JPH044299B2 - - Google Patents

Info

Publication number: JPH044299B2
Authority: JP; Japan
Prior art keywords: fatty acid; ester; oil; monoester; vitamin
Prior art date: 1982-05-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP57091466A

Other languages

English (en)

Japanese (ja)

Other versions

JPS58208215A (ja

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-31

Filing date

1982-05-31

Publication date

1992-01-27

1982-05-31 Application filed filed Critical

1982-05-31 Priority to JP57091466A priority Critical patent/JPS58208215A/ja

1983-03-18 Priority to GB08307543A priority patent/GB2120935B/en

1983-03-22 Priority to SE8301565A priority patent/SE461892B/sv

1983-03-25 Priority to CH1664/83A priority patent/CH656531A5/de

1983-03-25 Priority to DE3311008A priority patent/DE3311008C2/de

1983-03-30 Priority to FR8305239A priority patent/FR2527440B1/fr

1983-12-03 Publication of JPS58208215A publication Critical patent/JPS58208215A/ja

1992-01-27 Publication of JPH044299B2 publication Critical patent/JPH044299B2/ja

Status Granted legal-status Critical Current

Links

-1 fatty acid ester Chemical class 0.000 claims description 55
235000014113 dietary fatty acids Nutrition 0.000 claims description 36
229930195729 fatty acid Natural products 0.000 claims description 36
239000000194 fatty acid Substances 0.000 claims description 36
239000000203 mixture Substances 0.000 claims description 31
229930003231 vitamin Natural products 0.000 claims description 23
235000013343 vitamin Nutrition 0.000 claims description 23
239000011782 vitamin Substances 0.000 claims description 23
229940088594 vitamin Drugs 0.000 claims description 23
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 13
150000004665 fatty acids Chemical class 0.000 claims description 12
150000005691 triesters Chemical class 0.000 claims description 10
238000002156 mixing Methods 0.000 claims description 9
150000005690 diesters Chemical class 0.000 claims description 8
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 6
235000011187 glycerol Nutrition 0.000 claims description 6
239000002904 solvent Substances 0.000 claims description 6
229920001214 Polysorbate 60 Polymers 0.000 claims description 5
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 2
150000002148 esters Chemical class 0.000 claims description 2
MJNIWUJSIGSWKK-BBANNHEPSA-N Riboflavin butyrate Chemical compound CCCC(=O)OC[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)CN1C2=CC(C)=C(C)C=C2N=C2C1=NC(=O)NC2=O MJNIWUJSIGSWKK-BBANNHEPSA-N 0.000 claims 1
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 17
235000015112 vegetable and seed oil Nutrition 0.000 description 13
239000008158 vegetable oil Substances 0.000 description 13
FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 11
239000003921 oil Substances 0.000 description 10
235000019198 oils Nutrition 0.000 description 10
229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
230000000052 comparative effect Effects 0.000 description 6
229950004959 sorbitan oleate Drugs 0.000 description 6
235000019484 Rapeseed oil Nutrition 0.000 description 4
239000010497 wheat germ oil Substances 0.000 description 4
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
239000005642 Oleic acid Substances 0.000 description 3
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
229930003427 Vitamin E Natural products 0.000 description 3
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
238000005259 measurement Methods 0.000 description 3
239000000843 powder Substances 0.000 description 3
229950006451 sorbitan laurate Drugs 0.000 description 3
235000011067 sorbitan monolaureate Nutrition 0.000 description 3
235000019155 vitamin A Nutrition 0.000 description 3
239000011719 vitamin A Substances 0.000 description 3
235000019165 vitamin E Nutrition 0.000 description 3
229940046009 vitamin E Drugs 0.000 description 3
239000011709 vitamin E Substances 0.000 description 3
229940045997 vitamin a Drugs 0.000 description 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
150000001656 butanoic acid esters Chemical class 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
235000012424 soybean oil Nutrition 0.000 description 2
239000003549 soybean oil Substances 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
235000019871 vegetable fat Nutrition 0.000 description 2
150000003722 vitamin derivatives Chemical class 0.000 description 2
241000345998 Calamus manan Species 0.000 description 1
108010023302 HDL Cholesterol Proteins 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
229930003316 Vitamin D Natural products 0.000 description 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
238000013329 compounding Methods 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
125000005313 fatty acid group Chemical group 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000007902 hard capsule Substances 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
235000012950 rattan cane Nutrition 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
229950011392 sorbitan stearate Drugs 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Nutrition Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP57091466A 1982-05-31 1982-05-31 脂溶性ビタミン配合油溶組成物 Granted JPS58208215A (ja)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
JP57091466A JPS58208215A (ja)	1982-05-31	1982-05-31	脂溶性ビタミン配合油溶組成物
GB08307543A GB2120935B (en)	1982-05-31	1983-03-18	Fat-soluble vitamin preparation
SE8301565A SE461892B (sv)	1982-05-31	1983-03-22	Oljeloeslig komposition av vitamin b -butyrat
CH1664/83A CH656531A5 (de)	1982-05-31	1983-03-25	Praeparat von fettloeslichem vitamin in oel.
DE3311008A DE3311008C2 (de)	1982-05-31	1983-03-25	Öllösliche Zubereitung, die ein fettlösliches Vitamin enthält
FR8305239A FR2527440B1 (fr)	1982-05-31	1983-03-30	Composition oleosoluble contenant une vitamine soluble dans les matieres grasses

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP57091466A JPS58208215A (ja)	1982-05-31	1982-05-31	脂溶性ビタミン配合油溶組成物

Publications (2)

Publication Number	Publication Date
JPS58208215A JPS58208215A (ja)	1983-12-03
JPH044299B2 true JPH044299B2 (de)	1992-01-27

Family

ID=14027151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57091466A Granted JPS58208215A (ja)	1982-05-31	1982-05-31	脂溶性ビタミン配合油溶組成物

Country Status (6)

Country	Link
JP (1)	JPS58208215A (de)
CH (1)	CH656531A5 (de)
DE (1)	DE3311008C2 (de)
FR (1)	FR2527440B1 (de)
GB (1)	GB2120935B (de)
SE (1)	SE461892B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639724A (en)	1984-07-24	1997-06-17	Sandoz Ltd.	Cyclosporin galenic forms
JPS63130535A (ja) *	1986-11-19	1988-06-02	Nisshin Kagaku Kk	経口投与用抗ヒスタミン剤
US7081445B2 (en)	1989-02-20	2006-07-25	Novartis Ag	Cyclosporin galenic forms
GB9325445D0 (en)	1993-12-13	1994-02-16	Cortecs Ltd	Pharmaceutical formulations
GB2335854B (en)	1997-01-30	2001-04-25	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR8014M (de) *	1968-01-09	1970-07-27
US3962436A (en) *	1969-06-03	1976-06-08	Sumitomo Chemical Company, Limited	Pharmaceutical compositions having controlled rate of gastro-intestinal absorption
NL7012460A (de) *	1970-08-22	1972-02-24
US3932634A (en) *	1973-06-28	1976-01-13	Pfizer Inc.	High potency vitamin water dispersible formulations

1982
- 1982-05-31 JP JP57091466A patent/JPS58208215A/ja active Granted
1983
- 1983-03-18 GB GB08307543A patent/GB2120935B/en not_active Expired
- 1983-03-22 SE SE8301565A patent/SE461892B/sv not_active IP Right Cessation
- 1983-03-25 CH CH1664/83A patent/CH656531A5/de not_active IP Right Cessation
- 1983-03-25 DE DE3311008A patent/DE3311008C2/de not_active Expired
- 1983-03-30 FR FR8305239A patent/FR2527440B1/fr not_active Expired

Also Published As

Publication number	Publication date
SE8301565L (sv)	1983-12-01
SE8301565D0 (sv)	1983-03-22
GB8307543D0 (en)	1983-04-27
DE3311008C2 (de)	1986-04-10
JPS58208215A (ja)	1983-12-03
CH656531A5 (de)	1986-07-15
GB2120935B (en)	1985-10-23
FR2527440A1 (fr)	1983-12-02
FR2527440B1 (fr)	1987-05-15
SE461892B (sv)	1990-04-09
DE3311008A1 (de)	1983-12-01
GB2120935A (en)	1983-12-14

Publication	Publication Date	Title
DE68914856T3 (de)	2001-03-08	Synergetische Antioxydationsmischung.
EP0229652B1 (de)	1991-10-30	Stabilisiertes Tocopherol in trockenener freifliessender Partikelform
DE69201216T2 (de)	1995-05-18	Öllösliche Antioxydationsmischung.
US3932634A (en)	1976-01-13	High potency vitamin water dispersible formulations
EP2337834B1 (de)	2012-07-25	Antioxidationszusammensetzung für meeressöle mit tocopherol, rosmarinextrakt, ascorbinsäure und extrakt aus grünem tee
JPS603044B2 (ja)	1985-01-25	ビタミン剤
US5258179A (en)	1993-11-02	Protection of a food, cosmetic or pharmaceutical product against oxidation
CA1209922A (en)	1986-08-19	Emulsion-type composition for external use
JPH044299B2 (de)	1992-01-27
DE69024321T2 (de)	1996-05-15	Oxydationsschutz eines Nahrungsmittels, eines kosmetischen Produktes oder eines pharmazeutischen Produktes
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