JPH04500156A - 活性型ヒト好中球走化因子ポリペプチドの製造方法 - Google Patents
活性型ヒト好中球走化因子ポリペプチドの製造方法Info
- Publication number
- JPH04500156A JPH04500156A JP1509164A JP50916489A JPH04500156A JP H04500156 A JPH04500156 A JP H04500156A JP 1509164 A JP1509164 A JP 1509164A JP 50916489 A JP50916489 A JP 50916489A JP H04500156 A JPH04500156 A JP H04500156A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- ncf
- human
- dna
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5421—IL-8
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (3)
- 1.該ポリペプチド生産用発現ベクターを有する宿主を培養し、その形質転換体 破砕液から得られる沈澱画分を尿素又はグアニジン塩酸処理することを特徴とす る活性型ヒト好中球走化因子ポリペプチドの製造方法。
- 2.活性型ヒト好中球走化因子が下記式で表されるアミノ酸配列からなるポリペ プチドである請求の範囲第1項に記載の該ポリペプチドの製造方法。 【配列があります】
- 3.宿主が大腸菌である請求の範囲第1項に記載の該ポリペプチドの製造方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23774188A | 1988-08-29 | 1988-08-29 | |
US237,741 | 1988-08-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH04500156A true JPH04500156A (ja) | 1992-01-16 |
JP3053631B2 JP3053631B2 (ja) | 2000-06-19 |
Family
ID=22894964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1509164A Expired - Lifetime JP3053631B2 (ja) | 1988-08-29 | 1989-08-29 | 活性型ヒト好中球走化因子ポリペプチドの製造方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5401643A (ja) |
EP (1) | EP0431042B1 (ja) |
JP (1) | JP3053631B2 (ja) |
KR (1) | KR100197110B1 (ja) |
AT (1) | ATE113312T1 (ja) |
DE (1) | DE68919085T2 (ja) |
WO (1) | WO1990002178A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652338A (en) | 1988-03-16 | 1997-07-29 | The United States Of America As Represented By The Department Of Health And Human Services | Neutrophil chemotactic factor |
WO2004058797A2 (en) | 2002-12-16 | 2004-07-15 | Medarex, Inc. | Human monoclonal antibodies against interleukin 8 (il-8) |
EP1938220A4 (en) * | 2005-09-26 | 2013-11-20 | Coupons Inc | SYSTEM AND METHOD FOR COMPLETING THE CONTENT OF ELECTRONIC DOCUMENTS WITH LINKS TO INFORMATION PRESENTING A CONTEXTUAL INTEREST |
KR20200108868A (ko) | 2018-01-12 | 2020-09-21 | 브리스톨-마이어스 스큅 컴퍼니 | 암을 치료하기 위한 항-il-8 항체 및 항-pd-1 항체와의 조합 요법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4897348A (en) * | 1983-08-25 | 1990-01-30 | Sri International | Recombinant materials and methods for producing human connective tissue-activating peptide-III and analogs thereof |
GB2223225B (en) * | 1987-11-19 | 1992-07-08 | Sandoz Ltd | Neutrophil-activating factor: its production and use in treatment |
US5026639A (en) * | 1988-01-14 | 1991-06-25 | Nippon Mining Company, Limited | Method to improve mRNA translation and use thereof for production of platelet factor-4 |
-
1989
- 1989-08-29 AT AT89909925T patent/ATE113312T1/de not_active IP Right Cessation
- 1989-08-29 KR KR1019900700891A patent/KR100197110B1/ko not_active IP Right Cessation
- 1989-08-29 JP JP1509164A patent/JP3053631B2/ja not_active Expired - Lifetime
- 1989-08-29 DE DE68919085T patent/DE68919085T2/de not_active Expired - Lifetime
- 1989-08-29 WO PCT/US1989/003728 patent/WO1990002178A1/en active IP Right Grant
- 1989-08-29 EP EP89909925A patent/EP0431042B1/en not_active Expired - Lifetime
-
1992
- 1992-03-23 US US07/855,471 patent/US5401643A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1990002178A1 (en) | 1990-03-08 |
EP0431042A4 (en) | 1992-03-11 |
EP0431042B1 (en) | 1994-10-26 |
ATE113312T1 (de) | 1994-11-15 |
JP3053631B2 (ja) | 2000-06-19 |
KR900702031A (ko) | 1990-12-05 |
EP0431042A1 (en) | 1991-06-12 |
DE68919085D1 (de) | 1994-12-01 |
US5401643A (en) | 1995-03-28 |
DE68919085T2 (de) | 1995-04-06 |
KR100197110B1 (ko) | 1999-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0335243B1 (en) | Mutant human angiogenin (angiogenesis factor with superior angiogenin activity) genes therefor and methods of expression | |
DE3750056T2 (de) | Polypeptid-Mutanten des menschlichen TNF und für diese Mutanten codierende DNS. | |
JP3043764B2 (ja) | ミニ‐プロインシュリン、その製造および使用 | |
JPH0687778B2 (ja) | ヒト抗トロンビン▲iii▼ | |
JPS62275695A (ja) | 成熟型ヒト血清アルブミンの製造方法 | |
JP2002504494A (ja) | マウス及びヒトエンドスタチンの生産方法 | |
JPS62501679A (ja) | リポコルチンをコードするdna分子および形質転換宿主 | |
JPH04500156A (ja) | 活性型ヒト好中球走化因子ポリペプチドの製造方法 | |
JPS6361960B2 (ja) | ||
JPS6030687A (ja) | Dνa遺伝子,その製造法およびそれを含むプラスミド | |
AU612865B2 (en) | A modified human psti | |
JPH03505037A (ja) | ヒト好中球走化因子ポリペプチドの製造方法 | |
JPS6156078A (ja) | 酵母を宿主とする分泌発現ベクタ− | |
JPS6034915A (ja) | ポリペプチド | |
JP2829397B2 (ja) | フィブリン結合活性ポリペプチド | |
JP2698976B2 (ja) | 新規ポリペプチド及びそれをコードするdna | |
JPH04182498A (ja) | ポリペプチド | |
WO2003008594A1 (en) | Construction of the plasmid for expressing the thrombus-targeting thrombolytic fusion protein | |
JP2616784B2 (ja) | ヒトインターロイキン1ポリペプチド生産用高度形質発現プラスミド | |
JPH03133381A (ja) | 血小板ファクター4の発現ベクター、血小板ファクター4融合蛋白、形質転換微生物及び血小板ファクター4の製造法 | |
JPS6291198A (ja) | 抗腫瘍作用を有するポリペプチド | |
JP2893112B2 (ja) | ヒト単球走化性因子活性を有するポリペプチド及びそれをコードするdna | |
JPH029899A (ja) | 新規ポリペプチド及びそれをコードするdna並びにそれらの製法 | |
JPH02273179A (ja) | 新規な血栓溶解蛋白質,その製造法および該蛋白質からなる医薬 | |
JPS6119488A (ja) | 大腸菌を用いたマウスβ型インタ−フエロンの生産方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090407 Year of fee payment: 9 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090407 Year of fee payment: 9 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100407 Year of fee payment: 10 |
|
EXPY | Cancellation because of completion of term | ||
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100407 Year of fee payment: 10 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100407 Year of fee payment: 10 |