JP7330939B2 - 組成物 - Google Patents
組成物 Download PDFInfo
- Publication number
- JP7330939B2 JP7330939B2 JP2020501476A JP2020501476A JP7330939B2 JP 7330939 B2 JP7330939 B2 JP 7330939B2 JP 2020501476 A JP2020501476 A JP 2020501476A JP 2020501476 A JP2020501476 A JP 2020501476A JP 7330939 B2 JP7330939 B2 JP 7330939B2
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- JP
- Japan
- Prior art keywords
- use according
- glucomannan
- composition
- range
- daily dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 54
- 235000012054 meals Nutrition 0.000 claims description 42
- 229920002581 Glucomannan Polymers 0.000 claims description 32
- 229940046240 glucomannan Drugs 0.000 claims description 31
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 30
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/117—Flakes or other shapes of ready-to-eat type; Semi-finished or partly-finished products therefor
- A23L7/126—Snacks or the like obtained by binding, shaping or compacting together cereal grains or cereal pieces, e.g. cereal bars
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Description
a)グルコマンナン;
b)クロム;および
c)プレバイオティクス
を含む組成物が提供される。
a)グルコマンナン;
b)クロム;および
c)プレバイオティクス
を含む機能性食品が提供される。
以下の成分を含む「SlimBiome」配合物を表1に従って調製し、小袋に入れた。
SlimBiome(登録商標)配合物を含むカロリー制限食事代替品を購入した顧客からフィードバックを得るために、顧客調査を依頼した。調査の具体的な目的は、食事代替物の有効性、製品および風味の好感度、ならびに特定の成分の魅力を理解することであった。
全体として、カロリー制限食事代替範囲に対する応答は肯定的であり、回答者の大部分は、生成物を使用しており、生成物の味を好み、活性成分を動機づける利益として見出していた期間中に体重を減少させた。口頭コメントによると、回答者はより多くのフレーバーおよびフォーマットに範囲においてオープンであったが、多くの回答者は他の計画とは異なり、カロリー制限された食事代替範囲計画に固執していたことが示唆される。一部の回答者は、以前はダイエットに固執していなかったため、当該回答者にとっては普通ではなかったダイエットを楽しんだと述べ、一方、他の回答者は、当該回答者が決して空腹にならなかったと述べた。
1週間超にわたる計画上にいた者の100%は体重が減少したと述べた。3週間以上計画上にいた回答者の53%では、体重減少の中央値は合計で7~9ポンド(3.175~4.082kg)であった。平均して、回答者が計画上にいた時間が長ければ長いほど、記録された体重減少は大きくなった(すなわち、3週間計画上にいた回答者は、2週間計画上にいた回答者よりも平均して多く減少した)。回答者は、調査が実施された時点での総体重減少を記録するように求められただけであった)。
本研究は、飽食(充満)、満腹(食事間の空腹感/欲求)および食物摂取/選択に対するSlimBiome(登録商標)製剤の効果を決定するために実施した。製品耐性(および副作用)、認知能力(気分/欲求の形成)、ならびに食事計画/SlimBiome(登録商標)配合物を包含する食事代替製品の遵守に従うことの容易さも評価した。
この研究は、BMI>27.5~32.5kg/m2の21~65歳の40人の女性被験者に対して実施された。この研究は、2つのグループ:食事療法アドバイス+プラセボ(対照)または食事療法アドバイス+SlimBiomeを1日3回(試験)とする前向き無作為化並行群間試験の形態であった。
研究に含めるために、被験者はまた、以下の基準を満たさなければならなかった:前月内にカロリー制限食事に従わず、前年に有意な量の体重を失わなかった;過去2~4週間に身体活動レベルを増加させなかった、または試験中に身体活動レベルを変更しようとしなかった;カロリー制限食事に従う意思があることを含むすべての試験手順および制限に従う意思があり、従うことができ、従う可能性があった;およびほとんどの日常食を食べることができた。被験者は以下の理由で除外された:重大な健康上の問題があった;過去1ヶ月以内および/または試験期間中に食欲または体重に影響を及ぼすことが知られている薬剤またはサプリメントを服用していた;妊娠しているか、妊娠または授乳を予定していた;食物に対するアナフィラキシーの病歴があった;食物および/または研究材料(または密接に関連する化合物)またはそれらの述べられた成分のいずれかに対する既知のアレルギーまたは不耐性があった;BMI<27.5kg/m2または>32.5kg/m2を有していた;現在カロリー制限食事を受けているか、以前の年にかなりの量の体重を失っていると報告されていた;異常な食挙動をしていた;喫煙者および最近喫煙を中止した;検診から30日以内に別の実験研究に参加したか、治験薬/製品を施与された;過去2~4週間以内に身体活動を有意に変化させた、または試験中に変更しようとした;研究パラメーターの評価に干渉する可能性が高い全身的または局所的処置を受けていた;特定の食物回避食事に関するものであった;および食欲または摂食関連分野で働いていた。
すべての参加者は、標準的な食事アドバイスサプリメントに従い、追加のオンライン材料にアクセスした。当該参加者は、試験期間を通じて製品の一貫性を確保するために、使用前に製品の保管および使用条件について助言を受けた。参加者は、それぞれの商品(プラセボまたはSlimbiome(登録商標)配合物のいずれかを含む)を、3つの主食のそれぞれの前に水と共に毎日服用するように指示された。
以下のパラメーター:人体測定;気分(PANAS)および欲求(COEQ)測定;注意バイアス(視覚プローブ課題);食物選択(LFCT);食物応答性(PoF);幸福(PSSおよびBDI);プログラムの経験;および食欲の経験を、研究来院中に評価した。
各参加者は、合計3回の研究訪問(+スクリーニング)に参加した。評価は、T=0、1、および4週間で行い、以下の測定を行った。
・ 人体測定:体重、ウエスト周囲長、股関節周囲ボディマスインデックス(BMI)、インピーダンス(体脂肪)
・ グルコースレベル
・ VAS(Visual Analogue Scale)アンケート
空腹
充満
食欲/食に対する欲望
消費見通し
飽食/食事経験
口渇
悪心/副作用
・ 認知能力-食物の手がかりに対する気分/欲求/注意力の偏り
・ 食挙動(拘束された、外的な、感情的な食事をする人;スクリーニング時に測定)
・ 食物摂取量(食事摂取量-g/kcalおよび夕食の食事継続時間;食事選択-夕食スナックバーの消費/タイミング)
・ プログラムの経験(容易性/コンプライアンス)
・ 幸福
無作為二重盲検プラセボを使用したヒト試験では、プラセボと比較した場合、ピコリン酸クロムは食物摂取量(P<0.0001)、空腹レベル(P<0.05)、および脂肪欲求(P<0.0001)を低下させ、低下した体重低下につながる(P<0.08)。グルコマンナンは、低カロリー食事と併用した場合の体重減少に対するその有効性を実証する多くの研究によって支持されている。グルコマンナンおよびフルクタンのような可溶性繊維の両方は、炭水化物吸収を減速させることによって食後の満腹を増加させることによって作用する。これらの結果は、これらの成分の組み合わせが、相加または相乗効果を有することを示唆する。
食事代替スナックバーおよび脱水シェイク配合物を、以下の表5に定義されるような以下の組成に基づいて製造した。
201カロリーの健康的な食事代替バニラビーンシェイクは、次の成分で調合された:MCT(中鎖トリグリセリド脂肪)粉末、スキムミルク、グルテンフリーエンバク粉、大豆タンパク質(乳)、マルトデキストリン、天然香料、グルコマンナン配合物[オリゴフルクトース、グルコマンナン(コンニャク根抽出物)]、ピコリン酸クロム]、乳化剤(大豆レシチン)、マルチビタミンプレミックス(ビタミンA、チアミン(B1)、リボフラビン(B2)、ナイアシン(B3)、パントテン酸(B5)ビタミンB6、葉酸、ビタミンB12、ビタミンC、ビタミンD、ビタミンE、ビオチン、カルシウム、リン、カリウム、鉄、亜鉛、銅、ヨウ素、セレン、クロム、マンガン、マグネシウム、アマの種子、チア(サルビアヒスパニカ(Salvia hispanica))種子、グリーンパウダープレミックス(ブロッコリー、ホウレンソウ、クレソン、グリーンケール、オオムギ草、アルファルファ、コリアンダー、バジル、ローズマリー、タイム、ユッカルート、ケルプ、アボカド)、プレミックス(スピルリナ、クロレラ、バオバブフルーツパルプ、マカ)、増粘剤(キサンタンガム)、ライブプロバイオティクス細菌培養複合体(ラクトバチルスアシドフィルス(Lactobacillus Acidophilus)、ビフィドバクテリウムビフィダム(Bifidobacterium Bifidum))、甘味料(ステビオール配糖体)。このシェイクを、1gのグルコマンナン、2gのFOSおよび0.083gのクロムと共に配合した。
115カロリーの健康的なピーナッツスナックバーを、以下の成分:チョップドデート、グルテンフリーオートムギ(オートムギ、オートムギふすま19.8%)、空気焙煎ピーナッツ(17.1%)、サルタナス、ブランチドピーナッツ(7.5%)、ヒマワリ種子、野菜グリセリン、[オリゴフルクトース、グルコマンナン(コンニャク根抽出物)、ピコリン酸クロム]を用いて配合した。このバーを、0.5gのグルコマンナン、1gのFOSおよび0.041gのクロムと共に配合した。
Claims (18)
- a)グルコマンナン;
b)ピコリン酸クロム;
c)フルクトオリゴ糖(FOS);および
d)担体
を含む組成物の消化管細菌叢の多様性を増大させるための使用であって、前記グルコマンナンは前記担体と凝集している、使用(ヒトに対する医療行為を除く)。 - さらに、イヌリン、ガラクトオリゴ糖(GOS)、α-グルコオリゴ糖、β-グルカン、およびそれらの組み合わせから選択される1つ以上を含む、請求項1に記載の使用。
- 前記組成物が、0.6g~1.4gの範囲のグルコマンナン;60μg~100μgの範囲のピコリン酸クロム;および/または0.25g~4.0gの範囲のFOSを含む、請求項1または2に記載の使用。
- 前記組成物が、0.8g~1.2gの範囲のグルコマンナン;70μg~90μgの範囲のピコリン酸クロム;および/または1.0g~2.5gの範囲のFOSを含む、請求項1または2に記載の使用。
- 前記組成物が、1gで存在するグルコマンナン;79μgで存在するピコリン酸クロム;および/または1g~2gの範囲で存在するFOSを含む、請求項1または2に記載の使用。
- 前記組成物が機能性食品の形態である、請求項1~5のいずれか一項に記載の使用。
- 前記組成物が、食品、食品添加物、栄養補助食品、食事代替飲料またはスナックバーの形態である、請求項1~5のいずれか一項に記載の使用。
- 前記使用が、長期間にわたり胃腸細菌叢の多様性を増大させるためである、請求項1~7のいずれか一項に記載の使用。
- 前記組成物が、ビタミン、ミネラル、植物化学物質、抗酸化剤、およびそれらの組み合わせから選択される1つ以上の活性成分をさらに含む、請求項1~8のいずれか一項に記載の使用。
- 前記組成物がカロリー制御食事療法の一部として1日4回まで摂取される、請求項1~9のいずれか一項に記載の使用。
- 前記組成物が、減カロリー摂取食事療法の間および/または後に摂取される、請求項10に記載の使用。
- 前記組成物が、1.8g~4.2gの範囲の1日用量のグルコマンナン;180μg~300μgの範囲の1日用量のピコリン酸クロム;および/または1.0g~12gの範囲の1日用量のFOSを含む、請求項10または11に記載の使用。
- 前記組成物が、2.4g~3.6gの範囲の1日用量のグルコマンナン;210μg~270μgの範囲の1日用量のピコリン酸クロム;および/または1.5g~12gの範囲の1日用量のFOSを含む、請求項10または11に記載の使用。
- 前記組成物が、3gの1日用量のグルコマンナン;79μgの1日用量のピコリン酸クロム;および/または2g~12gの範囲の1日用量のFOSを含む、請求項10または11に記載の使用。
- 個体における体重減少を促進または維持する方法であって、請求項1~6のいずれか一項に記載の使用を含む方法(ヒトに対する医療行為を除く)。
- 前記組成物が1日4回まで投与される、請求項15に記載の方法。
- 前記組成物が、減カロリー摂取食事療法の前、最中(もしくはその一部として)、または後に投与される、請求項15または16のいずれかに記載の方法。
- 担体がマルトデキストリンまたはデキストランを含む、請求項1に記載の使用。
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JP2007508329A (ja) | 2003-10-17 | 2007-04-05 | ダイエット・フォーミュレイションズ・リミテッド | 体重減少用サプリメント |
CN105249466A (zh) | 2015-11-19 | 2016-01-20 | 刘庆华 | 降糖食物组合物 |
WO2016071693A1 (en) | 2014-11-05 | 2016-05-12 | Optibiotix Limited | Composition |
JP2016537018A (ja) | 2013-11-05 | 2016-12-01 | オプティバイオティクス リミテッド | 組成物 |
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US6733769B1 (en) * | 1999-05-06 | 2004-05-11 | Opta Food Ingredients, Inc. | Methods for lowering viscosity of glucomannan compositions, uses and compositions |
US6565847B1 (en) * | 2002-07-03 | 2003-05-20 | Vitacost.Com, Inc. | Thermogenic weight management composition |
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JP7479280B2 (ja) | 2017-11-17 | 2024-05-08 | アルケマ フランス | ブロックコポリマー発泡体 |
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US20200222451A1 (en) | 2020-07-16 |
JP2020528270A (ja) | 2020-09-24 |
GB201712151D0 (en) | 2017-09-13 |
JP2023012512A (ja) | 2023-01-25 |
EP3657962A1 (en) | 2020-06-03 |
CA3068787A1 (en) | 2019-01-31 |
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AU2018306467A1 (en) | 2020-01-23 |
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