JP6901398B2 - 注射デバイスのセンサ装置 - Google Patents
注射デバイスのセンサ装置 Download PDFInfo
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- JP6901398B2 JP6901398B2 JP2017546763A JP2017546763A JP6901398B2 JP 6901398 B2 JP6901398 B2 JP 6901398B2 JP 2017546763 A JP2017546763 A JP 2017546763A JP 2017546763 A JP2017546763 A JP 2017546763A JP 6901398 B2 JP6901398 B2 JP 6901398B2
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D5/00—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable
- G01D5/12—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means
- G01D5/14—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage
- G01D5/142—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage using Hall-effect devices
- G01D5/145—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage using Hall-effect devices influenced by the relative movement between the Hall device and magnetic fields
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
2 近位方向
10 センサ装置
12 細長部材
12a、b、c、d、e セクション
14 コーティング
20 センサ
21.1 センサ要素
22.2 センサ要素
22.3 センサ要素
24 センサアレイ
30 第2の部材
36 ねじ山
40 センサ制御部
42 電源
44 プロセッサ
46 ディスプレイ
48 通信ユニット
50 センサハウジング
52 固定部
100 注射デバイス
102 ハウジング
103 駆動機構
104 カートリッジホルダ
106 ニードルアセンブリ
108 内側針キャップ
110 外側針キャップ
112 保護キャップ
114 用量ダイヤル
116 投薬量窓
120 注射ボタン
122 カートリッジ
124 胴部
126 ピストン
128 封止材
130 ピストンロッド
132 圧力部片
140 用量インジケータ
150 駆動スリーブ
212 細長部材
212a、b、c、d、e セクション
214 コーティング
216 ねじ山
Claims (14)
- 注射デバイス(100)のハウジング(102)の内側で、注射デバイス(100)の少なくとも1つのデバイス部材(12;212;30)の軸方向位置を決定するための、注射デバイス(100)のセンサ装置(10)であって:
ハウジング(102)の内側に位置し、ハウジング(102)の軸方向(1、2)に延びるとともに、磁化が異なる少なくとも第1のセクション(12a;212a)および第2のセクション(12b、12c、12d;212b、212c、212d)を有する、細長部材(12、212)、ここで、第1のセクション(12a;212a)および第2のセクション(12b、12c、12d;212b、212c、212d)は互いに軸方向に隣接して位置し、軸方向に重なり合わないように軸方向(1、2)に互いに分離している、と、
第1および第2のセクション(12a、12b、12c、12d;212a、212b、212c、212d)のうちの少なくとも1つの軸方向位置を検出するためにハウジング(102)に取り付けられた、少なくとも1つの磁気センサ要素(22.1、22.2、22.3)とを含む、前記センサ装置。 - 細長部材(12;212)は、異なるように磁化された螺旋パターンのセクション(12a、12b、12c、12d;212a、212b、212c、212d)を含む、請求項1に記載のセンサ装置。
- 軸方向に分離された複数のセンサ要素(22.1、22.2、22.3)を有する磁気センサアレイ(24)をさらに含む、請求項1〜2のいずれか1項に記載のセンサ装置。
- 細長部材(12;212)は磁化材料から構成される、請求項1〜3のいずれか1項に記載のセンサ装置。
- 細長部材(12;212)は磁化コーティング(14;214)を含む、請求項1〜4のいずれか1項に記載のセンサ装置。
- 細長部材(12;212)の第1のセクション(12a;212a)および第2のセクション(12b、12c、12d;212b、212c、212d)の磁場ベクトルが軸方向(1、2)に対して垂直に広がる平面内にある、請求項1〜5のいずれか1項に記載のセンサ装置。
- 軸方向(1、2)に沿って見て、細長部材(12;212)の軸方向に隣接するセクション(12a、12b、12c、12d;212a、212b、212c、212d)の磁場ベクトルの方向が一定のオフセット角だけ変化する、請求項1〜6のいずれか1項に記載のセンサ装置。
- 細長部材(12)は、それぞれ異なる磁化を有している、少なくとも4つの軸方向に隣接するセクション(12a、12b、12c、12d;212a、212b、212c、212d)に分けられる、請求項1〜7のいずれか1項に記載のセンサ装置。
- 細長部材(12;212)は、ハルバッハアレイを構成する磁化の異なる、少なくとも4つの軸方向に隣接するセクション(12a、12b、12c、12d;212a、212b、212c、212d)を有する、請求項1〜8のいずれか1項に記載のセンサ装置。
- 第1の磁化を有する第一のセクション(12a;212a)および第2の磁化を有する第2のセクション(12b、12c、12d;212b、212c、212d)が、軸方向(1、2)に実質的に垂直な平面に、細長部材の断面全体にわたって延びる、請求項1〜9のいずれか1項に記載のセンサ装置。
- 細長部材(12;212)は、ピストンロッド(130)、用量インジケータ(140)、または注射デバイスの駆動部材(103)の駆動スリーブ(150)のうちの1つである、請求項1〜10のいずれか1項に記載のセンサ配置。
- 少なくとも1つのセンサ要素(22)またはセンサアレイ(24)は、注射デバイス(100)のハウジング(102)に取り付け可能なセンサハウジング(50)内に配置される、請求項1〜11のいずれか1項に記載のセンサ配置。
- 液体薬剤の用量を設定および注射するための注射デバイスであって、
薬剤が充填されたカートリッジ(122)を収容するためのハウジング(102)と、
カートリッジ(122)のピストン(126)と動作可能に係合するためのピストンロッド(130)を含む駆動機構(103)と、
ハウジング(102)に取り付けられた、またはハウジング(102)の内側に配置された、請求項1〜12のいずれか1項に記載のセンサ装置(10)とを含む、前記注射デバイス。 - 薬剤が充填されたカートリッジ(122)をさらに含む、請求項13に記載の注射デバイス。
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EP15158011.5 | 2015-03-06 | ||
EP15158011 | 2015-03-06 | ||
PCT/EP2016/054324 WO2016142216A1 (en) | 2015-03-06 | 2016-03-01 | Sensor arrangement for an injection device |
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JP2018507068A JP2018507068A (ja) | 2018-03-15 |
JP6901398B2 true JP6901398B2 (ja) | 2021-07-14 |
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EP (2) | EP3984573A1 (ja) |
JP (1) | JP6901398B2 (ja) |
CN (1) | CN107405453B (ja) |
DK (1) | DK3265151T3 (ja) |
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US11660400B2 (en) | 2023-05-30 |
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US10518040B2 (en) | 2019-12-31 |
EP3265151A1 (en) | 2018-01-10 |
HK1244727A1 (zh) | 2018-08-17 |
CN107405453A (zh) | 2017-11-28 |
CN107405453B (zh) | 2020-12-04 |
WO2016142216A1 (en) | 2016-09-15 |
EP3984573A1 (en) | 2022-04-20 |
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DK3265151T3 (da) | 2022-02-14 |
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