JP7307067B2 - モルフィナンのハロゲン化誘導体およびその使用 - Google Patents

モルフィナンのハロゲン化誘導体およびその使用 Download PDF

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Publication number: JP7307067B2
Authority: JP; Japan
Prior art keywords: compound; administered; formula; pain; group
Prior art date: 2017-12-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2020531724A

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English (en)

Japanese (ja)

Other versions

JPWO2019118583A5 (fr

JP2021506768A (ja

Inventor

レイモンドエー．チャベス，

スティーブンコリンズ，

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Xalud Therapeutics inc

Original Assignee

Xalud Therapeutics inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-12-12

Filing date

2018-12-12

Publication date

2023-07-11

2018-12-12 Application filed by Xalud Therapeutics inc filed Critical Xalud Therapeutics inc

2021-02-22 Publication of JP2021506768A publication Critical patent/JP2021506768A/ja

2023-04-19 Publication of JPWO2019118583A5 publication Critical patent/JPWO2019118583A5/ja

2023-07-11 Application granted granted Critical

2023-07-11 Publication of JP7307067B2 publication Critical patent/JP7307067B2/ja

Status Active legal-status Critical Current

2038-12-12 Anticipated expiration legal-status Critical

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ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
LVLANIHJQRZTPY-UHFFFAOYSA-N vinyl carbamate Chemical compound NC(=O)OC=C LVLANIHJQRZTPY-UHFFFAOYSA-N 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000002023 wood Substances 0.000 description 1
125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
239000011701 zinc Substances 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

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PCT/US2018/065185 WO2019118583A1 (fr)	2017-12-12	2018-12-12	Dérivés halogénés de morphinanes et leurs utilisations

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CN (1)	CN111698987A (fr)
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BR (1)	BR112020010901A2 (fr)
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CA3085321A1 (fr)	2019-06-20
AU2018383773A1 (en)	2020-06-11
US20230203053A1 (en)	2023-06-29
IL274610A (en)	2020-06-30
IL274610B1 (en)	2023-08-01
EP3723749A4 (fr)	2022-06-08
IL274610B2 (en)	2023-12-01
BR112020010901A2 (pt)	2020-11-17
EP3723749A1 (fr)	2020-10-21
KR20200097309A (ko)	2020-08-18
US20210087202A1 (en)	2021-03-25
WO2019118583A1 (fr)	2019-06-20
CA3085321C (fr)	2023-10-31
JP2021506768A (ja)	2021-02-22
CN111698987A (zh)	2020-09-22
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