JP7487860B2 - 光学検出システム - Google Patents
光学検出システム Download PDFInfo
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Description
ここにおいて、nは、流体の屈折率である。
ここにおいて、θは、前記パターンによって散乱される前記第1波の散乱角である。
本発明の一実施例において、前記複数の分割セルは、マトリックス(matrix)形態に配列され、前記複数の分割セルの数は、前記のサンプル内に含まれる微生物の予想個体数よりも多いこともある。
本発明の一実施例において、前記個別の波の情報は、当該分割セルから出射されるレーザースペックル中、第1時点で検出された前記レーザースペックルの第1画像情報と、第2時点で検出された前記レーザースペックルの第2画像情報と、第3時点で検出された前記レーザースペックルの第3画像情報とを含み、前記第1時点から前記第3時点は互いに異なる時点であり、前記制御部は、前記第1画像情報から前記第3画像情報の差を利用し、前記微生物の存在有無を判定することができる。
本発明の他の実施例において、波源と、前記波源から生成された波を第1経路または第2経路に転送する第1光学ユニットと、前記第1経路に配置され、固定された散乱媒体(static scattering medium)を含め、前記第1経路に沿って入射される第1波を散乱させ、第1スペックルを生成する第1スペックル生成ユニットと、前記第2経路に配置され、測定しようとする試料を含め、前記第2経路に沿って入射される第2波を散乱させて第2スペックルを生成する第2スペックル生成ユニットと、前記第1光学ユニットと前記第2スペックル生成ユニットとの間に配置される第2シャッターと、前記第1スペックルまたは第2スペックルを時系列順に検出する画像センサーと、前記画像センサーによって検出された前記第1スペックルを利用して前記第1スペックルの時間的相関関係(temporal correlation)を取得し、前記取得された第1スペックルの時間的相関関係に基づいて前記第2シャッターの動作を制御する制御部とを含む光学検出システムが提供される。
前述のこと以外の他の側面、特徴、および利点は、以下の図面、請求の範囲、および発明の詳細な説明から明らかになるだろう。
以下に添付された図面を参照し、以下の実施例を詳細に説明する。図面を参照して説明するときには、同一または対応する構成要素は、同一の図面符号を付与し、これに対する重複説明は省略する。
以下の実施例において、単数の表現は、文脈上、明確に別の意味を意図しない限り、複数の表現を含む。
ガラスのように、内部屈折率が均一な物質の場合は、光を照射したときに一定の方向に屈折する。 しかしながら、内部屈折率が不均一な物体にレーザーのような干渉光(coherent Light)を照射すると、物体の内部で非常に複雑な多重散乱(multiple scattering)が発生する。
よりも小さい場合に、内面1101に入射される第1波L11の反射率が高いので、意図する多重散乱の回数を増加させることが困難である。パイプユニット1110は、パターンが、上記の数式1を満足するように形成されることにより、内部空間における散乱率を増加させることができる。また、複数の溝gからなるパターンの深さdは、全てが同一である必要はなく、不規則に形成されても、各々の溝gの深さdが上記の数式1を満足すれば、十分な散乱率を確保することができる。このとき、パターンの深さdは、パイプユニット1110の断面の厚さを超えることはできない。
は時間相関係数、
は正規化された光強度、(x、y)はカメラの画素座標、tは測定された時間、Tは合計測定時間、τはタイムラグ(time lag)を示す。
は時間による平均光強度を示すことができる。
このとき、第1波L14において、時間に応じて性質が変化することなく、一定の特性を有する場合、第1スペックル生成ユニット4310によって生成された第1スペックルLS14も、固定された散乱媒体311によって時間に応じて一定のパターンを形成することができる。しかしながら、波源4100から生成される波L4、言い換えれば、第1波L14が、周囲の環境によってその性質が変化すると、これにより、第1スペックルLS14のパターンが変わる。
Claims (10)
- 波源と、
前記波源において生成された波を第1経路または第2経路に転送するよう構成された光学ユニットと、
前記第1経路に配置され、静止散乱媒体(static scattering medium)を含み、前記第1経路に沿って入射する第1波を散乱させ、第1スペックルを生成する第1スペックル生成ユニットと、
前記第2経路に配置され、測定される試料を含み、前記第2経路に沿って入射する第2波を散乱させ、第2スペックルを生成する第2スペックル生成ユニットと、
前記光学ユニットと前記第2スペックル生成ユニットとの間に配置される第2シャッターと、
前記第1スペックルまたは第2スペックルを時系列順に検出するよう構成された画像センサーと、
前記画像センサーによって前記検出された第1スペックルを利用して前記第1スペックルの時間的相関関係(temporal correlation)を取得し、前記取得された第1スペックルの時間的相関関係に基づいて前記第2シャッターの動作を制御するよう構成された制御部と、を含む光学検出装置。 - 前記制御部は、前記検出された第2スペックルを利用して前記検出された第2スペックルの時間的相関関係を取得し、前記取得した第2スペックルの時間的相関関係に基づいて、前記試料内の微生物の存在または前記微生物の濃度を推定する、請求項1に記載の光学検出装置。
- 前記制御部は、前記第1スペックルの時間的相関関係に基づいて前記第1波の性質変化を判定し、前記第1波の性質変化に応じて、前記第2シャッターの動作を制御する、請求項1に記載の光学検出装置。
- 前記制御部は、前記第1スペックルの時間相関係数を計算し、前記第1スペックルの前記時間相関係数が予め設定した範囲に該当する場合のみ、前記第2スペックルを検出するように第2シャッターを開放する、請求項3に記載の光学検出装置。
- 前記光学検出装置は、前記光学ユニットと前記第1スペックル生成ユニットとの間に配置される第1シャッターをさらに含み、
前記制御部は、前記第2シャッターが開放される間に、閉鎖されるように前記第1シャッターを制御する、請求項3に記載の光学検出装置。 - 前記第2スペックル生成ユニットは、前記試料内の前記第2波の多重散乱の回数を増幅させるために、多重散乱物質(multiple scattering material)を含む多重散乱増幅部をさらに備える、請求項1に記載の光学検出装置。
- 波源と、
前記波源において生成された波を第1経路または第2経路に転送するよう構成された光学ユニットと、
前記第1経路に配置され、対照群試料を含み、前記第1経路に沿って入射する第1波を散乱させ、第1スペックルを生成する第1スペックル生成ユニットと、
前記第1スペックルを時系列順に検出するよう構成された第1画像センサーと、
前記第2経路に配置され、測定群試料および培地を含み、前記第2経路に沿って入射する第2波を散乱させ、第2スペックルを生成する第2スペックル生成ユニットと、
前記第2スペックルを時系列順に検出するよう構成された第2画像センサーと、
前記検出された第1スペックルおよび前記検出された第2スペックルを利用して、前記対照群試料の第1濃度および前記測定群試料の第2濃度を推定し、前記第1濃度および前記第2濃度を利用して前記測定群試料内の生菌の存在を判定するよう構成された制御部と、を含む光学検出装置。 - 前記制御部は、前記検出された第1スペックルを利用して前記第1スペックルの時間的相関関係(temporal correlation)を取得した後、前記第1スペックルの時間的相関関係を利用して前記対照群試料の第1濃度を推定し、前記検出された第2スペックルを利用して前記第2スペックルの時間的相関関係を取得した後、前記第2スペックルの時間的相関関係を利用して前記測定群試料の第2濃度を推定する、請求項7に記載の光学検出装置。
- 前記測定群試料は、前記対照群試料をm倍に希釈した試料であり、前記制御部は、前記第2濃度と前記第1濃度とが等しくなる成長時間を取得した後、前記成長時間を利用して前記測定群試料内の生菌および死菌の割合を導出する、請求項7に記載の光学検出装置。
- 前記第2スペックル生成ユニットは、前記試料内の前記第2波の多重散乱の回数を増幅させるために、多重散乱物質(multiple scattering material)を含む多重散乱増幅部をさらに備える、請求項7に記載の光学検出装置。
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