JP2020503061A - 心血管性の効率に影響を与える栄養補助食品 - Google Patents
心血管性の効率に影響を与える栄養補助食品 Download PDFInfo
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- JP2020503061A JP2020503061A JP2019540483A JP2019540483A JP2020503061A JP 2020503061 A JP2020503061 A JP 2020503061A JP 2019540483 A JP2019540483 A JP 2019540483A JP 2019540483 A JP2019540483 A JP 2019540483A JP 2020503061 A JP2020503061 A JP 2020503061A
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- dietary supplement
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- extract
- astaxanthin
- haematococcus pluvialis
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- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 57
- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 13
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims abstract description 53
- 235000013793 astaxanthin Nutrition 0.000 claims abstract description 53
- 239000001168 astaxanthin Substances 0.000 claims abstract description 53
- 229940022405 astaxanthin Drugs 0.000 claims abstract description 53
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims abstract description 52
- 241000168517 Haematococcus lacustris Species 0.000 claims abstract description 28
- 239000000284 extract Substances 0.000 claims abstract description 26
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 9
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 9
- 239000002199 base oil Substances 0.000 claims abstract description 8
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 12
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 10
- YTMNONATNXDQJF-UBNZBFALSA-N chrysanthemin Chemical compound [Cl-].O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 YTMNONATNXDQJF-UBNZBFALSA-N 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 7
- 235000020688 green tea extract Nutrition 0.000 claims description 7
- 229940094952 green tea extract Drugs 0.000 claims description 7
- 244000163122 Curcuma domestica Species 0.000 claims description 6
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 6
- 230000003177 cardiotonic effect Effects 0.000 claims description 6
- 235000003373 curcuma longa Nutrition 0.000 claims description 6
- 239000004148 curcumin Substances 0.000 claims description 6
- 235000012754 curcumin Nutrition 0.000 claims description 6
- 229940109262 curcumin Drugs 0.000 claims description 6
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 6
- 235000013976 turmeric Nutrition 0.000 claims description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
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- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 5
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 5
- 229920002674 hyaluronan Polymers 0.000 claims description 5
- 229960003160 hyaluronic acid Drugs 0.000 claims description 5
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 235000005875 quercetin Nutrition 0.000 claims description 5
- 229960001285 quercetin Drugs 0.000 claims description 5
- 241000694540 Pluvialis Species 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 3
- 229960000984 tocofersolan Drugs 0.000 claims description 3
- 239000002076 α-tocopherol Substances 0.000 claims description 3
- 235000004835 α-tocopherol Nutrition 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims 3
- 239000008157 edible vegetable oil Substances 0.000 claims 1
- 229940057917 medium chain triglycerides Drugs 0.000 claims 1
- 235000014593 oils and fats Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 18
- 239000007901 soft capsule Substances 0.000 description 16
- 238000009472 formulation Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 239000013589 supplement Substances 0.000 description 6
- 230000001351 cycling effect Effects 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 4
- 230000037406 food intake Effects 0.000 description 4
- 238000011903 nutritional therapy Methods 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000036284 oxygen consumption Effects 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000195628 Chlorophyta Species 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 241000168525 Haematococcus Species 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 125000003999 astaxanthin group Chemical group 0.000 description 1
- 150000001514 astaxanthins Chemical class 0.000 description 1
- 230000037147 athletic performance Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 230000004065 mitochondrial dysfunction Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000036314 physical performance Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 125000001020 α-tocopherol group Chemical group 0.000 description 1
Classifications
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
ヘマトコッカス・プルビアリス由来のアスタキサンチンを含む栄養補助食品カプセルを使用する効果を評価するための研究を行った。より詳細には、健康な被験者に12mgのアスタキサンチンを8週間摂取してもらった。より詳細には、このアスタキサンチン栄養補助食品を、表1に示す成分と混和した。また、表1は各成分の量も示している。
アスタキサンチンの摂取によって、最大酸素摂取量(ランニング中のVO2max)又は最大パワー発揮能力(サイクリング中のワット数)を含む高強度運動条件における改善は見られなかった。興味深く、さらに意外なことに、アスタキサンチングループの被験者は、プラセボグループと比較して最大下ランニング強度(有酸素性作業閾値及び無酸素性作業閾値の両方)にて、有意〜10%低い平均心拍数を示し、アスタキサンチン摂取の高い「心臓滋養強壮」効果及び最大下有酸素性持久強度における優れた代謝効率を示唆している、しかし最大努力下では見られなかった。
Claims (22)
- ヘマトコッカス・プルビアリス抽出物(50%)と、
食用キャリアオイル(例えば中鎖トリグリセリド又は類似の食用油脂)(48%)と、
天然抗酸化物質(例えば、D−α−トコフェロール又はその他の天然抗酸化物質)(2%)と、を含む、栄養補助食品。 - ヘマトコッカス・プルビアリス抽出物に由来する1mg〜100mgのアスタキサンチンを含む、請求項1に記載の栄養補助食品。
- ソフトゲルカプセルとして製造される、請求項1〜2のいずれか一項に記載の栄養補助食品。
- さらに、
緑茶、
緑茶抽出物、
ケルセチン、
シアニジン−3−グルコシド(C3G)、
クルクミン/ウコン、
ボスウェリア(boswellia)、
ヒアルロン酸のうちの一種又は複数種を含む、請求項1〜3のいずれか一項に記載の栄養補助食品。 - 健康な成人に投与される場合に、心臓滋養強壮作用を促進するに効果的である、請求項1〜4のいずれか一項に記載の栄養補助食品。
- 健康な成人に投与される場合に、心血管性の効率の改善に効果的である、請求項1〜4のいずれか一項に記載の栄養補助食品。
- 被験者の心臓滋養強壮作用を促進する方法であって、
請求項1〜6のいずれか一項に記載の栄養補助食品を取得し、そして、
前記栄養補助食品を摂取することを含む、方法。 - 被験者の心血管性の効率を改善する方法であって、
請求項1〜6のいずれか一項に記載の栄養補助食品を取得し、そして、
前記栄養補助食品を摂取することを含む、方法。 - ヘマトコッカス・プルビアリス抽出物と、
食用キャリアオイルと、
天然抗酸化物質と、を含む、栄養補助食品。 - 前記食用キャリアオイルは中鎖トリグリセリドである、請求項9に記載の栄養補助食品。
- 前記天然抗酸化物質はD−α−トコフェロールである、請求項9に記載の栄養補助食品。
- 50%のヘマトコッカス・プルビアリス抽出物と、
48%の食用キャリアオイルと、
2%の天然抗酸化物質と、を含む、請求項9〜11のいずれか一項に記載の栄養補助食品。 - ヘマトコッカス・プルビアリス抽出物に由来する1mg〜100mgのアスタキサンチンを含む、請求項9〜12のいずれか一項に記載の栄養補助食品。
- ソフトゲルカプセル又は液体カプセルとして製造される、請求項9〜13のいずれか一項に記載の栄養補助食品。
- さらに、
緑茶、
緑茶抽出物、
ケルセチン、
シアニジン−3−グルコシド(C3G)、
クルクミン/ウコン、
ボスウェリア(boswellia)、
ヒアルロン酸のうちの一種又は複数種を含む、請求項9〜14のいずれか一項に記載の栄養補助食品。 - 5mg〜150mgの緑茶抽出物を含む、請求項15に記載の栄養補助食品。
- 1mg〜200mgのケルセチンを含む、請求項15に記載の栄養補助食品。
- 5mg〜400mgのC3Gを含む、請求項15に記載の栄養補助食品。
- 15mg〜250mgのクルクミン/ウコンを含む、請求項15に記載の栄養補助食品。
- 1mg〜100mgのボスウェリアを含む、請求項15に記載の栄養補助食品。
- 5mg〜150mgのヒアルロン酸を含む、請求項15に記載の栄養補助食品。
- 請求項9〜21のいずれか一項に記載の栄養補助食品の心臓滋養強壮作用を促進するか又は心血管性の効率を改善する薬物の製造における用途。
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