JPH03264523A - Bandage for application in oral cavity - Google Patents
Bandage for application in oral cavityInfo
- Publication number
- JPH03264523A JPH03264523A JP6208790A JP6208790A JPH03264523A JP H03264523 A JPH03264523 A JP H03264523A JP 6208790 A JP6208790 A JP 6208790A JP 6208790 A JP6208790 A JP 6208790A JP H03264523 A JPH03264523 A JP H03264523A
- Authority
- JP
- Japan
- Prior art keywords
- bandage
- photosensitive resin
- mucous membrane
- resin layer
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000214 mouth Anatomy 0.000 title abstract description 11
- 229920005989 resin Polymers 0.000 claims abstract description 36
- 239000011347 resin Substances 0.000 claims abstract description 36
- 239000000853 adhesive Substances 0.000 claims description 27
- 230000001070 adhesive effect Effects 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 17
- 210000004400 mucous membrane Anatomy 0.000 abstract description 16
- 229920001477 hydrophilic polymer Polymers 0.000 abstract description 11
- 229920002125 Sokalan® Polymers 0.000 abstract description 5
- 239000004584 polyacrylic acid Substances 0.000 abstract description 4
- 108010010803 Gelatin Proteins 0.000 abstract description 3
- 239000000783 alginic acid Substances 0.000 abstract description 3
- 235000010443 alginic acid Nutrition 0.000 abstract description 3
- 229920000615 alginic acid Polymers 0.000 abstract description 3
- 229960001126 alginic acid Drugs 0.000 abstract description 3
- 150000004781 alginic acids Chemical class 0.000 abstract description 3
- 239000008273 gelatin Substances 0.000 abstract description 3
- 229920000159 gelatin Polymers 0.000 abstract description 3
- 235000019322 gelatine Nutrition 0.000 abstract description 3
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract 4
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 239000000178 monomer Substances 0.000 description 12
- 210000002200 mouth mucosa Anatomy 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- -1 N-isobutylacrylate Chemical class 0.000 description 7
- 239000003999 initiator Substances 0.000 description 7
- 239000004014 plasticizer Substances 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000000704 physical effect Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000005266 casting Methods 0.000 description 4
- 230000035622 drinking Effects 0.000 description 4
- 230000007937 eating Effects 0.000 description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 description 4
- 239000005020 polyethylene terephthalate Substances 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000003505 polymerization initiator Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 description 2
- UZKWTJUDCOPSNM-UHFFFAOYSA-N 1-ethenoxybutane Chemical compound CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 2
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 description 2
- VVBLNCFGVYUYGU-UHFFFAOYSA-N 4,4'-Bis(dimethylamino)benzophenone Chemical compound C1=CC(N(C)C)=CC=C1C(=O)C1=CC=C(N(C)C)C=C1 VVBLNCFGVYUYGU-UHFFFAOYSA-N 0.000 description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 2
- 229920002799 BoPET Polymers 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 229930006711 bornane-2,3-dione Natural products 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000003504 photosensitizing agent Substances 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229920001567 vinyl ester resin Polymers 0.000 description 2
- 229920003067 (meth)acrylic acid ester copolymer Polymers 0.000 description 1
- NNNLYDWXTKOQQX-UHFFFAOYSA-N 1,1-di(prop-2-enoyloxy)propyl prop-2-enoate Chemical compound C=CC(=O)OC(CC)(OC(=O)C=C)OC(=O)C=C NNNLYDWXTKOQQX-UHFFFAOYSA-N 0.000 description 1
- 150000000181 1,2-naphthoquinones Chemical class 0.000 description 1
- LOZBSNNVCOJWGN-UHFFFAOYSA-N 1-benzylanthracene-9,10-dione Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3C(=O)C2=C1CC1=CC=CC=C1 LOZBSNNVCOJWGN-UHFFFAOYSA-N 0.000 description 1
- CTXUTPWZJZHRJC-UHFFFAOYSA-N 1-ethenylpyrrole Chemical compound C=CN1C=CC=C1 CTXUTPWZJZHRJC-UHFFFAOYSA-N 0.000 description 1
- IGGDKDTUCAWDAN-UHFFFAOYSA-N 1-vinylnaphthalene Chemical class C1=CC=C2C(C=C)=CC=CC2=C1 IGGDKDTUCAWDAN-UHFFFAOYSA-N 0.000 description 1
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 description 1
- BQZJOQXSCSZQPS-UHFFFAOYSA-N 2-methoxy-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(OC)C(=O)C1=CC=CC=C1 BQZJOQXSCSZQPS-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- PNHBPKCDVARZJS-UHFFFAOYSA-N CC(=C)C(O)=O.CC(=C)C(O)=O.C1CC2(C)C(=O)C(=O)C1C2(C)C Chemical compound CC(=C)C(O)=O.CC(=C)C(O)=O.C1CC2(C)C(=O)C(=O)C1C2(C)C PNHBPKCDVARZJS-UHFFFAOYSA-N 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- JZMPIUODFXBXSC-UHFFFAOYSA-N ethyl carbamate;prop-2-enoic acid Chemical compound OC(=O)C=C.OC(=O)C=C.CCOC(N)=O JZMPIUODFXBXSC-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- PBZROIMXDZTJDF-UHFFFAOYSA-N hepta-1,6-dien-4-one Chemical compound C=CCC(=O)CC=C PBZROIMXDZTJDF-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000012766 organic filler Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical class C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 description 1
- TZMFJUDUGYTVRY-UHFFFAOYSA-N pentane-2,3-dione Chemical compound CCC(=O)C(C)=O TZMFJUDUGYTVRY-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 125000003011 styrenyl group Chemical class [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000003017 thermal stabilizer Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- FUSUHKVFWTUUBE-UHFFFAOYSA-N vinyl methyl ketone Natural products CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、口腔内の損傷部や疾患部を保護するための、
あるいは口腔粘膜を介して薬物を吸収させるための口腔
内貼付用バンデージに関する。Detailed Description of the Invention (Industrial Application Field) The present invention provides a method for protecting damaged and diseased areas in the oral cavity.
Alternatively, the present invention relates to an intraoral bandage for absorbing a drug through the oral mucosa.
（従来の技術）
口腔内の損傷部や疾患部の保護を目的として、あるいは
口腔粘膜を介して所定の薬効成分を体内に吸収させるこ
とを目的として、口腔内貼付用バンデージが調製されて
いる。口腔内貼付用バンデージは、湿潤した口腔内粘膜
に貼付することが可能で、かつ唾液の分泌や飲食などに
より容易に剥離しないことが必要とされる。口腔内貼付
用バンデージとしては、例えば、特公昭５Ｂ−７６０５
号公報には、ヒドロキシプロピルセルロースとアクリル
酸（共）重合体またはその塩とを含む組成の口腔内貼付
用バンデージが開示されている。特開昭５！ｌ］−１８
６９１３号公報には、ゼラチンまたは寒天、グルテン、
カルボキシビニルポリマー及び酢酸ビニル又はガム類を
含む組成の口腔内貼付用バンデージが開示されている。(Prior Art) Bandages for intraoral application have been prepared for the purpose of protecting damaged or diseased areas in the oral cavity or for the purpose of absorbing certain medicinal ingredients into the body through the oral mucosa. Bandages for intraoral application are required to be able to be applied to moist oral mucosa and not to be easily peeled off due to saliva secretion, eating and drinking, etc. As a bandage for intraoral application, for example, Japanese Patent Publication No. 5B-7605
The publication discloses a bandage for intraoral application having a composition containing hydroxypropyl cellulose and an acrylic acid (co)polymer or a salt thereof. Tokukai Showa 5! l]-18
No. 6913 discloses gelatin or agar, gluten,
Intraoral bandages are disclosed whose compositions include carboxyvinyl polymers and vinyl acetate or gums.
特開昭６０２１５６２２号公報には、ポリビニルピロリ
ドン、ポリビニルアルコール、ポリエチレングリコール
、アルギン酸またはその塩、無水マレイン酸−メチルビ
ニルエーテル共重合体、及びアクリル酸（共）重合体を
含む組成の口腔内貼付用バンデージが開示されている。JP-A-60215622 discloses a bandage for intraoral application having a composition containing polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, alginic acid or its salt, maleic anhydride-methyl vinyl ether copolymer, and acrylic acid (co)polymer. is disclosed.
特開昭６０−１４２９２７号公報にはキトサンまたはキ
トサン誘導体を含む組成の口腔内貼付用バンデージが開
示されている。特開昭６１−２４９４７３号公報には、
ポリカルボン酸、ポリ無水カルボン酸及び酢酸ビニル共
重合体を含む組成の口腔内貼付用バンデージが開示され
ている。JP-A-60-142927 discloses a bandage for intraoral application having a composition containing chitosan or a chitosan derivative. In Japanese Patent Application Laid-open No. 61-249473,
An intraoral bandage having a composition comprising a polycarboxylic acid, a polycarboxylic anhydride, and a vinyl acetate copolymer is disclosed.
上記各公報のバンデージは、いずれも親水性ポリマーを
主成分とする基剤層を有している。このような親水性ポ
リマーは、口腔内において唾液などの少量の水分が付与
されると粘着性を有するようになり、口腔粘膜に付着す
る。しかし、親水性ポリマーは、唾液や飲食による過剰
の水分により膨潤し崩壊し易い。このような耐水性の欠
如を補うために、粘膜貼付性基剤及び耐水性のある粘膜
非貼付性基剤からなる２層構造のバンデージが提案され
ている。しかし、粘膜非貼付性基剤に耐水性を付与する
ためにはこの基剤の主成分は疎水性である必要があり、
この為に粘膜貼付性基剤との親和性が欠如しており、含
水時に貼付性基剤から非貼付性基剤が剥離し易くなると
いう欠点がある。The bandages disclosed in each of the above-mentioned publications all have a base layer containing a hydrophilic polymer as a main component. Such hydrophilic polymers become sticky when a small amount of water such as saliva is added to them in the oral cavity, and adhere to the oral mucosa. However, hydrophilic polymers tend to swell and disintegrate due to excess water from saliva or eating and drinking. In order to compensate for this lack of water resistance, a bandage with a two-layer structure consisting of a mucosal adhesive base and a water-resistant non-mucosal adhesive base has been proposed. However, in order to impart water resistance to a non-mucous membrane adhesive base, the main component of this base must be hydrophobic.
For this reason, it lacks affinity with mucosal adhesive bases, and has the disadvantage that non-adhesive bases tend to peel off from adhesive bases when hydrated.
また、貼付後もバンデージが柔らかすぎるため、飲食や
会話による物理的な影響を受は易く、バンデージが粘膜
から剥離し易いという欠点がある。Furthermore, since the bandage is too soft even after application, it is susceptible to physical effects from eating, drinking, and talking, and has the disadvantage that the bandage is easily peeled off from the mucous membrane.
（発明が解決しようとする課題）
本発明は、上記の欠点を解決するものであり、その目的
とするところは、口腔内粘膜にたいして、十分な付着性
を有し、かつ耐水性及び形状保持性に優れた口腔内貼付
用バンデージを提供することにある。(Problems to be Solved by the Invention) The present invention solves the above-mentioned drawbacks, and its purpose is to have sufficient adhesion to the oral mucosa, as well as water resistance and shape retention. The purpose of the present invention is to provide an excellent bandage for intraoral application.
（課題を解決するための手段）
本発明者らは、ある種の親水性高分子（可塑剤を含む場
合もある）を主成分として粘膜貼付性基剤を調製すると
、柔軟性がよく、湿潤した口腔内粘膜°面に対して貼付
性を有する基剤が得られる知見をこれまでの検討で得て
きた。この場合、粘膜貼付性基剤は、過剰な水分により
膨潤して貼付性が低下し、また、飲食や会話による物理
的な影響を受は易く、粘膜から剥離し易くなるという問
題点が生してきた。この問題を解決すべく検討した結果
、感光性樹脂を粘膜貼付性基剤の片面に設けることによ
り解決できることを発見し、本発明に到達したものであ
る。すなわち、本発明の口腔内貼付用バンデージは、粘
膜貼付性基剤層の片面に、感光性樹脂層が設けられてい
ることを特徴とする口腔内貼付用バンデージであり、こ
のことにより前記目的が遠戚される。このような構成と
することにより、貼付時は粘膜貼付性基剤本来の柔軟性
及び貼付性を有しており、貼付後は光照射による感光性
樹脂の硬化により、粘膜貼付性基剤への外部からの水分
の侵入を抑制し粘膜貼付性基剤に耐水性を付与すること
ができ、また、貼付時の形状を保持していることより物
理的な影響を受けにくくすることができ、貼付時間を向
上することが可能となる。また、粘膜貼付性基剤と感光
性樹脂が光照射時、化学的あるいは物理的に結合するた
め、含水時に粘膜貼付性基剤と感光性樹脂が剥離する現
象は認められない。(Means for Solving the Problems) The present inventors have discovered that when a mucosal adhesive base is prepared using a certain type of hydrophilic polymer (which may also contain a plasticizer) as a main component, it has good flexibility and moisturizing properties. In our previous studies, we have obtained the knowledge that a base material that can be applied to the oral mucosal surface can be obtained. In this case, the mucosal patch base swells with excess moisture, reducing its adhesion properties, and is easily affected by physical effects from eating, drinking, and talking, making it easy to peel off from the mucous membrane. Ta. As a result of studies to solve this problem, it was discovered that the problem could be solved by providing a photosensitive resin on one side of the mucosal adhesive base, and the present invention was achieved based on this finding. That is, the bandage for intraoral application of the present invention is a bandage for intraoral application, characterized in that a photosensitive resin layer is provided on one side of the base layer that can be applied to mucous membranes, thereby achieving the above-mentioned purpose. Become a distant relative. With this structure, when applied, it has the flexibility and adhesion properties inherent to a mucosal adhesive base, and after application, the photosensitive resin hardens by light irradiation, so that the mucosal adhesive base is hardened. It is possible to suppress the intrusion of moisture from the outside and give water resistance to the base for applying to mucous membranes, and since it maintains its shape when applied, it is less susceptible to physical effects, making it easier to apply to mucous membranes. It becomes possible to improve the time. Furthermore, since the mucosal adhesive base and the photosensitive resin are chemically or physically bonded during light irradiation, no phenomenon in which the mucosal adhesive base and the photosensitive resin peel off when water is absorbed is observed.
また必要に応じて、ラジカル反応を良好に進める目的あ
るいは、反応性モノマー等のマスキングの目的で、感光
性樹脂層上に光透過性の保護フィルムを設けても良い。Further, if necessary, a light-transmissive protective film may be provided on the photosensitive resin layer for the purpose of favorably advancing the radical reaction or for the purpose of masking reactive monomers and the like.
該粘膜貼付性基剤は、湿潤した粘膜に付着する性能を有
しておれば良く、一般には、親水性高分子を主成分とし
たものである。また、必要に応じて、可塑剤等を含有し
ても良い。親水性高分子の例としては、ゼラチン、アル
ギン酸（塩）、ペクチン、カラギナン等の天然高分子、
ポリビニルピロリドン、ポリアクリル酸（塩）、ポリビ
ニルアルコール、ヒドロキシプロピルセルロース等の合
成高分子が挙げられる。これらの高分子は、少量の水分
を吸収して口腔内粘膜に対して強力な付着力を有するよ
うになる。The mucosal adhesive base only needs to have the ability to adhere to moist mucous membranes, and generally contains a hydrophilic polymer as a main component. Moreover, a plasticizer etc. may be contained as needed. Examples of hydrophilic polymers include natural polymers such as gelatin, alginic acid (salt), pectin, and carrageenan;
Examples include synthetic polymers such as polyvinylpyrrolidone, polyacrylic acid (salt), polyvinyl alcohol, and hydroxypropylcellulose. These polymers absorb small amounts of water and have strong adhesion to the oral mucosa.
本発明に使用される感光性樹脂層は、一般に反応性モノ
マー、光重合開始剤、熱安定剤等をバインダー樹脂中に
分散させた複合材料から成る。また、必要に応じて、可
塑剤及び無機・有機フィラーを含有しても良い。この感
光性樹脂層の性能としては、可視または紫外光を照射す
る前は粘膜貼付性基剤同様柔軟な性状で、照射後は硬化
して透湿性の低い、形状を保持する物性を示す必要があ
る。The photosensitive resin layer used in the present invention is generally made of a composite material in which reactive monomers, photopolymerization initiators, thermal stabilizers, etc. are dispersed in a binder resin. Moreover, a plasticizer and an inorganic/organic filler may be contained as necessary. The performance of this photosensitive resin layer is that before it is irradiated with visible or ultraviolet light, it is flexible like a mucosal adhesive base, and after irradiation, it hardens and exhibits physical properties that allow it to maintain its shape with low moisture permeability. be.
反応性モノマーとしては、エチレン性２重結合を少なく
とも１個有する付加重合可能な化合物、例えば、α−シ
アノアクリル酸、（メタ）アクリル酸、ウレタン（メタ
）アクリル酸、クロトン酸もしくはマレイン酸等の酸と
１価または２価アル５
６
コールとのエステル類、更に、Ｎ−イソブチルアクリル
アくドのような（メタ）アクリルアくド類、酢酸ビニル
のようなカルボン酸のビニルエステル類、ブチルビニル
エーテルのようなビニルエーテルＬ Ｎ−ビニルピロリ
ドンのようなモノ−Ｎビニル化合物、スチレン誘導体な
どが挙げられる。Reactive monomers include addition-polymerizable compounds having at least one ethylenic double bond, such as α-cyanoacrylic acid, (meth)acrylic acid, urethane (meth)acrylic acid, crotonic acid, or maleic acid. Esters of acids and monovalent or divalent al56 alcohols, (meth)acrylates such as N-isobutylacrylate, vinyl esters of carboxylic acids such as vinyl acetate, butyl vinyl ether Examples include vinyl ethers such as L, mono-N vinyl compounds such as N-vinylpyrrolidone, and styrene derivatives.
特に、１官能性、多官能性の（メタ）アクリル酸エステ
ル類及び、ウレタン（メタ）アクリル酸エステル類が好
適である。Particularly suitable are monofunctional and polyfunctional (meth)acrylic esters and urethane (meth)acrylic esters.
光重合開始剤としては、活性光線により上記重合性単量
体を活性化し、重合を開始させる性質を有するものであ
れば良く、一般に光増感剤が用いられる。光増感剤は、
その吸収スペクトルの波長により、紫外光重合開始剤、
可視光重合開始剤に分類される。紫外光重合開始剤とし
ては、ベンゾインメチルエーテル、ベンズアルデヒド、
ベンゾフェノン、ミヒラーケトン、ベンジルアンスラキ
ノン等が挙げられる。可視光重合開始剤としては、ジア
セチル、ベンジル、２，３−ペンタジオン等の鎖状のα
−ジケ１〜ン化合物、カンファーキノン、ゼシクロ （
２，２，１）へブタン−２，３−ジオンの様な脂環式の
α−ジケトン化合物、α、βナフトキノン等の多核牛ノ
ン類が挙げられる。光源の装置の価格及び光線の人体に
対する安全性において、特に、可視光開始剤が好適であ
り、アミン等と併用して用いられる。Any photopolymerization initiator may be used as long as it has the property of activating the polymerizable monomer with actinic rays to initiate polymerization, and a photosensitizer is generally used. The photosensitizer is
Depending on the wavelength of its absorption spectrum, ultraviolet photopolymerization initiators,
Classified as a visible light polymerization initiator. As the ultraviolet photopolymerization initiator, benzoin methyl ether, benzaldehyde,
Examples include benzophenone, Michler's ketone, and benzyl anthraquinone. As a visible light polymerization initiator, a chain α such as diacetyl, benzyl, 2,3-pentadione, etc.
- Dikene compounds, camphorquinone, zecyclo (
2,2,1) Alicyclic α-diketone compounds such as hebutane-2,3-dione, and polynuclear bovine nons such as α and β naphthoquinones. In view of the cost of the light source device and the safety of the light rays to the human body, visible light initiators are particularly preferred, and are used in combination with amines and the like.
バインダー樹脂としては、α、β−不飽和エチレン系単
量体を構成単位とする高分子物質が用いられるが、この
α、β−不飽和エチレン系単量体としては、例えば、ス
チレン等のスチレン類；ビニルナフタレン類；エチレン
等のα−オレフィン類；塩化ビニル等のハロゲン化ビニ
ル類；酢酸ビニル等のビニルエステル頻；アクリル酸メ
チル等のアクリル酸エステル類；アクリロニトリル等の
（メタ）アクリル酸誘導体；ビニルメチルエーテル等の
ビニルエーテル類；ビニルメチルケトン等のビニルケト
ン類；Ｎ−ビニルピロール等のＮビニル化合物等が挙げ
られる。As the binder resin, a polymer substance having α,β-unsaturated ethylenic monomer as a constituent unit is used. Vinylnaphthalenes; α-olefins such as ethylene; vinyl halides such as vinyl chloride; vinyl esters such as vinyl acetate; acrylic acid esters such as methyl acrylate; (meth)acrylic acid derivatives such as acrylonitrile Vinyl ethers such as vinyl methyl ether; Vinyl ketones such as vinyl methyl ketone; N-vinyl compounds such as N-vinylpyrrole; and the like.
光透過性保護フィルムとしては、光透過性及び柔軟性が
要求され、必要に応して酸素不透過性等が要求される。A light transmitting protective film is required to have light transmittance and flexibility, and, if necessary, oxygen impermeability.
たとえば、ポリ酢酸ビニル、ポリエチレン、ポリエチレ
ンテレフタレート、ポリ塩化ビニル、（メタ）アクリル
酸エステル共重合体などが挙げられる。該保護フィルム
の厚みは、１〜１００μｍが好ましく、より好ましくは
５〜５０μｍである。Examples include polyvinyl acetate, polyethylene, polyethylene terephthalate, polyvinyl chloride, (meth)acrylic acid ester copolymer, and the like. The thickness of the protective film is preferably 1 to 100 μm, more preferably 5 to 50 μm.
本発明の口腔内貼付用バンデージは、例えば、次のよう
に調製される。粘膜貼付性基剤層は、上記親水性高分子
及び必要に応じて可塑剤を有機溶媒に均一に溶解または
分散し、必要に応じて薬効成分等の添加剤を混合し、こ
の混合物を剥離シート上に流延し、乾燥することにより
フィルム化して得られる。また、上記各成分を混練し、
得られた混練物を押し出し、プレス等によりフィルム化
しても良い。この粘膜貼付性基剤層の厚みは、１０〜５
０００μｍが好ましく、より好ましくは２０〜５００μ
ｍである。The bandage for intraoral application of the present invention is prepared, for example, as follows. The mucosal adhesive base layer is prepared by uniformly dissolving or dispersing the hydrophilic polymer and, if necessary, a plasticizer in an organic solvent, mixing additives such as medicinal ingredients, if necessary, and applying this mixture to a release sheet. It is obtained by casting on top and drying it to form a film. Also, knead each of the above ingredients,
The obtained kneaded product may be extruded and formed into a film by pressing or the like. The thickness of this mucosal adhesive base layer is 10 to 5
000 μm is preferable, more preferably 20 to 500 μm
It is m.
感光性樹脂層は、前記感光性樹脂成分からなるペースト
状物を剥離シートで挟み込み、プレスして得られる。ま
た、上記感光性樹脂成分を有機溶媒に均一に溶解または
分散し、これを剥離シートまたは光透過性保護フィルム
上に流延し、乾燥することにより、フィルム化して得ら
れる。感光性樹脂層の厚みは、５〜１０００μｍが好ま
しく、より好ましくは１０〜５００μｍである。The photosensitive resin layer is obtained by sandwiching a paste-like material made of the photosensitive resin component between release sheets and pressing. Alternatively, it can be obtained by uniformly dissolving or dispersing the photosensitive resin component in an organic solvent, casting it onto a release sheet or a light-transmitting protective film, and drying it to form a film. The thickness of the photosensitive resin layer is preferably 5 to 1000 μm, more preferably 10 to 500 μm.
このようにして得られた粘膜貼付性基剤層及び感光性樹
脂層を圧着プレスして、該口腔貼付用バンデージが得ら
れる。感光性樹脂層の上に、粘膜貼付性基剤の溶液を流
延・乾燥して積層する。あるいは、粘膜貼付性基剤の上
に、感光性樹脂の溶液を流延・乾燥して積層することに
より、該口腔内貼付用バンデージが得られる。The thus obtained mucosal adhesive base layer and photosensitive resin layer are pressure-pressed to obtain the oral cavity adhesive bandage. On the photosensitive resin layer, a solution of a mucosal adhesive base is cast and dried to be laminated. Alternatively, the bandage for intraoral application can be obtained by casting and drying a solution of a photosensitive resin on a mucosal adhesive base and laminating it.
（作用）
親水性高分子は、本来少量の水を吸収すると、強力な付
着力を有する。従って、フィルム状の粘膜貼付性基剤か
らなる口腔内貼付用バンデージを口腔粘膜に貼付すると
、親水性高分子が口腔内の水分を吸収し、粘着性を有す
るようになり口腔内粘膜表面に付着する。付着後光照射
により感光性樹脂が硬化することにより、貼付時の形状
を保持０
して口腔内の物理的な影響を受けに＜＜シ、かつ、単位
時間当たりの粘膜貼付性基剤の水分の吸収量が減少して
、より耐水性・耐久性に優れ、長時間にわたり口腔内粘
膜表面に貼付することが可能となる。(Function) Hydrophilic polymers inherently have a strong adhesive force when they absorb a small amount of water. Therefore, when an intraoral patch bandage made of a film-like mucosal adhesive base is applied to the oral mucosa, the hydrophilic polymer absorbs moisture in the oral cavity, becomes sticky, and adheres to the oral mucosal surface. do. After application, the photosensitive resin is cured by light irradiation, which maintains its shape when applied, making it less susceptible to the physical effects of the oral cavity, and reducing the water content of the mucosal adhesive base per unit time. This reduces the amount of absorption, making it more water resistant and durable, allowing it to be applied to the oral mucosal surface for a long period of time.
（実施例） 以下に本発明を実施例につき説明する。(Example) The invention will be explained below with reference to examples.
丈漏朝土
（Ａ）口腔内貼付用バンデージの調製
ポリアクリル酸（親水性高分子）２０重量部及びポリエ
チレングリコール（可塑剤）１０重量部をエタノール７
０重量部に均一に溶解させた。この溶液を表面シリコー
ン処理したポリエチレンテレフタレート （ＰＥＴ）フ
ィルム上に流延・乾燥し、厚み６０！１ｍのフィルム状
粘膜貼付性基剤層（１）を得た。Joro Asato (A) Preparation of bandage for intraoral application 20 parts by weight of polyacrylic acid (hydrophilic polymer) and 10 parts by weight of polyethylene glycol (plasticizer) were mixed with 7 parts by weight of ethanol.
It was uniformly dissolved in 0 parts by weight. This solution was cast on a polyethylene terephthalate (PET) film whose surface had been treated with silicone and dried to obtain a film-like base layer (1) for sticking to mucous membranes with a thickness of 60!1 m.
別に感光性樹脂として、下記の組成（数字は部数を示す
）
・ メチルメタクールート−エチレングリコールジメタ
クリレート（９’７：３） ３ ５の共重合体（
粒径５μｍ） ［バインダー樹脂］・ ポリメタク
リ）ト酸メチＩＬ（ＭＷ＝１００，０００）・ メタク
１ハシ酸メチ１シ
・ エチレングリコ−１１ジメタクリレート・ カンフ
ァーキノン
・ ジェタノールアミン
０
［バインダー 樹脂］
２
［反応性モノマー］
［反応性モノマー］
０．２
［光重合開始剤］
０．５
［光重合開始助剤コ
により、ペースト状物を得た。Separately, as a photosensitive resin, the following composition (numbers indicate parts): Copolymer of methyl metacoolite-ethylene glycol dimethacrylate (9'7:3) 35 (
Particle size: 5 μm) [Binder resin] Polymethacrylate) Methyl torate (MW = 100,000) Methyl methacrylate 1 Methyl hashate Ethylene glyco-11 dimethacrylate Camphorquinone Jetanolamine 0 [Binder resin] 2 [Reactive Monomer] [Reactive Monomer] 0.2 [Photopolymerization Initiator] 0.5 [A paste-like material was obtained using the photopolymerization initiation aid.
このペーストを表面シリコーン処理ＰＥＴフィルムで挟
み、１００ ｋｇ／ｃｉでプレスして、厚み４０ｔｌＩ
１１のフィルム状感光性樹脂層（ＩＩ）を得た。This paste was sandwiched between PET films treated with surface silicone and pressed at 100 kg/ci to a thickness of 40 tlI.
11 film-like photosensitive resin layers (II) were obtained.
以上のようにして得られたＩと■を１００ｋｇ／Ｃｌｌ
１で圧着プレスして厚み９０μｍの柔軟な口腔内貼付用
バンデージを得た。I and ■ obtained as above are 100kg/Cl
1 to obtain a flexible bandage for intraoral application with a thickness of 90 μm.
（Ｂ）バンデージの性能評価
再生豚皮を４０ｍｍφに打ち抜き、ステンレス板（４０
Ｘ４０ｍｍ）に両面テープで固定する。(B) Performance evaluation of bandage Punch out recycled pork skin into a 40 mm diameter stainless steel plate (40 mm diameter).
x40mm) with double-sided tape.
１
２
（Ａ）項で得られたバンデージを１０ｍｍφに打ち抜き
、この豚皮上に貼付し、有効波長領域４００〜５００ｎ
ｍのハロゲンランプ（５００Ｗ）を使用し、可視光を１
分間照射して、感光性樹脂を硬化した。このステンレス
板を蒸留水４００ｍ１の入った日本薬局方「溶出試験」
（第２法）の試験器に入れ、１１００ｒｐでパドルを
回転させながら６時間放置した。６時間後の付着状態を
観察した結果、バンデージの周囲はわずかに膨潤・溶解
しているものの、再生豚皮に十分付着しており、剥離す
るのに抵抗を示し、バンデージは一体化して剥離した。1 2 The bandage obtained in Section (A) was punched out to a diameter of 10 mm, pasted on the pig skin, and the effective wavelength range was 400 to 500 nm.
m halogen lamp (500W) and visible light
The photosensitive resin was cured by irradiation for a minute. This stainless steel plate was subjected to the Japanese Pharmacopoeia ``elution test'' with 400ml of distilled water.
(Method 2) and left for 6 hours while rotating the paddle at 1100 rpm. Observation of the adhesion state after 6 hours revealed that although the area around the bandage had slightly swelled and dissolved, it was sufficiently adhered to the regenerated pigskin and showed resistance to peeling, and the bandage was peeled off as a single piece. .
北較暴１
（Ａ）口腔内貼付用バンデージの調製
実施例１のフィルム状粘膜貼付性基剤層（Ｉ）のみから
なり、感光性樹脂層の設げられていないものを口腔内貼
付用バンデージとした。Kitakobyou 1 (A) Preparation of a bandage for intraoral application A bandage for intraoral application consisting only of the film-like mucosal adhesive base layer (I) of Example 1 and without a photosensitive resin layer. And so.
（Ｂ）バンデージの性能評価
比較例１の（Ａ）項で得られたバンデージを用い、実施
例１ （Ｂ）項と同様にして性能評価を行った。(B) Performance evaluation of bandage Using the bandage obtained in section (A) of Comparative Example 1, performance evaluation was performed in the same manner as in section (B) of Example 1.
バンデージは、１時間後には膨潤し、蒸留水中に溶解し
た。The bandage swelled after 1 hour and dissolved in distilled water.
丈胤鉄Ｌ
（Ａ）口腔内貼付用バンデージの調製
ポリアクリル酸１０重量部、ポリビニルピロリドン５重
量部、モノラウリン酸ソルビタン５重量部及びＥｕｉｄ
ｒａｇｉｔ ＲＳ （Ｒｏｍｅ Ｐｈａｒｍａ社製；メ
タアクリル酸エステル系ポリマー）５重量部をエタノー
ル１８０重量部に均一に溶解させた。この溶液を表面シ
リコーン処理したＰＥＴフィルム上に流延・乾燥して厚
み４０μｍのフィルム状粘膜貼付性基剤層（ＩＩＩ）を
得た。Jyutane Tetsu L (A) Preparation of bandage for intraoral application 10 parts by weight of polyacrylic acid, 5 parts by weight of polyvinylpyrrolidone, 5 parts by weight of sorbitan monolaurate, and Euid
5 parts by weight of ragit RS (manufactured by Rome Pharma; methacrylic acid ester polymer) was uniformly dissolved in 180 parts by weight of ethanol. This solution was cast on a PET film whose surface had been treated with silicone and dried to obtain a 40 μm thick film-like base layer (III) for sticking to mucous membranes.
別に感光性樹脂として、下記の組成（数字は部数を示す
）
・ ポリメタクリル酸メチル（ｌｌＷ＝２００，０００
） ４ ８［バインダー
樹脂］
・ メタクリル酸メチ１シ
４０［反応性モノマー］
・ トリメチロ−）シブロバシトリアクリレート
２３
４
［反応性モノマー］
・ ウレタンジアクリレート（新中村化学 Ｕ−２００
） １ ０［反応性モノマー］
・ カンファーキノン
０． ２［光重合開始剤］
・ ジェタノールアミン
０・ ５［光重合開始助剤
］
により、ペースト状物を得た。Separately, as a photosensitive resin, the following composition (numbers indicate parts) - Polymethyl methacrylate (llW = 200,000
) 4 8 [Binder
Resin] Methyl methacrylate
40 [Reactive monomer] ・Trimethylo-)sibrobacitriacrylate
23 4 [Reactive monomer] Urethane diacrylate (Shin Nakamura Chemical U-200
) 1 0 [Reactive monomer] Camphorquinone
0. 2 [Photopolymerization initiator] Jetanolamine
0.5 [Photopolymerization initiation aid] A paste-like material was obtained.
このペーストを４０μｍのニスメゾイカＶ（積水化学製
：無可塑剤軟質ポリ塩化ビニル）と表面シリコーン処理
ＰＥＴで挟み１００ ｋｇ／ｃＴＭでプレスして、厚み
１４０μｍの柔軟なニスメゾイカ■うごネート・フィル
ム状感光性樹脂層（ＩＶ）を得た。以上のようにして得
られた■と■を１００ｋｇ／ ｃＴＭで圧着プレスして
厚み１６０μｍの柔軟な口腔内貼付用バンデージを得た
。This paste was sandwiched between 40 μm Nismezoika V (manufactured by Sekisui Chemical Co., Ltd.: plasticizer-free soft polyvinyl chloride) and PET surface treated with silicone and pressed at 100 kg/cTM to form a flexible Nismezoica film with a thickness of 140 μm. A synthetic resin layer (IV) was obtained. The materials (1) and (2) obtained as described above were pressed at 100 kg/cTM to obtain a flexible bandage for intraoral application with a thickness of 160 μm.
（Ｂ）バンデージの性能評価
実施例２の（Ａ）項で得られたバンデージを用い、実施
例１ （Ｂ）項と同様にして性能評価を行った。(B) Performance evaluation of bandage Using the bandage obtained in Section (A) of Example 2, performance evaluation was performed in the same manner as in Section (B) of Example 1.
バンデージの周囲はわずかに膨潤・白化しているものの
、再生豚皮に十分付着しており、剥離するのに抵抗を示
し、バンデージは一体化して剥離した。Although the area around the bandage was slightly swollen and whitened, it was sufficiently adhered to the regenerated pigskin and showed resistance to peeling, and the bandage was peeled off as a unit.
また、バンデージを２０ｍｍφに打ち抜いたものを５人
のボランティアの口腔粘膜に貼付し、有効波長領域４０
０〜５００ｎｍのハロゲンランプ（５００Ｗ）を使用し
、可視光を１分間照射して、感光性樹脂を硬化した後、
剥離時間を測定した結果、平均剥離時間は、１５．８時
間であった。In addition, bandages were punched out to a diameter of 20 mm and pasted on the oral mucosa of five volunteers.
After curing the photosensitive resin by irradiating it with visible light for 1 minute using a 0-500 nm halogen lamp (500 W),
As a result of measuring the peeling time, the average peeling time was 15.8 hours.
夫誕咀走
（Ａ）口腔内貼付用バンデージの調製
実施例２と同様にしてフィルム状粘膜貼付性基剤層（Ｉ
ＩＩ）を得た。Preparation of a bandage for intraoral application (A) In the same manner as in Example 2, a film-like mucosal application base layer (I
II) was obtained.
別に感光性樹脂として、下記の組成（数字は部数を示す
）
・ ポリメタクリル酸メチル（ＭＷ＝１００．０００）
６ ０［バインダー 樹
脂］
・ エチレングリコールジアクリレート
２０［反応性モノマー］
５
６
・ トリメチＩＩ−Ｂプロパントリアクリレート
１０［反応性モノマー
コ
・ ポリエチレングリコール
１０［可塑剤］
・ カンフ７−キノン
０．２［重合開始剤］
・ ジェタノールアミン
０．５［重合開始助剤］
をテトラヒドロフランに３５Ｗ／Ｖ％となるよう溶解し
、４０μｍのニスメゾイカＶ上に乾燥後の厚みが５０μ
ｍとなるよう流延・乾燥することにより、厚み９０μｍ
の柔軟なニスメゾイカＶう５ネート・フィルム状感光性
樹脂層（Ｖ）を得た。Separately, as a photosensitive resin, the following composition (numbers indicate parts) - Polymethyl methacrylate (MW = 100.000)
6 0 [Binder resin] ・Ethylene glycol diacrylate
20 [Reactive Monomer] 5 6 ・Trimethy II-B propane triacrylate
10 [Reactive monomer co-polyethylene glycol
10 [Plasticizer] ・ Camph 7-quinone
0.2 [Polymerization initiator] Jetanolamine
0.5 [polymerization initiation aid] was dissolved in tetrahydrofuran to give a concentration of 35 W/V%, and the solution was placed on a 40 μm Nismezoica V to a thickness of 50 μm after drying.
By casting and drying to a thickness of 90 μm
A flexible film-like photosensitive resin layer (V) of Nismezoika V 5ate was obtained.
以上のようにして得られた■とＶを１００ ｋｇ／ｃｄ
ｌで圧着プレスして厚み１２０μｍの柔軟な口腔内貼付
用バンデージを得た。■ and V obtained as above are 100 kg/cd
A flexible bandage for intraoral application with a thickness of 120 μm was obtained by pressure-bonding with a pressurizer.
（Ｂ）バンデージの性能評価
実施例３の（Ａ）項で得られたバンデージを用い、実施
例１ （Ｂ）項と同様にして性能評価を行った。(B) Performance evaluation of bandage Using the bandage obtained in Section (A) of Example 3, performance evaluation was performed in the same manner as in Section (B) of Example 1.
バンデージの周囲はわずかに膨潤・白化しているものの
、再生豚皮に十分付着しており、剥離するのに抵抗を示
し、バンデージは一体化して剥離した。Although the area around the bandage was slightly swollen and whitened, it was sufficiently adhered to the regenerated pigskin and showed resistance to peeling, and the bandage was peeled off as a unit.
上漣彊４２
（Ａ）口腔内貼付用バンデージの調製
実施例２のフィルム状粘膜貼付性基剤層（１）のみから
なり、感光性樹脂層の設けられていないものを口腔内貼
付用バンデージとした。42 (A) Preparation of a bandage for intraoral application A bandage for intraoral application consisting of only the film-like mucosal adhesive base layer (1) of Example 2 and without a photosensitive resin layer was used. did.
（Ｂ）バンデージの性能評価
比較例２の（Ａ）項で得られたバンデージを用い、実施
例１ （Ｂ）項と同様にして性能評価を行った。(B) Performance evaluation of bandage Using the bandage obtained in section (A) of Comparative Example 2, performance evaluation was performed in the same manner as in section (B) of Example 1.
バンデージは、６時間後には全面膨潤・白化し、一部崩
壊しており、付着部分については剥離するのに抵抗を示
したが、実施例２．３と比較してその抵抗は弱かった。After 6 hours, the bandage was completely swollen and whitened, partially collapsed, and the attached portion showed resistance to peeling off, but the resistance was weaker than in Example 2.3.
（発明の効果）
本発明によれば、このように、口腔内粘膜に対して優れ
た貼付性を示し、かつ耐水性・持久性に７
８
優れた口腔内貼付用バンデージが提供される。このバン
デージは柔軟なシート状であるため貼付時に違和感を与
えることがなく、かつ、貼付後に感光性樹脂を硬化させ
ることによって、貼付時の形状を保持して、外部の物理
的な影響を受けにくくし、かつ、粘膜貼付性基剤の水分
の供給を抑制することにより、長時間安定に付着し、粘
膜の貼付部分を充分に保護する効果を有する。このよう
なバンデージは、長時間にわたり口腔粘膜表面に貼付す
ることが可能であり、例えば、口腔内の損傷部や疾患部
を充分に保護することができ、また、薬効成分を経粘膜
吸収させ、全身性作用・局所作用を発現させるための基
剤として有用である。(Effects of the Invention) According to the present invention, there is thus provided an intraoral patch bandage that exhibits excellent adhesion to the oral mucosa and has excellent water resistance and durability. Since this bandage is in a flexible sheet form, it does not cause any discomfort when applied, and by curing the photosensitive resin after application, it retains its shape when applied, making it less susceptible to external physical influences. In addition, by suppressing the supply of moisture to the mucosal adhesive base, it has the effect of stably adhering for a long time and sufficiently protecting the mucous membrane area to which it is applied. Such a bandage can be applied to the surface of the oral mucosa for a long period of time, and can, for example, sufficiently protect injured or diseased areas in the oral cavity. It is useful as a base for exerting systemic and local effects.
Claims (1)
れていることを特徴とする口腔内貼付用バンデージ。1. A bandage for intraoral application, characterized in that a photosensitive resin layer is provided on one side of a mucosal adhesive base layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2062087A JP2877423B2 (en) | 1990-03-13 | 1990-03-13 | Oral bandage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2062087A JP2877423B2 (en) | 1990-03-13 | 1990-03-13 | Oral bandage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03264523A true JPH03264523A (en) | 1991-11-25 |
| JP2877423B2 JP2877423B2 (en) | 1999-03-31 |
Family
ID=13189926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2062087A Expired - Fee Related JP2877423B2 (en) | 1990-03-13 | 1990-03-13 | Oral bandage |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2877423B2 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5462976A (en) * | 1992-02-05 | 1995-10-31 | Seikagaku Kogyo Kabushiki Kaisha | Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof |
| WO1998055079A3 (en) * | 1997-06-06 | 1999-03-04 | Procter & Gamble | A delivery system for an oral care substance using a strip of material having low flexural stiffness |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| JP2011219391A (en) * | 2010-04-06 | 2011-11-04 | Lintec Corp | Sheet for peeling horny layer and method for peeling horny layer |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US10285915B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
-
1990
- 1990-03-13 JP JP2062087A patent/JP2877423B2/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5462976A (en) * | 1992-02-05 | 1995-10-31 | Seikagaku Kogyo Kabushiki Kaisha | Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof |
| US5763504A (en) * | 1992-02-05 | 1998-06-09 | Seikagaku Kogyo Kabushiki Kaisha(Seikagaku Corporation) | Photcurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof |
| WO1998055079A3 (en) * | 1997-06-06 | 1999-03-04 | Procter & Gamble | A delivery system for an oral care substance using a strip of material having low flexural stiffness |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US10493016B2 (en) | 2002-09-11 | 2019-12-03 | The Procter & Gamble Company | Tooth whitening product |
| JP2011219391A (en) * | 2010-04-06 | 2011-11-04 | Lintec Corp | Sheet for peeling horny layer and method for peeling horny layer |
| US10285915B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
| US10285916B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2877423B2 (en) | 1999-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |