JP7501440B2 - バイオイナート配管及び液体クロマトグラフ - Google Patents
バイオイナート配管及び液体クロマトグラフ Download PDFInfo
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- JP7501440B2 JP7501440B2 JP2021079560A JP2021079560A JP7501440B2 JP 7501440 B2 JP7501440 B2 JP 7501440B2 JP 2021079560 A JP2021079560 A JP 2021079560A JP 2021079560 A JP2021079560 A JP 2021079560A JP 7501440 B2 JP7501440 B2 JP 7501440B2
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- Prior art keywords
- metal tube
- piping
- extension member
- bio
- inert
- Prior art date
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- 239000007788 liquid Substances 0.000 title claims description 10
- 239000002184 metal Substances 0.000 claims description 76
- 229910052751 metal Inorganic materials 0.000 claims description 76
- 239000011347 resin Substances 0.000 claims description 43
- 229920005989 resin Polymers 0.000 claims description 43
- 239000000463 material Substances 0.000 claims description 13
- 230000002093 peripheral effect Effects 0.000 claims description 7
- 239000000919 ceramic Substances 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 description 12
- 238000005219 brazing Methods 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 239000004696 Poly ether ether ketone Substances 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920002530 polyetherether ketone Polymers 0.000 description 3
- 238000005452 bending Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L9/00—Rigid pipes
- F16L9/14—Compound tubes, i.e. made of materials not wholly covered by any one of the preceding groups
- F16L9/147—Compound tubes, i.e. made of materials not wholly covered by any one of the preceding groups comprising only layers of metal and plastics with or without reinforcement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Sampling And Sample Adjustment (AREA)
- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Description
4 樹脂チューブ
6 金属チューブ
8,26 端部延長部材
9 第1部材
10 第2部材
12,30 第1面
14,32 第2面
16,34 貫通孔
18 第1部材の円筒部分
20,36 ろう材の層
22 フランジ部
24,38 貫通孔の縁
Claims (4)
- 分析装置に使用され、内部に流路が設けられ、前記流路の内壁が樹脂チューブによって構成され、前記樹脂チューブの外周面が金属チューブによって被覆されているバイオイナート配管であって、
前記樹脂チューブよりも硬質の材料で構成され、前記金属チューブの端面と対向接触する第1面及び前記第1面とは反対側を向く第2面を有し、前記金属チューブの内径と実質的に同一の内径をもつ貫通孔が前記第1面から前記第2面へ通じるように設けられており、前記金属チューブの端部に取り付けられている端部延長部材を備え、
前記端部延長部材の前記第2面における前記貫通孔の縁は面取りされた形状を有し、
前記樹脂チューブは前記端部延長部材の前記貫通孔に挿通され、前記樹脂チューブの端部が前記端部延長部材の前記第2面の前記貫通孔の前記縁の前記面取りされた形状に沿って前記流路の半径方向外側へ折り曲げられてフランジ部を形成しており、
前記端部延長部材は第1部材及び第2部材を有し、
前記第1部材は、互いに反対側を向く2つの端面を有し、前記2つの端面が前記第1面及び前記第2面であり、前記貫通孔の中心軸が前記金属チューブの中心軸と一致した状態で前記金属チューブに対して固着されている部材であり、
前記第2部材は、前記第1部材の一部が圧入されることによって前記第1部材と連結され、前記金属チューブの前記端部の外周面を覆っている中空筒状の部材である、バイオイナート配管。 - 前記端部延長部材は、前記金属チューブの前記端部が挿し込まれる窪みを有し、前記窪みの奥に前記金属チューブの前記端面と対向接触する前記第1面が設けられたスリーブである、請求項1に記載のバイオイナート配管。
- 前記端部延長部材は、金属又は硬質セラミックにより構成されている、請求項1又は2に記載のバイオイナート配管。
- 移動相の流れる経路に沿って複数の構成要素が配管により流体接続されることで構成される液体クロマトグラフであって、
前記配管が請求項1から3のいずれか一項に記載のバイオイナート配管である、液体クロマトグラフ。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021079560A JP7501440B2 (ja) | 2021-05-10 | 2021-05-10 | バイオイナート配管及び液体クロマトグラフ |
CN202210327646.5A CN115327011A (zh) | 2021-05-10 | 2022-03-30 | 生物惰性配管以及液相色谱仪 |
US17/726,082 US20220356964A1 (en) | 2021-05-10 | 2022-04-21 | Bioinert pipe and liquid chromatograph |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021079560A JP7501440B2 (ja) | 2021-05-10 | 2021-05-10 | バイオイナート配管及び液体クロマトグラフ |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022173696A JP2022173696A (ja) | 2022-11-22 |
JP7501440B2 true JP7501440B2 (ja) | 2024-06-18 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021079560A Active JP7501440B2 (ja) | 2021-05-10 | 2021-05-10 | バイオイナート配管及び液体クロマトグラフ |
Country Status (3)
Country | Link |
---|---|
US (1) | US20220356964A1 (ja) |
JP (1) | JP7501440B2 (ja) |
CN (1) | CN115327011A (ja) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120024411A1 (en) | 2010-07-16 | 2012-02-02 | Idex Health & Science Llc | Biocompatible Tubing for Liquid Chromatography Systems |
US20140131997A1 (en) | 2012-11-15 | 2014-05-15 | Dionex Softron Gmbh | Connector unit and connecting system for connecting capillaries, in particular for high-performance liquid chromatography |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2486679B (en) * | 2010-12-22 | 2017-10-04 | Agilent Technologies Inc | Dual-material approach for high pressure bioinert flow path components |
KR102184798B1 (ko) * | 2020-07-08 | 2020-11-30 | (주) 폴리텍 | 이형질 이음관 |
-
2021
- 2021-05-10 JP JP2021079560A patent/JP7501440B2/ja active Active
-
2022
- 2022-03-30 CN CN202210327646.5A patent/CN115327011A/zh active Pending
- 2022-04-21 US US17/726,082 patent/US20220356964A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120024411A1 (en) | 2010-07-16 | 2012-02-02 | Idex Health & Science Llc | Biocompatible Tubing for Liquid Chromatography Systems |
JP2013536417A (ja) | 2010-08-10 | 2013-09-19 | アイデックス ヘルス アンド サイエンス エルエルシー | 液体クロマトグラフィシステム用の生体適合性管 |
US20140131997A1 (en) | 2012-11-15 | 2014-05-15 | Dionex Softron Gmbh | Connector unit and connecting system for connecting capillaries, in particular for high-performance liquid chromatography |
JP2014098694A (ja) | 2012-11-15 | 2014-05-29 | Dionex Softron Gmbh | とりわけ高速液体クロマトグラフィ用の毛細管を連結するためのプラグユニットおよび連結システム |
Also Published As
Publication number | Publication date |
---|---|
US20220356964A1 (en) | 2022-11-10 |
CN115327011A (zh) | 2022-11-11 |
JP2022173696A (ja) | 2022-11-22 |
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