KR100610951B1 - Composition for Skin-antiacne - Google Patents

Composition for Skin-antiacne Download PDF

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KR100610951B1
KR100610951B1 KR1019980038350A KR19980038350A KR100610951B1 KR 100610951 B1 KR100610951 B1 KR 100610951B1 KR 1019980038350 A KR1019980038350 A KR 1019980038350A KR 19980038350 A KR19980038350 A KR 19980038350A KR 100610951 B1 KR100610951 B1 KR 100610951B1
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skin
acne
extract
external preparation
kill
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KR20000019981A (en
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조준환
이기무
공우식
서충석
강원형
이성낙
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애경산업(주)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
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  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

본 발명은 죽여(竹茹) 추출물을 함유하는 피부외용제에 관한 것으로, 죽여추출물에 의한 프로피오니박테리움 아크네(Propionibacterium acnes)의 생장을 억제함으로써 여드름치료에 유효한 피부외용제에 관한 것이다.The present invention relates to an external preparation for skin containing a bamboo extract, and to an effective external preparation for treating acne by inhibiting the growth of Propionibacterium acnes by kill extract.

본 발명은 죽여추출물이 피부외용제 전체 중량을 기준으로 0.001∼5중량% 함유되어 있는 피부외용제를 제공한다. The present invention provides an external preparation for killing which contains 0.001 to 5% by weight based on the total weight of the external preparation for skin.

본 발명의 죽여추출물은 여드름 균에 대해 우수한 항균활성을 갖기 때문에 여드름치료에 유효한 효과를 나타낸다.Kill extract of the present invention shows an effective effect in the treatment of acne because it has excellent antimicrobial activity against acne bacteria.

Description

죽여추출물을 함유한 여드름 치료용 피부외용제{Composition for Skin-antiacne}Skin external preparation for acne treatment containing killer extract {Composition for Skin-antiacne}

본 발명은 죽여(竹茹) 추출물을 함유하는 피부외용제에 관한 것으로, 죽여추출물에 의한 프로피오니박테리움 아크네(Propionibacterium acnes)의 생장을 억제함으로써 여드름치료에 유효한 피부외용제에 관한 것이다.The present invention relates to an external preparation for skin containing a bamboo extract, and to an effective external preparation for treating acne by inhibiting the growth of Propionibacterium acnes by kill extract.

일반적으로, 여드름은 피부의 모낭피지선에서 일어나는 염증성 질환으로 남성호르몬, 각질생산, 피지와 세균의 상호관계에 의해 생긴다. 사춘기가 되면 남녀 모두 남성호르몬의 분비가 왕성해져 모낭 옆에 붙어있는 피지선을 자극하게 되고 그 결과 피지선이 커져 많은 피지가 분비된다. 이와 동시에 털구멍, 즉 모공 입구의 각질층이 두꺼워지고 접착력이 높아져 모공이 좁아지거나 막히게 된다. 이와 같이 모공이 막히게 되면 세균(프로피오니박테리움 아크네)의 증식이 쉬어지게 되고 이 세균에 의한 피지의 분해로 인해 유리지방산이 생성된다. 이 때 유리지방산은 모공벽을 자극하고 피부 깊숙히 들어가 염증을 야기한다. 염증성 여드름은 면포 주위를 빨갛게 불거지게 하고 모공벽을 파괴하여 주위조직을 파괴하기 때문에 흉터를 생기게 한다. In general, acne is an inflammatory disease occurring in the hair follicle sebaceous glands of the skin and is caused by the interaction between male hormones, keratin production, sebum and bacteria. At puberty, both male and female sex hormones are active, stimulating the sebaceous glands attached to the hair follicles, and as a result, the sebaceous glands become larger and secrete much sebum. At the same time, the pores, ie, the stratum corneum at the pores entrance, become thicker and have higher adhesion, resulting in narrowing or clogging the pores. When the pores are blocked in this way, the propagation of bacteria (propionibacterium acne) becomes easy and free fatty acids are generated due to the decomposition of sebum by the bacteria. At this time, free fatty acids irritate the pores wall and deep into the skin causing inflammation. Inflammatory acne causes red scars around the scalp and destroys the pores and destroys surrounding tissue.

이러한 여드름을 치료하기 위하여, 예를 들어 피지 생성을 억제하는 항안드로겐제; 항염증 작용하는 비 스테로이드계 소염제; 항균효과가 있는 레조시놀, 유황 및 벤조일퍼옥사이드; 항생효과가 있는 테트라사이클린, 에리스로마이신 및 메크로사이클린 등을 사용하여 프로피오니박테리움 아크네균의 활성을 억제하는 방법 등이 있다. 최근에는 레티노익산 등의 비타민 A유도체를 이용한 치료방법도 많이 사용되고 있다.To treat such acne, for example, antiandrogens that inhibit sebum production; Non-inflammatory anti-inflammatory drugs that act anti-inflammatory; Antimicrobial resorcinol, sulfur and benzoyl peroxide; There is a method of inhibiting the activity of propionibacterium acne bacteria using tetracycline, erythromycin, and macrocycline having an antibiotic effect. Recently, many treatment methods using vitamin A derivatives such as retinoic acid have been used.

이러한 방법들은 여드름 치료에 어느 정도 성과를 거두고 있으나, 부작용이 있다는 문제점이 있다. 즉 호르몬제의 사용으로 인해 표피의 생장이 억제되거나, 호르몬제의 과다사용으로 인해 부작용이 유발된다고 보고되고 있다. 또 레티노익산과 벤조일퍼옥사이드 등의 사용으로 인해 피부자극과 접촉성 피부염을 야기할 우려가 있으며, 테트라사이클린 등의 항생물질은 내성균을 출현시킬 수 있고 광 과민반응이 일어날 수 있는 것으로 알려져 있다.These methods have some results in the treatment of acne, but there are problems with side effects. In other words, the growth of the epidermis is suppressed by the use of hormonal agents or side effects are caused by the overuse of the hormonal agents. In addition, the use of retinoic acid and benzoyl peroxide may cause skin irritation and contact dermatitis, and antibiotics such as tetracycline may introduce resistant bacteria and may cause photosensitive reactions.

본 발명자들은 이러한 문제점을 고려하여 여드름의 원인으로 알려진 프로피오니박테리움 아크네균에 대해 특이적인 항균작용을 가지며 장기간 사용해도 안정성이 높은 물질을 개발하기 위하여 각종 식물들을 대상으로 연구를 계속해 오던 중, 한방에서 사용되고 있는 죽여가 여드름 균에 대해 항균효과가 있다는 것을 발견하고 본 발명을 완성하였다.In view of these problems, the inventors of the present invention have been carrying out research on various plants in order to develop a substance having a specific antimicrobial activity against propionibacterium acne bacteria known as the cause of acne and having high stability even for long-term use. The killing being used in found that there is an antimicrobial effect against acne bacteria and completed the present invention.

본 발명은 피부외용제 전체 중량을 기준으로 0.001∼5중량% 함유되어 있는 죽여추출물을 함유한 피부외용제를 제공하는 것이다. The present invention provides a skin external preparation containing a kill extract containing 0.001 to 5% by weight based on the total weight of the external skin preparation.

본 발명의 죽여추출물은 하기의 시험예로부터 알 수 있는 바와 같이, 여드름 균에 대해 우수한 항균활성을 갖기 때문에 여드름치료에 유효한 효과를 나타낸다.Kill extract of the present invention, as can be seen from the following test example, because it has an excellent antibacterial activity against acne bacteria shows an effective effect in the treatment of acne.

죽여는 대나무의 녹색 외피에 해당되는 것으로 죽세공품 생산지에서 부산물로 나오는 것이다. 죽여는 옛날부터 한방에서 사용되고 있는 것으로, 그 성질은 차고, 열(熱)로 일어나는 해수(咳嗽), 담(痰), 번열(煩熱) 또는 어린이의 설사나 토사(吐瀉), 임부(姙婦)의 복통하혈(腹痛下血)에 사용되고 있다. It's the green skin of bamboo, which is a by-product from the place where bamboo products are produced. It has been used in oriental medicine since ancient times. It is used for abdominal pain bleeding.

이하 본 발명을 상세히 설명하면 다음과 같다.Hereinafter, the present invention will be described in detail.

본 발명에서 사용되는 죽여추출물은 죽세공품 산지에서 부산물로 수득된 죽여를 통상의 분쇄기로 분쇄하고 용매로 추출하는 것으로 추출방법은 공지의 방법으로도 가능하다. 사용되는 용매는 메탄올, 에탄올, 아세톤 등의 극성용매를 들 수 있으며, 바람직하게는 에탄올을 들 수 있다. 분쇄된 죽여를 5∼10배의 용매에 첨가하여 상온에서 1∼14일 동안 침적 추출하거나, 1∼5시간 동안 중탕하여 농축 죽여추출물을 생성한다.The kill extract used in the present invention may be pulverized with a conventional grinder and extracted with a solvent by killing the kill obtained as a by-product from the bamboo-producing area, the extraction method is also possible by a known method. Examples of the solvent used may include polar solvents such as methanol, ethanol and acetone, and preferably ethanol. The pulverized gruel is added to a solvent of 5 to 10 times to immerse and extract for 1 to 14 days at room temperature, or to be concentrated for 1 to 5 hours to produce a concentrated kill extract.

본 발명에 의한 죽여추출물을 피부외용제에 적용하는 경우 조성물 전체를 기준으로 0.001∼5중량%, 바람직하게는 0.01∼1중량%로 한다. 죽여추출물을 피부외용제에 사용하는 경우 용매에 용해시켜 사용한다. 즉 죽여추출물을 10∼100배의 용매에 용해시킨 후 그 용액을 통상의 구성성분과 혼합하여 피부외용제를 제조한다.When the kill extract according to the present invention is applied to the external preparation for skin, it is 0.001 to 5% by weight, preferably 0.01 to 1% by weight based on the whole composition. When kill extract is used in external preparations for skin, it is dissolved in a solvent and used. In other words, kill extracts are dissolved in 10 to 100 times the solvent and then the solution is mixed with the usual components to prepare a skin external preparation.

죽여추출물이 피부외용제에 5중량% 이상 함유되면 경시변화에 따른 색변화와 냄새가 나기 때문에 바람직하지 않다. 또한 용매에 잘 용해되지 않는다.If the kill extract is contained in more than 5% by weight of the skin external preparation, it is not preferable because the color change and smell according to the change over time. It also does not dissolve well in solvents.

본 발명에 의한 피부외용제에는 죽여추출물 외에 일반적으로 사용하는 각종 성분, 예를 들면 수성성분, 분말성분, 유분, 계면활성제, 보습제, 점증제, 방부제, 산화방지제, 향료, 색소 등을 배합한다. The external preparation for skin according to the present invention contains various components commonly used in addition to the kill extract, for example, an aqueous component, a powder component, an oil, a surfactant, a moisturizer, a thickener, a preservative, an antioxidant, a perfume, a pigment, and the like.

또 본 발명에 의한 죽여추출물은 의약품 또는 의약부외품에 적용할 수 있으며, 이 경우 종래 여드름 치료제에 많이 사용되고 있는 벤조일 퍼옥사이드, 테트라사이클린, 에리스로마이신 등의 항균제; 항안드로겐제, 스테로이드 등의 호르몬류; 레티노익산 등의 비타민 A 유도체와 병용하여 사용할 수 있다.In addition, the kill extract according to the present invention can be applied to medicines or quasi-drugs, in this case antibacterial agents such as benzoyl peroxide, tetracycline, erythromycin, which are widely used in conventional acne treatments; Hormones such as anti-androgens and steroids; It can be used in combination with vitamin A derivatives, such as retinoic acid.

피부외용제의 제형은 크림, 로션, 스킨로션, 팩, 화운데이션 등의 화장료뿐만 아니라 비누, 세안폼 등의 세안료로도 가능하다. 이와같은 화장료나 세안료는 통상의 방법으로 제조할 수 있다. Formulations of external skin preparations can be applied to face creams such as soaps and face wash foams as well as cosmetics such as creams, lotions, skin lotions, packs, and foundations. Such cosmetics and face washes can be manufactured by a conventional method.

피부외용제에 사용되는 죽여추출물은 하기의 시험예와 같이 여드름의 주요 원인의 하나로 알려진 프로피오니박테리움 아크네균의 활성을 저해한다.Kill extract used for external skin preparations inhibits the activity of propionibacterium acne bacteria known as one of the main causes of acne, as in the following test example.

이하 제조예 및 실시예를 들어 본 발명을 구체적으로 설명한다.Hereinafter, the present invention will be described in detail with reference to Preparation Examples and Examples.

(제조예)(Production example)

건조 분쇄된 죽여 100g을 에탄올 1ℓ에 첨가하여 실온에서 10일 동안 침적하여 추출 여과한 후, 그 여과액을 감압 증발하여 7.5g의 농축물을 얻었다.100 g of dry pulverized killer was added to 1 L of ethanol, immersed for 10 days at room temperature, extracted and filtered, and the filtrate was evaporated under reduced pressure to obtain 7.5 g of concentrate.

통상의 방법에 따라 하기와 같은 조성비로 화장료 및 세안료를 제조하였다. According to the conventional method, cosmetics and face washes were prepared in the following composition ratios.

(실시예 1) 유연화장수Example 1 Flexible Cosmetics

성분ingredient 함량(중량%)Content (% by weight) 살리실산 Salicylic acid 0.50.5 1,3-부틸렌글리콜 1,3-butylene glycol 5.05.0 모노라우린산 폴리옥시에틸렌소르비탄 Monolauric acid polyoxyethylene sorbitan 1.31.3 폴리옥시에틸렌 라우릴에테르 Polyoxyethylene lauryl ether 0.70.7 에탄올 ethanol 15.015.0 향료 Spices 0.20.2 방부제 antiseptic 적량Quantity 죽여추출물 Kill Extract 0.50.5 정제수 Purified water 잔부Balance

(실시예 2) 수렴화장수Example 2 Convergence Cosmetics

성분ingredient 함량(중량%)Content (% by weight) 구연산 Citric acid 0.10.1 살리실산 Salicylic acid 0.50.5 1,3-부틸렌글리콜 1,3-butylene glycol 5.05.0 폴리옥시에틸렌올레일에테르 Polyoxyethylene oleyl ether 0.80.8 에탄올 ethanol 30.030.0 향료 Spices 0.150.15 방부제 antiseptic 적량Quantity 죽여추출물 Kill Extract 1.01.0 정제수 Purified water 잔부Balance

(실시예 3) 크림Example 3 Cream

성 분ingredient 함량(중량%)Content (% by weight) 마카데미아오일 Macadamia Oil 2.02.0 스쿠알란 Squalane 3.03.0 스테아린산 Stearic acid 7.07.0 바셀린 vaseline 3.03.0 1,3-부틸렌글리콜 1,3-butylene glycol 7.07.0 모노스테아린산 폴리옥시 에틸렌소르비탄 Monostearic acid polyoxy ethylene sorbitan 1.31.3 자기유화형 모노스테아린산 글리세린 Self-emulsifying glycerin monostearate 2.72.7 에틸렌디아민테트라아세트산나트륨 Sodium Ethylenediaminetetraacetic Acid 0.050.05 글리세린 glycerin 4.04.0 향료 Spices 0.250.25 방부제 antiseptic 적량Quantity 산화방지제 Antioxidant 적량Quantity 죽여추출물 Kill Extract 0.50.5 정제수 Purified water 잔부Balance

(실시예 4) 로션Example 4 Lotion

성분ingredient 함량(중량%)Content (% by weight) 스테아린산 Stearic acid 0.50.5 에탄올 ethanol 10.010.0 바셀린 vaseline 1.01.0 스쿠알란 Squalane 2.52.5 유동파라핀 Liquid paraffin 6.06.0 모노올레인산폴리옥시에틸렌소르비탄 Monooleic acid polyoxyethylene sorbitan 1.51.5 1,3-부틸렌글리콜 1,3-butylene glycol 8.08.0 에틸렌디아민테트라아세트산나트륨 Sodium Ethylenediaminetetraacetic Acid 0.050.05 트리에탄올아민 Triethanolamine 0.80.8 향료 Spices 0.20.2 방부제 antiseptic 적량Quantity 산화방지제 Antioxidant 적량Quantity 죽여추출물 Kill Extract 0.250.25 정제수 Purified water 잔부Balance

(실시예 5) 유액상 파운데이션Example 5 Latex Liquid Foundation

성 분ingredient 함량(중량%)Content (% by weight) 스테아린산 Stearic acid 2.02.0 1,3-부틸렌글리콜 1,3-butylene glycol 2.02.0 세틸스테아릴알코올 Cetylstearyl alcohol 0.50.5 액상라놀린 Liquid lanolin 1.51.5 유동파라핀 Liquid paraffin 3.53.5 미리스틴산 이소프로필 Myristic acid isopropyl 4.54.5 카르복시에틸셀룰로오스 나트륨 Carboxyethylcellulose Sodium 0.30.3 벤토나이트 Bentonite 1.01.0 글리세린 glycerin 1.01.0 이산화티탄 Titanium dioxide 5.05.0 탈크 Talc 6.06.0 착색안료 Pigmentation Pigment 적량Quantity 향료 Spices 0.150.15 방부제 antiseptic 적량Quantity 산화방지제 Antioxidant 적량Quantity 죽여추출물 Kill Extract 0.10.1 정제수 Purified water 잔부Balance

(실시예 6) 비누Example 6 Soap

성 분ingredient 함량(중량%)Content (% by weight) 야자유지방산 Palm oil fatty acid 1.51.5 이산화티탄 Titanium dioxide 0.50.5 에틸렌디아민테트라아세트산디나트륨 Ethylenediaminetetrasodium acetate 0.150.15 향료 Spices 0.70.7 색소 Pigment 적량Quantity 죽여추출물 Kill Extract 0.70.7 비누칩베이스 Soap Chip Base 잔부Balance

(시험예 1)(Test Example 1)

죽여추출물의 항균활성시험 Antimicrobial Activity Test of Kill Extract

상기 제조예에서 수득한 죽여추출물에 대해 시험관 희석법에 의해 항균력을 측정하였다. 항균력시험은 가열 멸균한 뮬러 힌톤 액체배지(Muller Hinton Broth)에 죽여추출물을 50, 100, 200, 400, 800ppm으로 희석한 시료를 사용하였다. 시험관에 시험균 KCTC 3314(프로피오니박테리움 아크네균; 생명공학연구소 유전자은행에서 분양)을 넣고 37℃에서 혐기 배양을 실시하였다. 48∼72시간 동안 배양한 후 균의 증식(배지의 혼탁유무) 상태를 확인한 바, 최소발육저지농도(MIC)가 200ppm이었다. Antimicrobial activity was measured by in vitro dilution method for the kill extract obtained in Preparation Example. The antimicrobial activity test was used to kill the extract in 50, 100, 200, 400, 800ppm by killing the heat sterilized Muller Hinton Broth medium. Test tube KCTC 3314 (propionibacterium acne bacteria; sold by the Biotechnology Research Institute Gene Bank) was added to the test tube and anaerobic culture was performed at 37 ° C. After incubation for 48 to 72 hours, the growth of bacteria (medium turbidity) was confirmed. The minimum growth inhibition concentration (MIC) was 200 ppm.

(시험예 2)(Test Example 2)

벤조일퍼옥사이드의 항균활성시험 Antibacterial Activity Test of Benzoyl Peroxide

종래의 여드름치료제에 사용되는 벤조일퍼옥사이드를 사용하여 상기의 시험예 1과 같이 항균력을 측정하였다. 그 결과 MIC가 1000ppm이었다. Using the benzoyl peroxide used in conventional acne treatment was measured the antimicrobial activity as in Test Example 1. As a result, the MIC was 1000 ppm.

시료 sample MIC(ppm) MIC (ppm) 죽여추출물 Kill Extract 200ppm200 ppm 벤조일퍼옥사이드 Benzoyl peroxide 1000ppm1000 ppm

상기 표 1에 나타난 바와 같이, 죽여추출물이 종래의 여드름치료제에 유효 성분으로 사용되고 있는 벤조일퍼옥사이드에 비해 항균활성이 우수한 것으로 나타났다. As shown in Table 1, the kill extract was found to have superior antimicrobial activity compared to benzoyl peroxide used as an active ingredient in conventional acne treatments.

(시험예 3) (Test Example 3)

여드름 치료효과시험Acne Treatment Test

실시예 1에서 제조된 유연화장수를 사용하여 여드름치료에 대한 임상시험을 하였다. 여드름 보유자 30명을 15명씩 2군으로 나누어 본 발명에 의한 죽여추출물을 함유한 유연화장수를 사용한 군을 시험군으로 하고, 죽여추출물이 함유되지 않은 종래의 유연화장수를 사용한 군을 대조군으로 하여 매일 2회씩 6주 동안 얼굴에 적용하여 여드름치료 상태를 육안 및 사진촬영에 의해 확인하였다. 그 효과에 대한 판정을 표 2에 나타낸다.A clinical trial for acne treatment was conducted using the flexible cosmetic prepared in Example 1. Thirty acne holders were divided into two groups of 15 people each, and the group using the flexible cosmetics containing the kill extract according to the present invention was used as a test group, and the group using the conventional flexible cosmetics containing no kill extract was used as a control group every day. The acne treatment status was checked by visual and photographing by applying to the face six times a week. The judgment about the effect is shown in Table 2.

시험군(명)Test group (persons) 대조군(명)Control group 우수 Great 55 -- 양호 Good 88 66 무변화 No change 22 77 악화 worse -- 22 계 system 1515 1515

표 2에 나타난 바와 같이, 본 발명에 의한 죽여추출물을 함유한 화장료가 죽여추출물을 함유하지 않은 화장료보다 여드름 치료효과가 우수한 것으로 판명되었다.As shown in Table 2, the cosmetics containing the kill extract according to the present invention was found to be superior to the acne treatment effect than the cosmetic containing no kill extract.

Claims (2)

죽여추출물이 피부외용제 전체 중량을 기준으로 0.001∼5중량% 함유되어 있는 여드름 치료용 피부외용제.A skin external preparation for acne treatment wherein the killer extract contains 0.001 to 5% by weight based on the total weight of the external skin preparation. 제 1 항에 있어서, 상기 피부외용제는 화장료 또는 세안료인 죽여추출물을 함유한 여드름 치료용 피부외용제. The skin external preparation for acne treatment according to claim 1, wherein the skin external preparation contains a kill extract which is a cosmetic or face wash.
KR1019980038350A 1998-09-17 1998-09-17 Composition for Skin-antiacne KR100610951B1 (en)

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KR20010018665A (en) * 1999-08-20 2001-03-15 유상옥 A cosmetic composition containing Bambusae caulis in Taenian extracts
KR100439868B1 (en) * 2001-04-18 2004-07-12 주식회사 태평양 A compositions for skin external application containing the sap of bamboo
KR100490318B1 (en) * 2002-04-26 2005-05-17 주식회사 한생화장품 Method for obtaining Bambusae caulis in Taenian extract
KR100529542B1 (en) * 2003-03-05 2005-11-17 주식회사 사임당화장품 Extraction method of a effective component of a cosmetic, composition of cosmetic and a cosmetic
KR102132514B1 (en) 2017-06-30 2020-08-05 배재대학교 산학협력단 A cosmetic composition containing hot water extract or its ethyl acetate fraction from Sanguisorba officinalis having specific anti-microbial activity against acne-inducing bacterium
KR102133074B1 (en) 2017-06-30 2020-07-10 배재대학교 산학협력단 A cosmetic composition containing cold water extract or its ethyl acetate fraction from Sanguisorba officinalis having specific anti-microbial activity against acne-inducing bacterium

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