JPH039757A - Preparation of tablet - Google Patents
Preparation of tabletInfo
- Publication number
- JPH039757A JPH039757A JP14578089A JP14578089A JPH039757A JP H039757 A JPH039757 A JP H039757A JP 14578089 A JP14578089 A JP 14578089A JP 14578089 A JP14578089 A JP 14578089A JP H039757 A JPH039757 A JP H039757A
- Authority
- JP
- Japan
- Prior art keywords
- mortar
- lubricant
- peripheral surface
- lower pestle
- lower punch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000314 lubricant Substances 0.000 claims abstract description 52
- 239000004570 mortar (masonry) Substances 0.000 claims abstract description 33
- 230000002093 peripheral effect Effects 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000002994 raw material Substances 0.000 claims description 8
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 12
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000003595 mist Substances 0.000 abstract 1
- 238000007906 compression Methods 0.000 description 8
- 230000006835 compression Effects 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 238000000748 compression moulding Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- -1 sucrose fatty acid Ester Chemical class 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000004663 powder metallurgy Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0005—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses
- B30B15/0011—Details of, or accessories for, presses; Auxiliary measures in connection with pressing for briquetting presses lubricating means
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Glanulating (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は医薬品、医薬部外品、化粧品、農薬、飼料、食
品、粉末冶金業等における錠剤の製造方法に関するもの
である。詳しくは、打錠成型時における下杵と臼との間
の摩擦を著しく小さくすることができる錠剤製造法に関
する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a method for producing tablets in pharmaceuticals, quasi-drugs, cosmetics, agricultural chemicals, feeds, foods, powder metallurgy, and the like. Specifically, the present invention relates to a tablet manufacturing method that can significantly reduce the friction between the lower punch and the die during tablet compression.
［従来の技術］
貫通する内孔を有する臼と、該臼に嵌合する上杵及び下
杵とを有する打錠機を用い、該内孔内部において上杵と
下杵との間で原料を圧縮して錠剤を成型する錠剤製造法
は、従来より広く用いられている（例えば特公昭４１−
１１２７３号、同４７−３１８２７号、同４８−２０１
０３号など）。[Prior Art] A tabletting machine having a die having a penetrating inner hole, and an upper punch and a lower punch that fit into the die is used, and raw materials are compressed between the upper and lower punches inside the inner hole. The tablet manufacturing method of forming tablets by compression has been widely used (for example,
No. 11273, No. 47-31827, No. 48-201
03 etc.).
ところで、打錠機を用いて錠剤を製造する場合、原料粉
末は一般に微細な粉末であり、その表面活性が高く、ス
ティッキング・パインディング等の障害が発生し易い。By the way, when manufacturing tablets using a tablet press, the raw material powder is generally a fine powder and has a high surface activity, which tends to cause problems such as sticking and binding.
特に下杵と臼との間に微細な粉末が入り込んで摩擦が大
きくなり、下杵の動きが悪く（キシミ）なる。この結果
、下杵の損傷が起こり、安定した連続打錠が不可能にな
る。In particular, fine powder gets trapped between the lower pestle and the mortar, increasing friction and causing the lower pestle to move poorly (squeak). As a result, damage to the lower punch occurs, making stable continuous tableting impossible.
そこで、日内壁面あるいは上下柱面との間の摩擦を減少
させ、スティッキング・パインディング等の障害を除去
する目的で、滑沢剤（タルク、ステアリン酸、ステアリ
ン酸マグネシウム、水素添加植物油、ショ糖脂肪酸エス
テル等）を予め粉体に混合し、しかる後に圧縮成型する
ことが行なわれている。Therefore, in order to reduce the friction between the inner wall surface or the upper and lower columnar surfaces and remove obstacles such as sticking and binding, lubricants (talc, stearic acid, magnesium stearate, hydrogenated vegetable oil, sucrose fatty acid Ester, etc.) are mixed into powder in advance and then compression molded.
また、特公昭４１−１１２７３号には、下杵が臼の最下
部に位置する状態において滑沢剤を上杵、下杵の粉体接
触面及び白の内面に噴射した後粉体を日内に充填して圧
縮成型することが示されている。In addition, in Japanese Patent Publication No. 41-11273, with the lower punch located at the lowest part of the mortar, a lubricant is sprayed onto the powder contact surfaces of the upper and lower punches and the inner surface of the white, and then the powder is removed within a day. Filling and compression molding is indicated.
特公昭４７−３１８２７号には、固体潤滑剤粒子を圧縮
成型機の押型に導入し、上記捌滑剤を上記押型中で圧縮
し、押型の壁に残る潤滑剤の膜以外は上記押型から潤滑
剤を除去し、上記押型に加工物質を導入し、加工物質を
成型する方法が記載されている。Japanese Patent Publication No. 47-31827 discloses that solid lubricant particles are introduced into a mold of a compression molding machine, the lubricant is compressed in the mold, and the lubricant is removed from the mold except for the lubricant film remaining on the wall of the mold. A method is described in which the material is removed, a processed material is introduced into the mold, and the processed material is molded.
特公昭４８−２０１０３号には、滑沢剤の微粉を粉体の
まま上杵、下杵の粉体接触部及び日内面に吹き付けた後
、日内に圧縮成型すべき粉体を充填する連続圧縮成型法
が記載されている。Japanese Patent Publication No. 48-20103 describes a continuous compression method in which fine powder of a lubricant is sprayed as a powder onto the powder-contacting parts of the upper and lower punches and on the inside surface of the punch, and then filled with powder to be compression-molded within the same day. The molding method is described.
［発明が解決しようとする課題］
原料粉体中に滑沢剤を混合する方法にあっては、杵と臼
との間の摩擦を十分に小さくするためには、一般に相当
に多量の滑沢剤を必要とする。[Problems to be Solved by the Invention] In the method of mixing a lubricant into raw material powder, in order to sufficiently reduce the friction between the punch and the die, a considerably large amount of lubricant is generally used. Requires agent.
また、圧縮する粉体の粒度分布や粉体に含まれる水分に
よっては滑沢剤の量を調整する必要がある。しかし、こ
の際滑沢剤が過多になると、圧縮成型物の強度が低下し
たり、錠剤の崩壊性が著しく悪くなる場合が多い。Further, it is necessary to adjust the amount of lubricant depending on the particle size distribution of the powder to be compressed and the moisture contained in the powder. However, when the lubricant is used in an excessive amount, the strength of the compression molded product often decreases and the disintegration properties of the tablet deteriorate significantly.
特公昭４１−１１２７３号、同４７
３１８２７号及び同４８−２０１０３号に記載の方法で
は、臼の内孔表面のうち下杵との摺動画や下杵の側周面
に付着する滑沢剤の量が一定せず、得られた錠剤の物性
（例えば崩壊性）が個々に異なるという欠点があった。In the methods described in Japanese Patent Publications No. 41-11273, No. 47-31827, and No. 48-20103, the lubricant adhering to the sliding part of the inner hole surface of the mortar with the lower punch and the side surface of the lower punch is removed. There were disadvantages in that the amount was not constant and the physical properties (for example, disintegration properties) of the obtained tablets were different.
特に医薬品錠剤の場合にあっては、その崩壊性が個々に
異なることは、期待する効能・効果が十分に発揮できな
いことを意味しており、治療効果の点で好ましいもので
はない。Particularly in the case of pharmaceutical tablets, the fact that their disintegration properties differ from one another means that the expected efficacy and effect cannot be fully exerted, which is not desirable in terms of therapeutic effects.
本発明は、上記従来の問題点を解決し、下杵の損傷を起
こさず、既設の打錠機をそのまま使用して安定した錠剤
製造を可能とする方法を提供することを目的とするもの
である。The purpose of the present invention is to solve the above-mentioned conventional problems and provide a method that enables stable tablet production without damaging the lower punch and using an existing tablet press as is. be.
［課題を解決するための手段及び作用］本発明は、貫通
する内孔を有する白と、該臼に嵌合する上杵及び下杵と
を有する打錠機を用い、該内孔内部において上杵と下杵
との間で原料を圧縮して錠剤を成型する錠剤製造法にお
いて、下杵の先端以外の部分において下杵と臼内周面と
の間に間隙を形成しておき、粉末状滑沢剤を粉末のまま
下杵と臼内周面との間に、空気もしくは窒素等の不活性
気体による噴射法などにより供給することにより、下杵
と臼との間の摩擦を減することを特徴とするものである
。[Means and effects for solving the problems] The present invention uses a tabletting machine having a penetrating inner hole, and an upper punch and a lower punch that fit into the die, In a tablet manufacturing method in which a tablet is formed by compressing the raw material between a punch and a lower punch, a gap is formed between the lower punch and the inner peripheral surface of the mortar at a portion other than the tip of the lower punch, To reduce the friction between the lower punch and the mortar by supplying a powdered lubricant between the lower punch and the inner peripheral surface of the mortar by spraying air or an inert gas such as nitrogen. It is characterized by:
かかる本発明方法によると、臼内周面と下杵外周面との
間に所要量の滑沢剤が均一に供給されるようになり、下
杵がきわめて円滑に上下動し得るようになる。According to the method of the present invention, the required amount of lubricant is uniformly supplied between the inner peripheral surface of the mortar and the outer peripheral surface of the lower punch, and the lower punch can move up and down extremely smoothly.
なお、本発明において滑沢剤としては、タルク、ステア
リン酸、ステアリン酸マグネシウム、水素添加植物油、
ショ糖脂肪酸エステルなど各種のものを用い得る。In the present invention, lubricants include talc, stearic acid, magnesium stearate, hydrogenated vegetable oil,
Various types such as sucrose fatty acid ester can be used.
以下に図面を参照して本発明の詳細な説明するが、これ
によって錠剤を構成する成分の種類、錠剤の形状、滑沢
剤の種類、供給量、供給方法、並びに打錠機等が限定さ
れるわけではない。The present invention will be described in detail below with reference to the drawings, but this will limit the types of ingredients constituting the tablet, the shape of the tablet, the type of lubricant, the amount of supply, the method of supply, the tablet press, etc. It's not like that.
第１図はロータリー打錠機を用いて本発明を実施してい
る状態を示す概略的な縦断面図である。FIG. 1 is a schematic longitudinal cross-sectional view showing the state in which the present invention is implemented using a rotary tablet press.
第１図において、ロータリー打錠機の回転盤！に臼２が
装着されている。この臼２の内孔２ａに上下動自在に下
杵４が嵌挿されている。符号３は下杵４のガイド装置を
示す。In Figure 1, the turntable of a rotary tablet press! Mortar 2 is attached to. A lower punch 4 is fitted into the inner hole 2a of this mortar 2 so as to be movable up and down. Reference numeral 3 indicates a guide device for the lower punch 4.
下杵４のうち日内孔２ａに挿入される部分は、その先端
部４ａを除き、日内孔２ａよりも所要程度小径となって
おり、臼内周面と下杵外周面との間に間隙Ａが形成され
ている。なお、先端部４ａは日内孔２ａの内径よりもご
くわずか（例えば１０〜２０μｍ程度）小径となってお
り、下杵４は日内孔２ａと滑らかに摺動し、しかも間隙
Ａに供給された滑沢剤が製品錠剤に混入しないよう構成
されている。The portion of the lower punch 4 that is inserted into the inner hole 2a, except for its tip 4a, has a diameter smaller than that of the inner hole 2a by a required degree, and there is a gap A between the inner peripheral surface of the mortar and the outer peripheral surface of the lower punch. is formed. Note that the tip portion 4a has a diameter slightly smaller (for example, about 10 to 20 μm) than the inner diameter of the inner diameter hole 2a, so that the lower punch 4 slides smoothly on the inner diameter hole 2a, and moreover, the lower punch 4 can slide smoothly on the inner diameter of the inner diameter hole 2a. It is designed to prevent the thickening agent from contaminating the product tablet.
この間隙Ａに滑沢剤を噴霧状に供給するためにバイブ５
が配設されている。なお、前記回転盤１の下杵通過孔１
ａは下向に向って次第に拡径するテーバ孔となっており
、バイブ５から噴出された滑沢剤が前記間１５Ｉ Ａ内
に供給され易くなるよう構成されている。A vibrator 5 is used to supply the lubricant in the form of a spray to this gap A.
is installed. In addition, the lower punch passage hole 1 of the rotary disk 1
A is a tapered hole whose diameter gradually increases downward, and is configured so that the lubricant ejected from the vibrator 5 can be easily supplied into the gap 15IA.
バイブ５の後端は滑沢剤Ｓの容器６の上部に接続されて
いる。該容器６内には空気供給管７が差し込まれており
、バルブ８及び流量計９を介して圧縮空気が容器６内の
下部に導入可能とされている。容器６はバイブレータ１
０により加振可能に設置されている。The rear end of the vibrator 5 is connected to the upper part of the lubricant S container 6. An air supply pipe 7 is inserted into the container 6, and compressed air can be introduced into the lower part of the container 6 via a valve 8 and a flow meter 9. Container 6 is vibrator 1
It is installed so that it can be vibrated by 0.
なお、ロータリー打錠機には、過剰な滑沢剤を吸引排出
するために、吸引ダクト１１が接続されたカバーケース
１２が設けられている。Note that the rotary tablet press is provided with a cover case 12 to which a suction duct 11 is connected in order to suction and discharge excess lubricant.
このように構成された第１図の装置による錠剤の製造方
法を次に説明する。A method for manufacturing tablets using the apparatus shown in FIG. 1 constructed as described above will now be described.
臼２が装着された回転盤１は、上杵（図示路）及び杵４
と共に駆動装置（図示路）により鉛直軸心回りに回転さ
れる。The rotary disk 1 on which the mortar 2 is attached has an upper punch (path shown) and a punch 4.
At the same time, it is rotated around the vertical axis by a drive device (path shown).
バイブ５から滑沢剤が間ｆＩＭ Ａに向って連続的に噴
出され、滑沢剤が臼２の内孔２ａの内周面と下杵４の外
周面とに均一に付着される。下杵４の下降に伴なって、
余剰な滑沢剤は下杵４の先端部分４ａによってかき落と
され、滑沢剤が臼２の内周面と下杵４の外周面とに少量
だけ均一に付着、残留した状態となる。この付着残留し
た滑沢剤は、下杵先端部分４ａの外周面と口内孔２ａの
内周面との間に介在するようになり、下杵４がぎわめて
円滑に内孔２ａ内を上下動するようになる。The lubricant is continuously ejected from the vibrator 5 toward the center fIM A, and the lubricant is uniformly adhered to the inner circumferential surface of the inner hole 2a of the mortar 2 and the outer circumferential surface of the lower punch 4. As the lower pestle 4 descends,
The excess lubricant is scraped off by the tip portion 4a of the lower punch 4, and a small amount of the lubricant uniformly adheres to and remains on the inner peripheral surface of the mortar 2 and the outer peripheral surface of the lower punch 4. This residual lubricant is interposed between the outer peripheral surface of the lower punch tip portion 4a and the inner peripheral surface of the inner hole 2a, and the lower punch 4 can move up and down inside the inner hole 2a very smoothly. Begins to move.
下杵４が下勅限まで下降された後、臼２の内孔２ａ内に
錠剤化される原料粉末Ｐが供給される。After the lower punch 4 is lowered to the lower limit, the raw material powder P to be tabletted is supplied into the inner hole 2a of the mortar 2.
その後、内孔２ａ内に上杵（図示路）が上方から嵌挿さ
れ、上杵と下杵４との間で原料粉末を強力に圧縮して錠
剤化する。Thereafter, an upper punch (path shown) is inserted into the inner hole 2a from above, and the raw material powder is strongly compressed between the upper punch and the lower punch 4 to form a tablet.
その後、上杵が臼から抜き出されると共に、下杵４が上
昇し、錠剤を回転盤１の上面から突出するように押し上
げる。そして、錠剤が下杵４から回転盤１の上に移され
、さらに回転盤１の側方のシュート（図示路）に落とし
込まれて収集される。Thereafter, the upper punch is pulled out from the mortar, and the lower punch 4 is raised to push up the tablet so that it protrudes from the upper surface of the rotary disk 1. The tablets are then transferred from the lower punch 4 onto the rotary disk 1, further dropped into a chute (path shown) on the side of the rotary disk 1, and collected.
上記工程を繰り返すことにより、錠剤が連続的に製造さ
れる。By repeating the above steps, tablets are continuously manufactured.
上記工程において、滑沢剤の噴出を行なうためにはバル
ブ８を開放し、容器６内に圧縮空気を導入する。この空
気は容器６内を上昇し、滑沢剤Ｓの粉末を伴なってバイ
ブ５から流出し、これによって滑沢剤がバイブ５から噴
出される。この噴出量は、バルブ８の開度を調節するこ
とにより制御できる。In the above process, in order to spray out the lubricant, the valve 8 is opened and compressed air is introduced into the container 6. This air rises within the container 6 and flows out of the vibrator 5 together with the lubricant S powder, whereby the lubricant is jetted out from the vibrator 5. This amount of ejection can be controlled by adjusting the opening degree of the valve 8.
この噴出時に回転盤１の下方に飛散した滑沢剤や、下杵
４の下動時にかき落とされた滑沢剤はダクト１１を介し
て排出され、必要に応じ捕集され、再利用される。The lubricant scattered below the rotary disk 1 during this spouting and the lubricant scraped off when the lower punch 4 moves downward are discharged through the duct 11, collected as necessary, and reused. .
なお、本発明においては、バイブ５から滑沢剤を間欠的
に噴出させるようにしても良い。In the present invention, the lubricant may be intermittently jetted from the vibrator 5.
また、第１図ではバイブ５が１本のみ示されているが、
複数本設置し、同一の内孔に向って２以上のバイブから
滑沢剤を供給するようにしても良い。なお、バイブ５を
複数本に分岐させるようにしても良い。In addition, although only one vibrator 5 is shown in FIG. 1,
A plurality of vibrators may be installed, and the lubricant may be supplied from two or more vibrators toward the same inner hole. Note that the vibrator 5 may be branched into a plurality of parts.
前記バイブレータ１０は常時又は間欠的（定期的、不定
期的のいずれであっても良い。）に作動され、容器６内
の空気供給管７の先端を常に滑沢剤内に十分に深く埋没
した状態とする。The vibrator 10 is operated constantly or intermittently (either regularly or irregularly), and the tip of the air supply pipe 7 in the container 6 is always buried sufficiently deep in the lubricant. state.
上記説明はロータリー打錠機を用いたものであるが、エ
キセントリック型打錠機についても同様にして本発明を
実施できることはいうまでもない。Although the above explanation uses a rotary tablet press, it goes without saying that the present invention can be practiced in the same manner with an eccentric tablet press.
以下、具体的な実施例及び比較例について説明する。Hereinafter, specific examples and comparative examples will be described.
実施例１
第１表に示す調合割合の粉末をよく混合し、第１図に示
したロータリー打錠機にて８ｍｍφのレンズ錠を１分当
り７２０錠の割合で製造した。Example 1 Powders having the proportions shown in Table 1 were thoroughly mixed, and 8 mmφ lens tablets were manufactured at a rate of 720 tablets per minute using the rotary tablet press shown in FIG.
第 １
表
実施例２
第２表に示す調合割合の粉末をよく混合し、エキセント
リック型打錠機にて１０ｍｍφのフラット錠を１分当り
２４錠の割合で作製した。Table 1 Example 2 Powders having the proportions shown in Table 2 were thoroughly mixed, and 10 mmφ flat tablets were produced at a rate of 24 tablets per minute using an eccentric tablet press.
第 ２ 表
バイブ５からは滑沢剤（本例ではタルク）を１分当り１
０ｍｇの割合で連続的に噴出させた。Table 2 From Vibe 5, apply lubricant (talc in this example) at 1 rate per minute.
It was continuously ejected at a rate of 0 mg.
その結果、滑沢剤の調合量が少ない処方２の場合であっ
ても下杵４は常にきわめて円滑に上下動し、製造された
錠剤の硬度も十分に高いものであった。As a result, even in the case of Formulation 2 in which the amount of lubricant was small, the lower punch 4 always moved up and down extremely smoothly, and the hardness of the manufactured tablets was also sufficiently high.
比較例１
実施例１において、バイブ５からの滑沢剤の噴出を行な
わなかったところ、滑沢剤の調合量の少ない処方２の場
合には下杵４にキシミが生じ、連続打錠できなかった。Comparative Example 1 In Example 1, when the lubricant was not ejected from the vibrator 5, in the case of Formulation 2 in which the amount of lubricant was small, the lower punch 4 creaked, making continuous tabletting impossible. Ta.
滑沢剤の調合量の多い処方１では、得られた錠剤の硬度
が低く、実用上支障があった。In Formulation 1, which contained a large amount of lubricant, the resulting tablets had low hardness, which was a practical problem.
バイブ５からは滑沢剤（本例ではステアリン酸マグネシ
ウム）を１分当り２ｍｇの割合で連続的に噴出させた。A lubricant (magnesium stearate in this example) was continuously ejected from the vibrator 5 at a rate of 2 mg per minute.
その結果、滑沢剤の配合の少ない処方４の場合にあって
も、下杵４は常にぎわめて円滑に上下動した。As a result, even in the case of formulation 4, which contained less lubricant, the lower punch 4 always moved up and down very smoothly.
比較例２
実施例２において、バイブ５からの滑沢剤の噴出を行な
わなかったところ、滑沢剤の調合量が少ない処方４の場
合のみならず滑沢剤の調合量の多い処方３の場合であっ
てもスティッキング、パインディングが発生し、正常な
打錠ができなかった。Comparative Example 2 In Example 2, the lubricant was not ejected from the vibrator 5, which resulted in not only the case of prescription 4 with a small amount of lubricant blended but also the case of prescription 3 with a large amount of lubricant blended. However, sticking and binding occurred and normal tablet compression was not possible.
［発明の効果］
以上の実施例及び比較例からも明らかな通り、本発明に
よれば次の優れた効果が得られる。[Effects of the Invention] As is clear from the above Examples and Comparative Examples, the following excellent effects can be obtained according to the present invention.
■ 下杵にキシミ等が発生せず、きわめて安定した打錠
が可能となる。■ The lower punch does not squeak, allowing for extremely stable tableting.
■ 錠剤とされる原料粉末に対し予め混合する滑沢剤の
量を減することが可能であり、滑沢剤による崩壊性の悪
化、錠剤硬度の低下を防止することができる。(2) It is possible to reduce the amount of lubricant to be mixed in advance with the raw material powder used for tablets, and it is possible to prevent deterioration of disintegration and decrease in tablet hardness due to the lubricant.
■ 滑沢剤は臼と下杵の間に少量だけ均一に付着し、圧
縮成型される粉体層に入り込むことはない。このため、
圧縮成型物は常に均一で安定した性状を有する。■ A small amount of lubricant adheres uniformly between the mortar and the lower punch, and does not enter the powder layer that is being compression molded. For this reason,
Compression molded products always have uniform and stable properties.
第１図は実施例方法の説明図である。
２・・・臼、 ２ａ・・・臼の内孔、４・・・下
杵、 ５・・・バイブ、６・・・容器、 ９・
・・流量計。FIG. 1 is an explanatory diagram of an embodiment method. 2... Mortar, 2a... Inner hole of the mortar, 4... Lower pestle, 5... Vibrator, 6... Container, 9.
··Flowmeter.
Claims (1)
杵とを有する打錠機を用い、該内孔内部において上杵と
下杵との間で原料を圧縮して錠剤を成型する錠剤製造法
において、下杵の先端以外の部分において下杵と臼内周
面との間に間隙を形成しておき、粉末状滑沢剤を粉末の
まま下杵と臼内周面との間に供給することにより、下杵
と臼との間の摩擦を減することを特徴とする錠剤製造法
。Using a tablet machine having a die having a penetrating inner hole, and an upper punch and a lower punch that fit into the die, the raw material is compressed between the upper and lower punches inside the inner hole to form a tablet. In the tablet manufacturing method by molding, a gap is formed between the lower punch and the inner peripheral surface of the mortar at a portion other than the tip of the lower punch, and the powdered lubricant is applied between the lower punch and the inner peripheral surface of the mortar in powder form. A tablet manufacturing method characterized by reducing friction between a lower punch and a mortar by feeding the lower punch and the mortar between the two.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1145780A JP2748563B2 (en) | 1989-06-08 | 1989-06-08 | Tablet manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1145780A JP2748563B2 (en) | 1989-06-08 | 1989-06-08 | Tablet manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH039757A true JPH039757A (en) | 1991-01-17 |
| JP2748563B2 JP2748563B2 (en) | 1998-05-06 |
Family
ID=15392999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1145780A Expired - Fee Related JP2748563B2 (en) | 1989-06-08 | 1989-06-08 | Tablet manufacturing method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2748563B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05318198A (en) * | 1992-05-25 | 1993-12-03 | Tsumura & Co | Manufacture of tablet |
| JPH08276128A (en) * | 1995-03-14 | 1996-10-22 | Montecatini Technol Srl | Pelletized catalyst and catalyst support |
| WO1999027887A1 (en) * | 1997-12-03 | 1999-06-10 | Kyowa Hakko Kogyo Co., Ltd. | Process for the production of tablets and tablets |
| EP0999039A2 (en) * | 1998-11-02 | 2000-05-10 | Sumitomo Special Metals Co., Ltd. | Powder pressing apparatus and powder pressing method |
-
1989
- 1989-06-08 JP JP1145780A patent/JP2748563B2/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05318198A (en) * | 1992-05-25 | 1993-12-03 | Tsumura & Co | Manufacture of tablet |
| JPH08276128A (en) * | 1995-03-14 | 1996-10-22 | Montecatini Technol Srl | Pelletized catalyst and catalyst support |
| WO1999027887A1 (en) * | 1997-12-03 | 1999-06-10 | Kyowa Hakko Kogyo Co., Ltd. | Process for the production of tablets and tablets |
| EP0999039A2 (en) * | 1998-11-02 | 2000-05-10 | Sumitomo Special Metals Co., Ltd. | Powder pressing apparatus and powder pressing method |
| EP0999039A3 (en) * | 1998-11-02 | 2000-05-24 | Sumitomo Special Metals Co., Ltd. | Powder pressing apparatus and powder pressing method |
| US6482349B1 (en) | 1998-11-02 | 2002-11-19 | Sumitomo Special Metals Co., Ltd. | Powder pressing apparatus and powder pressing method |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2748563B2 (en) | 1998-05-06 |
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