JP7037842B2 - 光学検出システム - Google Patents
光学検出システム Download PDFInfo
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- JP7037842B2 JP7037842B2 JP2020556926A JP2020556926A JP7037842B2 JP 7037842 B2 JP7037842 B2 JP 7037842B2 JP 2020556926 A JP2020556926 A JP 2020556926A JP 2020556926 A JP2020556926 A JP 2020556926A JP 7037842 B2 JP7037842 B2 JP 7037842B2
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Description
本発明の一実施例において、前記複数の分割セルは、マトリックス(matrix)形態に配列され、前記複数の分割セルの数は、前記のサンプル内に含まれる微生物の予想個体数よりも多いこともある。
本発明の一実施例において、前記個別の波の情報は、当該分割セルから出射されるレーザースペックル中、第1時点で検出された前記レーザースペックルの第1画像情報と、第2時点で検出された前記レーザースペックルの第2画像情報と、第3時点で検出された前記レーザースペックルの第3画像情報とを含み、前記第1時点から前記第3時点は互いに異なる時点であり、前記制御部は、前記第1画像情報から前記第3画像情報の差を利用し、前記微生物の存在有無を判定することができる。
本発明の他の実施例において、波源と、前記波源から生成された波を第1経路または第2経路に転送する第1光学ユニットと、前記第1経路に配置され、固定された散乱媒体(static scattering medium)を含め、前記第1経路に沿って入射される第1波を散乱させ、第1スペックルを生成する第1スペックル生成ユニットと、前記第2経路に配置され、測定しようとする試料を含め、前記第2経路に沿って入射される第2波を散乱させて第2スペックルを生成する第2スペックル生成ユニットと、前記第1光学ユニットと前記第2スペックル生成ユニットとの間に配置される第2シャッターと、前記第1スペックルまたは第2スペックルを時系列順に検出する画像センサーと、前記画像センサーによって検出された前記第1スペックルを利用して前記第1スペックルの時間的相関関係(temporal correlation)を取得し、前記取得された第1スペックルの時間的相関関係に基づいて前記第2シャッターの動作を制御する制御部とを含む光学検出システムが提供される。
前述のこと以外の他の側面、特徴、および利点は、以下の図面、請求の範囲、および発明の詳細な説明から明らかになるだろう。
以下に添付された図面を参照し、以下の実施例を詳細に説明する。図面を参照して説明するときには、同一または対応する構成要素は、同一の図面符号を付与し、これに対する重複説明は省略する。
以下の実施例において、単数の表現は、文脈上、明確に別の意味を意図しない限り、複数の表現を含む。
ガラスのように、内部屈折率が均一な物質の場合は、光を照射したときに一定の方向に屈折する。 しかしながら、内部屈折率が不均一な物体にレーザーのような干渉光(coherent Light)を照射すると、物体の内部で非常に複雑な多重散乱(multiple scattering)が発生する。
よりも小さい場合に、内面1101に入射される第1波L11の反射率が高いので、意図する多重散乱の回数を増加させることが困難である。パイプユニット1110は、パターンが、上記の数式1を満足するように形成されることにより、内部空間における散乱率を増加させることができる。また、複数の溝gからなるパターンの深さdは、全てが同一である必要はなく、不規則に形成されても、各々の溝gの深さdが上記の数式1を満足すれば、十分な散乱率を確保することができる。このとき、パターンの深さdは、パイプユニット1110の断面の厚さを超えることはできない。
は時間相関係数、
は正規化された光強度、(x、y)はカメラの画素座標、tは測定された時間、Tは合計測定時間、τはタイムラグ(time lag)を示す。
このとき、第1波L14において、時間に応じて性質が変化することなく、一定の特性を有する場合、第1スペックル生成ユニット4310によって生成された第1スペックルLS14も、固定された散乱媒体311によって時間に応じて一定のパターンを形成することができる。しかしながら、波源4100から生成される波L4、言い換えれば、第1波L14が、周囲の環境によってその性質が変化すると、これにより、第1スペックルLS14のパターンが変わる。
Claims (14)
- 第1断面と、前記第1断面に対向する第2断面と、前記第1断面および前記第2断面を貫通して内部空間を形成する内面を含むボディ部とを備え、
前記ボディ部の前記内面は、前記内部空間に位置する流体内で前記第1断面と前記第2断面との間に入射する第1波の多重散乱(multiple scattering)の回数を増幅させるためのパターンが形成される多重散乱増幅領域を備え、
前記パターンは、前記内面から予め設定した深さdを有する複数の溝が予め設定した間隔Λに配列されて形成される、パイプユニット。 - 前記パターンの前記深さdおよび前記間隔Λは、前記第1波の波長λに基づいて決定される、請求項1に記載のパイプユニット。
- 前記ボディ部には、前記流体内で多重散乱され、出射される第2波を検出する検出部に案内する1つ以上の出射ホールが形成される、請求項1に記載のパイプユニット。
- 前記出射ホールが2つ以上存在する場合、前記出射ホールは、前記ボディ部の互いに異なる位置に配置される、請求項5に記載のパイプユニット。
- 第1断面を通して流入される流体が第2断面を通して排出されるように、前記第1断面と前記第2断面とを貫通する内部空間が形成されるボディ部を備え、前記内部空間に位置する流体内で前記第1断面と前記第2断面との間に入射する第1波の多重散乱(multiple scattering)の回数を増幅させるための多重散乱増幅領域を含むパイプユニットと、
前記パイプユニットの前記流体に向かって前記第1波を照射する波源と、
前記パイプユニットの外部に配置され、前記の照射された第1波が前記流体内で多重散乱されて発生するレーザースペックル(laser speckle)を予め設定した第1時点ごとに検出する検出部と、
前記検出されたレーザースペックルを利用して前記検出されたレーザースペックルの時間的相関関係(temporal correlation)を取得し、前記取得した時間的相関関係に基づいて前記流体内の不純物の存在をリアルタイム(real-time)で推定する制御部と、を含み、
前記パイプユニットの前記ボディ部には、前記流体内で多重散乱され、出射される第2波を前記検出部に案内する1つ以上の出射ホールが形成され、
前記ボディ部は、前記内部空間を囲む内面を備え、
前記ボディ部の前記内面に前記多重散乱増幅領域が備えられ、前記第1波の多重散乱(multiple scattering)の回数を増幅させるためのパターンが形成され、
前記パターンは、前記内面から予め設定した深さdを有する複数の溝が予め設定した間隔Λに配列されて形成される、不純物検出システム。 - 前記パターンの前記深さdおよび前記間隔Λは、前記第1波の波長λに基づいて決定される、請求項7に記載の不純物検出システム。
- 前記出射ホールから出射される前記第2波は、前記検出部により予め設定した測定速度以上に前記レーザースペックルを検出するために、1mW/cm2以上のパワーの範囲を有する、請求項7に記載の不純物検出システム。
- 前記検出部の前記測定速度において、前記流体が前記出射ホールを通過する時間は、前記第1時点間の時間よりも大きくなるように設定される、請求項11に記載の不純物検出システム。
- 前記出射ホールが2つ以上存在する場合、前記出射ホールは、前記ボディ部の円周方向に沿って互いに異なる位置に配置され、
前記検出部は、前記出射ホールの数に対応するように備えられる、請求項7に記載の不純物検出システム。 - 前記第1波は、200nm~1.8μmの波長範囲を有する、請求項7に記載の不純物検出システム。
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DE102014108630A1 (de) | 2014-06-18 | 2015-12-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung und Verfahren zur Durchführung optischer Messungen an fluiden Substanzen in Gefäßen mit einer Längsrichtung |
WO2017086719A1 (ko) | 2015-11-17 | 2017-05-26 | 한국과학기술원 | 혼돈파 센서를 이용한 시료 특성 탐지 장치 |
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US20210102883A1 (en) | 2021-04-08 |
JP7487860B2 (ja) | 2024-05-21 |
JP2023129747A (ja) | 2023-09-15 |
JP2021520500A (ja) | 2021-08-19 |
US20210080369A1 (en) | 2021-03-18 |
US11156541B2 (en) | 2021-10-26 |
US11280716B2 (en) | 2022-03-22 |
JP2022078159A (ja) | 2022-05-24 |
JP7315991B2 (ja) | 2023-07-27 |
WO2019221557A1 (ko) | 2019-11-21 |
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