JPH0346115B2 - - Google Patents

Info

Publication number: JPH0346115B2
Authority: JP; Japan
Prior art keywords: cystine; cysteine; culture solution; atc; culture
Prior art date: 1982-06-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP9947782A

Other languages

English (en)

Japanese (ja)

Other versions

JPS58216692A (ja

Inventor

Tadao Kobayashi

Takashi Udagawa

Teruya Shirata

Noboru Kurihara

Mitsuyoshi Nakamura

Hiroi Yoshii

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ajinomoto Co Inc

Original Assignee

Ajinomoto Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-10

Filing date

1982-06-10

Publication date

1991-07-15

1982-06-10 Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc

1982-06-10 Priority to JP9947782A priority Critical patent/JPS58216692A/ja

1983-12-16 Publication of JPS58216692A publication Critical patent/JPS58216692A/ja

1991-07-15 Publication of JPH0346115B2 publication Critical patent/JPH0346115B2/ja

Status Granted legal-status Critical Current

Links

LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims description 37
229960003067 cystine Drugs 0.000 claims description 37
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 35
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 27
235000018417 cysteine Nutrition 0.000 claims description 27
244000005700 microbiome Species 0.000 claims description 14
239000004158 L-cystine Substances 0.000 claims description 9
235000019393 L-cystine Nutrition 0.000 claims description 9
230000003698 anagen phase Effects 0.000 claims description 7
235000001014 amino acid Nutrition 0.000 claims description 6
150000001413 amino acids Chemical class 0.000 claims description 6
238000012258 culturing Methods 0.000 claims description 6
230000032683 aging Effects 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
239000004201 L-cysteine Substances 0.000 claims description 4
235000013878 L-cysteine Nutrition 0.000 claims description 4
239000011593 sulfur Substances 0.000 claims description 4
229910052717 sulfur Inorganic materials 0.000 claims description 4
VHPXSBIFWDAFMB-UHFFFAOYSA-N 2-amino-Delta(2)-thiazoline-4-carboxylic acid Chemical compound NC1=[NH+]C(C([O-])=O)CS1 VHPXSBIFWDAFMB-UHFFFAOYSA-N 0.000 claims description 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
235000015097 nutrients Nutrition 0.000 claims description 2
CDMKLKAZVMTVHX-UHFFFAOYSA-N 4,5-dihydro-1,3-thiazol-3-ium-4-carboxylate Chemical compound OC(=O)C1CSC=N1 CDMKLKAZVMTVHX-UHFFFAOYSA-N 0.000 claims 1
150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
239000000243 solution Substances 0.000 description 35
238000006243 chemical reaction Methods 0.000 description 15
108090000790 Enzymes Proteins 0.000 description 12
102000004190 Enzymes Human genes 0.000 description 12
230000001580 bacterial effect Effects 0.000 description 10
230000000694 effects Effects 0.000 description 8
238000000034 method Methods 0.000 description 8
239000000203 mixture Substances 0.000 description 7
239000002609 medium Substances 0.000 description 6
230000005070 ripening Effects 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
241000894006 Bacteria Species 0.000 description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
239000013078 crystal Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
239000002994 raw material Substances 0.000 description 4
239000000758 substrate Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
241001600125 Delftia acidovorans Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
241000589565 Flavobacterium Species 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
241000192041 Micrococcus Species 0.000 description 3
241000589516 Pseudomonas Species 0.000 description 3
229910052799 carbon Inorganic materials 0.000 description 3
239000001963 growth medium Substances 0.000 description 3
238000004128 high performance liquid chromatography Methods 0.000 description 3
239000012264 purified product Substances 0.000 description 3
241000590020 Achromobacter Species 0.000 description 2
241001453369 Achromobacter denitrificans Species 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
241000193764 Brevibacillus brevis Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
241000588914 Enterobacter Species 0.000 description 2
241000588698 Erwinia Species 0.000 description 2
241000588724 Escherichia coli Species 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
241000191938 Micrococcus luteus Species 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
241000607715 Serratia marcescens Species 0.000 description 2
238000005273 aeration Methods 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
239000000284 extract Substances 0.000 description 2
230000012010 growth Effects 0.000 description 2
239000000411 inducer Substances 0.000 description 2
229910001410 inorganic ion Inorganic materials 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000009423 ventilation Methods 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
241000588986 Alcaligenes Species 0.000 description 1
241000193830 Bacillus <bacterium> Species 0.000 description 1
241000186146 Brevibacterium Species 0.000 description 1
241000125240 Dimorpha Species 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241000588915 Klebsiella aerogenes Species 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
241000721603 Mycoplana Species 0.000 description 1
241001135976 Mycoplana dimorpha Species 0.000 description 1
241000588701 Pectobacterium carotovorum Species 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
241000192023 Sarcina Species 0.000 description 1
241000607720 Serratia Species 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
238000002441 X-ray diffraction Methods 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
241000319304 [Brevibacterium] flavum Species 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000003679 aging effect Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
229940092559 enterobacter aerogenes Drugs 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
238000002816 microbial assay Methods 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000011785 micronutrient Substances 0.000 description 1
235000013369 micronutrients Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
229930014626 natural product Natural products 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000011002 quantification Methods 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000011218 seed culture Methods 0.000 description 1
DUIOPKIIICUYRZ-UHFFFAOYSA-N semicarbazide Chemical compound NNC(N)=O DUIOPKIIICUYRZ-UHFFFAOYSA-N 0.000 description 1
UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)

JP9947782A 1982-06-10 1982-06-10 含硫アミノ酸の製造方法 Granted JPS58216692A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP9947782A JPS58216692A (ja)	1982-06-10	1982-06-10	含硫アミノ酸の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP9947782A JPS58216692A (ja)	1982-06-10	1982-06-10	含硫アミノ酸の製造方法

Publications (2)

Publication Number	Publication Date
JPS58216692A JPS58216692A (ja)	1983-12-16
JPH0346115B2 true JPH0346115B2 (fr)	1991-07-15

Family

ID=14248386

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9947782A Granted JPS58216692A (ja)	1982-06-10	1982-06-10	含硫アミノ酸の製造方法

Country Status (1)

Country	Link
JP (1)	JPS58216692A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106676157A (zh) *	2017-02-20	2017-05-17	南华大学	军团菌菌体制备氨基酸构型转换试剂的应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102007007333A1 (de)	2007-02-14	2008-08-21	Wacker Chemie Ag	Verfahren zur Reinigung von L-Cystein

1982
- 1982-06-10 JP JP9947782A patent/JPS58216692A/ja active Granted

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106676157A (zh) *	2017-02-20	2017-05-17	南华大学	军团菌菌体制备氨基酸构型转换试剂的应用

Also Published As

Publication number	Publication date
JPS58216692A (ja)	1983-12-16

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JP4197754B2 (ja)	2008-12-17	乳酸又はコハク酸の製造方法
EP0046284B1 (fr)	1984-11-28	Procédé pour la préparation de l'acide 2,5-dicéto-D-gluconique et microorganismes pour la mise en oeuvre du procédé
JPH0342074B2 (fr)	1991-06-26
US5916782A (en)	1999-06-29	Process for producing aspartase and process for producing L-aspartic acid
JPH0346115B2 (fr)	1991-07-15
JP4198147B2 (ja)	2008-12-17	有機酸の製造方法
US5288620A (en)	1994-02-22	Process for the production of optically active 2-hydroxy-4-phenyl-3-butenoic acid
JP3709007B2 (ja)	2005-10-19	フマル酸の製造法
JPS6036446A (ja)	1985-02-25	Ｌ−α−アミノ酸の製造方法
JP2518218B2 (ja)	1996-07-24	微生物菌体の製造方法
US3138540A (en)	1964-06-23	Manufacture of glutamic acid by fermentation
EP0295622B1 (fr)	1993-09-29	Procédé pour la production de l-tryptophane
JP4269416B2 (ja)	2009-05-27	α−ハロ−α，β−飽和カルボニル化合物の製造方法
JPS58116690A (ja)	1983-07-11	Ｄ−β−ヒドロキシアミノ酸の製造法
JPH0349555B2 (fr)	1991-07-29
JPS608119B2 (ja)	1985-02-28	Ｌ−含硫アミノ酸の製造法
JPS63219389A (ja)	1988-09-13	ジ−ｄ−フラクトシルフラノ−ス１，２′：２，３′ジアンハイドライドの製造法
JPS6117475B2 (fr)	1986-05-07
JPH0525476B2 (fr)	1993-04-13
JPS6128398A (ja)	1986-02-08	Ｌ−バリンの製造法
JPH02257874A (ja)	1990-10-18	ロドコッカス属細菌及びそれを用いる２―ヒドロキシ酪酸の製造法
JPH08154692A (ja)	1996-06-18	Ｄ−２−アミノ酪酸の製造方法
JPH0353916B2 (fr)	1991-08-16
JPH0329395B2 (fr)	1991-04-24
JPS61257196A (ja)	1986-11-14	２−オキソ−オキサゾリジン−４−カルボン酸のラセミ化法

JPH0346115B2 - - Google Patents

Info

Links

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=14248386

Family Applications (1)

Country Status (1)

Cited By (1)

Families Citing this family (1)

Cited By (1)

Also Published As

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