JP7329245B2 - 心血管性の効率に影響を与える栄養補助食品 - Google Patents
心血管性の効率に影響を与える栄養補助食品 Download PDFInfo
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- astaxanthin
- haematococcus pluvialis
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- 235000015872 dietary supplement Nutrition 0.000 title description 32
- 230000002526 effect on cardiovascular system Effects 0.000 title description 9
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- 235000013793 astaxanthin Nutrition 0.000 claims description 54
- 239000001168 astaxanthin Substances 0.000 claims description 54
- 229940022405 astaxanthin Drugs 0.000 claims description 54
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 53
- 241000168517 Haematococcus lacustris Species 0.000 claims description 30
- 239000000284 extract Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 22
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 8
- YTMNONATNXDQJF-UBNZBFALSA-N chrysanthemin Chemical compound [Cl-].O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 YTMNONATNXDQJF-UBNZBFALSA-N 0.000 claims description 7
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 6
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- 235000003392 Curcuma domestica Nutrition 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 239000002199 base oil Substances 0.000 claims description 4
- 230000003177 cardiotonic effect Effects 0.000 claims description 4
- 235000003373 curcuma longa Nutrition 0.000 claims description 4
- 239000004148 curcumin Substances 0.000 claims description 4
- 235000012754 curcumin Nutrition 0.000 claims description 4
- 229940109262 curcumin Drugs 0.000 claims description 4
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 4
- 235000013976 turmeric Nutrition 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- 235000018062 Boswellia Nutrition 0.000 claims description 3
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 3
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 3
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- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 3
- 235000005875 quercetin Nutrition 0.000 claims description 3
- 229960001285 quercetin Drugs 0.000 claims description 3
- 229960000984 tocofersolan Drugs 0.000 claims description 3
- 239000002076 α-tocopherol Substances 0.000 claims description 3
- 235000004835 α-tocopherol Nutrition 0.000 claims description 3
- 240000007551 Boswellia serrata Species 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- 125000001020 α-tocopherol group Chemical group 0.000 claims description 2
- 241000195493 Cryptophyta Species 0.000 description 17
- 239000007901 soft capsule Substances 0.000 description 16
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- 229940068196 placebo Drugs 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000036284 oxygen consumption Effects 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 241001608538 Boswellia Species 0.000 description 1
- 241000195628 Chlorophyta Species 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 241001493577 Haematococcaceae Species 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 125000003999 astaxanthin group Chemical group 0.000 description 1
- 150000001514 astaxanthins Chemical class 0.000 description 1
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- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
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- 239000003814 drug Substances 0.000 description 1
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- 230000009931 harmful effect Effects 0.000 description 1
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- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
- 230000004065 mitochondrial dysfunction Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Description
ヘマトコッカス・プルビアリス由来のアスタキサンチンを含む栄養補助食品カプセルを使用する効果を評価するための研究を行った。より詳細には、健康な被験者に12mgのアスタキサンチンを8週間摂取してもらった。より詳細には、このアスタキサンチン栄養補助食品を、表1に示す成分と混和した。また、表1は各成分の量も示している。
アスタキサンチンの摂取によって、最大酸素摂取量(ランニング中のVO2max)又は最大パワー発揮能力(サイクリング中のワット数)を含む高強度運動条件における改善は見られなかった。興味深く、さらに意外なことに、アスタキサンチングループの被験者は、プラセボグループと比較して最大下ランニング強度(有酸素性作業閾値及び無酸素性作業閾値の両方)にて、有意~10%低い平均心拍数を示し、アスタキサンチン摂取の高い「心臓滋養強壮」効果及び最大下有酸素性持久強度における優れた代謝効率を示唆している、しかし最大努力下では見られなかった。
Claims (5)
- 健康な成人の運動中における有酸素性作業閾値の平均心拍数及び無酸素性作業閾値の平均心拍数を減少させるための、心臓滋養強壮作用を有する組成物であって、
前記組成物は、ヘマトコッカス・プルビアリス抽出物に由来するアスタキサンチンと、中鎖トリグリセリドである食用キャリアオイルと、D-α-トコフェロールである天然抗酸化物質と、を含む、組成物。 - 前記ヘマトコッカス・プルビアリス抽出物におけるアスタキサンチンの含有量が、1mg以上200mg以下である、請求項1に記載の組成物。
- 前記ヘマトコッカス・プルビアリス抽出物におけるアスタキサンチンの含有量が、1mg以上40mg以下である、請求項1に記載の組成物。
- 前記ヘマトコッカス・プルビアリス抽出物におけるアスタキサンチンの含有量が、1mg以上20mg以下である、請求項1に記載の組成物。
- 前記組成物は、さらに、
緑茶抽出物、
ケルセチン、
シアニジン-3-グルコシド(C3G)、
クルクミン/ウコン、
ボスウェリア(boswellia)、
ヒアルロン酸、のうちの一種又は複数種を含む、請求項1に記載の組成物。
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