JP7387650B2 - 電気刺激療法のecapによる制御 - Google Patents
電気刺激療法のecapによる制御 Download PDFInfo
- Publication number
- JP7387650B2 JP7387650B2 JP2020569874A JP2020569874A JP7387650B2 JP 7387650 B2 JP7387650 B2 JP 7387650B2 JP 2020569874 A JP2020569874 A JP 2020569874A JP 2020569874 A JP2020569874 A JP 2020569874A JP 7387650 B2 JP7387650 B2 JP 7387650B2
- Authority
- JP
- Japan
- Prior art keywords
- pulse
- ecap
- pulses
- notification
- amplitude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000638 stimulation Effects 0.000 title claims description 438
- 238000002560 therapeutic procedure Methods 0.000 title claims description 109
- 238000012545 processing Methods 0.000 claims description 129
- 230000001225 therapeutic effect Effects 0.000 claims description 71
- 230000000763 evoking effect Effects 0.000 claims description 59
- 230000036982 action potential Effects 0.000 claims description 50
- 150000001875 compounds Chemical class 0.000 claims description 50
- 230000004044 response Effects 0.000 claims description 36
- 230000015654 memory Effects 0.000 claims description 34
- 230000000694 effects Effects 0.000 claims description 33
- 230000002051 biphasic effect Effects 0.000 claims description 31
- 230000001965 increasing effect Effects 0.000 claims description 20
- 230000003247 decreasing effect Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 description 94
- 238000011282 treatment Methods 0.000 description 48
- 238000012360 testing method Methods 0.000 description 40
- 210000001519 tissue Anatomy 0.000 description 38
- 230000008859 change Effects 0.000 description 35
- 210000000278 spinal cord Anatomy 0.000 description 26
- 230000006870 function Effects 0.000 description 23
- 238000010586 diagram Methods 0.000 description 22
- 210000005036 nerve Anatomy 0.000 description 18
- 230000007423 decrease Effects 0.000 description 17
- 238000004891 communication Methods 0.000 description 15
- 230000016507 interphase Effects 0.000 description 14
- 230000001537 neural effect Effects 0.000 description 14
- 210000002569 neuron Anatomy 0.000 description 14
- 230000001276 controlling effect Effects 0.000 description 12
- 208000002193 Pain Diseases 0.000 description 11
- 230000008713 feedback mechanism Effects 0.000 description 11
- 230000004913 activation Effects 0.000 description 10
- 230000004936 stimulating effect Effects 0.000 description 9
- 230000001939 inductive effect Effects 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000001681 protective effect Effects 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 230000035807 sensation Effects 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 5
- 210000000578 peripheral nerve Anatomy 0.000 description 5
- 230000001902 propagating effect Effects 0.000 description 5
- 210000004556 brain Anatomy 0.000 description 4
- 230000002452 interceptive effect Effects 0.000 description 4
- 210000004126 nerve fiber Anatomy 0.000 description 4
- 241001494479 Pecora Species 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 230000004323 axial length Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 3
- 230000007383 nerve stimulation Effects 0.000 description 3
- 208000035824 paresthesia Diseases 0.000 description 3
- 230000008447 perception Effects 0.000 description 3
- 208000000094 Chronic Pain Diseases 0.000 description 2
- 208000034347 Faecal incontinence Diseases 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 201000001880 Sexual dysfunction Diseases 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 206010046543 Urinary incontinence Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 210000003050 axon Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000013500 data storage Methods 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 231100000872 sexual dysfunction Toxicity 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 206010069632 Bladder dysfunction Diseases 0.000 description 1
- 229910001200 Ferrotitanium Inorganic materials 0.000 description 1
- 208000014540 Functional gastrointestinal disease Diseases 0.000 description 1
- 206010017815 Gastric perforation Diseases 0.000 description 1
- 206010021518 Impaired gastric emptying Diseases 0.000 description 1
- 229920000106 Liquid crystal polymer Polymers 0.000 description 1
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 208000021642 Muscular disease Diseases 0.000 description 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 1
- 208000023610 Pelvic Floor disease Diseases 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000007637 bowel dysfunction Diseases 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000002999 depolarising effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000001827 electrotherapy Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000001288 gastroparesis Diseases 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000009251 neurologic dysfunction Effects 0.000 description 1
- 208000015015 neurological dysfunction Diseases 0.000 description 1
- 230000008555 neuronal activation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 210000003903 pelvic floor Anatomy 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000010248 power generation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36062—Spinal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36064—Epilepsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36071—Pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
- A61N1/36085—Eating disorders or obesity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36107—Sexual dysfunction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/3615—Intensity
- A61N1/36153—Voltage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36171—Frequency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36175—Pulse width or duty cycle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0553—Paddle shaped electrodes, e.g. for laminotomy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36178—Burst or pulse train parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36182—Direction of the electrical field, e.g. with sleeve around stimulating electrode
- A61N1/36185—Selection of the electrode configuration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Developmental Disabilities (AREA)
- Psychology (AREA)
- Electrotherapy Devices (AREA)
Description
Claims (13)
- システムであって、
刺激生成回路であって、
電気刺激療法を患者に送達することであって、前記電気刺激療法が、ある期間にわたって所定のパルス周波数で複数の通知パルスを含み、前記複数の通知パルスが、パラメータ値の第1の集合によって少なくとも部分的に定義される、送達することと、
前記ある期間にわたって複数の制御パルスを送達することであって、前記複数の制御パルスが、前記複数の通知パルスのうちの少なくともいくつかの通知パルスとインターリーブされ、前記複数の制御パルスが、前記パラメータ値の第1の集合とは異なるパラメータ値の第2の集合によって少なくとも部分的に定義される、送達することと、を行うように構成されている刺激生成回路と、
処理回路であって、
前記複数の制御パルスのうちの各制御パルスの後、かつ前記複数の通知パルスのうちの後続の通知パルスの前に、感知されたそれぞれの誘発複合活動電位(ECAP:evoked compound action potential)を受信することと、
少なくとも1つのそれぞれの誘発複合活動電位(ECAP)の特性が目標誘発複合活動電位(ECAP)特性から逸脱したとの判定に応じて、前記電気刺激療法の前記複数の通知パルスを少なくとも部分的に定義する前記パラメータ値の第1の集合のうちの1つ以上のパラメータ値を調整することと、
前記刺激生成回路を用いて、前記パラメータ値の第1の集合のうちの前記調整された1つ以上のパラメータ値に従って、前記患者に前記電気刺激療法を送達することと、を行うように構成されている、処理回路と、
を含む、システム。 - 1つ以上のプロセッサと、
前記目標誘発複合活動電位(ECAP)特性を示す、上限を有する誘発複合活動電位(ECAP)調整ウィンドウをさらに含み、
前記1つ以上のプロセッサが、
前記複数の制御パルスのうちの各制御パルスの後の前記それぞれの誘発複合活動電位(ECAP)の振幅に基づいて、少なくとも1つのそれぞれの誘発複合活動電位(ECAP)の代表的な振幅を計算することと、
前記代表的な振幅が前記誘発複合活動電位(ECAP)調整ウィンドウの上限を超える場合、前記少なくとも1つのそれぞれの誘発複合活動電位(ECAP)に続く前記複数の通知パルスのうちの1つ以上の通知パルスの振幅を減少させることと、
を行うようにさらに構成され、
前記代表的な振幅が、
i) 単一の誘発複合活動電位(ECAP)の振幅、
ii)2つ以上の誘発複合活動電位(ECAP)の平均、
iii)2つ以上のそれぞれの誘発複合活動電位(ECAP)の中央値振幅、
iv)2つ以上のそれぞれの誘発複合活動電位(ECAP)の移動平均、
v)最後の4つの感知された誘発複合活動電位(ECAP)の平均振幅、
vi) 最後の4つより少ないまたはより多くの誘発複合活動電位(ECAP)の平均振幅、
のいずれかである、
請求項1に記載のシステム。 - 1つ以上のプロセッサと、
前記目標誘発複合活動電位(ECAP)特性を示す、下限を有する誘発複合活動電位(ECAP)調整ウィンドウをさらに含み、
前記1つ以上のプロセッサが、
前記複数の制御パルスのうちの各制御パルスの後の前記それぞれの誘発複合活動電位(ECAP)の振幅に基づいて、少なくとも1つのそれぞれの誘発複合活動電位(ECAP)の代表的な振幅を計算することと、
前記代表的な振幅が前記誘発複合活動電位(ECAP)調整ウィンドウの下限を下回る場合、前記少なくとも1つのそれぞれの誘発複合活動電位(ECAP)に続く前記複数の制御パルスのうちの1つ以上の制御パルスの振幅を増加させることと、
を行うようにさらに構成され、
前記代表的な振幅が、
i) 単一の誘発複合活動電位(ECAP)の振幅、
ii)2つ以上の誘発複合活動電位(ECAP)の平均、
iii)2つ以上のそれぞれの誘発複合活動電位(ECAP)の中央値振幅、
iv)2つ以上のそれぞれの誘発複合活動電位(ECAP)の移動平均、
v)最後の4つの感知された誘発複合活動電位(ECAP)の平均振幅、
vi) 最後の4つより少ないまたはより多くの誘発複合活動電位(ECAP)の平均振幅、
のいずれかである、
請求項1に記載のシステム。 - 誘発複合活動電位(ECAP)調整ウィンドウを記憶するように構成されているメモリと、
1つ以上の電極と、をさらに含み、
前記刺激生成回路が、
前記1つ以上の電極を用いて、前記患者に電気刺激療法を送達することと、
前記複数の制御パルスを、前記1つ以上の電極を用いて、前記患者に送達することと、を行うようにさらに構成されている、請求項2または3に記載のシステム。 - 前記複数の通知パルスのうちの各通知パルスのパルス幅が、300マイクロ秒超であり、1000マイクロ秒未満である、請求項1~4のいずれか一項に記載のシステム。
- 前記複数の通知パルスの前記所定のパルス周波数が、400ヘルツ未満である、請求項1~5のいずれか一項に記載のシステム。
- 前記複数の制御パルスのうちの各制御パルスのパルス幅が、300マイクロ秒未満である、請求項1~6のいずれか一項に記載のシステム。
- 前記刺激生成回路が、
複数の時間イベントのうちの各時間イベント中に、前記複数の制御パルスのうちの1つの制御パルスを送達するようにさらに構成されており、
前記複数の時間イベントのうちの各時間イベントが、前記ある期間にわたって前記所定のパルス周波数において、前記複数の通知パルスのうちの連続する通知パルス間の時間を含む、請求項1~7のいずれか一項に記載のシステム。 - 前記刺激生成回路が、
複数の時間イベントのうちの各時間イベント中に、前記複数の制御パルスのうちの2つ以上の制御パルスを送達するようにさらに構成されており、
前記複数の時間イベントのうちの各時間イベントが、前記ある期間にわたって前記所定のパルス周波数において、前記複数の通知パルスのうちの連続する通知パルス間の時間を含む、請求項1~7のいずれか一項に記載のシステム。 - 前記パラメータ値の第1の集合のうちの1つ以上のパラメータ値が、パルス振幅、パルス幅、パルス周波数、およびパルス形状のうちの少なくとも1つを含む、請求項1~9のいずれか一項に記載のシステム。
- センサをさらに含み、
前記1つ以上のプロセッサが、
前記センサから、前記患者の活動レベルが変化したことを示す信号を受信することと、
前記信号の受信に応じて、前記刺激生成回路を用いて前記患者に送達される前記複数の制御パルスの所定のパルス周波数の増加または減少の一方と、行うようにさらに構成されている、請求項1~10のいずれか一項に記載のシステム。 - 前記複数の通知パルスのうちの各通知パルスが、受動的な再充電相が後に続く単相(monophasic)パルスであり、前記複数の制御パルスのうちの各制御パルスが、二相パルスである、請求項1~11のいずれか一項に記載のシステム。
- 前記複数の制御パルスが、複数の非治療パルスを含み、前記複数の通知パルスが、複数の治療パルスを含む、請求項1~12のいずれか一項に記載のシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862688221P | 2018-06-21 | 2018-06-21 | |
US62/688,221 | 2018-06-21 | ||
PCT/US2019/038573 WO2019246579A1 (en) | 2018-06-21 | 2019-06-21 | Ecap based control of electrical stimulation therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021529572A JP2021529572A (ja) | 2021-11-04 |
JP7387650B2 true JP7387650B2 (ja) | 2023-11-28 |
Family
ID=67211924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020569874A Active JP7387650B2 (ja) | 2018-06-21 | 2019-06-21 | 電気刺激療法のecapによる制御 |
Country Status (6)
Country | Link |
---|---|
US (2) | US11129989B2 (ja) |
EP (3) | EP4085971B1 (ja) |
JP (1) | JP7387650B2 (ja) |
CN (1) | CN112351814A (ja) |
AU (1) | AU2019288749B2 (ja) |
WO (1) | WO2019246579A1 (ja) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112351813A (zh) | 2018-06-21 | 2021-02-09 | 美敦力公司 | 电刺激治疗的基于ecap的控制 |
WO2021067873A1 (en) * | 2019-10-04 | 2021-04-08 | Nalu Medical, Inc. | Stimulation apparatus |
US11547855B2 (en) | 2019-10-25 | 2023-01-10 | Medtronic, Inc. | ECAP sensing for high frequency neurostimulation |
US20210121698A1 (en) * | 2019-10-25 | 2021-04-29 | Medtronic, Inc. | Sub-threshold stimulation based on ecap detection |
US11931582B2 (en) | 2019-10-25 | 2024-03-19 | Medtronic, Inc. | Managing transient overstimulation based on ECAPs |
US12011595B2 (en) | 2019-12-19 | 2024-06-18 | Medtronic, Inc. | Control pulses and posture for ECAPs |
US10931273B1 (en) | 2020-01-31 | 2021-02-23 | Infineon Technologies Ag | Circuit for controlling a switching device to deliver power to a load |
US12023505B2 (en) | 2020-02-05 | 2024-07-02 | Boston Scientific Neuromodulation Corporation | Selection of sensing electrodes in a spinal cord stimulator system using sensed stimulation artifacts |
US20210275817A1 (en) * | 2020-03-06 | 2021-09-09 | Medtronic, Inc. | Controlling electrical stimulation based on a sensed stimulation signal |
US20230166112A1 (en) * | 2020-04-20 | 2023-06-01 | University Of Florida Research Foundation, Inc. | Simultaneous bilateral stimulation using neurostimulator |
US11857793B2 (en) | 2020-06-10 | 2024-01-02 | Medtronic, Inc. | Managing storage of sensed information |
US20210387002A1 (en) * | 2020-06-10 | 2021-12-16 | Medtronic, Inc. | Control policy settings for electrical stimulation therapy |
US11944819B2 (en) | 2020-07-09 | 2024-04-02 | Medtronic, Inc. | Analyzing ECAP signals |
US20230398360A1 (en) * | 2020-08-28 | 2023-12-14 | Saluda Medical Pty Ltd | Feedback Loop Control of Neuromodulation Device |
US11707626B2 (en) | 2020-09-02 | 2023-07-25 | Medtronic, Inc. | Analyzing ECAP signals |
US20220062638A1 (en) * | 2020-09-02 | 2022-03-03 | Medtronic, Inc. | PHASE ALIGNMENT OF ECAPs |
US11648402B2 (en) | 2020-09-30 | 2023-05-16 | Medtronic, Inc. | Lead integrity and closed-loop algorithm diagnostic |
US11559689B2 (en) | 2020-09-30 | 2023-01-24 | Medtronic, Inc. | Noise detection and modulation of closed-loop therapy action |
US11547860B2 (en) * | 2020-09-30 | 2023-01-10 | Medtronic, Inc. | Closed-loop therapy stimulation response to patient adjustment |
WO2022076913A1 (en) * | 2020-10-08 | 2022-04-14 | Medtronic, Inc. | Low energy multimodal stimulation |
US11896828B2 (en) * | 2020-10-30 | 2024-02-13 | Medtronic, Inc. | Implantable lead location using ECAP |
AU2021409714A1 (en) * | 2020-12-23 | 2023-08-10 | Medtronic, Inc. | Electrical stimulation therapy |
EP4277697A1 (en) * | 2021-01-13 | 2023-11-22 | Medtronic, Inc. | Multimodal stimulation control based on ecaps |
US20240066304A1 (en) * | 2021-01-13 | 2024-02-29 | Medtronic, Inc. | Ratiometric control for electrical stimulation |
WO2022183194A1 (en) * | 2021-02-24 | 2022-09-01 | Medtronic, Inc. | Neurostimulation titration system |
US20220266027A1 (en) * | 2021-02-24 | 2022-08-25 | Boston Scientific Neuromodulation Corporation | Closed Loop Control in Spinal Cord Stimulation |
CN116887886A (zh) * | 2021-02-24 | 2023-10-13 | 美敦力公司 | 电刺激治疗的参数选择 |
WO2022183198A1 (en) * | 2021-02-24 | 2022-09-01 | Medtronic, Inc. | Neurostimulation titration and programming based on patient feedback |
WO2022183163A1 (en) * | 2021-02-24 | 2022-09-01 | Medtronic, Inc. | Local field potential (lfp) sensing for neurostimulation control |
WO2023017406A1 (en) * | 2021-08-10 | 2023-02-16 | Medtronic, Inc. | Spinal cord injury therapy based on evoked compound action potentials |
WO2023081180A1 (en) * | 2021-11-05 | 2023-05-11 | Boston Scientific Neuromodulation Corporation | Closed loop stimulation based on response avoidance |
CN114404800B (zh) * | 2021-12-22 | 2022-09-27 | 应脉医疗科技(上海)有限公司 | 神经刺激装置、***、电子设备及存储介质 |
WO2023205858A1 (en) * | 2022-04-28 | 2023-11-02 | Saluda Medical Pty Limited | Improved programming of neural stimulation therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017173493A1 (en) | 2016-04-05 | 2017-10-12 | Saluda Medical Pty Ltd | Improved feedback control of neuromodulation |
WO2018080753A1 (en) | 2016-10-28 | 2018-05-03 | Medtronic, Inc. | Controlling electrical stimulation therapy |
WO2018106813A1 (en) | 2016-12-06 | 2018-06-14 | Medtronic, Inc. | High frequency neurostimulation for pelvic symptom control |
Family Cites Families (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5603726A (en) | 1989-09-22 | 1997-02-18 | Alfred E. Mann Foundation For Scientific Research | Multichannel cochlear implant system including wearable speech processor |
AUPN533195A0 (en) | 1995-09-07 | 1995-10-05 | Cochlear Pty. Limited | Derived threshold and comfort level for auditory prostheses |
US6505078B1 (en) * | 1996-04-04 | 2003-01-07 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue |
US5800465A (en) | 1996-06-18 | 1998-09-01 | Medtronic, Inc. | System and method for multisite steering of cardiac stimuli |
DE69728173T2 (de) | 1996-06-20 | 2005-02-03 | Advanced Bionics Corp., Sylmar | Selbsteinstellendes cochleares implantatsystem |
US6314325B1 (en) | 1998-04-07 | 2001-11-06 | William R. Fitz | Nerve hyperpolarization method and apparatus for pain relief |
US6421566B1 (en) | 1998-04-30 | 2002-07-16 | Medtronic, Inc. | Selective dorsal column stimulation in SCS, using conditioning pulses |
US6289247B1 (en) | 1998-06-02 | 2001-09-11 | Advanced Bionics Corporation | Strategy selector for multichannel cochlear prosthesis |
ATE412445T1 (de) | 2000-07-26 | 2008-11-15 | Boston Scient Neuromodulation | Stimulationssystem |
US7263402B2 (en) | 2001-08-13 | 2007-08-28 | Advanced Bionics Corporation | System and method of rapid, comfortable parameter switching in spinal cord stimulation |
US7076292B2 (en) | 2002-04-25 | 2006-07-11 | Medtronic, Inc. | Optical communication of neurostimulation-system information |
US7206640B1 (en) | 2002-11-08 | 2007-04-17 | Advanced Bionics Corporation | Method and system for generating a cochlear implant program using multi-electrode stimulation to elicit the electrically-evoked compound action potential |
US20080221640A1 (en) | 2002-11-08 | 2008-09-11 | Overstreet Edward H | Multi-electrode stimulation to elicit electrically-evoked compound action potential |
MXPA05014141A (es) | 2003-06-24 | 2006-03-09 | Healthonics Inc | Aparato y metodo para estimulo bioelectrico, aceleracion de sanado, alivio del dolor y desvitalizacion de patogeno. |
US7792583B2 (en) | 2004-03-16 | 2010-09-07 | Medtronic, Inc. | Collecting posture information to evaluate therapy |
US7333858B2 (en) | 2004-03-31 | 2008-02-19 | Cochlear Limited | Pulse burst electrical stimulation of nerve or tissue fibers |
US7577480B2 (en) | 2005-03-31 | 2009-08-18 | Medtronic, Inc. | System for waveform stimulation compensating electrode polarization |
US7734352B2 (en) | 2005-09-19 | 2010-06-08 | Second Sight Medical Products, Inc. | Sub-threshold stimulation to precondition neurons for supra-threshold stimulation |
US7689289B2 (en) * | 2006-03-22 | 2010-03-30 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue with paired pulses |
US8090446B2 (en) * | 2007-04-19 | 2012-01-03 | Advanced Neuromodulation Systems, Inc. | Methods and systems for establishing neural stimulation parameters and providing neural stimulation |
US7742810B2 (en) | 2007-05-23 | 2010-06-22 | Boston Scientific Neuromodulation Corporation | Short duration pre-pulsing to reduce stimulation-evoked side-effects |
US8612019B2 (en) * | 2007-05-23 | 2013-12-17 | Boston Scientific Neuromodulation Corporation | Coupled monopolar and multipolar pulsing for conditioning and stimulation |
US7634315B2 (en) | 2007-05-31 | 2009-12-15 | Pacesetter, Inc. | Techniques to monitor and trend nerve damage and recovery |
US8855777B2 (en) | 2008-05-09 | 2014-10-07 | Medtronic, Inc. | Programming techniques for peripheral nerve field stimulation |
US8346368B2 (en) | 2008-05-30 | 2013-01-01 | Cochlear Limited | Sound processing method and system |
US8708934B2 (en) | 2008-07-11 | 2014-04-29 | Medtronic, Inc. | Reorientation of patient posture states for posture-responsive therapy |
US8504150B2 (en) | 2008-07-11 | 2013-08-06 | Medtronic, Inc. | Associating therapy adjustments with posture states using a stability timer |
US8923984B2 (en) | 2008-09-17 | 2014-12-30 | Saluda Medical Pty Limited | Knitted electrode assembly for an active implantable medical device |
US20100274312A1 (en) * | 2009-04-22 | 2010-10-28 | Konstantinos Alataris | Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods |
GB0821325D0 (en) | 2008-11-21 | 2008-12-31 | Ucl Business Plc | Method and apparatus for performing deep brain stimulation with an electric field |
DK2396072T3 (da) | 2009-01-14 | 2013-04-08 | Spinal Modulation Inc | Stimulerende elektrode-leveringssystem |
WO2010104569A1 (en) | 2009-03-09 | 2010-09-16 | Neurds Inc. | System and method for wireless power transfer in implantable medical devices |
JP2012523268A (ja) | 2009-04-08 | 2012-10-04 | ナショナル・アイシーティ・オーストラリア・リミテッド | 移植可能医療デバイスの縫いつけコンポーネント |
EP2586488B1 (en) | 2009-04-22 | 2017-03-15 | Nevro Corporation | Selective high frequency spinal cord modulation for inhibiting pain with reduced side effects, and associated systems |
US9764147B2 (en) * | 2009-04-24 | 2017-09-19 | Medtronic, Inc. | Charge-based stimulation intensity programming with pulse amplitude and width adjusted according to a function |
US9566439B2 (en) | 2009-07-20 | 2017-02-14 | Saluda Medical Pty Limited | Neuro-stimulation |
WO2011019935A1 (en) | 2009-08-12 | 2011-02-17 | Medtronic, Inc. | Dorsal column stimulation therapy |
US8768481B2 (en) | 2009-08-28 | 2014-07-01 | Boston Scientific Neuromodulation Corporation | Methods to avoid frequency locking in a multi-channel neurostimulation system using a greatest common divisor rule |
BR112012001910A2 (pt) | 2009-09-21 | 2019-09-24 | Medtronic Inc | formas de onda para terapia de estimulo eletrico |
US9446231B2 (en) | 2009-11-23 | 2016-09-20 | Boston Scientific Neuromodulation Corporation | Neurostimulation system and method for compounding current to minimize current sources |
WO2011066478A1 (en) | 2009-11-26 | 2011-06-03 | National Ict Australia Limited (Nicta) | Forming feedthroughs for hermetically sealed housings using two-material powder injection molding |
US9242094B2 (en) * | 2010-01-12 | 2016-01-26 | The Johns Hopkins University | Implantable vestibular prosthesis |
WO2012027791A1 (en) | 2010-08-31 | 2012-03-08 | National Ict Australia Ltd | Distributed implant systems |
US8422313B2 (en) | 2010-12-16 | 2013-04-16 | International Business Machines Corporation | Reduced power consumption memory circuitry |
ES2698902T3 (es) * | 2011-05-13 | 2019-02-06 | Saluda Medical Pty Ltd | Aparato para aplicación de un estímulo neuronal |
US9872990B2 (en) | 2011-05-13 | 2018-01-23 | Saluda Medical Pty Limited | Method and apparatus for application of a neural stimulus |
WO2012155183A1 (en) | 2011-05-13 | 2012-11-22 | National Ict Australia Ltd | Method and apparatus for measurement of neural response - a |
EP2707087B1 (en) | 2011-05-13 | 2018-05-02 | Saluda Medical Pty Limited | Method and apparatus for controlling a neural stimulus - e |
WO2012155190A1 (en) | 2011-05-13 | 2012-11-22 | National Ict Australia Ltd | Method and apparatus for measurement of neural response |
US8712534B2 (en) | 2011-10-28 | 2014-04-29 | Medtronic, Inc. | Combined high and low frequency stimulation therapy |
EP2782636B1 (en) | 2011-11-24 | 2017-12-13 | Saluda Medical Pty Limited | Coatings for active implantable medical devices |
WO2013075171A1 (en) | 2011-11-24 | 2013-05-30 | National Ict Australia Ltd | Electrode assembly for an active implantable medical device |
US9403008B2 (en) | 2012-01-30 | 2016-08-02 | University Of Iowa Research Foundation | Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord |
US8676331B2 (en) | 2012-04-02 | 2014-03-18 | Nevro Corporation | Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for automated parameter selection |
US9604058B2 (en) | 2012-04-06 | 2017-03-28 | Boston Scientific Neuromodulation Corporation | Method for achieving low-back spinal cord stimulation without significant side-effects |
US8751009B2 (en) * | 2012-04-24 | 2014-06-10 | Medtronic, Inc. | Techniques for confirming a volume of effect of sub-perception threshold stimulation therapy |
US8923976B2 (en) | 2012-04-26 | 2014-12-30 | Medtronic, Inc. | Movement patterns for electrical stimulation therapy |
WO2013183302A1 (ja) | 2012-06-08 | 2013-12-12 | パナソニック株式会社 | 音響光学撮像装置 |
US9339655B2 (en) * | 2012-06-30 | 2016-05-17 | Boston Scientific Neuromodulation Corporation | System and method for compounding low-frequency sources for high-frequency neuromodulation |
US20140031905A1 (en) | 2012-07-12 | 2014-01-30 | Purdue Research Foundation | Burst pulse tissue stimulation method and apparatus |
DK2908904T3 (da) | 2012-11-06 | 2020-12-14 | Saluda Medical Pty Ltd | System til styring af vævs elektriske tilstand |
WO2014071446A1 (en) | 2012-11-06 | 2014-05-15 | Saluda Medical Pty Ltd | Method and system for controlling electrical conditions of tissue ii |
JP6400028B2 (ja) * | 2013-02-22 | 2018-10-03 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 複合パルス列を生成するために柔軟性の増大した神経刺激システム |
US9533148B2 (en) | 2013-02-22 | 2017-01-03 | Boston Scientific Neuromodulation Corporation | Neurostimulation system and method for automatically adjusting stimulation and reducing energy requirements using evoked action potential |
CN105163801B (zh) | 2013-02-22 | 2017-11-07 | 波士顿科学神经调制公司 | 具有用于组合脉冲串的装置的多通道神经调制*** |
CN113368397A (zh) * | 2013-03-15 | 2021-09-10 | 波士顿科学神经调制公司 | 用于递送亚阈值治疗到患者的***和方法 |
US20140277282A1 (en) | 2013-03-15 | 2014-09-18 | Boston Scientific Neuromodulation Corporation | Use of compound action potentials to automatically adjust neurostimulation therapy in response to postural changes of patient |
US9707396B2 (en) | 2013-06-21 | 2017-07-18 | Medtronic, Inc. | Cortical potential monitoring |
AU2014302297B2 (en) * | 2013-06-28 | 2017-04-13 | Boston Scientific Neuromodulation Corporation | Electrode selection for sub-threshold modulation therapy |
CN105407964B (zh) * | 2013-07-26 | 2018-05-04 | 波士顿科学神经调制公司 | 提供调制治疗而无感知的*** |
AU2014342267B2 (en) * | 2013-11-01 | 2017-07-06 | Boston Scientific Neuromodulation Corporation | Systems for delivering sub-threshold therapy at a midline |
WO2015070281A1 (en) | 2013-11-15 | 2015-05-21 | Saluda Medical Pty Ltd | Monitoring brain neural potentials |
EP3071100B1 (en) | 2013-11-22 | 2024-01-03 | Saluda Medical Pty Limited | Method and device for detecting a neural response in a neural measurement |
JP6404564B2 (ja) | 2013-12-24 | 2018-10-10 | 株式会社東芝 | デコーダ、デコード方法およびプログラム |
US20170135624A1 (en) | 2014-03-28 | 2017-05-18 | Saluda Medical Pty Ltd | Assessing Neural State from Action Potentials |
ES2801348T3 (es) | 2014-05-05 | 2021-01-11 | Saluda Medical Pty Ltd | Medición neurológica mejorada |
US9393430B2 (en) | 2014-05-17 | 2016-07-19 | Thync Global, Inc. | Methods and apparatuses for control of a wearable transdermal neurostimulator to apply ensemble waveforms |
AU2015264561B2 (en) | 2014-05-20 | 2020-02-20 | Nevro Corporation | Implanted pulse generators with reduced power consumption via signal strength/duration characteristics, and associated systems and methods |
US9302112B2 (en) | 2014-06-13 | 2016-04-05 | Pacesetter, Inc. | Method and system for non-linear feedback control of spinal cord stimulation |
US10688301B2 (en) | 2014-07-24 | 2020-06-23 | Synapstim Ltd. | Device and methods for delivery of stimulation to a body tissue |
ES2873255T3 (es) * | 2014-07-25 | 2021-11-03 | Saluda Medical Pty Ltd | Dosificación de estimulación neurológica |
US9993646B2 (en) * | 2014-09-23 | 2018-06-12 | Boston Scientific Neuromodulation Corporation | Sub-perception modulation responsive to patient input |
US9814880B2 (en) | 2014-09-23 | 2017-11-14 | Boston Scientific Neuromodulation Corporation | Short pulse width stimulation |
US9597507B2 (en) * | 2014-10-31 | 2017-03-21 | Medtronic, Inc. | Paired stimulation pulses based on sensed compound action potential |
US9610448B2 (en) * | 2014-11-12 | 2017-04-04 | Pacesetter, Inc. | System and method to control a non-paresthesia stimulation based on sensory action potentials |
US9956404B2 (en) | 2014-11-19 | 2018-05-01 | Medtronic, Inc. | Electrical stimulation to inhibit bladder and/or bowel contraction |
US10213148B2 (en) | 2014-12-05 | 2019-02-26 | Pacesetter, Inc. | Spinal cord stimulation guidance system and method of use |
US20160158551A1 (en) * | 2014-12-05 | 2016-06-09 | Pacesstter, Inc. | System and method for dorsal root block during spinal cord stimulation |
US9572984B2 (en) | 2014-12-08 | 2017-02-21 | Pacesetter, Inc. | System and method for coupling burst and tonic stimulation |
US20160166164A1 (en) | 2014-12-11 | 2016-06-16 | Saluda Medical Pty Limited | Method and Apparatus for Detecting Neural Injury |
US10588698B2 (en) | 2014-12-11 | 2020-03-17 | Saluda Medical Pty Ltd | Implantable electrode positioning |
WO2016090436A1 (en) | 2014-12-11 | 2016-06-16 | Saluda Medical Pty Ltd | Method and device for feedback control of neural stimulation |
US9387325B1 (en) | 2014-12-19 | 2016-07-12 | Pacesetter, Inc. | System and method to control dorsal root stimulation parameters based on frequency decomposition |
US20160206883A1 (en) * | 2015-01-19 | 2016-07-21 | Pacesetter, Inc. | System and method for current steering neurostimulation |
CA2973855A1 (en) | 2015-04-09 | 2016-10-13 | Saluda Medical Pty Ltd | Electrode to nerve distance estimation |
US10434308B2 (en) * | 2015-05-29 | 2019-10-08 | Medtronic, Inc. | Impedance matching and electrode conditioning in patient interface systems |
EP3302258A4 (en) | 2015-05-31 | 2018-11-21 | Saluda Medical Pty Limited | Monitoring brain neural activity |
CN107613861B (zh) | 2015-06-01 | 2021-10-26 | 闭环医疗私人有限公司 | 运动纤维神经调节 |
DK3181192T3 (da) | 2015-12-17 | 2020-07-20 | Oticon Medical As | System til hurtig erhvervelse af fremkaldte kombinerede virkningspotentialeregistreringer |
WO2017106539A1 (en) | 2015-12-18 | 2017-06-22 | Medtronic, Inc. | High duty cycle electrical stimulation therapy |
WO2017100866A1 (en) | 2015-12-18 | 2017-06-22 | Saluda Medical Pty Ltd | Measurement of neural response |
WO2017136552A1 (en) * | 2016-02-02 | 2017-08-10 | Enteromedics Inc. | High-frequency low duty cycle patterns for neural regulation |
US10406368B2 (en) | 2016-04-19 | 2019-09-10 | Boston Scientific Neuromodulation Corporation | Pulse generator system for promoting desynchronized firing of recruited neural populations |
US20170361103A1 (en) * | 2016-06-15 | 2017-12-21 | Pacesetter, Inc. | System and Method for Interleaved Neurostimulation |
WO2017219096A1 (en) | 2016-06-24 | 2017-12-28 | Saluda Medical Pty Ltd | Neural stimulation for reduced artefact |
US10525268B2 (en) * | 2016-08-23 | 2020-01-07 | Medtronic, Inc. | Delivery of independent interleaved programs to produce higher-frequency electrical stimulation therapy |
US10569088B2 (en) | 2016-09-16 | 2020-02-25 | Medtronic, Inc. | Dorsal spinal column characterization with evoked potentials |
US10639479B2 (en) * | 2016-11-11 | 2020-05-05 | Medtronic, Inc. | Stimulation vector selection using pulse width data |
WO2018136493A1 (en) * | 2017-01-17 | 2018-07-26 | Veressa Medical, Inc. | System for identifying a target medical device implant site |
WO2018187241A1 (en) * | 2017-04-03 | 2018-10-11 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
US10933242B2 (en) * | 2017-09-29 | 2021-03-02 | Medtronic, Inc. | Therapy parameter selection based on ECAP feedback |
US10926092B2 (en) | 2018-01-08 | 2021-02-23 | Boston Scientific Neuromodulation Corporation | Automatic adjustment of sub-perception therapy in an implantable stimulator using detected compound action potentials |
EP3755430A1 (en) * | 2018-06-01 | 2020-12-30 | Boston Scientific Neuromodulation Corporation | Interleaving stimulation patterns provided by an implantable pulse generator |
CN112351813A (zh) | 2018-06-21 | 2021-02-09 | 美敦力公司 | 电刺激治疗的基于ecap的控制 |
US11931582B2 (en) * | 2019-10-25 | 2024-03-19 | Medtronic, Inc. | Managing transient overstimulation based on ECAPs |
US20210121698A1 (en) * | 2019-10-25 | 2021-04-29 | Medtronic, Inc. | Sub-threshold stimulation based on ecap detection |
-
2019
- 2019-06-21 JP JP2020569874A patent/JP7387650B2/ja active Active
- 2019-06-21 EP EP22181766.1A patent/EP4085971B1/en active Active
- 2019-06-21 AU AU2019288749A patent/AU2019288749B2/en active Active
- 2019-06-21 EP EP19737398.8A patent/EP3810260B1/en active Active
- 2019-06-21 US US16/449,152 patent/US11129989B2/en active Active
- 2019-06-21 CN CN201980041352.2A patent/CN112351814A/zh active Pending
- 2019-06-21 WO PCT/US2019/038573 patent/WO2019246579A1/en unknown
- 2019-06-21 EP EP23208235.4A patent/EP4295898A3/en active Pending
-
2021
- 2021-09-24 US US17/484,848 patent/US20220008730A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017173493A1 (en) | 2016-04-05 | 2017-10-12 | Saluda Medical Pty Ltd | Improved feedback control of neuromodulation |
WO2018080753A1 (en) | 2016-10-28 | 2018-05-03 | Medtronic, Inc. | Controlling electrical stimulation therapy |
WO2018106813A1 (en) | 2016-12-06 | 2018-06-14 | Medtronic, Inc. | High frequency neurostimulation for pelvic symptom control |
Also Published As
Publication number | Publication date |
---|---|
EP3810260A1 (en) | 2021-04-28 |
US20190388692A1 (en) | 2019-12-26 |
EP3810260B1 (en) | 2022-07-27 |
JP2021529572A (ja) | 2021-11-04 |
EP4085971B1 (en) | 2023-12-13 |
EP4085971A1 (en) | 2022-11-09 |
US20220008730A1 (en) | 2022-01-13 |
EP4295898A2 (en) | 2023-12-27 |
US11129989B2 (en) | 2021-09-28 |
EP4295898A3 (en) | 2024-02-21 |
WO2019246579A1 (en) | 2019-12-26 |
AU2019288749A1 (en) | 2020-11-19 |
CN112351814A (zh) | 2021-02-09 |
AU2019288749B2 (en) | 2024-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7387650B2 (ja) | 電気刺激療法のecapによる制御 | |
JP7344231B2 (ja) | 電気刺激療法のecapによる制御 | |
US11071863B2 (en) | Controlling electrical stimulation therapy | |
US12011595B2 (en) | Control pulses and posture for ECAPs | |
US11813457B2 (en) | Hysteresis compensation for detection of ECAPs | |
US20210121698A1 (en) | Sub-threshold stimulation based on ecap detection | |
US11931582B2 (en) | Managing transient overstimulation based on ECAPs | |
US11202912B2 (en) | Posture-based control of electrical stimulation therapy | |
US20220401737A1 (en) | Latency compensation for detection of ecaps | |
WO2024026422A1 (en) | Selective nerve fiber stimulation for therapy | |
AU2021420682A1 (en) | Hybrid control policy for ecap-servoed neuromodulation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220617 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230524 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20230526 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230804 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230825 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230828 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20231017 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20231115 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7387650 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |