JP2586275B2 - Chemical injection tool - Google Patents
Chemical injection toolInfo
- Publication number
- JP2586275B2 JP2586275B2 JP4079378A JP7937892A JP2586275B2 JP 2586275 B2 JP2586275 B2 JP 2586275B2 JP 4079378 A JP4079378 A JP 4079378A JP 7937892 A JP7937892 A JP 7937892A JP 2586275 B2 JP2586275 B2 JP 2586275B2
- Authority
- JP
- Japan
- Prior art keywords
- chemical
- balloon
- control unit
- flow
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000126 substance Substances 0.000 title claims description 165
- 239000007924 injection Substances 0.000 title claims description 51
- 238000002347 injection Methods 0.000 title claims description 51
- 239000000243 solution Substances 0.000 claims description 113
- 239000003814 drug Substances 0.000 claims description 50
- 239000007788 liquid Substances 0.000 claims description 48
- 229940079593 drug Drugs 0.000 claims description 41
- 238000011144 upstream manufacturing Methods 0.000 claims description 8
- 239000013013 elastic material Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 2
- 238000004891 communication Methods 0.000 description 11
- 229920000915 polyvinyl chloride Polymers 0.000 description 9
- 239000004800 polyvinyl chloride Substances 0.000 description 9
- 230000037452 priming Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000036760 body temperature Effects 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 244000043261 Hevea brasiliensis Species 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 229920003052 natural elastomer Polymers 0.000 description 4
- 229920001194 natural rubber Polymers 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 238000001802 infusion Methods 0.000 description 3
- 229920001195 polyisoprene Polymers 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- 241000405070 Percophidae Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920003002 synthetic resin Polymers 0.000 description 2
- 239000000057 synthetic resin Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- ZAAQJFLUOUQAOG-UHFFFAOYSA-N 4-benzyl-2,6-ditert-butylphenol Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CC=2C=CC=CC=2)=C1 ZAAQJFLUOUQAOG-UHFFFAOYSA-N 0.000 description 1
- 229920000459 Nitrile rubber Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241000289371 Ornithorhynchus anatinus Species 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 238000000944 Soxhlet extraction Methods 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 210000003323 beak Anatomy 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002857 polybutadiene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は所定量の薬液を体内に、
注入するための薬液注入用具に関し、更に詳しくは、バ
ル−ン内に加圧状態で貯蔵した薬液を、一定速度で患者
に注入することができる薬液注入用具に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention
More specifically, the present invention relates to a drug solution injection device capable of injecting a drug solution stored under pressure in a balloon at a constant rate into a patient.
【０００２】[0002]
【従来の技術】従来より、抗生物質、抗ガン剤、麻酔剤
等の薬液を血管、膀胱等に少しずつ注入する手段とし
て、弾性材料からなるバル−ンに薬液を収納し、バル−
ンの収縮力を利用して薬液を長時間にわたって人体に持
続注入する器具（特表昭６２−５０１３３３号公報）が
知られている。該公報に記載されている薬液注入用具は
バル−ンを収納するバル−ン部と、微細径パイプからな
る流量制御部を有するチュ−ブとからなり、該流量制御
部がチュ−ブ下流端の接続具に隣接して配置されたもの
である。バル−ン内に充填された薬液はチュ−ブを通っ
て接続具に接続された静脈針等から患者に注入される。
バル−ン内の薬液は最初チュ−ブ内の空気を追い出しな
がらチュ−ブ内を薬液で充満していくが、微細径パイプ
からなる流量制御部がチュ−ブ下流端の接続具に隣接し
て配置されているので、チュ−ブの液体プライミング時
間が短いのがこの用具の特徴である。2. Description of the Related Art Conventionally, as a means for injecting a drug solution such as an antibiotic, an anticancer drug, an anesthetic, etc. little by little into a blood vessel, a bladder or the like, the drug solution is stored in a balloon made of an elastic material.
An instrument for continuously injecting a drug solution into a human body over a long period of time by utilizing the contraction force of a gas (Japanese Patent Publication No. 62-501333) is known. The chemical liquid injection tool described in this publication comprises a balloon portion for accommodating a balloon, and a tube having a flow rate control section comprising a fine diameter pipe, wherein the flow rate control section is located at the downstream end of the tube. Are arranged adjacent to the connecting device of (1). The drug solution filled in the balloon is injected into a patient through a tube through a venous needle or the like connected to a connector.
The chemical solution in the balloon first fills the inside of the tube with the chemical solution while expelling the air in the tube, but a flow rate control unit composed of a fine-diameter pipe is adjacent to the connector at the downstream end of the tube. It is a feature of this device that the tube is primed so that the liquid priming time of the tube is short.
【０００３】[0003]
【発明が解決しょうとする課題】しかしながら、かかる
薬液注入用具の薬液注入流量は、図７の薬液注入用具の
薬液流出速度と温度との関係を示すグラフでも明らかな
ように、雰囲気温度によって薬液流出速度が大きな影響
を受ける。図７はバル−ン材料が異なる２種類の異なる
型の薬液注入用具を使用して、雰囲気温度を30℃〜40℃
に変更したときの薬液流出速度の変化を示したものであ
る。図７に示すように雰囲気温度が高くなるにつれて、
薬液流出速度は大きくなる。However, as shown in the graph of FIG. 7 showing the relationship between the chemical outflow speed and the temperature of the chemical infusion tool, the chemical infusion flow rate of the chemical infusion tool depends on the ambient temperature. Speed is greatly affected. FIG. 7 shows an atmosphere temperature of 30 ° C. to 40 ° C. using two different types of chemical injection tools having different balloon materials.
This shows the change in the drug solution outflow speed when changing to. As shown in FIG. 7, as the ambient temperature increases,
The drug solution outflow speed increases.
【０００４】一方、特表昭６２−５０１３３３号公報に
記載の薬液注入用具は、流量制御部が静脈針等を接続す
る接続具46に隣接して患者の腕に静脈針とともに絆創膏
等で固着されて患者の体内に薬液の注入が行われるの
で、薬液の流速が患者の腕の体温によって影響を受ける
問題がある。そして患者の腕の体温は、個人差およびそ
の時の患者の状態によって32℃〜40℃付近まで異なるの
で、薬液を所望時間で患者の体内に供給するためには、
その状態に応じた多くの品種の薬液注入用具を予め準備
しなければならない問題がある。更に、この薬液注入用
具はバル−ン内の薬液を患者に注入するのに長いチュ−
ブを使用しているために、チュ−ブが途中で捩れてチュ
−ブ内径が閉塞し、薬液の流れがその箇所で停止するこ
とがあった。 On the other hand, in a drug solution injecting device described in Japanese Patent Publication No. 62-501333, a flow control unit is fixed to a patient's arm with a venous needle together with a bandage or the like adjacent to a connecting device 46 for connecting a venous needle or the like. Therefore, there is a problem that the flow rate of the drug solution is affected by the body temperature of the arm of the patient because the drug solution is injected into the patient's body. And since the body temperature of the patient's arm varies from around 32 ° C to around 40 ° C depending on individual differences and the condition of the patient at that time, in order to supply the drug solution to the patient's body in a desired time,
There is a problem that it is necessary to prepare many kinds of liquid medicine injection tools corresponding to the state. In addition, for this chemical injection
The device is a long tube to inject the medicinal solution in the balloon into the patient.
The tube is twisted in the middle because the tube is used.
-The inside diameter of the valve is blocked and the flow of the chemical stops at that point.
There was.
【０００５】本発明者等はこれらの課題を解決するため
に、流量制御部を患者の腕の体温の影響を受けない位
置、すなわち、接続具46から離れた位置に設置して患者
に薬液を注入することを試みたが、薬液注入開始時にお
ける薬液流通チュ−ブ内の空気を追い出してチュ−ブ内
を薬液で充満させる、いわゆるプライミング時間が長く
なる欠点があった。本発明の目的は薬液を患者に注入す
るときに、薬液流通チュ−ブが捩れて薬液の流れが停止
することなく、患者の腕の体温の影響を受けないで薬液
を所定速度で患者に注入することができ、かつプライミ
ング時間の短い薬液注入用具を提供することである。In order to solve these problems, the present inventors set the flow control unit at a position not affected by the body temperature of the patient's arm, that is, at a position away from the connecting device 46, and apply a chemical solution to the patient. Attempts were made to inject, but there was a drawback in that the so-called priming time was prolonged, in which the air in the chemical solution flow tube at the start of the injection of the chemical solution was filled with the chemical solution. An object of the present invention is to inject a drug solution into a patient.
Chemical flow tube twists and stops the flow of chemical
Without is to provide a short liquid injection tool is not affected by the temperature of the patient's arm can be injected into the patient a drug solution at a predetermined speed, and the priming time.
【０００６】[0006]
【課題を解決するための手段】本発明は加圧状態で薬液
を貯蔵し、かつ開口部から薬液を注入および流出させる
弾性材料からなるバル−ン部と、前記バル−ン部を収納
し、その開口部に薬液注入部および薬液流出部が固着さ
れてなるハウジングと、前記薬液流出部から延びた薬液
流通チュ−ブと、該チュ−ブに配置された薬液量を制御
するための流量制御部とからなる薬液注入用具におい
て、前記流量制御部は内径10〜 500μのパイプからな
り、該流量制御部からその下流に位置する接続具までの
薬液流通チュ−ブの内径が、該流量制御部からその上流
に位置する薬液流出部方向へ延びた薬液流通チュ−ブの
内径に比較して小さく、かつ前記流量制御部の内径より
大きいことを特徴とする薬液注入用具である。また、本
発明は前記薬液注入用具において、流量制御部からその
下流に位置する接続具までの薬液流通チュ−ブの内径
が、該流量制御部からその上流に位置する薬液流出部方
向へ延びた薬液流通チュ−ブの内径に対して15％〜85％
である薬液注入用具である。更に、本発明は前記薬液注
入用具において、流量制御部からその下流に位置する接
続具までの距離が少なくとも30cmである薬液注入用具で
ある。SUMMARY OF THE INVENTION According to the present invention, there is provided a balloon portion made of an elastic material for storing a drug solution in a pressurized state and injecting and flowing a drug solution from an opening, and accommodating the balloon portion. A housing having a chemical solution injection portion and a chemical solution outflow portion fixed to the opening, a chemical solution distribution tube extending from the chemical solution outflow portion, and a flow rate control for controlling the amount of the chemical solution disposed in the tube; The flow control unit comprises a pipe having an inner diameter of 10 to 500 μm, and the inner diameter of the chemical flow tube from the flow control unit to the connector positioned downstream thereof is the flow control unit. Is smaller than the inner diameter of the chemical flow tube extending in the direction of the chemical liquid outlet located upstream of the flow controller , and is smaller than the inner diameter of the flow control unit.
It is a chemical injection tool characterized by being large . According to the present invention, in the chemical liquid injection tool, the inner diameter of the chemical liquid flow tube from the flow control part to the connector positioned downstream thereof extends in the direction of the chemical liquid outlet part located upstream from the flow control part. 15% to 85% of the inner diameter of the chemical distribution tube
It is a chemical injection tool. Further, the present invention is the chemical injection tool, wherein the distance from the flow control unit to the connector positioned downstream thereof is at least 30 cm.
【０００７】[0007]
【作用】本発明は薬液をバル−ン内に充填して膨張した
バル−ンの収縮力を利用して、バル−ン内の薬液を患者
に注入するものである。バル−ン内の薬液の流出速度を
制御する流量制御部は薬液流通チュ−ブの下流端に設置
された接続具から離れた位置に設けられている。その結
果、流量制御部は腕の体温の影響を受けないで所望する
流速でバル−ン内の薬液を流出することができる。ま
た、流量制御部からその下流に位置する接続具までの薬
液流通チュ−ブの内径が該流量制御部からその上流に位
置する薬液流出部方向へ延びたチュ−ブの内径と比較し
て小さいので、微細径のパイプからなる流量制御部を通
過した薬液は比較的早い速度で流量制御部から下流のチ
ュ−ブ内の空気を追い出してチュ−ブ全体を薬液で充満
させることができる。According to the present invention, the medicinal solution in the balloon is injected into the patient by using the contraction force of the balloon which is filled with the medicinal solution and expanded. The flow rate control unit for controlling the outflow speed of the chemical solution in the balloon is provided at a position remote from a connector provided at the downstream end of the chemical solution flow tube. As a result, the flow control unit can discharge the drug solution in the balloon at a desired flow rate without being affected by the body temperature of the arm. Also, the inner diameter of the chemical liquid flow tube from the flow control unit to the connector located downstream thereof is smaller than the inner diameter of the tube extending from the flow control unit toward the chemical liquid outlet located upstream of the flow control unit. Therefore, the chemical liquid that has passed through the flow rate control section composed of the fine-diameter pipe can expel air in the tube downstream from the flow rate control section at a relatively high speed, thereby filling the entire tube with the chemical liquid.
【０００８】[0008]
【実施例】以下実施例で本発明の薬液注入用具の一例を
説明する。図１は本発明の薬液注入用具の一実施例の説
明図、図２は図１のバル−ンに薬液を充填したときのバ
ル−ン部の拡大断面図、図３は図１に示す薬液流通チュ
−ブのコネクタ−とルア−テ−パ−状アダプタ−の拡大
断面図、図４は図３に示すコネクタ−をルア−テ−パ−
状アダプタ−に挿入したときの状態を示す説明図、図５
はシリンジ内薬液をバル−ンに注入するときの説明図で
あってシリンジとバル−ン部が接続していない状態を示
す説明図、図６は図５に示すシリンジから薬液をバル−
ン内へ充填しているときの説明図、図７は２種類の薬液
注入用具の雰囲気温度における薬液流出速度を示すグラ
フ、図８は特開平２−１１１６０号公報の第５図に示す
バル−ン部と薬液流通チュ−ブとが接続していない状態
を示す説明図、図９は特表昭６２−５０１３３３号公報
に示す薬液注入用具の一部を使用した用具の説明図であ
る。DESCRIPTION OF THE PREFERRED EMBODIMENTS The following is a description of an embodiment of the chemical injection tool of the present invention in the following embodiments. FIG. 1 is an explanatory view of one embodiment of a chemical injection tool of the present invention, FIG. 2 is an enlarged sectional view of a balloon portion when a balloon is filled with a chemical, and FIG. 3 is a chemical shown in FIG. FIG. 4 is an enlarged sectional view of a connector of a distribution tube and a luer taper adapter. FIG. 4 shows a luer taper of the connector shown in FIG.
FIG. 5 is an explanatory view showing a state when inserted into a shape adapter.
FIG. 6 is an explanatory view showing a state in which the syringe is not connected to the balloon portion when the liquid medicine in the syringe is injected into the balloon. FIG. 6 is a view showing the state in which the liquid medicine is discharged from the syringe shown in FIG.
FIG. 7 is a graph showing the outflow rate of a chemical solution at ambient temperature of two types of chemical injection tools, and FIG. 8 is a valve diagram shown in FIG. 5 of JP-A-2-11160. FIG. 9 is an explanatory view showing a state in which the connecting portion and the chemical liquid distribution tube are not connected, and FIG. 9 is an explanatory view of a tool using a part of the chemical liquid injection tool disclosed in Japanese Patent Publication No. 62-501333.
【０００９】図１および図２において、薬液注入用具は
バル−ン部ａと薬液流通チュ−ブｂとから構成されてい
る。バル−ン部ａは薬液が収容される部分であるととも
に、該薬液を人体の注入箇所へ移動せしめる駆動部分で
あり、棒状内軸１と、該内軸１に滑動自在に外装されて
なる円筒状外軸２と、これらの両軸の外部に設けられた
バル−ン３と、内軸１と一体に形成された内軸受け４と
で構成されている。外軸２の一端であって、内軸１に外
装される側と反対側の端部には傘状部材５が固着されて
いる。In FIG. 1 and FIG. 2, the chemical injection tool comprises a balloon portion a and a chemical distribution tube b. The balloon portion a is a portion for accommodating the medicinal solution and a driving portion for moving the medicinal solution to an injection point of a human body, and includes a rod-shaped inner shaft 1 and a cylindrical member slidably mounted on the inner shaft 1. An outer shaft 2, a balloon 3 provided outside these two shafts, and an inner bearing 4 formed integrally with the inner shaft 1. An umbrella-shaped member 5 is fixed to one end of the outer shaft 2 on the side opposite to the side on which the outer shaft 2 is externally mounted.
【００１０】バル−ン３は筒状または球状の形状をして
おり、内軸１および外軸２を被覆するようにこれら両軸
の外部に設けられており、その一端は内軸１に、他端は
外軸２にＯ−リングなどのシ−ル手段６によって気密に
密着固定されている。バル−ン３は、患者への薬液注入
量、注入時間などに応じて種々の大きさ、肉厚のものを
用いることができ、本発明においては特に限定されるも
のでない。バル−ン３は薬液を充填することによって膨
張し、円筒状のバル−ンでは半径方向とともに長手方向
にも膨張しうる構造になっている。The balloon 3 has a cylindrical or spherical shape, and is provided outside the inner shaft 1 and the outer shaft 2 so as to cover the inner shaft 1 and the outer shaft 2. The other end is airtightly fixed to the outer shaft 2 by a sealing means 6 such as an O-ring. The balloon 3 can be of various sizes and thicknesses depending on the amount of the drug solution injected into the patient, the injection time, and the like, and is not particularly limited in the present invention. The balloon 3 expands by filling with a chemical solution, and the cylindrical balloon has such a structure that it can expand not only in the radial direction but also in the longitudinal direction.
【００１１】外軸２はバル−ン３の動きに付随して内軸
１をガイドとして軸方向に移動し、その位置とバル−ン
３内に残っている薬液の量との関係は一定であるので内
軸１またはハウジング７に目盛りを設けることで薬液の
流出量を確認することができる。外軸２の一端であっ
て、内軸１に外装されている側と反対側の端部には、必
要により耐水圧フイルタ−８が設けられる。この耐水圧
フイルタ−８は薬液注入時にバル−ン３内に残存してい
る空気を外部に追い出す役割を果たす部材であり、ポリ
エステル、弗素樹脂またはこれらをラミネ−トしたもの
などで作製することができる。The outer shaft 2 moves in the axial direction with the inner shaft 1 as a guide accompanying the movement of the balloon 3. The relationship between the position of the outer shaft 2 and the amount of the chemical remaining in the balloon 3 is constant. Therefore, by providing a scale on the inner shaft 1 or the housing 7, the outflow amount of the chemical solution can be confirmed. At one end of the outer shaft 2, which is on the opposite side to the side of the inner shaft 1 that is externally provided, a water-resistant filter 8 is provided as necessary. The water-resistant filter 8 is a member that plays a role in expelling air remaining in the balloon 3 to the outside at the time of injecting a chemical solution, and can be made of polyester, fluorine resin, or a laminate of these. it can.
【００１２】バル−ン３は弾性材料からなり、その材料
としてはシリコ−ンゴム、ブチルゴム、ニトリルブタジ
ェンゴム、ポリ-1,4−ブタジェン、ポリイソプレン、ポ
リウレタン、ブタジェンスチレン共重合体、ポリスチレ
ンポリブタジエンブロック共重合体の水素添加物質など
の弾性重合体または天然ゴム、これらの重合体混合物、
またはこれらの物質の添加剤を除去したのち人体に無害
の酸化防止剤を添加した加工物質、またはラミネ−ト等
が挙げられる。The balloon 3 is made of an elastic material such as silicone rubber, butyl rubber, nitrile butadiene rubber, poly-1,4-butadiene, polyisoprene, polyurethane, butadiene styrene copolymer, polystyrene polybutadiene. Elastic polymers or natural rubbers such as hydrogenated block copolymers, polymer mixtures of these,
Alternatively, a processed material obtained by removing an additive of these substances and then adding an antioxidant harmless to the human body, or a laminate may be used.
【００１３】内軸１の一端であって、外軸２が外装され
る側と反対側の端部には、内軸受け４が該内軸１と一体
に形成されている。該内軸受け４は短円筒状部材であ
り、その内軸１側端部には薬液流出入口が形成されてい
る。薬液流出入口は内軸受け４の内部を介してハウジン
グ７の薬液通路13と連通している。ハウジング７はバル
−ン３が外部の鋭利な物体に触れて破損するのを防止す
るとともに、バル−ン自体のピンホ−ルなどの欠陥によ
ってバル−ン３から液洩れが発生した場合に外部に薬液
が飛散しないように薬液を密封する機能を果たすもので
ある。ハウジング７の適宜の箇所には空気抜きの窓部10
が形成されており、該窓部10には空気は通過させるが薬
液は通過させない疎水性フイルタ−11を設けるのが好ま
しい。An inner bearing 4 is formed integrally with the inner shaft 1 at one end of the inner shaft 1 opposite to the side on which the outer shaft 2 is provided. The inner bearing 4 is a short cylindrical member, and a chemical solution outflow port is formed at an end of the inner shaft 1 on the inner shaft 1 side. The chemical liquid outflow port communicates with the chemical liquid passage 13 of the housing 7 via the inside of the inner bearing 4. The housing 7 prevents the balloon 3 from being damaged by touching an external sharp object, and is provided to the outside when liquid leaks from the balloon 3 due to a defect such as a pinhole of the balloon itself. It functions to seal the chemical so that the chemical does not scatter. An air vent window 10 is provided at an appropriate place in the housing 7.
The window 10 is preferably provided with a hydrophobic filter 11 that allows air to pass therethrough but does not allow a chemical solution to pass therethrough.
【００１４】ハウジング７の一端面はキャップ12により
閉じられており、該キャップ12の中央部分には薬液をバ
ル−ン３内に注入したり、該バル−ン３より薬液を所定
箇所に注入する際に薬液の流路となる薬液通路13が形成
されている。薬液通路13には、図３〜図６に示されるよ
うにバル−ン３側からダックビルタイプの逆止弁14、固
定デイスク15およびシ−ル手段16が設けられている。ダ
ックビルタイプの逆止弁14は弁の閉鎖端がカモノハシの
嘴のような尖った形状をしており、バル−ン３内部への
薬液の流通は許すが、その逆方向の流れは阻止する構造
となっている。逆止弁14としては、前記ダックビルタイ
プの弁のほかにも傘弁、フラップ弁、ポペット弁、ボ−
ル弁などを用いることができ、これらの弁材料としては
弗素樹脂、ナイロン、ポリオレフイン、ポリ塩化ビニ
ル、ポリカ−ボネ−ト、シリコ−ン樹脂などが挙げられ
る。固定デイスク15は逆止弁14の基板を支持するもので
あり、中央部には薬液の流出流入のための開口部17が形
成されている。開口部17は薬液流出部および薬液注入部
を兼用している。本実施例の薬液注入用具における薬液
流出部は、図２〜図６に示す固定デイスク15に定められ
るが、図８に示すようなバル−ン３内の薬液を薬液注入
用栓体49に薬液流通チュ−ブ部ｂの端部にある穿刺針を
穿刺して患者に注入する薬液注入用具においては、薬液
流出部は該栓体49である。また、特開平２-11160号公報
の第１図に示すような薬液流入ル−ト13と薬液流出ル−
ト14とが分岐してなる薬液注入用具においては、薬液流
出部は接続部10である。One end surface of the housing 7 is closed by a cap 12, and a chemical solution is injected into the balloon 3 into the center portion of the cap 12, or a chemical solution is injected from the balloon 3 to a predetermined location. At this time, a chemical solution passage 13 which is a flow path of the chemical solution is formed. As shown in FIGS. 3 to 6, the chemical liquid passage 13 is provided with a duckbill-type check valve 14, a fixed disk 15, and a sealing means 16 from the balloon 3 side. The check valve 14 of the duckbill type has a structure in which the closed end of the valve has a pointed shape like a platypus beak, and allows the flow of the chemical solution into the balloon 3 but prevents the flow in the reverse direction. It has become. The check valve 14 may include an umbrella valve, a flap valve, a poppet valve,
For example, a fluorine resin, nylon, polyolefin, polyvinyl chloride, polycarbonate, silicone resin and the like can be used. The fixed disk 15 supports the substrate of the check valve 14, and has an opening 17 formed at the center thereof for outflow and inflow of the chemical solution. The opening 17 also serves as a drug solution outflow portion and a drug solution injecting portion. The liquid outlet of the liquid injector according to the present embodiment is defined on the fixed disk 15 shown in FIGS. 2 to 6, and the liquid in the balloon 3 as shown in FIG. In a drug solution injection tool for puncturing a patient by puncturing a puncture needle at the end of the flow tube portion b, the drug solution outlet is the plug 49. Also, as shown in FIG. 1 of JP-A-2-11160, a chemical solution inflow route 13 and a chemical solution outflow route are shown.
In the drug solution injection tool that branches off from the port 14, the drug solution outflow portion is the connecting portion 10.
【００１５】接続具であるロックアダプタ−19と固定デ
イスク15により形成された環状凹所18内には、シ−ル手
段16たるＯ−リングが配設されている。このＯ−リング
の内径は連通パイプの外径と同一もしくはそれより小さ
く、これによって連通パイプを薬液通路13内に挿入した
ときのシ−ル性が高められるようになっている。ロック
アダプタ−19は内面がルア−テ−パ−状に形成されたほ
ぼ円筒状の接続具である。このロックアダプタ−19はキ
ャップ12に形成された凹所20内に嵌め込まれている。ロ
ックアダプタ−19の端部外周には薬液流通チュ−ブｂを
接続するためのネジ部21が形成されている。An O-ring serving as sealing means 16 is provided in an annular recess 18 formed by a lock adapter 19 and a fixed disk 15 which are connecting tools. The inner diameter of the O-ring is equal to or smaller than the outer diameter of the communication pipe, so that the sealing property when the communication pipe is inserted into the chemical solution passage 13 is improved. The lock adapter 19 is a substantially cylindrical connecting member having an inner surface formed in a luer taper shape. The lock adapter 19 is fitted in a recess 20 formed in the cap 12. On the outer periphery of the end of the lock adapter 19, a screw portion 21 for connecting the chemical solution flowing tube b is formed.
【００１６】薬液流通チュ−ブｂはロックアダプタ−19
に接続される接続具であるコネクタ−部30と、薬液量を
制御するための流量制御部31と、薬液注入チュ−ブ32
と、接続具33とで構成されている。コネクタ−部30の一
端にはロックアダプタ−19に接続されたときに、逆止弁
14を押し開いてバル−ン３内部に連通しうる長さを有す
る連通パイプ34が設けられている。この連通パイプ34は
ポリカ−ボネ−ト、ポリ塩化ビニル、ポリオレフインな
どの合成樹脂やステンレスなどの金属で作製することが
できる。連通パイプ34はコネクタ−部30の内周面に固着
されている。連通パイプ34の突出部の長さは、図４に示
されるようにコネクタ−部30とロックアダプタ−19が接
続されたときにダックビルタイプの逆止弁14を押し広げ
うる長さに設定されている。これにより逆止弁14の逆止
効果が強制的に解除されて、注入針を用いなくともバル
−ン3 内に充填された薬液の流出が可能になる。コネク
タ−部側のネジ部35はロクアダプタ−19に形成されたネ
ジ部21との螺合によりバル−ン部ａと薬液流通チュ−ブ
ｂとの接続が行われる。この接続は螺合以外に嵌合で行
うようにしてもよい。The chemical solution distribution tube b is a lock adapter-19.
Connector part 30 which is a connecting tool connected to the apparatus, a flow control part 31 for controlling the amount of the chemical, and a chemical injection tube 32
And a connection tool 33. When one end of the connector part 30 is connected to the lock adapter 19, a check valve
There is provided a communication pipe 34 having a length capable of pushing the opening 14 to communicate with the inside of the balloon 3. The communication pipe 34 can be made of a synthetic resin such as polycarbonate, polyvinyl chloride, or polyolefin, or a metal such as stainless steel. The communication pipe 34 is fixed to the inner peripheral surface of the connector part 30. As shown in FIG. 4, the length of the projecting portion of the communication pipe 34 is set to such a length that the duckbill check valve 14 can be expanded when the connector portion 30 and the lock adapter 19 are connected. I have. As a result, the check effect of the check valve 14 is forcibly released, and the chemical solution filled in the balloon 3 can flow out without using an injection needle. The screw portion 35 on the connector portion side is connected to the balloon portion a and the chemical solution flowing tube b by screwing with the screw portion 21 formed on the location adapter 19. This connection may be made by fitting other than screwing.
【００１７】流量制御部31は薬液の流量を制御する部分
であり、本出願人が既に出願した特開平２-11160号ある
いは特開平3-140163号で提案した内径が微細内径の金属
製パイプ、合成樹脂製パイプ、ガラス製パイプなどを用
いることができる。流量制御部31は内径10〜 500μの微
細内径のパイプからなる。流量制御部の長さは１cm以上
で、外径は内径の５〜５００倍の大きさである。流量制
御部の長さが30mmを超えると、特開平２-11160号の第６
図に示すような捲縮構造をしたものが薬液流通チュ−ブ
の長さが短くなって好ましい。The flow rate control section 31 is a section for controlling the flow rate of the chemical solution. The flow rate control section 31 is a metal pipe having a fine inner diameter proposed in Japanese Patent Application Laid-Open Nos. Hei 2-11160 and Hei 3-140163 already filed by the present applicant. A synthetic resin pipe, a glass pipe, or the like can be used. The flow control unit 31 is composed of a pipe having a fine inner diameter of 10 to 500 μm. The length of the flow control unit is 1 cm or more, and the outer diameter is 5 to 500 times the inner diameter. If the length of the flow control section exceeds 30 mm, the sixth section of Japanese Patent Application Laid-Open No.
The one having a crimped structure as shown in the figure is preferable because the length of the tube for flowing a chemical solution is short.
【００１８】薬液流通チュ−ブｂにおいて、流量制御部
31は接続具33から離れた位置に設置される。流量制御部
からその下流に位置する接続具までの薬液流通チュ−ブ
ｄは、その内径が流量制御部31からその上流に位置する
薬液流出部方向へ延びた薬液流通チュ−ブｃの内径に比
較して小さく、流量制御部31の内径より大きい。薬液流
通チュ−ブｃと薬液流通チュ−ブｄの内径の比率は、薬
液流通チュ−ブｄの長さによっても異なるが、薬液流通
チュ−ブｄの内径は薬液流通チュ−ブｃの内径に対して
15％〜85％、好ましくは30％〜70％である。薬液流通チ
ュ−ブｂの長さは少なくとも50cm、好ましくは70〜150c
m である。そのために、チュ−ブ内径が細すぎると、チ
ュ−ブが途中で捩れた場合チュ−ブ内径が閉塞してしま
う危険があるので薬液流通チュ−ブｄの内径は流量制御
部31の内径より大きいのが好ましい。そして、薬液流通
チュ−ブｄの長さが薬液流通チュ−ブｂの長さに占める
割合を20〜50％になるように配置することによってチュ
−ブ内径が閉塞する危険は更に少なくなる。薬液流通チ
ュ−ブｄの長さは少なくとも30cmあるのが、腕の温度の
影響を受けなくて好ましい。In the chemical liquid distribution tube b, a flow control unit
31 is installed at a position away from the connection tool 33. The inside diameter of the chemical flow tube d extending from the flow control unit to the connector located downstream thereof is equal to the inside diameter of the chemical flow tube c extending from the flow control unit 31 toward the upstream of the chemical solution outlet. It is smaller and larger than the inner diameter of the flow control unit 31 . The ratio of the inner diameter of the chemical distribution tube c to the inner diameter of the chemical distribution tube d depends on the length of the chemical distribution tube d, but the inner diameter of the chemical distribution tube d is equal to the inner diameter of the chemical distribution tube c. Against
It is 15% to 85%, preferably 30% to 70%. Chemical distribution
The length of the tube b is at least 50 cm, preferably 70 to 150 c.
m. If the inner diameter of the tube is too small,
If the tube is twisted in the middle, the inner diameter of the tube will be blocked.
The inner diameter of the chemical flow tube d is flow rate controlled because of the risk of
Preferably, it is larger than the inner diameter of the part 31. And chemical solution distribution
The length of the tube d occupies the length of the chemical distribution tube b.
By arranging the ratio to be 20-50%,
The risk of blockage of the valve bore is further reduced . The length of the chemical solution distribution tube d is preferably at least 30 cm without being affected by the temperature of the arm.
【００１９】連通パイプ34と流量制御部31との間には、
バル−ン３内の薬液に含有されている微小物質を除去す
るためのフイルタ−が設けられていてもよい。フイルタ
−は流量制御部31の前に設置されるのが好ましく、繊維
状物、焼結物等が使用される。薬液流通チュ−ブｂは軟
質ポリ塩化ビニル、ポリプロピレン、ポリエステルなど
からなり、その他端にはルア−テ−パ−状の接続具33が
設けられ、接続具33を介して静脈針やＰＳＶセットなど
が接続される。接続具33には静脈圧などにより薬液が逆
流するのを防止するための逆止弁（表示せず）を装備し
てもよい。なお、本発明の薬液注入用具は、特公平３-5
5142号公報、特表平1-501451号公報、特開平２-11160号
公報、特開平3-170163号公報等に記載された薬液注入用
具にも使用されることができる。Between the communication pipe 34 and the flow control unit 31,
A filter for removing minute substances contained in the chemical solution in the balloon 3 may be provided. The filter is preferably installed before the flow control unit 31, and a fibrous material, a sintered material, or the like is used. The chemical solution distribution tube b is made of a soft polyvinyl chloride, polypropylene, polyester, or the like, and a luer-taper-shaped connecting device 33 is provided at the other end. Is connected. The connector 33 may be provided with a check valve (not shown) for preventing the chemical solution from flowing backward due to venous pressure or the like. The tool for injecting a drug solution of the present invention is disclosed in
It can also be used for a drug solution injection tool described in JP-A-5142, JP-T1-501451, JP-A-2-11160, JP-A-3-170163 and the like.
【００２０】次に、本発明の薬液注入用具の使用方法の
一例について説明する。薬液のバル−ンへの注入は、図
５および図６に示すように薬液通路内に注射器のシリン
ジを挿入し、このシリンジをロックアダプタ−19のルア
−テ−パ−状の内周面に押しつけるようにして行われ
る。このときシリンジ22の針基先端は逆止弁14の入口側
にある。挿入部は注入口が広くなった分だけ、従来の注
射針による場合に比較して充填圧が小さくなり、注入が
容易になるとともに短時間で注入操作を終了させること
ができる。Next, an example of a method for using the drug solution injection tool of the present invention will be described. As shown in FIGS. 5 and 6, a syringe of a syringe is inserted into the drug solution passage and the syringe is inserted into a luer-tapered inner peripheral surface of the lock adapter 19 as shown in FIGS. It is done by pressing. At this time, the needle base tip of the syringe 22 is on the inlet side of the check valve 14. As the injection port is widened, the filling pressure of the insertion portion is smaller than that of the conventional injection needle, so that the injection becomes easy and the injection operation can be completed in a short time.
【００２１】薬液を充填するにつれて、バル−ン３は膨
張する。この際、バル−ン３内に残存している内部空気
は耐水圧フイルタ−８を通って外部に追い出される。ま
た、バル−ン３の拡張とともに内軸１に外装されている
外軸２は長手方向にスライドし、ハウジング７面に沿っ
て進んでいく。所定量の薬液充填が終わると注射器をロ
ックアダプタ−19から抜き取る。薬液充填完了時には、
傘状部材５とハウジング７の端部内面とが合致し、バル
−ン３膨張時の曲がりと振動によるバル−ンの破裂が防
止される。次に図４に示されるように薬液流出アセンブ
リ部ｂのコネクタ−部30とロックアダプタ−19内とを接
続する。この際、コネクタ−部30の連通パイプ34は逆止
弁14を押し広げて、バル−ン３内部と連通パイプ34とが
連通状態になる。その後は接続具33を介してＰＳＶセッ
トなどに接続し空気抜きなどの所定の操作を行った後
に、バル−ン３内の薬液は流量制御部31によって流量を
制御されながら患者の体内に薬液の注入が行われる。As the liquid medicine is filled, the balloon 3 expands. At this time, the internal air remaining in the balloon 3 is expelled to the outside through the water pressure resistant filter 8. Further, with the expansion of the balloon 3, the outer shaft 2 externally mounted on the inner shaft 1 slides in the longitudinal direction and advances along the surface of the housing 7. When the prescribed amount of the drug solution has been filled, the syringe is removed from the lock adapter-19. At the completion of filling the chemical,
The umbrella-shaped member 5 and the inner surface of the end of the housing 7 coincide with each other, so that the balloon is prevented from being ruptured due to bending and vibration when the balloon 3 expands. Next, as shown in FIG. 4, the connector portion 30 of the chemical solution outflow assembly portion b and the inside of the lock adapter 19 are connected. At this time, the communication pipe 34 of the connector part 30 pushes and expands the check valve 14, so that the inside of the balloon 3 and the communication pipe 34 are in communication. Thereafter, after connecting to a PSV set or the like via the connector 33 and performing a predetermined operation such as air bleeding, the liquid medicine in the balloon 3 is injected into the patient's body while the flow rate is controlled by the flow rate control unit 31. Is performed.
【００２２】[0022]
【実施例１】加硫された天然ゴム製管状体（小峰ゴム社
製）をアセトン・ヘキサン混合溶剤（混合容積比１：
２）でソックスレ−抽出を３時間行い、天然ゴム製管状
体中の添加剤を抽出除去した。次いで該管状体を１，
３，５−トリメチル−２，４，６−トリス（３，５−ジ
−ｔ−ブチル−４−ヒドロキシベンジル）ベンゼン（以
下ＢＨＴという）をアセトン・ヘキサン混合溶剤（混合
容積比１：２）の溶液（濃度0.01g/ml）中に25℃の温度
で24時間浸漬し、該管状体中に酸化防止剤であるＢＨＴ
を含浸させた。その後管状体をエタノ−ルで洗浄し25℃
の温度で12時間乾燥させた。この処理済天然ゴム製管状
体を図１に示す薬液注入用具に組み込み、60mlの水をバ
ル−ン内に充填した。次いで極細のポリ塩化ビニル製パ
イプ（外径1.00mm、内径 0.060mm、長さ115mm)を特開平
２-11160号の第６図に示すような捲縮構造にしてケ−ス
に収納して流量制御部にした。捲縮構造をしたポリ塩化
ビニル製パイプが収納されているケ−ス部分の長さは22
mmであった。この流量制御部は３日間でバル−ン内の薬
液を患者に注入するように制御されたものである。薬液
流通チュ−ブもポリ塩化ビニル製であり、その大きさは
薬液流通チュ−ブｃが外径2.8mm 、内径0.5mm 、長さ56
4mm であり、薬液流通チュ−ブｄが外径2.65mm、内径0.
3 mm、長さ336mm であった。次いで、バル−ン部ａの薬
液流出側を下方にして、バル−ン内の水を接続具33に取
りつけた静脈針からヘッド差約50mmにして滴下した。バ
ル−ン部ａの薬液流出側を下方にした時から、バル−ン
内の水が静脈針から最初に滴下するまでの時間をＮ＝10
で測定したプライミングの平均時間を表１に示す。Example 1 A vulcanized natural rubber tubular body (manufactured by Komine Rubber Co., Ltd.) was mixed with an acetone / hexane mixed solvent (mixing volume ratio 1: 1).
In 2), Soxhlet extraction was performed for 3 hours, and the additives in the natural rubber tubular body were extracted and removed. The tubular body is then
3,5-Trimethyl-2,4,6-tris (3,5-di-t-butyl-4-hydroxybenzyl) benzene (hereinafter referred to as BHT) is mixed with an acetone / hexane mixed solvent (mixing volume ratio 1: 2). Immersed in a solution (concentration 0.01 g / ml) at a temperature of 25 ° C. for 24 hours, and BHT as an antioxidant
Was impregnated. Thereafter, the tubular body is washed with ethanol, and the temperature is 25 ° C.
At a temperature of 12 hours. The treated natural rubber tubular body was assembled into the chemical injection tool shown in FIG. 1 and 60 ml of water was filled in the balloon. Next, a very fine polyvinyl chloride pipe (outside diameter 1.00 mm, inside diameter 0.060 mm, length 115 mm) was crimped as shown in FIG. 6 of JP-A-2-11160, and stored in a case. Control unit. The length of the case where the crimped polyvinyl chloride pipe is stored is 22
mm. This flow control unit is controlled so that the drug solution in the balloon is injected into the patient in three days. The chemical distribution tube is also made of polyvinyl chloride. The size of the chemical distribution tube c is 2.8 mm in outer diameter, 0.5 mm in inner diameter, and 56 mm in length.
4 mm, the chemical distribution tube d has an outer diameter of 2.65 mm and an inner diameter of 0.
It was 3 mm long and 336 mm long. Next, the water in the balloon was dropped from the venous needle attached to the connector 33 with the head difference being about 50 mm with the chemical solution outflow side of the balloon portion a facing downward. The time from when the chemical solution outflow side of the balloon section a is lowered to when the water in the balloon first drops from the venous needle is N = 10.
Table 1 shows the average priming time measured in the above.
【００２３】[0023]
【比較例１】実施例１で使用した薬液注入用具におい
て、薬液流通チュ−ブｄの大きさが外径2.8mm 、内径0.
5mm 、長さ336mm と薬液流通チュ−ブｄの内径を薬液流
通チュ−ブｃと同じにして実施例１と同様の条件でプラ
イミング測定した時の平均時間を表１に示す。COMPARATIVE EXAMPLE 1 In the chemical injection device used in Example 1, the size of the chemical distribution tube d was 2.8 mm in outer diameter and 0.2 mm in inner diameter.
Table 1 shows the average time when the priming measurement was carried out under the same conditions as in Example 1 with the same length of 5 mm, the length of 336 mm and the inner diameter of the chemical flow tube d.
【００２４】[0024]
【実施例２】実施例１で使用した薬液注入用具におい
て、流量制御部のみを極細のポリ塩化ビニル製パイプ
（外径1.00mm、内径 0.060mm、長さ240mm)に変更した薬
液注入用具を使用した。この流量制御部は７日間でバル
−ン内の薬液を患者に注入するように制御された薬液注
入用具である。実施例１と同様の測定条件でプライミン
グ時間を測定した。その結果を表１に示す。[Example 2] In the chemical liquid injection tool used in Example 1, a chemical liquid injection tool was used in which only the flow control unit was changed to a very thin polyvinyl chloride pipe (outside diameter 1.00 mm, inside diameter 0.060 mm, length 240 mm). did. This flow control unit is a chemical liquid injection tool controlled to inject the liquid chemical in the balloon into the patient in seven days. The priming time was measured under the same measurement conditions as in Example 1. Table 1 shows the results.
【００２５】[0025]
【比較例２】実施例２で使用した薬液注入用具におい
て、薬液流通チュ−ブｄの大きさが外径2.8mm 、内径0.
5mm 、長さ336mm とチュ−ブの内径を薬液流通チュ−ブ
ｃと同じにして実施例１と同様の条件でプライミング測
定した時の平均時間を表１に示す。[Comparative Example 2] In the drug solution injection tool used in Example 2, the size of the drug solution flowing tube d was 2.8 mm in outer diameter and 0.2 mm in inner diameter.
Table 1 shows the average time when the priming measurement was performed under the same conditions as in Example 1 with the same length of 5 mm, length of 336 mm and inner diameter of the tube as that of the chemical solution flowing tube c.
【００２６】[0026]
【表１】 [Table 1]
【００２７】表１から明らかなように、流量制御部の下
流に位置する接続具までの薬液流通チュ−ブｄの内径
を、流量制御部の上流に位置する薬液流出部方向へ延び
た薬液流通チュ−ブｃの内径と比較して小さくした場合
の実施例１および実施例２の薬液注入用具は、薬液流通
チュ−ブｃと薬液流通チュ−ブｄの内径が同じである比
較例１および比較例２の薬液注入用具と比較してプライ
ミング時間は著しく短い。As is apparent from Table 1, the inside diameter of the chemical solution flow tube d to the connector located downstream of the flow control unit is increased by the flow rate of the chemical solution extending in the direction of the chemical solution outlet portion located upstream of the flow control unit. The chemical solution injection tools of Examples 1 and 2 in which the inner diameter of the tube c is smaller than the inner diameter of the tube c are the same as those of Comparative Examples 1 and 2 in which the inner diameters of the drug solution flowing tubes c and d are the same. The priming time is remarkably short as compared with the chemical injection tool of Comparative Example 2.
【００２６】[0026]
【実施例３】シリコ−ン製バル−ン（内径 6.8mm、外径
8.4mm、肉厚 0.8mm）を図８に示す薬液注入用具に組み
込み、60mlの生理食塩水を注射器で栓体49からバル−ン
内に充填した。次いで極細のポリ塩化ビニル製パイプ
（外径1.00mm、内径 0.060mm、長さ42mm) を特開平２-1
1160号の第６図に示すような捲縮構造にしてケ−スに収
納した流量制御部を使用した。捲縮構造をしたポリ塩化
ビニル製パイプが収納されているケ−ス部分の長さは22
mmであった。この流量制御部は１日間でバル−ン内の薬
液を患者に注入するように制御されたものである。薬液
流通チュ−ブにおける流量制御部31の配置は実施例１と
同様に薬液流通チュ−ブｃが外径2.8mm 、内径0.5mm 、
長さ564mm であり、薬液流通チュ−ブｄが外径2.65mm、
内径0.3 mm、長さ336mm であった。薬液が充填されたバ
ル−ン部ａの栓体49に薬液流通チュ−ブｂの穿刺針51が
穿刺されることによって、バル−ン43内の薬液は棒状内
軸42が外軸41の内部に内挿されながら薬液流通チュ−ブ
ｃを通り流量制御部31で流量を制御されながら薬液流通
チュ−ブｄを経て接続具33に接続された静脈針から患者
に注入される。次いで、バル−ン部ａの薬液流出側を下
方にして、ヘッド差50mmでバル−ン内の生理食塩水を接
続具33に取りつけた静脈針から滴下した。薬液滴下は28
℃、32℃、36℃および40℃の各雰囲気温度中で行われ
た。バル−ン内の薬液が50ml滴下されるまでの各雰囲気
温度における平均排出速度（ml／時）を図７に示す。Embodiment 3 Silicone balloon (inner diameter 6.8mm, outer diameter
8.4 mm and a wall thickness of 0.8 mm) were assembled in the drug solution injection tool shown in FIG. 8, and 60 ml of physiological saline was filled into the balloon from the plug 49 with a syringe. Then, a very fine polyvinyl chloride pipe (outer diameter 1.00 mm, inner diameter 0.060 mm, length 42 mm) was placed in Japanese Patent Laid-Open No. 2-1.
A flow control unit housed in a case with a crimped structure as shown in FIG. 6 of No. 1160 was used. The length of the case where the crimped polyvinyl chloride pipe is stored is 22
mm. The flow control unit is controlled so that the liquid medicine in the balloon is injected into the patient in one day. The arrangement of the flow rate control unit 31 in the chemical liquid distribution tube is the same as in the first embodiment, with the chemical liquid distribution tube c having an outer diameter of 2.8 mm, an inner diameter of 0.5 mm,
The length is 564 mm, and the chemical distribution tube d has an outer diameter of 2.65 mm.
It had an inner diameter of 0.3 mm and a length of 336 mm. When the puncture needle 51 of the chemical distribution tube b is pierced into the plug 49 of the balloon portion a filled with the chemical, the chemical in the balloon 43 is turned into a rod-shaped inner shaft 42 inside the outer shaft 41. The liquid is passed through the liquid medicine flow tube c while the flow rate is controlled by the flow rate control unit 31 and is injected into the patient from the venous needle connected to the connector 33 through the liquid medicine flow tube d. Next, the saline solution in the balloon was dropped from a vein needle attached to the connector 33 with the head difference of 50 mm with the drug solution outflow side of the balloon portion a downward. 28 under drug droplets
C., 32.degree. C., 36.degree. C. and 40.degree. FIG. 7 shows the average discharge rate (ml / hour) at each ambient temperature until 50 ml of the chemical in the balloon was dropped.
【００２７】[0027]
【実施例４】特表昭62−501333号公報の第１図に示す薬
液注入用具であるバクスタ−インヒュ−ザ（24時間タイ
プ、バル−ン材料：ポリイソプレン）の薬液流通チュ−
ブ部を実施例３で使用した薬液流通チュ−ブ部ｂに特表
昭62−501333号公報の第１図のチュ−ブ基端部36ａの箇
所で繋ぎ換えた図９に示す薬液注入用具を使用した。図
９において、薬液注入口52からバル−ン54に注入された
薬液は薬液流出部53から薬液流通チュ−ブｃを通り流量
制御部31で流量を制御されながら薬液流通チュ−ブｄを
経て接続具33に接続された注射針から患者に注入され
る。測定試験は実施例３と同様にバル−ン部ａの薬液流
出側を下方にして、ヘッド差50mmでバル−ン内の生理食
塩水を接続具33に取りつけた静脈針から滴下した。薬液
滴下は28℃、32℃、36℃および40℃の各雰囲気温度中で
行われた。バル−ン内の薬液が50ml滴下されるまでの各
雰囲気温度における平均排出速度（ml／時）を図７に示
す。Example 4 A chemical solution distribution tube of Baxter Infuser (24-hour type, balloon material: polyisoprene) which is a chemical solution injection tool shown in FIG. 1 of JP-T-62-501333.
The chemical liquid injection tool shown in FIG. 9 in which the tube part is connected to the chemical liquid distribution tube part b used in Example 3 at the base end 36a of the tube shown in FIG. 1 of Japanese Patent Publication No. Sho 62-501333. It was used. In FIG. 9, the chemical liquid injected from the chemical liquid inlet 52 into the balloon 54 passes through the chemical liquid flowing tube c from the chemical liquid outlet 53, and passes through the chemical liquid flowing tube d while the flow rate is controlled by the flow rate control unit 31. It is injected into the patient from the injection needle connected to the connection device 33. In the measurement test, as in Example 3, the saline solution in the balloon was dropped from the vein needle attached to the connector 33 with the head difference of 50 mm with the liquid solution outflow side of the balloon part a downward. The dropping was performed at ambient temperatures of 28 ° C, 32 ° C, 36 ° C and 40 ° C. FIG. 7 shows the average discharge rate (ml / hour) at each ambient temperature until 50 ml of the chemical in the balloon was dropped.
【００２８】図７から明らかなように、雰囲気温度が高
くなるにつれてバル−ン内薬液の平均排出速度は大きく
なる。そしてバル−ン材料がポリイソプレンである実施
例４の薬液注入用具の方が、シリコ−ンのバル−ン材料
からなる実施例３の薬液注入用具と比較して雰囲気温度
による薬液の排出速度の影響が大きい。As is apparent from FIG. 7, the average discharge speed of the chemical in the balloon increases as the ambient temperature increases. The chemical injection tool of Example 4 in which the balloon material is polyisoprene has a lower discharge rate of the chemical solution depending on the ambient temperature than the chemical injection tool of Example 3 in which the balloon material is made of silicone. A large impact.
【００２９】[0029]
【発明の効果】本発明の薬液注入用具は、バル−ン内の
薬液の流出速度を制御する流量制御部が薬液流通チュ−
ブの下流端に設置された接続具から離れた位置に設けら
れているので、流量制御部は腕の体温の影響を受けない
で所望する流速でバル−ン内の薬液を流出することがで
き、薬液注入用具の品種を少なくすることができる。ま
た、流量制御部からその下流に位置する接続具までの薬
液流通チュ−ブの内径が該流量制御部からその上流に位
置する薬液流出部方向へ延びたチュ−ブの内径と比較し
て小さく、かつ流量制御部の内径より大きいのでチュ−
ブが捩れてもチュ−ブ内径が閉塞することなく薬液はチ
ュ−ブ内を流れ、薬液は比較的早い速度でチュ−ブ内の
空気を追い出してチュ−ブ全体を薬液で充満させること
ができる。According to the present invention, the flow rate control section for controlling the outflow rate of the chemical in the balloon has a chemical flow tube.
Since it is provided at a position distant from the connecting device provided at the downstream end of the valve, the flow control unit can discharge the drug solution in the balloon at a desired flow rate without being affected by the body temperature of the arm. In addition, it is possible to reduce the number of types of chemical injection tools. Also, the inside diameter of the chemical liquid flow tube from the flow control unit to the connector located downstream thereof is smaller than the internal diameter of the tube extending from the flow control unit toward the chemical liquid outlet located upstream of the flow control unit. , And larger than the inner diameter of the flow control unit.
Even if the tube is twisted, the chemical solution can be
The chemical solution flows through the tube, and the chemical solution expels the air in the tube at a relatively high speed, so that the entire tube can be filled with the chemical solution.
【図１】本発明の薬液注入用具の一実施例の説明図。FIG. 1 is an explanatory view of one embodiment of a drug solution injection tool of the present invention.
【図２】図１のバル−ンに薬液を充填したときのバル−
ン部の拡大断面図。FIG. 2 is a perspective view of a balloon when a chemical solution is filled in the balloon of FIG. 1;
FIG.
【図３】図１に示す薬液流通チュ−ブのコネクタ−とル
ア−テ−パ−状アダプタ−の拡大断面図FIG. 3 is an enlarged sectional view of a connector and a luer taper adapter of the chemical liquid distribution tube shown in FIG.
【図４】図３に示すコネクタ−をルア−テ−パ−状アダ
プタ−に挿入したときの状態を示す説明図。FIG. 4 is an explanatory view showing a state when the connector shown in FIG. 3 is inserted into a luer-tapered adapter.
【図５】シリンジ内薬液をバル−ンに注入するときの説
明図であってシリンジとバル−ン部が接続していない状
態を示す説明図。FIG. 5 is an explanatory view when injecting the drug solution in the syringe into the balloon, and is an explanatory view showing a state where the syringe and the balloon section are not connected.
【図６】図５に示すシリンジから薬液をバル−ン内へ充
填しているときの説明図。FIG. 6 is an explanatory view when a chemical is filled into the balloon from the syringe shown in FIG. 5;
【図７】２種類の薬液注入用具の雰囲気温度における薬
液流出速度を示すグラフ。FIG. 7 is a graph showing a chemical solution outflow speed at ambient temperature of two types of chemical solution injection tools.
【図８】特開平２−１１１６０号公報の第５図に示すバ
ル−ン部と薬液流通チュ−ブとが接続していない状態を
示す説明図。FIG. 8 is an explanatory view showing a state in which the balloon portion and the chemical solution distribution tube shown in FIG. 5 of JP-A-2-11160 are not connected.
【図９】特表昭６２−５０１３３３号公報に示す薬液注
入用具の一部を使用した用具の説明図。FIG. 9 is an explanatory view of a tool using a part of a drug solution injection tool disclosed in Japanese Patent Publication No. 62-501333.
ａ バル−ン部 ｂ 薬液流通チュ−ブ部 １、42 内軸 ２、41 外軸 ３、43、54 バル−ン ７、46 ハウジング 14 逆止弁 17、53 薬液流出部 19 ロックアダプタ− 30 コネクタ−部 31 流量制御部 34 連通パイプ 49 栓体 51 穿刺針 a Balloon b Chemical tube 1,42 Inner shaft 2,41 Outer shaft 3,43,54 Balloon 7,46 Housing 14 Check valve 17,53 Chemical outlet 19 Lock adapter-30 Connector − Part 31 Flow control part 34 Communication pipe 49 Plug body 51 Puncture needle
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 平２−11160（ＪＰ，Ａ) 特開 平３−77559（ＪＰ，Ａ) 特開 平３−140163（ＪＰ，Ａ) 特開 平３−155872（ＪＰ，Ａ) ────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-2-11160 (JP, A) JP-A-3-77559 (JP, A) JP-A-3-140163 (JP, A) JP-A-3- 155872 (JP, A)
Claims (3)
ら薬液を注入および流出させる弾性材料からなるバル−
ン部を収納し、その開口部に薬液注入部および薬液流出
部が固着されてなるハウジングと、前記薬液流出部から
延びた薬液流通チュ−ブと、該チュ−ブの両端から離れ
た位置に配置された薬液量を制御するための流量制御部
とからなる薬液注入用具において、前記流量制御部は内
径１０〜５００μのパイプからなり、該流量制御部から
その下流に位置する接続具までの薬液流通チュ−ブの内
径が該流量制御部からその上流に位置する薬液流出部方
向へ延びた薬液流通チュ−ブの内径に比較して小さく、
かつ前記流量制御部の内径より大きいことを特徴とする
薬液注入用具。1. A valve made of an elastic material for storing a medicinal solution in a pressurized state and for injecting and flowing out the medicinal solution from an opening.
A housing in which a chemical solution injecting portion and a chemical solution outflow portion are fixed to the opening portion, a chemical solution flowing tube extending from the chemical solution outflow portion, and separated from both ends of the tube.
And a flow rate control unit for controlling the amount of the chemical solution disposed at a predetermined position, wherein the flow rate control unit comprises a pipe having an inner diameter of 10 to 500 μ, and a connector positioned downstream from the flow rate control unit. Up to the inside diameter of the chemical flow tube extending from the flow control unit to the direction of the chemical solution outlet located upstream thereof,
A chemical liquid injection tool characterized by being larger than the inner diameter of the flow control unit .
具までの薬液流通チュ−ブの内径が、該流量制御部から
その上流に位置する薬液流出部方向へ延びた薬液流通チ
ュ−ブの内径に対して15％〜85％である請求項１記載の
薬液注入用具。2. An inner diameter of a chemical flow tube extending from a flow control section to a connector positioned downstream thereof is a diameter of a chemical flow tube extending from the flow control section toward a chemical flow outlet located upstream of the flow control section. The drug solution injection device according to claim 1, wherein the amount is 15% to 85% with respect to the inner diameter.
具までの距離が少なくとも30cmである請求項１または２
記載の薬液注入用具。3. The method according to claim 1, wherein the distance from the flow control unit to the connector located downstream thereof is at least 30 cm.
The liquid medicine injection tool according to the above.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4079378A JP2586275B2 (en) | 1992-02-28 | 1992-02-28 | Chemical injection tool |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4079378A JP2586275B2 (en) | 1992-02-28 | 1992-02-28 | Chemical injection tool |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05237194A JPH05237194A (en) | 1993-09-17 |
| JP2586275B2 true JP2586275B2 (en) | 1997-02-26 |
Family
ID=13688214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4079378A Expired - Fee Related JP2586275B2 (en) | 1992-02-28 | 1992-02-28 | Chemical injection tool |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2586275B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3152149B2 (en) * | 1996-05-23 | 2001-04-03 | 株式会社ニッショー | Flow control device with priming mechanism |
| JP7213528B2 (en) * | 2018-10-25 | 2023-01-27 | 株式会社フューチャーリアライズ | pressurized drug injector |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0687898B2 (en) * | 1988-06-29 | 1994-11-09 | 株式会社ニッショー | Balloon infusor |
| JPH0377559A (en) * | 1989-08-21 | 1991-04-03 | Nissho Corp | Liquid continuous injection apparatus |
| JP2598529B2 (en) * | 1989-10-26 | 1997-04-09 | 株式会社ニッショー | Balloon infuser |
| JP2637579B2 (en) * | 1989-11-13 | 1997-08-06 | 株式会社ニッショー | Balloon infuser |
-
1992
- 1992-02-28 JP JP4079378A patent/JP2586275B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05237194A (en) | 1993-09-17 |
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