JPH03133460A - Balloon infuser - Google Patents
Balloon infuserInfo
- Publication number
- JPH03133460A JPH03133460A JP1271111A JP27111189A JPH03133460A JP H03133460 A JPH03133460 A JP H03133460A JP 1271111 A JP1271111 A JP 1271111A JP 27111189 A JP27111189 A JP 27111189A JP H03133460 A JPH03133460 A JP H03133460A
- Authority
- JP
- Japan
- Prior art keywords
- balloon
- liquid
- stress
- infuser
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 claims abstract description 37
- 239000000126 substance Substances 0.000 claims abstract description 34
- 239000007924 injection Substances 0.000 claims abstract description 15
- 238000002347 injection Methods 0.000 claims abstract description 15
- 239000013013 elastic material Substances 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims description 30
- 239000008155 medical solution Substances 0.000 claims description 24
- 239000000463 material Substances 0.000 abstract description 7
- 238000012856 packing Methods 0.000 abstract 2
- 239000000243 solution Substances 0.000 description 46
- 229940079593 drug Drugs 0.000 description 23
- 238000010586 diagram Methods 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- 230000008602 contraction Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 244000043261 Hevea brasiliensis Species 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920003052 natural elastomer Polymers 0.000 description 3
- 229920001194 natural rubber Polymers 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 239000004800 polyvinyl chloride Substances 0.000 description 3
- 229920003002 synthetic resin Polymers 0.000 description 3
- 239000000057 synthetic resin Substances 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 101100136092 Drosophila melanogaster peng gene Proteins 0.000 description 1
- 229920000459 Nitrile rubber Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
- A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野］
本発明は所定量の薬液を血管、膀胱等に、少しずつ持続
して注入するためのバルーンインフューザーに関し、更
に詳しくは、バルーン内に加圧状態で貯蔵した薬液を、
一定速度で長時間少しずつ持続して患者に注入すること
ができるバルーンインフューザーに関する。[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a balloon infuser for continuously injecting a predetermined amount of a medicinal solution into a blood vessel, bladder, etc. Chemical solutions stored under pressure are
This invention relates to a balloon infuser that can be continuously injected into a patient little by little at a constant rate over a long period of time.
従来より、抗生物質や抗ガン剤等の薬液を血管、膀胱等
に少しずつ注入する方法として、弾性材料からなるバル
ーンに薬液を収納し、バルーンの収縮力を利用して薬液
を長時間にわたって血管等に持続注入する装置として、
特開昭５０−１０８７９０号公報等が知られており、ま
たバルーン材料としては薬液を充填したバルーンの内圧
を薬液の排出が終わるまでほぼ一定速度で供給すること
ができる材料が好ましく、そのような材料として特公昭
５９−４８８８１号公報に合成ポリイソプレンが挙げら
れている。Traditionally, as a method for injecting antibiotics, anticancer drugs, and other medicinal solutions little by little into blood vessels, bladders, etc., the medicinal solution is stored in a balloon made of elastic material, and the contraction force of the balloon is used to inject the medicinal solution into the blood vessel over a long period of time. As a device for continuous injection, etc.
JP-A-50-108790 is known, and the balloon material is preferably a material that can supply the internal pressure of a balloon filled with a medical solution at a substantially constant rate until the discharge of the medical solution is completed. As a material, synthetic polyisoprene is mentioned in Japanese Patent Publication No. 59-48881.
しかしながら、かかるバルーン材料を用いた薬液注入装
置は、薬液を長期間バルーン内に貯蔵保持しておくと、
バルーンが破袋することがあり、バルーン内部の薬液が
患者に直接触れたりして危険である。また、薬液を充填
して膨張したバルーンの形状が安定化しないために性能
が不安定になるｆ頃向があった。However, in liquid drug injection devices using such balloon materials, if the drug liquid is stored and retained in the balloon for a long period of time,
The balloon may break and the medical solution inside the balloon may come into direct contact with the patient, which is dangerous. Additionally, the shape of the balloon filled with the chemical solution and inflated was not stabilized, leading to unstable performance.
（！ｆ！ｆｆを解決するための手段〕
本発明者等はかかる課題を解決するために、種々検討し
た結果、本発明に到達した。(Means for Solving !f!ff) In order to solve this problem, the present inventors conducted various studies and arrived at the present invention.
すなわち、本発明は加圧状態で薬液を貯蔵し、かつ開口
部から薬液を注入および流出する弾性材料からなるバル
ーン部と、前記バルーン部を収納し、その開口部に薬液
注入部および薬液流出部が固着されてなるハウジングと
、前記薬液流出部から延びた薬液流通路と、該流通路に
配置された薬液量を制御するための流量１制御部とから
なるバルーンインフューザーにおいて、前記弾性材料か
らなるバルーン部の応力がエネルギー弾性の一部を欠如
してなるバルーンインフューザーである。That is, the present invention includes a balloon section made of an elastic material that stores a medical solution under pressure and injects and flows out the medical solution from an opening; In the balloon infuser, the balloon infuser includes a housing to which is fixedly attached, a liquid medicine flow path extending from the liquid medicine outlet, and a flow rate 1 control part arranged in the flow passage for controlling the amount of the liquid medicine, wherein This is a balloon infuser in which the stress in the balloon part lacks part of the energy elasticity.
また本発明は前記バルーンインフューザーにおいて、未
処理の弾性材料からなるバルーンに液体または気体を薬
液充填予定量以上に充填し、次いで液体または気体の一
部を除去して１時間以上バルーンの膨張状態を保持する
前処理を施したバルーン部を使用するバルーンインフュ
ーザーである。Further, in the balloon infuser of the present invention, the balloon made of an untreated elastic material is filled with liquid or gas to an amount exceeding the planned amount of the drug solution, and then a part of the liquid or gas is removed to keep the balloon inflated for one hour or more. This is a balloon infuser that uses a balloon part that has been pretreated to retain the air.
（作用〕
本発明は薬液をバルーン内に充填して膨張したバルーン
の収縮力を利用して、バルーン内の薬液を患者に注入す
るものであり、その際未処理の弾性材料からなるバルー
ンを前処理して一次弾性ヒステリシス曲線の応力からエ
ネルギー弾性の一部を欠如したバルーンを使用するもの
であり、バルーン膨張時の応力は未処理のバルーンより
小さいために、バルーンの保持時の破袋が少ないし、応
力−歪曲線がなすヒステリシス、すなわち応力曲線と歪
曲線がなす面積が未処理のバルーンより小さいために一
定速度を持続して、バルーン内の薬液を患者に注入する
ことができるし、また膨張時のバルーンを一定の形状に
することができる。(Function) The present invention is to fill a balloon with a medical solution and use the contraction force of the inflated balloon to inject the medical solution inside the balloon into a patient. This method uses a balloon that has been treated to remove some of the energy elasticity from the stress of the primary elastic hysteresis curve, and because the stress when the balloon is inflated is smaller than that of an untreated balloon, there is less chance of bag breakage when the balloon is held. However, due to the hysteresis of the stress-strain curve, that is, the area formed by the stress curve and the strain curve is smaller than that of an untreated balloon, the drug solution in the balloon can be injected into the patient at a constant rate. The balloon can have a certain shape when inflated.
以下実施例で本発明の詳細な説明する。 The present invention will be explained in detail below with reference to Examples.
第１図は本発明のバルーンインフューザーの一実施例の
平面図、第２図は第１図に示すバルーンインフューザー
のバルーン部であって薬液を充填した時の様子を示す拡
大断面図、第３図および第６図はバルーンの応力−歪曲
線図、第４図は第３ニ示シタバルーンを使用した時のバ
ルーンインフューザーの液量排出線図、第５図は第４図
の時間当たりの液量排出線図を示す。FIG. 1 is a plan view of an embodiment of the balloon infuser of the present invention, FIG. 2 is an enlarged cross-sectional view of the balloon portion of the balloon infuser shown in FIG. Figures 3 and 6 are stress-strain curve diagrams of the balloon, Figure 4 is a fluid volume discharge diagram of the balloon infuser when using the 3rd-display balloon, and Figure 5 is the hourly diagram of Figure 4. The liquid volume discharge diagram is shown.
図中Ａはバルーン部、１は外軸、２は内軸、３はバルー
ン、６はハウジング、１２は分岐路、１５は薬液注入用
栓体、１７はクランプ、１８は流量制御部を示す。In the figure, A indicates a balloon portion, 1 indicates an outer shaft, 2 indicates an inner shaft, 3 indicates a balloon, 6 indicates a housing, 12 indicates a branch path, 15 indicates a stopper for liquid injection, 17 indicates a clamp, and 18 indicates a flow rate control section.
第１図および第２図において、バルーン部Ａは薬液が充
填される部分であるとともに、該薬液を人体の注入加除
へ移動せしめる駆動部分であり、円筒状外軸１と、該外
軸１内に滑動自在に内装されてなる内軸２と、これらの
両軸の外部に設けられたバルーン３と、前記外軸１の一
端であって、内軸２が内装される側と反対側の端部に接
続された薬液流入部および薬液流出部とで抗生されてい
る。外軸１および内軸２はポリカーボネート、ポリエチ
レン、ポリプロピレン等の合成樹脂からなる。バルーン
３は筒状の形状をしており、外軸１および内軸２を被覆
するように両軸の外部に設けられており、その一端は外
軸ｌにまた他端は０リング５または金属の螺旋状止め栓
等のシール手段によって気密に密着固定されている。外
軸ｌの内部は内軸２が滑動する部分であるとともにバル
ーン３内に充填された薬液が人体へ徐々に流出する時の
流路でもある。従って、外軸１の内面と内軸２の外面と
の間には、０．５〜３鴫程度のクリアランスを設けるよ
うにするのが好ましい、バルーン３は患者への薬液注入
量、注入時間等に応じて種々の大きさ、肉厚のものを用
いることができ、本発明に限定されるものでないが、概
ねの値を示すならば、外形は２〜３０ｍであり、肉厚は
０．１〜２．０鵬であり、また長さは３〜３０ｃｍであ
る。バルーン３は薬液を充填することによって半径方向
とともに長手方向にも膨張しうる構造になっている。内
軸２はバルーン３の動きに付随して外軸１内を出たり入
ったりし、その位置とバルーン３内に残っている薬液の
量との関係は一定であるので、後述するハウジング６に
目盛を設けることによって薬液の流出量を確認すること
ができる。In FIGS. 1 and 2, a balloon part A is a part filled with a medical solution, and is also a driving part that moves the medical solution to the human body for injection and removal. an inner shaft 2 slidably installed inside the shaft, a balloon 3 provided on the outside of both shafts, and one end of the outer shaft 1 opposite to the side where the inner shaft 2 is installed. Antibiotics are applied to a chemical solution inlet and a drug solution outlet connected to the section. The outer shaft 1 and the inner shaft 2 are made of synthetic resin such as polycarbonate, polyethylene, polypropylene, etc. The balloon 3 has a cylindrical shape and is provided outside the outer shaft 1 and the inner shaft 2 so as to cover the outer shaft 1 and the inner shaft 2. One end of the balloon 3 is attached to the outer shaft 1, and the other end is attached to an O-ring 5 or a metal It is tightly and tightly fixed by a sealing means such as a spiral stopper. The inside of the outer shaft 1 is the part on which the inner shaft 2 slides, and is also a flow path through which the medicinal solution filled in the balloon 3 gradually flows out to the human body. Therefore, it is preferable to provide a clearance of about 0.5 to 3 mm between the inner surface of the outer shaft 1 and the outer surface of the inner shaft 2. Various sizes and wall thicknesses can be used depending on the situation, and the present invention is not limited to this, but as a rough example, the outer diameter is 2 to 30 m, and the wall thickness is 0.1 m. ~2.0cm, and the length is 3~30cm. The balloon 3 has a structure that can be expanded not only in the radial direction but also in the longitudinal direction by filling it with a medical solution. The inner shaft 2 moves in and out of the outer shaft 1 along with the movement of the balloon 3, and the relationship between its position and the amount of drug remaining in the balloon 3 is constant. By providing a scale, it is possible to check the amount of chemical solution flowing out.
バルーン３は弾性材料からなるバルーン部の応力がエネ
ルギー弾性の一部を欠如してなるものであり、未処理の
弾性材料からなるバルーンに液体または気体を薬液充填
予定量以上に充填し、次いで液体または気体の一部を除
去して１時間以上バルーンの膨張状態を保持する前処理
を施して製造される。Balloon 3 is a balloon made of an elastic material in which the stress in the balloon part lacks a part of the energy elasticity. Alternatively, the balloon is manufactured by performing pretreatment to remove part of the gas and maintain the balloon in an expanded state for one hour or more.
エネルギー弾性の一部を欠如した弾性材料からなるバル
ーン３は未処理の弾性材料からなるバルンと比べて、膨
張時の応力は若干低下するが、バルーンの膨張時と収縮
時のなすヒステリシス曲線の歪時の応力差が小さくなる
。その結果、バルーン内に充填した薬液をほぼ一定速度
で人体に注入することができる。未処理の弾性材料から
欠如するエネルギー弾性の割合は好ましくは２０〜９０
％、特に３５〜７５％が好ましい、かかるバルーンは未
処理の弾性材料からなるバルーンに気体または液体を薬
液充填量以上に充填し、次いで気体または液体の一部を
排出し、その状態で１時間以上バルーンを保持すること
によって製造される。バルーンに充填する気体または液
体の充填量はバルーンの薬液充填量以上であるが、バル
ーンの実使用時の圧力より少なくとも１０％、好ましく
は２０〜５０％である。使用する気体としては空気また
は不活性ガス、液体としては水が好ま しい。気体また
は液体の排出量は少なくとも３％、好ましくは１０〜３
０％であり、保持時間は１時間以上、好ましくは１日以
上、更に好ましくは１〜２週間である。バルーン材料と
してはシリコーンゴム、ブチルゴム、ニトリルブタジェ
ンゴム、ポリ−１，４−ブタジェン、ポリイソプレン、
ポリウレタン、ブタジェンスチレン共重合体などの弾性
重合 体または天然ゴム、これらの重合体混合物、ラミ
ネート等が挙げられる。Balloon 3, which is made of an elastic material that lacks a portion of its energy elasticity, has a slightly lower stress during inflation than a balloon made of an untreated elastic material, but the distortion of the hysteresis curve that occurs when the balloon is inflated and deflated. The difference in stress during this time becomes smaller. As a result, the medical solution filled in the balloon can be injected into the human body at a substantially constant rate. The percentage of energy elasticity missing from the untreated elastic material is preferably between 20 and 90.
%, particularly preferably 35 to 75%. Such a balloon is made of an untreated elastic material and is filled with gas or liquid to an amount equal to or higher than the drug filling amount, then part of the gas or liquid is evacuated, and the balloon is kept in that state for 1 hour. Manufactured by holding the balloon over. The amount of gas or liquid to be filled into the balloon is equal to or greater than the amount of drug solution filled into the balloon, but is at least 10%, preferably 20 to 50%, of the pressure when the balloon is actually used. The gas used is preferably air or an inert gas, and the liquid used is preferably water. The gas or liquid discharge rate is at least 3%, preferably 10-3
0%, and the retention time is 1 hour or more, preferably 1 day or more, and more preferably 1 to 2 weeks. Balloon materials include silicone rubber, butyl rubber, nitrile butadiene rubber, poly-1,4-butadiene, polyisoprene,
Examples include elastic polymers such as polyurethane and butadiene styrene copolymer, natural rubber, mixtures of these polymers, and laminates.
ハウジング６はバルーン３が外部の物体に触れて破損す
るのを防止するとともに、バルーン自体のピンホール等
の欠陥によってバルーンから液洩れが発生した場合に、
外部に薬液が飛散しないように薬液を密封する機能を有
している。ハウジング６はポリ塩化ビニル、ポリプロピ
レン、ポリカーボネート等の合成樹脂からなるのが好ま
しい。The housing 6 prevents the balloon 3 from being damaged by contact with external objects, and also prevents liquid from leaking from the balloon due to defects such as pinholes in the balloon itself.
It has the function of sealing the chemical solution to prevent it from scattering to the outside. The housing 6 is preferably made of synthetic resin such as polyvinyl chloride, polypropylene, polycarbonate, or the like.
ハウジング６は薬液の注入状況を外部から目視にて観察
できるように透明な材料からなるのが好ましい。The housing 6 is preferably made of a transparent material so that the injection status of the chemical solution can be visually observed from the outside.
ハウジング６は万一バルーン３が破損しても、薬液が外
部に洩れないようにバルーン部Ａを密封状態で覆うもの
であるが、内部を完全に気密状態にすると、バルーン３
内に薬液を注入するにつれて内部の空気が圧縮されて圧
力が高くなり、ある程度以上には薬液を注入することが
できなくなる不都合が生じる。そごで、ハウジング６の
適宜の箇所に空気抜きの開口部７を形成し、該開口部７
に空気は通過するが、薬液は通過させない疎水フィルタ
ー８が設けられている。疎水性フィルター８の材質とし
ては、ポリエステル、弗素樹脂あるいは両者のラミネー
ト等が挙げられる。The housing 6 seals and covers the balloon part A to prevent the chemical solution from leaking outside even if the balloon 3 is damaged. However, if the inside is made completely airtight, the balloon 3
As the medicinal solution is injected into the chamber, the air inside is compressed and the pressure increases, causing the inconvenience that the medicinal solution cannot be injected beyond a certain level. Then, an air vent opening 7 is formed at an appropriate location in the housing 6, and the opening 7 is
A hydrophobic filter 8 is provided which allows air to pass through but not the chemical solution. Examples of the material for the hydrophobic filter 8 include polyester, fluororesin, or a laminate of both.
外軸１の一端であって、内軸２が内装される側と反対側
の端部には薬液流入部および薬液流出部（以下接続部と
いう）１０が接続されている。この接続部１０は薬液の
バルーン内への流入または薬液のバルーンからの流出の
通路となる部分である。A chemical liquid inlet and a chemical liquid outlet (hereinafter referred to as a connecting part) 10 are connected to one end of the outer shaft 1, which is opposite to the side where the inner shaft 2 is installed. The connecting portion 10 is a passage for the medical solution to flow into the balloon or for the medical solution to flow out from the balloon.
接続部１０のハウジング６の反対側の端部には分岐路１
２が接続されている０本実施例では、この分岐路１２は
Ｙ字管で構成されている。分岐路１２は薬液流入路１３
と薬液流出路１４とからなっており、ポリオレフィン、
ポリ塩化ビニル、ポリカーボネート等で作製されている
。薬液流入路１３の先端には注射器（図示せず）等を利
用して薬液をバルーン３内に注入することができる薬液
注入用栓体１５が設けられている。薬液注入用栓体１５
はシリコーンゴムなどのゴム状弾性体からなり、耐刺通
性（薬液注入針を多数回突き刺しても液密性が保持され
、内部の薬液が洩れないような性質をいう）に優れた栓
体をうることができる。At the end of the connection 10 opposite the housing 6 there is a branch 1
In this embodiment, this branch path 12 is constructed of a Y-shaped pipe. The branch path 12 is a chemical liquid inflow path 13
and a chemical liquid outflow path 14, which contains polyolefin,
It is made of polyvinyl chloride, polycarbonate, etc. A drug solution injection stopper 15 is provided at the tip of the drug solution inflow path 13, which allows the drug solution to be injected into the balloon 3 using a syringe (not shown) or the like. Chemical solution injection stopper 15
is a plug made of a rubber-like elastic material such as silicone rubber, and has excellent puncture resistance (a property that maintains liquid tightness even when punctured with a chemical injection needle many times and prevents the internal chemical from leaking). can be obtained.
一方、薬液流出路１４の先端には、薬液流出チューブ１
１が接続されており、このチューブ１１は薬液の流れを
随時停止させることができるクランプエフと後述する流
量制御部１８を有している。On the other hand, a chemical liquid outflow tube 1 is provided at the tip of the chemical liquid outflow path 14.
1 is connected to the tube 11, and this tube 11 has a clamp-F that can stop the flow of the chemical solution at any time and a flow rate control section 18, which will be described later.
流量制御部１８は薬液の流量を制御する部分であり、本
実施例では極細のパイプで構成されている。The flow rate control unit 18 is a part that controls the flow rate of the chemical liquid, and in this embodiment, it is composed of an extremely thin pipe.
パイプはステンレスなどの金属、セラミックまたはポリ
オレフィン、ポリ塩化ビニル、ポリエステルなどの合成
樹脂が使用され、その内径は１０〜５００μ、長さは１
〜５０００ａｏである。パイプの内径がＩＯμ未満であ
ると、薬液中の空気の混入などで薬液の流れが停止する
傾向があり、５００μを超えると、薬液流量の制御が困
難になる傾向がある。パイプの長さが１鵬未満であると
、薬液量の制御が困難になる傾向がある。また、５００
０ＩＩＩＩ１１を超えると、装置が大きくなりすぎる傾
向があるが、その際にはパイプをバネ状またはスパイラ
ル状の捲縮構造にして軸方向にある程度伸縮しうるよう
にし、パイプをケーシング内に収納することで流量制御
部１８を小型化することができる。The pipe is made of metal such as stainless steel, ceramic or synthetic resin such as polyolefin, polyvinyl chloride, polyester, etc., and its inner diameter is 10 to 500μ and the length is 1
~5000ao. If the inner diameter of the pipe is less than IOμ, the flow of the chemical tends to stop due to air being mixed into the chemical, and if it exceeds 500μ, it tends to become difficult to control the flow rate of the chemical. If the length of the pipe is less than 1 inch, it tends to be difficult to control the amount of the chemical solution. Also, 500
If it exceeds 0III11, the device tends to become too large, but in that case, the pipe should be made into a spring-like or spiral-like crimped structure so that it can expand and contract to some extent in the axial direction, and the pipe should be housed in a casing. Accordingly, the flow rate control section 18 can be downsized.
薬液流出チューブ１１の先端部にはルアーテーパ−にな
った接続具１９が設けられており、該接続具Ｉ９を介し
て静脈針やＰＳｖセクトなどが接続される。A Luer tapered connector 19 is provided at the distal end of the drug solution outflow tube 11, and a venous needle, PSv sector, etc. is connected via the connector I9.
接続具１９には、静脈圧などにより薬液が逆流するのを
防止するために逆止弁（図示せず）を設けてもよい。The connector 19 may be provided with a check valve (not shown) to prevent the medical solution from flowing back due to venous pressure or the like.
次に、本発明のバルーンインフューザーの使用方法を第
１図に基づいて説明する。Next, a method of using the balloon infuser of the present invention will be explained based on FIG.
薬液の注入は、例えば注射器の注射針を薬液注入用栓体
１５に刺し込んでバルーン３内に薬液を充填する。この
際薬液が人体側へ流出しないようにクランプ１７を停止
の状態にしておく必要がある。To inject the drug solution, for example, the needle of a syringe is inserted into the drug solution injection stopper 15 to fill the balloon 3 with the drug solution. At this time, it is necessary to keep the clamp 17 in a stopped state so that the medicinal solution does not flow out toward the human body.
所定の量の薬液の充填が終わると、注射針を薬液注入用
栓体６から抜き取る。その後は実際の薬液注入箇所に応
じて患者の体内に薬液の注入が行われる。When a predetermined amount of the drug solution is filled, the injection needle is removed from the drug solution injection stopper 6. Thereafter, the medicinal solution is injected into the patient's body according to the actual medicinal solution injection location.
実施例エ
シリコーン製バルーン（内径６ 、８ ｒｍ 、外径８
．４鵬、肉厚０．８ｍｍ）内に空気をゲージ圧２３０ｍ
ｍｌ（ｇになるまで吹き込んだ後、バルーン内の空気を
除去してゲージ圧１８５ｍｍＨｇまで下げ、４日間放置
したところ、ゲージ圧はＩ １０ ｒｒｍ Ｈ＆まで下
った。バルーン内のゲージ圧は圧力モニター（コスモ計
器製０Ｐ−３１０）で測定した。このように前処理した
バルーンは処理前よりエネルギー弾性力の一部が欠如し
た応力を有し、第３図の応力−歪曲線にみられるように
、薬液量の増加に対して、バルーンの内圧は殆ど変わら
ない状態を示し、また薬液排出時もほぼ一定の圧力で供
給することができる。バルーンを第１図に示すバルーン
インフューザーに組み込み、６０Ｉｄの生理食塩水を注
射器で栓体１５からバルーン内に充填した。次いで極細
のステンレスバイブ（外径０．３ｍｍ、内径０．１ｍｍ
、長さ２５０ｍｍ）の流量制御部を用いて、バルーン内
の薬液を接続具１９に取りつけた静脈針から滴下した。Example Esilicon balloon (inner diameter 6,8 rm, outer diameter 8
．． 4 Peng, wall thickness 0.8 mm) with a gauge pressure of 230 m
ml (g), the air inside the balloon was removed to lower the gauge pressure to 185 mmHg, and when it was left for 4 days, the gauge pressure dropped to I 10 rrm H&.The gauge pressure inside the balloon was monitored by the pressure monitor ( The balloons pretreated in this way had a stress that lacked a part of the energy elastic force compared to before the treatment, as seen in the stress-strain curve in Figure 3. The internal pressure of the balloon shows almost no change as the amount of chemical solution increases, and even when the drug solution is discharged, it can be supplied at a nearly constant pressure.The balloon was assembled into the balloon infuser shown in Figure 1, and a 60Id. Physiological saline was filled into the balloon from the stopper 15 using a syringe. Next, an ultra-fine stainless steel vibrator (outer diameter 0.3 mm, inner diameter 0.1 mm) was inserted into the balloon.
, length 250 mm), the drug solution in the balloon was dripped from the intravenous needle attached to the connector 19.
この時のバルーン内の薬液量とバルーン内圧の関係を第
３図に示す、またバルーン内の薬液の排出時間に対する
排出量の関係を第４図に示す。更にバルーン内の薬液の
排出時間に対する時間当たりの排出量の関係を第５図に
示す。FIG. 3 shows the relationship between the amount of the chemical solution in the balloon and the balloon internal pressure at this time, and FIG. 4 shows the relationship between the amount of the drug solution in the balloon and the discharge time. Furthermore, FIG. 5 shows the relationship between the discharge amount per hour and the discharge time of the chemical solution in the balloon.
比較例１
実施例１において、シリコーン製バルーンを前処理せず
に、実施例１で使用したバルーンインフューザーに取付
けて、実施例１と同様に薬液をバルーン内に充填した後
、バルーン内の薬液を排出した。その結果を第３〜５図
に示す。Comparative Example 1 In Example 1, a silicone balloon was attached to the balloon infuser used in Example 1 without being pretreated, and a medical solution was filled into the balloon in the same manner as in Example 1. was discharged. The results are shown in Figures 3-5.
第３〜５図で明らかなように、前処理した実施例１のバ
ルーンインフューザーはバルーン内の薬液排出時のバル
ーン内圧の変化が少ないために、未処理の比較例１のバ
ルーンインフューザーと比較して、長時間に亙ってほぼ
一定の排出量で薬液を供給することができる。As is clear from Figures 3 to 5, the pretreated balloon infuser of Example 1 was compared with the untreated balloon infuser of Comparative Example 1 because there was little change in the balloon internal pressure when the medical solution was discharged from the balloon. As a result, the chemical solution can be supplied at a substantially constant discharge rate over a long period of time.
実施例２
小時ゴム社製天然ゴムバルーン（内径５ｍ、外径７ｍｓ
、肉厚１９）内にゲージ圧が６５０ｍｍＨＨになるまで
水を充填した後、バルーン内の水を一部除去してゲージ
圧５００ ＷＨＨにし、２日間この状態を保持した。こ
のように前処理したバルーンは処理前よりエネルギー弾
性力の一部が欠如した応力を有し、このバルーンを実施
例１で使用したバルーンインフューザーに取りつけて６
０ｄの生理食塩水を充填したバルーンインフューザーは
第６図の応力−歪曲線にみられるように、薬液の増加量
に対してバルーンのなす膨張圧とバルーン内の薬液を排
出する時になすバルーンの収縮圧との差が小さく、バル
ーン内の薬液がほぼ一定の流出速度で排出することを示
している。またこの前処理したバルーン２０個に水をゲ
ージ圧５００ ｍ Ｈｇまで充填し、１０日間耐久テス
トしたところ、１個も破損がなかった。Example 2 Natural rubber balloon manufactured by Koji Rubber Co., Ltd. (inner diameter 5 m, outer diameter 7 ms)
, wall thickness 19) was filled with water until the gauge pressure reached 650 mmHH, then part of the water inside the balloon was removed to make the gauge pressure 500 WHH, and this state was maintained for 2 days. The balloon pretreated in this way has a stress that lacks a part of the energy elastic force compared to before treatment, and this balloon is attached to the balloon infuser used in Example 1 and 6
As shown in the stress-strain curve in Figure 6, a balloon infuser filled with 0d of physiological saline has a change in the inflation pressure of the balloon with respect to the increase in the amount of medical solution and the pressure of the balloon when discharging the medical solution inside the balloon. The difference between the contraction pressure and the contraction pressure is small, indicating that the medicinal solution inside the balloon is discharged at a nearly constant outflow rate. Furthermore, when 20 of the pretreated balloons were filled with water to a gauge pressure of 500 m Hg and subjected to a 10-day durability test, none of them were damaged.
比較例２
実施例２において、天然ゴム製バルーンを前処理せずに
、実施例１で使用したバルーンインフューザーに取りつ
けて、実施例２と同様に薬液をバルーン内に充填した後
、バルーン内の薬液を排出した。その時の薬液量に対す
るバルーンのなす圧力との関係を第６図に示す。Comparative Example 2 In Example 2, a natural rubber balloon was attached to the balloon infuser used in Example 1 without pretreatment, and after filling the balloon with a medical solution in the same manner as in Example 2, the inside of the balloon was The drug solution was discharged. FIG. 6 shows the relationship between the amount of chemical solution and the pressure exerted by the balloon at that time.
第６図にみられるように、比較例２の応力−歪曲線は膨
張時と収縮時のなす応力差が実施例２と比較して大きく
、バルーン内の薬液の流出速度が一定でない、またこの
バルーン１０個に水をゲージ圧５００ ｍ Ｈｇまで充
填し、１０日間耐久テストしたところ、５日以内に１０
個のバルーンが破裂した。As seen in FIG. 6, the stress-strain curve of Comparative Example 2 shows that the difference in stress between expansion and contraction is larger than that of Example 2, and the flow rate of the chemical solution inside the balloon is not constant. When 10 balloons were filled with water to a gauge pressure of 500 m Hg and a 10-day durability test was carried out, the
balloons burst.
本発明のバルーンインフューザーは予め前処理して一次
弾性ヒステリシス曲線の応力からエネルギー弾性力の一
部を欠如したバルーンを使用するので、バルーン内の薬
液をほぼ一定の速度で患者に注入することができる。The balloon infuser of the present invention uses a balloon that has been pretreated to eliminate a portion of the energy elastic force from the stress of the first-order elastic hysteresis curve, so it is possible to inject the drug solution in the balloon into the patient at a nearly constant rate. can.
また本発明のバルーンインフューザーはバルーン膨張時
の応力が未処理のバルーンと比較して小さいために、薬
液保持時のバルーンの破袋が少ない。Furthermore, since the balloon infuser of the present invention has less stress when the balloon is inflated than an untreated balloon, the balloon is less likely to break when holding a medical solution.
第１図は本発明のバルーンインフューザーの一実施例の
平面図、第２図は第１図に示すバルーンインフューザー
のバルーン部であって薬液を充填した時の様子を示す拡
大断面図、第３図および第６図はバルーンの応力−歪曲
線図、第４図は第３ニ示シタバルーンを使用した時のバ
ルーンインフューザーの液量排出線図、第５図は第４図
の時間当たりの液量排出線図を示す。
図中Ａはバルーン部、１は外軸、２は内軸、３はバルー
ン、６はハウジング、１２は分岐路、１５は薬液注入用
栓体、１７はクランプ、１ｇは流量制御部を示す。FIG. 1 is a plan view of an embodiment of the balloon infuser of the present invention, FIG. 2 is an enlarged cross-sectional view of the balloon portion of the balloon infuser shown in FIG. Figures 3 and 6 are stress-strain curve diagrams of the balloon, Figure 4 is a fluid volume discharge diagram of the balloon infuser when using the 3rd-display balloon, and Figure 5 is the hourly diagram of Figure 4. The liquid volume discharge diagram is shown. In the figure, A indicates a balloon portion, 1 indicates an outer shaft, 2 indicates an inner shaft, 3 indicates a balloon, 6 indicates a housing, 12 indicates a branch channel, 15 indicates a stopper for drug injection, 17 indicates a clamp, and 1g indicates a flow rate control section.
Claims (2)
注入および流出する弾性材料からなるバルーン部と、 前記バルーン部を収納し、その開口部に薬液注入部およ
び薬液流出部が固着されてなるハウジングと、 前記薬液流出部から延びた薬液流通路と、 該流通路に配置された薬液量を制御するための流量制御
部とからなるバルーンインフューザーにおいて、 前記弾性材料からなるバルーン部の応力がエネルギー弾
性の一部を欠如してなるバルーンインフューザー。(1) A balloon section made of an elastic material that stores a medical solution under pressure and injects and flows out the medical solution from an opening; the balloon section is accommodated, and a medical solution injection part and a medical solution outflow part are fixed to the opening; In the balloon infuser, the balloon infuser includes: a housing made of a liquid medicine; a liquid medicine flow path extending from the liquid medicine outlet; and a flow rate control part arranged in the flow passage for controlling the amount of the liquid medicine; the balloon part made of the elastic material; The stress of the balloon infuser becomes devoid of some of the energy elasticity.
気体を薬液充填予定量以上に充填し、次いで液体または
気体の一部を除去して１時間以上バルーンの膨張状態を
保持する前処理を施したバルーン部である請求項１記載
のバルーンインフューザー。(2) A balloon made of an untreated elastic material is filled with liquid or gas to an amount greater than the planned amount of chemical liquid, and then a pretreatment is performed to remove a portion of the liquid or gas and maintain the balloon in an inflated state for one hour or more. 2. The balloon infuser according to claim 1, wherein the balloon part has a cylindrical shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1271111A JPH03133460A (en) | 1989-10-18 | 1989-10-18 | Balloon infuser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1271111A JPH03133460A (en) | 1989-10-18 | 1989-10-18 | Balloon infuser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03133460A true JPH03133460A (en) | 1991-06-06 |
Family
ID=17495491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1271111A Pending JPH03133460A (en) | 1989-10-18 | 1989-10-18 | Balloon infuser |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03133460A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07222798A (en) * | 1993-06-25 | 1995-08-22 | Nissho Corp | Transfusion set and medicinal liquid injecting device using the same |
-
1989
- 1989-10-18 JP JP1271111A patent/JPH03133460A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07222798A (en) * | 1993-06-25 | 1995-08-22 | Nissho Corp | Transfusion set and medicinal liquid injecting device using the same |
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