JPH01149706A - Skin-beautifying cosmetic - Google Patents
Skin-beautifying cosmeticInfo
- Publication number
- JPH01149706A JPH01149706A JP62307452A JP30745287A JPH01149706A JP H01149706 A JPH01149706 A JP H01149706A JP 62307452 A JP62307452 A JP 62307452A JP 30745287 A JP30745287 A JP 30745287A JP H01149706 A JPH01149706 A JP H01149706A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- skin
- extraction
- cosmetic
- licorice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 24
- 239000000284 extract Substances 0.000 claims abstract description 33
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 17
- 239000003960 organic solvent Substances 0.000 claims abstract description 15
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 13
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 14
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 14
- 229940010454 licorice Drugs 0.000 claims description 14
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000002087 whitening effect Effects 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims 1
- 238000000605 extraction Methods 0.000 abstract description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract description 11
- 239000002904 solvent Substances 0.000 abstract description 10
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract description 6
- 238000010992 reflux Methods 0.000 abstract description 4
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract description 3
- 150000002632 lipids Chemical class 0.000 abstract description 3
- 230000003647 oxidation Effects 0.000 abstract description 3
- 238000007254 oxidation reaction Methods 0.000 abstract description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract description 2
- 239000004378 Glycyrrhizin Substances 0.000 abstract description 2
- 238000004332 deodorization Methods 0.000 abstract description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 abstract description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 abstract description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 abstract description 2
- 235000019410 glycyrrhizin Nutrition 0.000 abstract description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract description 2
- 238000010438 heat treatment Methods 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000007787 solid Substances 0.000 abstract description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 2
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 238000003809 water extraction Methods 0.000 abstract 1
- 229940069445 licorice extract Drugs 0.000 description 16
- 241000202807 Glycyrrhiza Species 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 102000003425 Tyrosinase Human genes 0.000 description 7
- 108060008724 Tyrosinase Proteins 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- -1 lipid peroxides Chemical class 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 206010040829 Skin discolouration Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 2
- 208000003351 Melanosis Diseases 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229960004441 tyrosine Drugs 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- ZTVIKZXZYLEVOL-DGKWVBSXSA-N 2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester Chemical group C([C@H]1CC[C@@H](C2)N1C)C2OC(=O)C(O)C1=CC=CC=C1 ZTVIKZXZYLEVOL-DGKWVBSXSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000007765 cera alba Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 description 1
- FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical compound CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- YKYONYBAUNKHLG-UHFFFAOYSA-N n-Propyl acetate Natural products CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、色白化粧料に関するものである。[Detailed description of the invention] [Industrial application field] TECHNICAL FIELD The present invention relates to fair skin cosmetics.
肌の色が白いことは古くから美人の条件に挙げられるほ
どであり、色白に対する日本人の願望は強い。肌色の白
さは先天的なものもあるが、色白の人でも、何の対策も
講じなかった場合、皮膚は種々の原因で容易に黒くなる
から、色白を保つためには古来多くの工夫がなされてい
る。Fair skin has long been considered a condition for beauty, and Japanese people have a strong desire for fair skin. Fairness of skin may be congenital, but even for fair-skinned people, if no measures are taken, the skin can easily darken due to various reasons, so many techniques have been used since ancient times to maintain fair skin. being done.
現在、皮膚が黒くなる原因としては、アミノ酸の一種で
あるチロシンにチロシナーゼが作用することによる色素
・メラニンの生成、紫外線による活性酸素発生の影響、
さらには皮脂中の過酸化脂質等の関与、などが考えられ
ている。そこで、従来、アスコルビン酸、過酸化水素、
コロイドイオウ、チロシナーゼ活性阻害作用を有する各
種動植物抽出物（たとえば特開昭５８−２２５００４号
公報記載のイソフラボン化合物）等を化粧料に配合する
ことにより、上記原因による皮膚黒色化を防止すること
が提案され、一部、実施されている。しかしながら、ア
スコルビン酸類は酸化され易く、それを配合した化粧料
の変色、変臭を招くという欠点がある。また過酸化水素
は、安全性や安定性の点で問題があるとされている。コ
ロイドイオウは、異臭を放つため、一般的な化粧料へ配
合することができない。動植物抽出物系のものは、その
効果が十分でなく、また、安定性や色、臭気等の点でも
問題があり、実用可能なものはほとんどない。Currently, the causes of skin darkening include the production of pigment/melanin due to the action of tyrosinase on tyrosine, a type of amino acid, and the effects of active oxygen generation due to ultraviolet rays.
Furthermore, the involvement of lipid peroxides in sebum is thought to be involved. Therefore, conventionally, ascorbic acid, hydrogen peroxide,
It has been proposed that skin blackening caused by the above causes can be prevented by incorporating colloidal sulfur, various animal and plant extracts with tyrosinase activity inhibiting effects (for example, isoflavone compounds described in JP-A-58-225004) into cosmetics. and some of them have been implemented. However, ascorbic acids are easily oxidized and have the drawback of causing discoloration and odor in cosmetics containing them. Furthermore, hydrogen peroxide is said to have problems in terms of safety and stability. Colloidal sulfur cannot be incorporated into general cosmetics because it gives off a strange odor. The effects of animal and plant extracts are not sufficient, and there are also problems with stability, color, odor, etc., and there are almost no practical ones.
加えて、上記従来の色白作用物質は、紫外線吸収、チロ
シナーゼ活性阻害、メラニンの還元、脂質の酸化防止等
のいずれかにしか有効でなく、シたがって、上述のよう
に発生原因が種々ある皮膚黒色化を十分防止するには複
数の物質を併用しなければならず、そのため、化粧料中
のこれら色白作用物質の配合比率が高くなって、製品化
に困難をきたしたり、化粧料としては使いにくいものに
なるという問題があった。In addition, the above-mentioned conventional skin lightening agents are only effective in absorbing ultraviolet rays, inhibiting tyrosinase activity, reducing melanin, and preventing lipid oxidation. In order to sufficiently prevent blackening, multiple substances must be used together, and as a result, the proportion of these skin-lightening substances in cosmetics increases, making it difficult to commercialize the product or making it difficult to use as a cosmetic. The problem was that it became difficult.
本発明の目的は、上述のような現状に鑑み、多くの皮膚
黒色化原因のいずれに対しても少量で有効な色白作用物
質を用いた、製造容易でしかも使い易い色白化粧料を提
供することにある。In view of the above-mentioned current situation, it is an object of the present invention to provide a skin-lightening cosmetic that is easy to produce and use, using a skin-lightening substance that is effective in a small amount against any of the many causes of skin darkening. It is in.
本発明は、甘草の疎水性有機溶媒抽出物を化粧料基剤に
配合することにより、上記目的を達成したものである。The present invention has achieved the above object by incorporating a hydrophobic organic solvent extract of licorice into a cosmetic base.
本発明の色白化粧料に配合される甘草の疎水性有機溶媒
抽出物とは、甘草またはその水（もしくは含水有機溶媒
）抽出残液（たとえば甘草からグリチルリチンを抽出し
た残渣）を疎水性有機溶媒で抽出して得られる抽出物で
ある。抽出用疎水性有機溶媒の例としては、メチルエチ
ルケトン等の低級脂肪族ケトン：ジオキサン、エチルエ
ーテル等の低級脂肪族エーテル；石油エーテル、ｎ−ヘ
キサン、シクロヘキサン、トルエン、ベンゼン等の揮発
性炭化水素；塩化メチレン、クロロホルムなど炭素原子
数１〜４のハロゲン化炭化水素：酢酸エチル、酢酸ｎ−
プロピル、酢酸イソブチルなど炭素原子数３〜７のエス
テル：およびこれらの溶媒の２種以上の混合物がある。The hydrophobic organic solvent extract of licorice that is blended into the fairing cosmetics of the present invention refers to the residual liquid of licorice or its water (or water-containing organic solvent) extraction (for example, the residue of glycyrrhizin extracted from licorice) in a hydrophobic organic solvent. It is an extract obtained by extraction. Examples of hydrophobic organic solvents for extraction include lower aliphatic ketones such as methyl ethyl ketone; lower aliphatic ethers such as dioxane and ethyl ether; volatile hydrocarbons such as petroleum ether, n-hexane, cyclohexane, toluene, and benzene; Halogenated hydrocarbons having 1 to 4 carbon atoms such as methylene and chloroform: ethyl acetate, n-acetate
Esters having 3 to 7 carbon atoms such as propyl and isobutyl acetate; and mixtures of two or more of these solvents.
これらの溶媒により甘草から有効成分を抽出するには、
被処理原料を約３〜５倍量の抽出溶媒に浸漬して還流下
に加熱するか、約５〜１０倍量の抽出溶媒に常温で浸漬
すればよい。得られる抽出液から溶媒を留去して得られ
る抽出物は、特有の臭気を有する茶褐色の固体である。To extract the active ingredients from licorice using these solvents,
The raw material to be treated may be immersed in about 3 to 5 times the amount of extraction solvent and heated under reflux, or immersed in about 5 to 10 times the amount of extraction solvent at room temperature. The extract obtained by distilling off the solvent from the obtained extract is a brown solid with a characteristic odor.
この抽出物は、多くの場合そのままで利用することがで
きるが、必要ならば、その効力に影響がない範囲で、脱
臭、脱色等の精製処理を施してから用いてもよい。In many cases, this extract can be used as it is, but if necessary, it may be used after being subjected to purification treatments such as deodorization and decolorization as long as its efficacy is not affected.
本発明の色白化粧料の、化粧料としての態様は特に制限
されるものではない。例えば、化粧水、クリーム、乳液
、パックなど、各種皮膚用化粧料が有り得る。そして、
甘草の疎水性有機溶媒抽出物以外の化粧料基剤にも制限
はない。The embodiment of the fair skin cosmetic of the present invention as a cosmetic is not particularly limited. For example, there may be various skin cosmetics such as lotion, cream, milky lotion, and pack. and,
There are no restrictions on the cosmetic base other than the hydrophobic organic solvent extract of licorice.
甘草の疎水性有機溶媒抽出物の好ましい配合量は、化粧
料の種類、用いる甘草抽出物の品質、期待される色白効
果の程度によっても異なるが、通常０．００５％〜１％
の範囲にある。The preferred blending amount of the hydrophobic organic solvent extract of licorice varies depending on the type of cosmetic, the quality of the licorice extract used, and the expected degree of skin whitening effect, but it is usually 0.005% to 1%.
within the range of
甘草の疎水性有機溶媒抽出物は水に不溶であるが、これ
を溶解させる化粧料基剤または助剤としては、アルコー
ル、高級脂肪酸、モノグリセリド等の乳化剤、１．３−
ブチレングリコール、プロピレングリコール、油脂等が
ある。The hydrophobic organic solvent extract of licorice is insoluble in water, but cosmetic bases or auxiliaries for dissolving it include alcohol, higher fatty acids, emulsifiers such as monoglycerides, 1.3-
These include butylene glycol, propylene glycol, oils and fats, etc.
本発明の色白化粧料に配合される甘草の疎水性有機溶媒
抽出物は、その作用の根源物質は定かでないが、従来公
知のインフラポン化合物よりも、また甘草の水または親
水性有機溶媒による抽出物よりも、はるかにすぐれたチ
ロシナーゼ阻害活性を有すると共に、紫外線吸収能と脂
質の酸化防止能力をも併せ持つものであり、それにより
、単独で、前記皮膚黒色化の複数原因に対応することが
できる。また、安定性や安全性の点でも問題がない。し
たがって、本発明の色白化粧料は、色白化作用物質の配
合量が少なくてすみ、他の化粧料基剤の配合が制限され
ることもなく、製造、使用、ともに容易なすぐれたもの
である。The hydrophobic organic solvent extract of licorice that is incorporated into the skin-lightening cosmetic of the present invention is more effective than the conventionally known infrapon compounds, and the hydrophobic organic solvent extract of licorice combined with water or hydrophilic organic solvent is It has far superior tyrosinase inhibitory activity than other substances, and also has ultraviolet absorption ability and lipid oxidation prevention ability, so it can independently address the multiple causes of skin darkening. . Furthermore, there are no problems in terms of stability or safety. Therefore, the skin-whitening cosmetic of the present invention requires only a small amount of the skin-whitening substance to be blended, does not limit the blending of other cosmetic bases, and is easy to manufacture and use. .
以下、実施例および実験例を示して本発明を説明する。 The present invention will be explained below with reference to Examples and Experimental Examples.
なお、各側において用いた甘草抽出物は、下記の方法で
得られたものである。The licorice extract used on each side was obtained by the following method.
甘草抽出物Ａ：甘せ根粉砕物１ ｋｇを５ａのジエチル
エーテルとともに２時間還流下に加熱してジエチルエー
テル可溶成分を抽出した。抽出液を分離した抽出残渣に
ついて同様の操作を繰り返し、合計３０１の抽出液を得
た。この抽出液の溶媒を留去し、さらに減圧乾燥して、
抽出物３５ｇを得た。これを甘草抽出物Ａとする。Licorice Extract A: 1 kg of ground licorice root was heated under reflux for 2 hours with diethyl ether of 5a to extract diethyl ether-soluble components. The same operation was repeated for the extraction residue from which the extract was separated, and a total of 301 extracts were obtained. The solvent of this extract was distilled off and further dried under reduced pressure.
35 g of extract was obtained. This is called licorice extract A.
甘草抽出物Ｂ：甘せ根粉砕物２ｋｇをＬｏｌｌの酢酸エ
チルに常温で５時間浸漬して、酢酸エチル可溶成分を抽
出した。抽出液を分離した抽出残渣について同様の操作
を繰返し、合計３０Ｑの抽出液を得た。この抽出液の溶
媒を留去し、さらに減圧乾燥して、抽出物７２ｇを得た
。これを甘草抽出物Ｂとする。Licorice Extract B: 2 kg of crushed Licorice root was immersed in Loll's ethyl acetate for 5 hours at room temperature to extract ethyl acetate soluble components. The same operation was repeated for the extraction residue from which the extract was separated to obtain a total of 30Q of extracts. The solvent of this extract was distilled off, and the extract was further dried under reduced pressure to obtain 72 g of an extract. This is called licorice extract B.
甘草抽出物Ｃａｎ−ヘキサン５部およびメチルエチルケ
トン２部からなる混合溶媒１０αとせ草根粉砕物１ｋｇ
を２時間還流下に加熱して、溶媒可溶成分を抽出した。Licorice extract Can - mixed solvent 10α consisting of 5 parts of hexane and 2 parts of methyl ethyl ketone and 1 kg of pulverized grass roots
was heated under reflux for 2 hours to extract solvent-soluble components.
抽出液を分離した抽出残渣について同様の操作を繰り返
し、合計２００の抽出液を得た。この抽出液の溶媒を留
去し、さらに減圧乾燥して、抽出物５０ｇを得た。これ
を甘草抽出物Ｃとする。The same operation was repeated for the extraction residue from which the extract was separated to obtain a total of 200 extracts. The solvent of this extract was distilled off, and the extract was further dried under reduced pressure to obtain 50 g of an extract. This is called licorice extract C.
実験例１
甘草抽出物Ａ−Ｃについて、下記の方法によチロシナー
ゼ阻害活性を測定した。Experimental Example 1 The tyrosinase inhibitory activity of licorice extracts AC was measured by the following method.
甘草抽出物を少量のエタノールに溶解し、Ｉ／１５Ｍ−
リン酸カリウム緩衝液（ｐＨ６，８）で希釈し、１１０
０ｐｐ試験液とした。この試験液１ｍｌに同緩衝液で調
製したチロシナーゼ溶液３０ ｕｎｉｔ／ｍｌを１ｍｌ
加え、３７０Ｃで１０分間ブレインキュベートした。こ
れに同緩衝液で調製した０、００３％Ｌ−チロシン溶液
１ｍｌを加え、３７°Ｃで１５分間インキュベートし、
直ちに４７５ｎｍにおける吸光度を測定した。その結果
、甘草抽出物Ａ〜Ｃはいずれも９０％以上のチロシナー
ゼ阻害活性を示した。Licorice extract was dissolved in a small amount of ethanol, and I/15M-
Diluted with potassium phosphate buffer (pH 6,8), 110
It was set as a 0pp test liquid. Add 1 ml of tyrosinase solution 30 units/ml prepared with the same buffer to 1 ml of this test solution.
and incubated at 370C for 10 minutes. 1 ml of 0,003% L-tyrosine solution prepared with the same buffer was added to this, and incubated at 37°C for 15 minutes.
Absorbance at 475 nm was immediately measured. As a result, all licorice extracts A to C exhibited tyrosinase inhibitory activity of 90% or more.
実験例２
甘草抽出物Ａをエタノールに溶解し、８０ ｐｐｍ試験
溶液とした。この試験溶液の２２０〜４４０ｎｍの吸光
度を、分光光度計にてエタノールを対照として測定した
。その結果は図１のとおりで、２９０〜３２０ｎｍのＵ
Ｖ−Ｂ域に強い吸収があり、それより弱いが３２０〜４
００ｎｍのＵＶ−Ａ域にも吸収を示した。Experimental Example 2 Licorice extract A was dissolved in ethanol to prepare an 80 ppm test solution. The absorbance of this test solution at 220 to 440 nm was measured using a spectrophotometer using ethanol as a control. The results are shown in Figure 1, and the U
There is strong absorption in the V-B region, weaker than that at 320-4
It also showed absorption in the UV-A region of 00 nm.
実験例３
甘草抽出物Ａを牛脂に０．０１５％混合したのち、基準
油脂分析試験法に準じてＡＯＭ試験を行なった。Experimental Example 3 After 0.015% of licorice extract A was mixed with beef tallow, an AOM test was conducted according to the standard oil and fat analysis test method.
過酸化物価が１００になる時間は、甘草抽出物無添加の
対照品が９時間であったのに対し、甘草抽出物Ａを混合
したことにより６５時間にのびた。The time for the peroxide value to reach 100 was 9 hours for the control product without the addition of licorice extract, but it was extended to 65 hours by mixing licorice extract A.
実施例１
■ エタノール １５．０％モ
ノラウリン酸ポリオキシエチレンソルビクン（２０ＥＯ
） １．０パラオキシ安息香酸
０．２香料
０．２甘草抽出物Ａ Ｏ，
０２■ 精製水 ７２．０グ
リセリン ５．０！、３−ブチレ
ングリコール ６．０色素
適量上記■■（室温にて混合し均一溶液
としたもの）を用意し、■を撹拌しつつ■を徐々に添加
して、化粧水を調製した。Example 1 ■ Ethanol 15.0% polyoxyethylene sorbicun monolaurate (20EO
) 1.0 paraoxybenzoic acid
0.2 fragrance
0.2 Licorice extract A O,
02 ■ Purified water 72.0 Glycerin 5.0! , 3-butylene glycol 6.0 dye
An appropriate amount of the above ■■ (mixed at room temperature to form a homogeneous solution) was prepared, and while stirring ■, gradually added ■ to prepare a lotion.
この化粧水を２０〜４０才の女性２０人に毎日被用させ
た。２週間使用後の効果をシミの軽減度、肌の変化等に
ついて観察すると共に、本人記入のアンケート調査によ
り調べた。This lotion was applied daily to 20 women between the ages of 20 and 40. The effects after two weeks of use were observed in terms of the degree of reduction in age spots, changes in skin, etc., and were also investigated through a questionnaire survey filled out by the user.
その結果、効果あり７名、やや効果あり１０名、効果な
し３名と判定され、有効率は８５％で、非常に優れた効
果をもつことが確認された。As a result, it was determined that the drug was effective in 7 patients, moderately effective in 10 patients, and not effective in 3 patients, and the efficacy rate was 85%, confirming that it is extremely effective.
実施例２
■ ステアリン酸 １５％セタノ
ール １．０甘草抽出物１３
０．０４■ 水酸化カリウム
０．７プロピレングリコール
３，０殺菌・防腐剤 適
量精製水 、 ７５％■ 香料
上記■を８２°Ｃに、■を８０°Ｃに、それぞれ加熱溶
解し、撹拌しなから■を■に徐々に加えて乳化を行う。Example 2 ■ Stearic acid 15% Cetanol 1.0 Licorice extract 13
0.04■ Potassium hydroxide
0.7 propylene glycol
3.0 Sterilization/preservative Appropriate amount of purified water, 75% ■ Fragrance Dissolve the above ■ above at 82°C and ■ at 80°C, respectively. While stirring, gradually add ■ to ■ to emulsify. .
５０℃にて■を添加し、３０°Ｃまで冷却して、シミ、
ソバカス防止バニシングクリームを調製した。Add ■ at 50°C, cool to 30°C, remove stains,
An anti-freckle vanishing cream was prepared.
実施例３
■ スクワラン ５．０％ワセ
リン ２．０サラシミツロ
ウ ０．５セスキオレイン酸ソルビ
タン ０．８ポリオキシエチレンオレイルエーテ
ル
（２０ＥＯ） １．２甘草抽出物
ｃ ｏ、ｏｓ■ 殺菌・防腐剤
適量プロピレングリコール１％
水溶液 ５．０エタノール
３，２カルボキシビニルポリマー（１％水溶液）１８
．０
水酸化カリウム ０．１精製水
６３．９■ 香料
上記■を７５°Ｃに、■を７３°Ｃに、それぞれ加熱溶
解し、撹拌しなから■を■に徐々に加えて乳化を行う。Example 3 ■ Squalane 5.0% Vaseline 2.0 White beeswax 0.5 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether (20EO) 1.2 Licorice extract c o, os■ Disinfectant/preservative Appropriate amount propylene Glycol 1%
Aqueous solution 5.0 ethanol
3,2 carboxyvinyl polymer (1% aqueous solution) 18
．． 0 Potassium hydroxide 0.1 Purified water
63.9■ Perfume Dissolve the above (■) and (2) at 75°C and 73°C by heating, respectively, and while stirring, gradually add (2) to (2) to emulsify.
その後■を加えてから３０°Ｃに冷却して、シミ、ソバ
カス防止エモリエントローションを調製した。Thereafter, (1) was added and the mixture was cooled to 30°C to prepare an emollient lotion for preventing stains and freckles.
ｒｇＪＩは、本発明の化粧料に配合される甘草の疎水性
有機溶媒抽出物の一例の紫外線吸収曲線である。rgJI is an ultraviolet absorption curve of an example of a hydrophobic organic solvent extract of licorice that is blended into the cosmetic of the present invention.
Claims (1)
ことを特徴とする色白化粧料。A whitening cosmetic characterized by containing a hydrophobic organic solvent extract of licorice as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62307452A JPH01149706A (en) | 1987-12-07 | 1987-12-07 | Skin-beautifying cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62307452A JPH01149706A (en) | 1987-12-07 | 1987-12-07 | Skin-beautifying cosmetic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01149706A true JPH01149706A (en) | 1989-06-12 |
Family
ID=17969232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62307452A Pending JPH01149706A (en) | 1987-12-07 | 1987-12-07 | Skin-beautifying cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01149706A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05331035A (en) * | 1992-05-27 | 1993-12-14 | Sansho Seiyaku Co Ltd | External preparation for skin |
| JPH06107532A (en) * | 1992-09-28 | 1994-04-19 | Kao Corp | Cosmetic for fair skin and beauty |
| EP2092837A1 (en) | 2008-02-25 | 2009-08-26 | Inha-Industry Partnership Institute | Compositions for skin whitening comprising (2Z, 8Z) - matricaria acid methyl ester |
| US8563054B2 (en) | 2005-03-15 | 2013-10-22 | Maruzen Pharmaceuticals Co., Ltd. | Anti-inflammatory agent |
| CN104784098A (en) * | 2015-04-01 | 2015-07-22 | 广西大学 | Speckle-diluting and whitening glycyrrhiza glabra mask powder |
| WO2022171292A1 (en) | 2021-02-12 | 2022-08-18 | Symrise Ag | Medicament for prevention and treatment of hyperpigmentation |
-
1987
- 1987-12-07 JP JP62307452A patent/JPH01149706A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05331035A (en) * | 1992-05-27 | 1993-12-14 | Sansho Seiyaku Co Ltd | External preparation for skin |
| JPH06107532A (en) * | 1992-09-28 | 1994-04-19 | Kao Corp | Cosmetic for fair skin and beauty |
| US8563054B2 (en) | 2005-03-15 | 2013-10-22 | Maruzen Pharmaceuticals Co., Ltd. | Anti-inflammatory agent |
| EP2092837A1 (en) | 2008-02-25 | 2009-08-26 | Inha-Industry Partnership Institute | Compositions for skin whitening comprising (2Z, 8Z) - matricaria acid methyl ester |
| CN104784098A (en) * | 2015-04-01 | 2015-07-22 | 广西大学 | Speckle-diluting and whitening glycyrrhiza glabra mask powder |
| WO2022171292A1 (en) | 2021-02-12 | 2022-08-18 | Symrise Ag | Medicament for prevention and treatment of hyperpigmentation |
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