ １０．０ 乳酸ソーダ キサンタンガム（ケルトロール商品名）メチルパラベン エチルパラベン ＥＤＴＡ−３Ｎａ 香 料 イオン交換水 く常法〉 常法によりクリームを製造した。0.5 0.015 0.01 0.1 Remaining amount Example 2 Cream 1.3-butylene glycol polyethylene glycol 4000 glycerin Squalane vaseline Cetostearyl alcohol Polyoxyethylene (20 moles) oleyl alcohol ether glyceryl monostearate Sodium salt of tranexamic acid elastin weight% 5.0 1.0 2.0 20.0 5.0 3.0 1.5 1.5 20.0 10.0 lactic acid soda Xanthan gum (Keltrol brand name) Methylparaben ethylparaben EDTA-3Na fragrance ion exchange water common law A cream was produced by a conventional method.
２．０ ０．０５ ０．１ ０．２ ０．０１ ０．２ 残量 比較例２ クリーム １．３−ブチレングリコール ポリエチレングリコール４０００ グリセリン スクワラン ワセリン セトステアリルアルコール ポリオキシエチレン（２０モル） オレイルアルコールエーテル グリセリールモノステアレート 重量％ ５．０ １．０ ２．０ ２０．０ ５．０ ３．０ １．５ １．５ エラスチン 乳酸ソーダ キサンタンガム（ケルトロール商品名）メチルパラベン エチルパラベン ＥＤＴＡ−３Ｎａ 香 料 イオン交換水 く常法〉 常法によりクリームを製造した。2.0 0.05 0.1 0.2 0.01 0.2 Remaining amount Comparative Example 2 Cream 1.3-butylene glycol polyethylene glycol 4000 glycerin Squalane vaseline Cetostearyl alcohol Polyoxyethylene (20 moles) oleyl alcohol ether glyceryl monostearate weight% 5.0 1.0 2.0 20.0 5.0 3.0 1.5 1.5 elastin lactic acid soda Xanthan gum (Keltrol brand name) Methylparaben ethylparaben EDTA-3Na fragrance ion exchange water common law A cream was produced by a conventional method.
１０．０ ２．０ ０．０５ ０．１ ０．２ ０．０１ ０．２ 残量 実施例３ 乳 液 グリセリン スクワラン ワセリン セトステアリルアルコール ポリオキシエチレン（２０モル） オレイルアルコールエーテル グリセリールモノオレート トラネキサム酸 重量％ ２．０ ５．０ １．０ ０．３ １．５ １．５ １０．０ ポリアクリル酸ナトリウム エチルパラベン ゼラチン 苛性カリ ＥＤＴＡ−３Ｎａ 香 料 イオン交換水 く製法〉 常法により乳液を得た。10.0 2.0 0.05 0.1 0.2 0.01 0.2 Remaining amount Example 3 Milk liquid glycerin Squalane vaseline Cetostearyl alcohol Polyoxyethylene (20 moles) oleyl alcohol ether glyceryl monooleate tranexamic acid weight% 2.0 5.0 1.0 0.3 1.5 1.5 10.0 Sodium polyacrylate ethylparaben gelatin caustic potash EDTA-3Na fragrance ion exchange water Manufacturing method A milky lotion was obtained by a conventional method.
０．０３ ２ ７．０ ０．１ ０．０３ ０．２ 残 量 比較例３ 乳 液 グリセリン スクワラン ワセリン セトステアリルアルコール ポリオキシエチレン（２０モル） オレイルアルコールエーテル グリセリールモノオレート ポリアクリル酸ナトリウム エチルパラベン 重量％ ２．０ ５．０ １．０ ０．３ １．５ １．５ ０．０３ ０．２ ゼラチン 苛性カリ ＥＤＴＡ−３Ｎａ 香 料 イオン交換水 〈製法〉 常法により乳液を得た。0.03 2 7.0 0.1 0.03 0.2 Remaining amount Comparative example 3 Milk liquid glycerin Squalane vaseline Cetostearyl alcohol Polyoxyethylene (20 moles) oleyl alcohol ether glyceryl monooleate Sodium polyacrylate ethylparaben weight% 2.0 5.0 1.0 0.3 1.5 1.5 0.03 0.2 gelatin caustic potash EDTA-3Na fragrance ion exchange water <Manufacturing method> A milky lotion was obtained by a conventional method.
７．０
０．１
０．０３
０．２
残 量
表
表
表
表
４
表
表
表１〜６の結果から明らかなように、本発明の化粧料は
、肌のうるおい、肌のハリ、翌朝のうるおいか従来品に
比べ極めて優れていた。さらに、美白効果にも優れてい
た。7.0 0.1 0.03 0.2 Remaining Amount Table Table 4 As is clear from the results in Tables 1 to 6, the cosmetic of the present invention improves skin moisture, skin firmness, and the next morning's results. It was extremely moisturizing compared to conventional products. Furthermore, it also had an excellent whitening effect.
実施例４ パック プロピレングリコール ポリエチレングリコール４゜ グリセリン エタノール トラネキサム酸 ポリビニルアルコール オリーブ油 乳 酸 カゼイン カルボキシメチルセルロース メチルパラヘン エチルパラベン 苛性カリ ＥＤＴＡ−３Ｎａ 重量％ ２．０ ００ ３．０ １５．０ １０．０ １５．０ １０．０ ３．０ １．０ １０．０ ０．０７ ０．１ ０．１ ０．０２ ０．０１ 香 料 イオン交換水 く製法〉 常法によりパックを得た。Example 4 Pack Propylene glycol Polyethylene glycol 4° glycerin ethanol tranexamic acid polyvinyl alcohol olive oil lactic acid casein carboxymethyl cellulose Methylparahen ethylparaben caustic potash EDTA-3Na weight% 2.0 00 3.0 15.0 10.0 15.0 10.0 3.0 1.0 10.0 0.07 0.1 0.1 0.02 0.01 fragrance ion exchange water Manufacturing method The puck was obtained by conventional methods.
０．１ 残 量 実施例５ ヘアクリーム ミツロウ ワセリン 流動パラフィン ポリオキシエチレン（５モル） ステアリン酸エステル ポリオキシエチレン（６モル） オレイルアルコールエーテル ポリオキシエチレン（６モル） セチルアルコールエーテル トラネキサム酸 エラスチン 精製水 香 料 防腐剤 重量％ ３．０ １５．０ ４２．０ ３．０ ２．０ １．０ ７．０ ５．０ 余 量 量 〈製法〉 常法によりヘアクリームを得た。0.1 Remaining amount Example 5 Hair cream Beeswax vaseline liquid paraffin Polyoxyethylene (5 moles) Stearic acid ester Polyoxyethylene (6 moles) oleyl alcohol ether Polyoxyethylene (6 moles) cetyl alcohol ether tranexamic acid elastin purified water fragrance Preservative weight% 3.0 15.0 42.0 3.0 2.0 1.0 7.0 5.0 The rest amount amount <Manufacturing method> A hair cream was obtained by a conventional method.
実施例４〜５はいずれも皮膚の新陳代謝を活発にし、皮
膚の粘弾力を増し、皮膚の保護と水分の保持性に優れ、
適度なうるおい、肌のハリを与えさらに、美白効果にも
優れていた。Examples 4 and 5 all activate skin metabolism, increase skin elasticity, and have excellent skin protection and moisture retention.
It provided just the right amount of moisture and firmness to the skin, and also had an excellent whitening effect.
Claims (1)
または二種以上と、トラネキサム酸、もしくはその塩類
、もしくはその誘導体、またはこれらの混合物とを配合
することを特徴とする皮膚外用剤。(1) An external preparation for skin, comprising one or more selected from the group consisting of proteins and protein decomposition products, and tranexamic acid, salts thereof, derivatives thereof, or mixtures thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2079654A JP2620770B2 (en) | 1990-03-28 | 1990-03-28 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2079654A JP2620770B2 (en) | 1990-03-28 | 1990-03-28 | External preparation for skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03279315A true JPH03279315A (en) | 1991-12-10 |
| JP2620770B2 JP2620770B2 (en) | 1997-06-18 |
Family
ID=13696124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2079654A Expired - Lifetime JP2620770B2 (en) | 1990-03-28 | 1990-03-28 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2620770B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000143477A (en) * | 1998-11-02 | 2000-05-23 | Kao Corp | Pack cosmetic |
| JP2000256163A (en) * | 1999-03-05 | 2000-09-19 | Shiseido Co Ltd | Skin lotion |
| JP2002003358A (en) * | 2000-06-23 | 2002-01-09 | Shiseido Co Ltd | Skin care preparation |
| JP2015034155A (en) * | 2013-08-09 | 2015-02-19 | 丸善製薬株式会社 | Epidermal keratinocyte proliferation promoter, and atp production promoter |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54163828A (en) * | 1978-06-14 | 1979-12-26 | Nippi Inc | Cosmotic composition |
| JPS6092205A (en) * | 1983-10-26 | 1985-05-23 | Kanebo Ltd | Emulsified cosmetic |
| JPS62185100A (en) * | 1986-02-10 | 1987-08-13 | Ichimaru Fuarukosu Kk | Casein for compounding to cosmetic and cosmetic containing same |
-
1990
- 1990-03-28 JP JP2079654A patent/JP2620770B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54163828A (en) * | 1978-06-14 | 1979-12-26 | Nippi Inc | Cosmotic composition |
| JPS6092205A (en) * | 1983-10-26 | 1985-05-23 | Kanebo Ltd | Emulsified cosmetic |
| JPS62185100A (en) * | 1986-02-10 | 1987-08-13 | Ichimaru Fuarukosu Kk | Casein for compounding to cosmetic and cosmetic containing same |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000143477A (en) * | 1998-11-02 | 2000-05-23 | Kao Corp | Pack cosmetic |
| JP2000256163A (en) * | 1999-03-05 | 2000-09-19 | Shiseido Co Ltd | Skin lotion |
| JP2002003358A (en) * | 2000-06-23 | 2002-01-09 | Shiseido Co Ltd | Skin care preparation |
| JP2015034155A (en) * | 2013-08-09 | 2015-02-19 | 丸善製薬株式会社 | Epidermal keratinocyte proliferation promoter, and atp production promoter |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2620770B2 (en) | 1997-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6099849A (en) | Skin care moisturizers and cleansers | |
| US6579516B1 (en) | Methods of delivering materials into the skin, and compositions used therein | |
| JP3803030B2 (en) | Topical composition containing whey protein | |
| JPH0552806B2 (en) | ||
| JP2000169321A (en) | Cell activation agent and preparation for external use for skin and skin cleaning agent containing the activation agent | |
| JPH0375523B2 (en) | ||
| JPS59134706A (en) | Cosmetic | |
| US5637304A (en) | Cosmetical or pharmaceutical compositions comprising deacylated glycerophospholipids for topical use | |
| JPH0859450A (en) | External preparation for skin | |
| JPH0665049A (en) | External preparation for skin | |
| JP2004051521A (en) | Cosmetic containing dry cosmetic ingredient in nonwoven fabric | |
| JP2004075562A (en) | External preparation for skin | |
| JPH11139951A (en) | Cosmetic | |
| EP0204586A2 (en) | Stabilizer for hair compositions and such compositions | |
| JPH0532556A (en) | Skin agent for external use | |
| JPH03279315A (en) | External preparation of skin | |
| NZ199153A (en) | Cosmetic moisturiser composition | |
| JP3784442B2 (en) | Topical skin preparation | |
| JPH069422A (en) | Promoter for biosynthesis of hyaluronic acid | |
| KR20010018805A (en) | Cosmetic compositions for anti-inflammation and anti-irritation containing ponciri fructus extracts as effective ingredients | |
| JPH06279294A (en) | Collagen synthesis promoter | |
| JPH11302147A (en) | Cosmetic | |
| JPH09176030A (en) | Medicine for stimulating secretion of sebum | |
| CA2959542A1 (en) | Compositions and methods for mitigating skin irritation | |
| JPH08198741A (en) | Biological hyarulonic acid synthesis promoter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090404 Year of fee payment: 12 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100404 Year of fee payment: 13 |
|
| EXPY | Cancellation because of completion of term |