JPH01311014A - Antimicrobial skin drug for external use - Google Patents
Antimicrobial skin drug for external useInfo
- Publication number
- JPH01311014A JPH01311014A JP13890688A JP13890688A JPH01311014A JP H01311014 A JPH01311014 A JP H01311014A JP 13890688 A JP13890688 A JP 13890688A JP 13890688 A JP13890688 A JP 13890688A JP H01311014 A JPH01311014 A JP H01311014A
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- skin
- agent
- sucrose ester
- antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title abstract description 5
- 229940079593 drug Drugs 0.000 title abstract description 5
- 230000000845 anti-microbial effect Effects 0.000 title abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 21
- 239000000194 fatty acid Substances 0.000 claims abstract description 21
- 229930195729 fatty acid Natural products 0.000 claims abstract description 21
- -1 sucrose ester Chemical class 0.000 claims abstract description 20
- 239000005720 sucrose Substances 0.000 claims abstract description 15
- 229930006000 Sucrose Natural products 0.000 claims abstract description 14
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 13
- 206010000496 acne Diseases 0.000 abstract description 7
- 210000002374 sebum Anatomy 0.000 abstract description 6
- 230000028327 secretion Effects 0.000 abstract description 6
- 239000003112 inhibitor Substances 0.000 abstract description 4
- 230000003054 hormonal effect Effects 0.000 abstract description 3
- 239000002674 ointment Substances 0.000 abstract description 3
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 239000002778 food additive Substances 0.000 abstract description 2
- 235000013373 food additive Nutrition 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 239000003410 keratolytic agent Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 239000006210 lotion Substances 0.000 abstract description 2
- 210000004400 mucous membrane Anatomy 0.000 abstract description 2
- 239000007787 solid Substances 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000004599 antimicrobial Substances 0.000 abstract 2
- 239000003212 astringent agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004040 coloring Methods 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 16
- 244000005700 microbiome Species 0.000 description 7
- 208000002874 Acne Vulgaris Diseases 0.000 description 6
- 241000186429 Propionibacterium Species 0.000 description 5
- 241000186427 Cutibacterium acnes Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 229940055019 propionibacterium acne Drugs 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 208000020154 Acnes Diseases 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 241001464974 Cutibacterium avidum Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229940055009 propionibacterium avidum Drugs 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 125000005480 straight-chain fatty acid group Chemical group 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は抗菌性皮膚外用剤、特にヒトの皮膚上における
有害な微生物の増殖を抑制するのに有効な皮膚外用剤に
関するものである。DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an antibacterial skin preparation for external use, particularly to a skin preparation for external use that is effective in inhibiting the growth of harmful microorganisms on human skin.
ニキビは主として思春期に発現する皮膚疾患で病名を尋
常性座街といい臨床的には“毛嚢脂線系を中心に毛孔に
起こる慢性の炎症性変化“と定義されている。Acne is a skin disease that primarily occurs during adolescence, and its name is vulgaris zagai, and clinically it is defined as ``chronic inflammatory changes that occur in the pores, mainly in the pilosebaceous system.''
ニキビの病因は現在まだ明らかではなく、種々の要因が
複雑に絡み合っている皮膚疾患ではあるが、一般には皮
脂分泌過剰９子嚢角化２毛嚢内細菌が重要な役割を果た
していると考えられる。The etiology of acne is currently not clear, and although it is a skin disease in which various factors are intricately intertwined, it is generally believed that excessive sebum secretion, 9 ascus keratinization, and 2 bacteria within the hair follicle play an important role.
一般に多用されているニキビ治療薬として皮脂分泌抑制
剤がある。しかし皮脂分泌抑制剤である女性ホルモンは
表皮の生長を抑制し、脂腺の分泌を減少きせるものであ
るが、ホルモン剤が引き起こす副作用は思春期の男女に
とって好ましいものではない。Sebum secretion inhibitors are commonly used acne treatment drugs. However, female hormones, which are sebum secretion inhibitors, suppress the growth of the epidermis and reduce the secretion of sebaceous glands, but the side effects caused by hormones are not favorable for adolescent men and women.
またヒトの皮膚上には、プロピオニバクテリウム・アク
ネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎ
ｅｓ）、プロピオニバクテリウム・アビダム（Ｐｒｏｐ
ｉｏｎｉｂａｃｔｅｒｉｕｍａｖｉｄｕｍ）等のプロピ
オニバクテリウム属の微生物が常在しており、これらの
微生物が何らかの原因によって増殖するとニキビの悪化
や皮膚の炎症が起こると考えられている。Also, on human skin, Propionibacterium acnes (Propionibacterium acnes)
es), Propionibacterium avidum (Prop
Microorganisms of the genus Propionibacterium, such as ionibacterium avidum, are resident, and it is thought that when these microorganisms proliferate for some reason, acne worsens and skin inflammation occurs.
本発明者らは、ホルモン様副作用を示さず皮膚に対して
温和でかつ、ニキビ治療効果に優れた薬剤を得るべく鋭
意研究を行った結果、炭素数８〜１８を有する脂肪酸の
ショ糖エステルが、ヒトの皮膚上に在住するプロピオニ
バクテリウム・アクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅ
ｒｉｕｍ ａｃｎｅｓ）やプロピ才二バタテリウム・
アビダム（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａ
ｖｉｄｕｎ）等のプロピオニバクテリウム属の微生物に
対して高い抗菌作用をもち、かつ皮膚上の脂質を取り過
ぎることなく余分な脂質を除去する効果を有することを
見い出し本発明を完成した。The present inventors conducted extensive research to obtain a drug that exhibits no hormone-like side effects, is gentle on the skin, and has an excellent acne treatment effect. , Propionibacterium acnes, which lives on human skin.
rium acnes) and propybacterium.
Avidum (Propionibacterium a)
The present invention has been completed by discovering that it has a high antibacterial effect against microorganisms belonging to the genus Propionibacterium, such as Propionibacterium (Vidun), and has the effect of removing excess lipids from the skin without removing too much.
即ち、本発明は炭素数８〜１８を有する脂肪酸のショ糖
エステルを含有することを特徴とする抗菌性皮膚外用剤
に関する。That is, the present invention relates to an antibacterial skin preparation for external use, which is characterized by containing a sucrose ester of a fatty acid having 8 to 18 carbon atoms.
本発明に用いられるショ糖脂肪酸エステルは炭素数８〜
１８を有する脂肪酸のショ糖エステルである。ショ糖脂
肪酸エステルに用いられる脂肪酸はカプリル酸、カプリ
ン酸、ラウリン酸、ミリスチン酸、パルミチン醜、ステ
アリン酸等の炭素数８〜１８の飽和又は不飽和の直鎖脂
肪酸でありこれらの脂肪酸は単独またはその混合物でも
よい。The sucrose fatty acid ester used in the present invention has 8 to 8 carbon atoms.
It is a sucrose ester of fatty acid with 18. The fatty acids used in the sucrose fatty acid ester are saturated or unsaturated straight chain fatty acids having 8 to 18 carbon atoms, such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid, and these fatty acids can be used alone or in combination. A mixture thereof may also be used.
本発明の炭素数８〜１８を有する脂肪酸のショ糖脂肪酸
エステルは、ショ糖のモノ、ジ、トリ。The sucrose fatty acid ester of a fatty acid having 8 to 18 carbon atoms according to the present invention includes mono-, di-, and tri-sucrose.
テトラ、ペンタの脂肪酸エステルであり中でも、モノ、
ジの脂肪酸エステルが望ましく、これらは単独またはそ
の混合物で用いることができる。Tetra and penta fatty acid esters, among which mono,
Di fatty acid esters are preferred and these can be used alone or in mixtures thereof.
本発明に用いられるショ糖脂肪酸エステルは、脂肪酸の
炭素数が７以下の場合は、皮膚への刺激が強く、また炭
素数が１９以上の場合はその効果が期待できない。The sucrose fatty acid ester used in the present invention is highly irritating to the skin when the fatty acid has 7 or fewer carbon atoms, and cannot be expected to be effective when the fatty acid has 19 or more carbon atoms.
本発明に用いられるショ糖脂肪酸エステルの皮膚外用剤
への配合量は、剤型にもよるが好ましくはｏ、ｏｏｓ％
（重量部）以上である。The amount of sucrose fatty acid ester used in the present invention to be incorporated into the skin external preparation depends on the dosage form, but is preferably o, oos%.
(parts by weight) or more.
本発明の抗菌性皮膚外用剤の性状はクリーム。The antibacterial skin external preparation of the present invention is in the form of a cream.
軟膏、ローション等の液体状及び洗顔料等の固体状等の
性状で使用できる。It can be used in liquid form such as ointments and lotions, and solid form such as facial cleansers.
本発明の抗菌性皮膚外用剤には、ヘキサクロロフェン等
の抗菌剤、エストラジオール等の皮脂分泌抑制剤、ビタ
ミンＡ酸等の角質溶解剤、ヒアルロン酸等の保湿剤、界
面活性剤、増粘剤、収斂剤、ｐＨ調整剤、香料２色素、
アルコール、水等の補助成分を本発明の効果を損なわな
い範囲で適宜配合することができる。The antibacterial skin external preparation of the present invention includes antibacterial agents such as hexachlorophene, sebum secretion inhibitors such as estradiol, keratolytic agents such as vitamin A acid, humectants such as hyaluronic acid, surfactants, thickeners, Astringent, pH adjuster, fragrance 2 pigment,
Auxiliary components such as alcohol and water may be appropriately blended within a range that does not impair the effects of the present invention.
本発明に用いられるショ糖脂肪酸エステルは、食品添加
物に指定されており、体内摂取においてもその安全性が
確認されており、また皮膚および粘膜に対しても刺激性
が殆どないことが知られている。The sucrose fatty acid ester used in the present invention is designated as a food additive, and its safety when ingested into the body has been confirmed, and it is also known to have almost no irritation to the skin and mucous membranes. ing.
本発明のショ糖脂肪酸エステルはヒトの皮膚上のプロピ
オニバクテリウム属の微生物の表面の細胞膜上に作用し
て微生物の増殖を抑制し、また微生物の体内酵素に対し
活性阻害を起こすことによる微生物の発育阻害作用によ
るものと推定きれる、またショ糖脂肪酸エステルはＨＬ
Ｂ値の大きい界面活性剤であるために、ニキビ等の発生
原因となる皮脂の除去効果もあり、これらの作用が複合
して優れた効果を示すものと考えられる。The sucrose fatty acid ester of the present invention acts on the cell membrane of the surface of Propionibacterium microorganisms on human skin, suppressing the growth of microorganisms, and inhibiting the activity of enzymes in the microorganism's body. It is presumed that this is due to the growth inhibiting effect of HL.
Since it is a surfactant with a large B value, it also has the effect of removing sebum, which is a cause of acne and the like, and it is thought that these effects combine to exhibit an excellent effect.
次に本発明を試験例によって、より詳細に説明する。Next, the present invention will be explained in more detail using test examples.
試験例１゜
ＣＡＭブイヨン培地（日水製薬株式会社製）に寒天を０
．２５％添加した半流動培地にショ糖モノパルミチン酸
エステル（リョートーシュガーエステルＰ−１５７０，
三菱化成食品（株）製）を２００ｐｐｍ、４００ｐｐｍ
、６００ｐｐｍ、８００ｐｐｍになるように添加し、試
験管３本に５ｍ１分注し試験用培地とした。Test Example 1 CAM broth medium (manufactured by Nissui Pharmaceutical Co., Ltd.) with 0 agar
．． Sucrose monopalmitate ester (Ryoto Sugar Ester P-1570,
manufactured by Mitsubishi Kasei Foods Co., Ltd.) at 200 ppm and 400 ppm.
, 600 ppm, and 800 ppm, and 5 ml was dispensed into three test tubes to prepare a test medium.
この試験培地にあらかじめＣＡＭブイヨン培地で調製し
たプロピ才二バタテリウム・アクネスＲＩＭＤ１６４０
００１菌液を初発菌数１．２Ｘ１０’／ｍｌとなるよう
に加えＣＯ，インキュベーターで３７℃で培養し３日、
６日、９日ごとに菌数をＣＡＭ寒天培地で測定した。そ
の結果を表１に示した。Propibataterium acnes RIMD1640 prepared in advance with CAM broth medium was added to this test medium.
Add 001 bacterial solution to an initial bacterial count of 1.2 x 10'/ml and culture at 37°C in a CO incubator for 3 days.
The number of bacteria was measured on CAM agar medium every 6th and 9th day. The results are shown in Table 1.
比較例１゜
試験例１においてショ糖脂肪酸エステルを添加しない以
外は、全く同じにして菌数を測定した。Comparative Example 1 The bacterial count was measured in exactly the same manner as Test Example 1 except that sucrose fatty acid ester was not added.
その結果を表１に示した。The results are shown in Table 1.
実施例１゜ 下記の処方に従って洗顔剤を調製した。Example 1゜ A facial cleanser was prepared according to the following recipe.
リョートシュガーエステル １５．０ 部Ｐ−１５
７０（商品名）
ステアリン酸 １５．４ 部スクワラ
ン ８．３ 部大豆油
６．７ 部力セイカリ
３．０ 部プロピレングリコール
１．６ 部端製水 ５０．０
部実施例２゜
下記の処方に従ってゲル軟膏を調製した。Ryoto Sugar Ester 15.0 parts P-15
70 (Product name) Stearic acid 15.4 parts Squalane 8.3 parts Soybean oil
6.7 Part power Seikari
3.0 parts propylene glycol
1.6 Part end water production 50.0
Example 2 A gel ointment was prepared according to the following recipe.
リョートシュガーエステル ２．６ 部Ｐ−１５
７０（商品名）
ポリエチレングリコール １９．５ 部＃６０
０
尿素 １．３ 部カロボキ
シビニルボリマ−１，０部
ヒアルロン酸 ０．１ 部トリエ
タノールアミン ０．３ 部端製水
７５．２ 部〔本発明の効果〕
本発明により優れた抗菌性を有し、かつホルモン様副作
用がなく、皮膚対しても温和な抗菌性皮膚外用剤を提供
することができる。Ryoto Sugar Ester 2.6 parts P-15
70 (Product name) Polyethylene glycol 19.5 parts #60
0 urea 1.3 parts Carboxyvinyl polymer-1.0 parts Hyaluronic acid 0.1 part Triethanolamine 0.3 parts
75.2 parts [Effects of the present invention] The present invention makes it possible to provide an antibacterial skin external preparation that has excellent antibacterial properties, has no hormone-like side effects, and is mild to the skin.
Claims (1)
することを特徴とする抗菌性皮膚外用剤Antibacterial skin external preparation characterized by containing sucrose ester of fatty acid having 8 to 18 carbon atoms
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13890688A JPH01311014A (en) | 1988-06-06 | 1988-06-06 | Antimicrobial skin drug for external use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13890688A JPH01311014A (en) | 1988-06-06 | 1988-06-06 | Antimicrobial skin drug for external use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01311014A true JPH01311014A (en) | 1989-12-15 |
Family
ID=15232899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13890688A Pending JPH01311014A (en) | 1988-06-06 | 1988-06-06 | Antimicrobial skin drug for external use |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01311014A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5607760A (en) * | 1995-08-03 | 1997-03-04 | The Procter & Gamble Company | Disposable absorbent article having a lotioned topsheet containing an emollient and a polyol polyester immobilizing agent |
| US5624676A (en) * | 1995-08-03 | 1997-04-29 | The Procter & Gamble Company | Lotioned tissue paper containing an emollient and a polyol polyester immobilizing agent |
| US5705164A (en) * | 1995-08-03 | 1998-01-06 | The Procter & Gamble Company | Lotioned tissue paper containing a liquid polyol polyester emollient and an immobilizing agent |
| JP2000506499A (en) * | 1995-12-16 | 2000-05-30 | バイヤースドルフ・アクチエンゲゼルシヤフト | Use of sugar derivatives as antibacterial, antifungal and / or antiviral actives |
| EP0875239A3 (en) * | 1997-05-03 | 2002-03-06 | Beiersdorf Aktiengesellschaft | Use of esters of fatty acids with Di- or oligosaccharids against the adhesion of microorganisms |
| JP2002255711A (en) * | 2001-02-28 | 2002-09-11 | Kobayashi Pharmaceut Co Ltd | Antibacterial composition |
| JP2002255775A (en) * | 2001-02-28 | 2002-09-11 | Kobayashi Pharmaceut Co Ltd | Antibacterial agent for axillary odor bacteria |
| JP2003089660A (en) * | 2001-09-18 | 2003-03-28 | Mitsubishi-Kagaku Foods Corp | Method for preventing lotion from degeneration |
| JP2013538866A (en) * | 2010-10-06 | 2013-10-17 | バイオ スキンケア リミテッド | Composition for skin treatment |
| JP2015528822A (en) * | 2012-08-07 | 2015-10-01 | トレル、 ジャン ノエル | Inhibition of pathogenic microorganism adhesion by sucrose stearate and / or sorbitan ester in cosmetic treatment of skin atopy |
| JP2018070536A (en) * | 2016-11-01 | 2018-05-10 | 株式会社桃谷順天館 | Acnes bacterial strain selective antibacterial agent |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63500516A (en) * | 1985-06-13 | 1988-02-25 | トピカル システムズ リミテッド | Composition |
-
1988
- 1988-06-06 JP JP13890688A patent/JPH01311014A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63500516A (en) * | 1985-06-13 | 1988-02-25 | トピカル システムズ リミテッド | Composition |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5607760A (en) * | 1995-08-03 | 1997-03-04 | The Procter & Gamble Company | Disposable absorbent article having a lotioned topsheet containing an emollient and a polyol polyester immobilizing agent |
| US5624676A (en) * | 1995-08-03 | 1997-04-29 | The Procter & Gamble Company | Lotioned tissue paper containing an emollient and a polyol polyester immobilizing agent |
| US5705164A (en) * | 1995-08-03 | 1998-01-06 | The Procter & Gamble Company | Lotioned tissue paper containing a liquid polyol polyester emollient and an immobilizing agent |
| JP2000506499A (en) * | 1995-12-16 | 2000-05-30 | バイヤースドルフ・アクチエンゲゼルシヤフト | Use of sugar derivatives as antibacterial, antifungal and / or antiviral actives |
| EP0875239A3 (en) * | 1997-05-03 | 2002-03-06 | Beiersdorf Aktiengesellschaft | Use of esters of fatty acids with Di- or oligosaccharids against the adhesion of microorganisms |
| JP2002255711A (en) * | 2001-02-28 | 2002-09-11 | Kobayashi Pharmaceut Co Ltd | Antibacterial composition |
| JP2002255775A (en) * | 2001-02-28 | 2002-09-11 | Kobayashi Pharmaceut Co Ltd | Antibacterial agent for axillary odor bacteria |
| JP2003089660A (en) * | 2001-09-18 | 2003-03-28 | Mitsubishi-Kagaku Foods Corp | Method for preventing lotion from degeneration |
| JP2013538866A (en) * | 2010-10-06 | 2013-10-17 | バイオ スキンケア リミテッド | Composition for skin treatment |
| JP2015528822A (en) * | 2012-08-07 | 2015-10-01 | トレル、 ジャン ノエル | Inhibition of pathogenic microorganism adhesion by sucrose stearate and / or sorbitan ester in cosmetic treatment of skin atopy |
| JP2018070536A (en) * | 2016-11-01 | 2018-05-10 | 株式会社桃谷順天館 | Acnes bacterial strain selective antibacterial agent |
| WO2018084112A1 (en) * | 2016-11-01 | 2018-05-11 | 株式会社桃谷順天館 | Acne strain-selective antibacterial agent |
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